Deficiency in the Nuclease Activity of Xeroderma Pigmentosum G in Mice Leads to Hypersensitivity to UV Irradiation

Molecular and Cellular Biology

Volumn 24, Issue 6, 2004, Pages 2237-2242

  Tian, Ming ^a   Jones, David A ^a   Smith, Michele ^a   Shinkura, Reiko ^a   Alt, Frederick W ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENDONUCLEASE; GENE PRODUCT; IMMUNOGLOBULIN HEAVY CHAIN; NUCLEASE; PROTEIN XPG; UNCLASSIFIED DRUG;

ANIMAL MODEL; ARTICLE; DNA ADDUCT; DNA DAMAGE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME DEFICIENCY; EXCISION REPAIR; GENE MUTATION; GROWTH DISORDER; INCIDENCE; MOUSE; NONHUMAN; PHENOTYPE; PHOTOALLERGY; POINT MUTATION; POSTNATAL GROWTH; PRIORITY JOURNAL; PROTEIN DEGRADATION; SKIN CANCER; SUNLIGHT; ULTRAVIOLET IRRADIATION; XERODERMA PIGMENTOSUM;

ANIMALS; BASE SEQUENCE; DNA REPAIR; DNA, COMPLEMENTARY; DNA-BINDING PROTEINS; ENDONUCLEASES; HUMANS; IMMUNOGLOBULIN CLASS SWITCHING; MICE; MICE, MUTANT STRAINS; NUCLEAR PROTEINS; PHENOTYPE; POINT MUTATION; SKIN; TRANSCRIPTION FACTORS; ULTRAVIOLET RAYS; XERODERMA PIGMENTOSUM;

ANIMALIA;

EID: 1542284083     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.24.6.2237-2242.2004     Document Type: Article

References (33)

1. Araujo, S. J., E. A. Nigg, and R. D. Wood. 2001. Strong functional interactions of TFIIH with XPC and XPG in human DNA nucleotide excision repair, without a preassembled repairosome. Mol. Cell. Biol. 21:2281-2291.
2. Berneburg, M., and A. R. Lehmann. 2001. Xeroderma pigmentosum and related disorders: defects in DNA repair and transcription. Adv. Genet. 43:71-102.
3. Bessho, T. 1999. Nucleotide excision repair 3′ endonuclease XPG stimulates the activity of base excision repair enzyme thymine glycol DNA glycosylase. Nucleic Acids Res. 27:979-983.
4. Constantinou, A., D. Gunz, E. Evans, P. Lalle, P. A. Bates, R. D. Wood., and S. G. Clarkson. 1999. Conserved residues of human XPG protein important for nuclease activity and function in nucleotide excision repair. J. Biol. Chem. 274:5637-5648.
5. de Boer, J., and J. H. Hoeijmakers. 2000. Nucleotide excision repair and human syndromes. Carcinogenesis 21:453-460.
6. de Vries, A., C. T. van Oostrom, F. M. Hofhuis, P. M. Dortant, R. J. Berg, F. R. de Gruijl, P. W. Wester, C. F. van Kreijl, P. J. Capel, H. van Steeg, and S. J. Verbeek. 1995. Increased susceptibility to ultraviolet-B and carcinogens of mice lacking the DNA excision repair gene XPA. Nature 377:169-173.
7. Emmert, S., H. Slor, D. B. Busch, S. Batko, R. B. Albert, D. Coleman, S. G. Khan, B. Abu-Libdeh, J. J. DiGiovanna, B. B. Cunningham, M. M. Lee, J. Crollick, H. Inui, T. Ueda, M. Hedayati, L. Grossman, T. Shahlavi, J. E. Cleaver, and K. H. Kraemer. 2002. Relationship of neurologic degeneration to genotype in three xeroderma pigmentosum group G patients. J. Investig. Dermatol. 118:972-982.
8. Harada, Y. N., N. Shiomi, M. Koike, M. Ikawa, M. Okabe, S. Hirota, Y. Kitamura, M. Kitagawa, T. Matsunaga, O. Nikaido, and T. Shiomi. 1999. Postnatal growth failure, short life span, and early onset of cellular senescence and subsequent immortalization in mice lacking the xeroderma pigmentosum group G gene. Mol. Cell. Biol. 19:2366-2372.
9. Iyer, N., M. S. Reagan, K. J. Wu, B. Canagarajah, and E. C. Friedberg. 1996. Interactions involving the human RNA polymerase II transcription/nucleotide excision repair complex TFIIH, the nucleotide excision repair protein XPG, and Cockayne syndrome group B (CSB) protein. Biochemistry 35: 2157-2167.
10. Klungland, A., M. Hoss, D. Gunz, A. Constantinou, S. G. Clarkson, P. W. Doetsch, P. H. Bolton, R. D. Wood, and T. Lindahl. 1999. Base excision repair of oxidative DNA damage activated by XPG protein. Mol. Cell 3:33-42.
11. Lakso, M., J. G. Pichel, J. R. Gorman, B. Sauer, Y. Okamoto, E. Lee, F. W. Alt, and H. Westphal. 1996. Efficient in vivo manipulation of mouse genomic sequences at the zygote stage. Proc. Natl. Acad. Sci. USA 93:5860-5865.
12. Lalle, P., T. Nouspikel, A. Constantinou, F. Thorel, and S. G. Clarkson. 2002. The founding members of xeroderma pigmentosum group G produce XPG protein with severely impaired endonuclease activity. J. Investig. Dermatol. 118:344-351.
13. Lee, S. K., S. L. Yu, L. Prakash, and S. Prakash. 2002. Requirement of yeast RAD2, a homolog of human XPG gene, for efficient RNA polymerase II transcription. Implications for Cockayne syndrome. Cell 109:823-834.
14. Ludwig, D. L., J. S. Mudgett, M. S. Park, A. V. Perez-Castro, and M. A. MacInnes. 1996. Molecular cloning and structural analysis of the functional mouse genomic XPG gene. Mamm. Genome 7:644-649.
15. Matsunaga, T., D. Mu, C. H. Park, J. T. Reardon, and A. Sancar. 1995. Human DNA repair excision nuclease. Analysis of the roles of the subunits involved in dual incisions by using anti-XPG and anti-ERCC1 antibodies. J. Biol. Chem. 270:20862-20869.
16. McWhir, J., J. Selfridge, D. J. Harrison, S. Squires, and D. W. Melton. 1993. Mice with DNA repair gene (ERCC-1) deficiency have elevated levels of p53, liver nuclear abnormalities and die before weaning. Nat. Genet. 5:217-224.
17. Mu, D., C. H. Park, T. Matsunaga, D. S. Hsu, J. T. Reardon, and A. Sancar. 1995. Reconstitution of human DNA repair excision nuclease in a highly defined system. J. Biol. Chem. 270:2415-2418.
18. Mueser, T. C., N. G. Nossal, and C. C. Hyde. 1996. Structure of bacteriophage T4 RNase H, a 5′ to 3′ RNA-DNA and DNA-DNA exonuclease with sequence similarity to the RAD2 family of eukaryotic proteins. Cell 85:1101-1112.
19. Nakane, H., S. Takeuchi, S. Yuba, M. Saijo, Y. Nakatsu, H. Murai, Y. Nakatsuru, T. Ishikawa, S. Hirota, Y. Kitamura, Y. Kato, Y. Tsunoda, H. Miyauchi, T. Horio, T. Tokunaga, T. Matsunaga, O. Nikaido, Y. Nishimune, Y. Okada, and K. Tanaka. 1995. High incidence of ultraviolet-B- or chemical-carcinogen-induced skin tumours in mice lacking the xeroderma pigmentosum group A gene. Nature 377:165-168.
20. Nouspikel, T., and S. G. Clarkson. 1994. Mutations that disable the DNA repair gene XPG in a xeroderma pigmentosum group G patient. Hum. Mol. Genet. 3:963-967.
21. Nouspikel, T., P. Lalle, S. A. Leadon, P. K. Cooper, and S. G. Clarkson. 1997. A common mutational pattern in Cockayne syndrome patients from xeroderma pigmentosum group G: implications for a second XPG function. Proc. Natl. Acad. Sci. USA 94:3116-3121.
22. O'Donovan, A., A. A. Davies, J. G. Moggs, S. C. West, and R. D. Wood. 1994. XPG endonuclease makes the 3′ incision in human DNA nucleotide excision repair. Nature 371:432-435.
23. Petit, C., and A. Sancar. 1999. Nucleotide excision repair: from E. coli to man. Biochimie 81:15-25.
24. Sands, A. T., A. Abuin, A. Sanchez, C. J. Conti, and A. Bradley. 1995. High susceptibility to ultraviolet-induced carcinogenesis in mice lacking XPC. Nature 377:162-165.
25. Shinkura, R., M. Tian, M. Smith, K. Chua, Y. Fujiwara, and F. W. Alt. 2003. The influence of transcriptional orientation on endogenous switch region function. Nat. Immunol. 4:435-441.
26. Svejstrup, J. Q., P. Vichi, and J. M. Egly. 1996. The multiple roles of transcription/repair factor TFIIH. Trends Biochem. Sci. 21:346-350.
27. Tian, M., and F. W. Alt. 2000. Transcription-induced cleavage of immunoglobulin switch regions by nucleotide excision repair nucleases in vitro. J. Biol. Chem. 275:24163-24172.
28. Tian, M., R. Shinkura, N. Shinkura, and F. W. Alt. 2004. Growth retardation, early death, and DNA repair defects in mice deficient for the nucleotide excision repair enzyme XPF. Mol. Cell. Biol. 24:1200-1205.
29. Wakasugi, M., J. T. Reardon, and A. Sancar. 1997. The non-catalytic function of XPG protein during dual incision in human nucleotide excision repair. J. Biol. Chem. 272:16030-16034.
30. Weeda, G., I. Donker, J. de Wit, H. Morreau, R. Janssens, C. J. Vissers, A. Nigg, H. van Steeg, D. Bootsma, and J. H. Hoeijmakers. 1997. Disruption of mouse ERCC1 results in a novel repair syndrome with growth failure, nuclear abnormalities and senescence. Curr. Biol. 7:427-439.
31. Winter, A. G., K. Samuel, K. T. Hsia, and D. W. Melton. 2003. The repair and recombination enzyme ERCC1 is not required for immunoglobulin class switching. DNA Repair 2:561-569.
32. Wood, R. D., S. J. Araujo, R. R. Ariza, D. P. Batty, M. Biggerstaff, E. Evans, P. H. Gaillard, D. Gunz, B. Koberle, I. Kuraoka, J. G. Moggs, J. K. Sandall, and M. K. Shivji. 2000. DNA damage recognition and nucleotide excision repair in mammalian cells. Cold Spring Harbor Symp. Quant. Biol. 65:173-182.
33. Yu, K., F. Chedin, C. L. Hsieh, T. E. Wilson, and M. R. Lieber. 2003. R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells. Nat. Immunol. 4:442-451.