Palindromic but not G-rich sequences are targets of class switch recombination

International Immunology

Volumn 13, Issue 4, 2001, Pages 495-505

  Tashiro, J ^a   Kinoshita, K ^a   Honjo, T ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Artificial switch constructs; B lymphoma cells; Breakpoint sequence; S sequence; Secondary structure

Indexed keywords

ADENINE; GUANINE; PALINDROMIC DNA; RECOMBINASE; REPETITIVE DNA; SINGLE STRANDED DNA; THYMINE;

ANIMAL CELL; ARTICLE; AT RICH SEQUENCE; B CELL LYMPHOMA; CHICKEN; CONTROLLED STUDY; DNA CLEAVAGE; DNA RECOMBINATION; DNA SEQUENCE; DNA STRAND BREAKAGE; DNA STRUCTURE; DNA TRANSCRIPTION; GENE CONSTRUCT; LYMPHOMA CELL LINE; MOLECULAR CLONING; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; STRUCTURE ANALYSIS; TELOMERE; XENOPUS;

XENOPUS;

EID: 0035067615     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/13.4.495     Document Type: Article

References (42)

1. V(D) J recombination: On the cutting edge
2. Somatic hypermutation of immunoglobulin genes
3. Immunoglobulin class switching
4. Unique and unprecedented recombination mechanisms in class switching
5. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme
6. Activation cytidine deaminase (AID) deficiency causes autosomal recessive form of the hyper-IgM syndrome (HIGM2)
7. Target specificity of immunoglobulin class switch recombination is not determined by nucleotide sequences of S regions
8. Class switch recombination of the chicken IgH chain genes: Implications for the primordial switch region repeats
9. Microsites for immunoglobulin switch recombination breakpoints from Xenopus to mammals
10. Nucleotide sequence analysis of the C.AKR Lyt-2a gene: Structural polymorphism in alleles encoding the Lyt-2.1 T-cell surface alloantigen
11. SRα promoter: An efficient and versatile mammalian cDNA expression system composed of the simian virus 40 early promoter and the R-U5 segment of human T-cell leukemia virus type 1 long terminal repeat
12. pEF-BOS, a powerful mammalian expression vector
13. Dominant positive and negative selection using a hygromycin phosphotransferase-thymidine kinase fusion gene
14. Chicken immunoglobulin mu-chain gene: Germline organization and tandem repeats characteristics of class switch recombination
15. Telomeres: Do the ends justify the means?
16. Mapping and characterization of three YAC clones containing TTAGGG arrays
17. -) thymocytes
18. + cells
19. Formation of parallel four-stranded complexes by guanine-rich motifs in DNA and its implications for meiosis
20. A sodium-potassium switch in the formation of four-stranded G4-DNA
21. Repetitive sequences in class-switch recombination regions of immunoglobulin heavy chain genes
22. Human immunoglobulin transgenes undergo rearrangement, somatic mutation and class switching in mice that lack endogenous IgM
23. Functional transplant of megabase human immunoglobulin loci recapitulates human antibody response in mice
24. Secondary structure for the apolipoprotein B mRNA editing site. Au-binding proteins interact with a stem loop
25. Changing genetic information through RNA editing
26. Functional importance of sequence in the stem-loop of a transcription terminator
27. DNA sequences at immnoglobulin switch region recombination sites
28. Frequent occurrence of deletions and duplications during somatic hypermutation: Implications for oncogene translocations and heavy chain disease
29. Somatic hypermutation introduces insertions and deletions into immunoglobulin V genes
30. Cell-cycle-regulated DNA double-strand breaks in somatic hypermutation of immunoglobulin genes
31. DNA double-strand breaks in immunoglobulin genes undergoing somatic hypermutation
32. Somatic hypermutation of immunoglubulin gens is inked to transcription initiation
33. The transcriptional promoter regulates hypermutation of the antibody heavy chain locus
34. Somatic hypermutation in the heavy chain locus correlates with transcription
35. A hypermutable insert in an immunoglobulin transgene contains hotspots of somatic mutation and sequences predicting highly stable structures in the RNA transcript
36. Lambda ZAP: A bacteriophage lambda expression vector with in vivo excision properties
37. Telomeres: Do the ends justify the means?
38. Mapping and characterization of three YAC clones containing TTAGGG arrays
39. μ gene is composed of simple tandem repetitive sequences
40. The complete murine immunoglobulin class switch region of the alpha heavy chain gene-hierarchic repetitive structure and recombination breakpoints
41. Immunoglobulin transgenes as targets for somatic hypermutation
42. BCL-6 mutations in normal germinal center B cells: Evidence of somatic hypermutation acting outside lg loci