Mutations occur in the Ig Sμ region but rarely in Sγ regions prior to class switch recombination

EMBO Journal

Volumn 22, Issue 21, 2003, Pages 5893-5903

  Schrader, Carol E ^a   Bradley, Sean P ^a   Vardo, Joycelyn ^a   Mochegova, Sofia N ^a   Flanagan, Erin ^a   Stavnezer, Janet ^b  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b NONE

Author keywords

Class switch recombination; Mismatch repair; Msh2; Mutations; TdT

Indexed keywords

ARGINYLGLYCYLTYROSYLTRYPTOPHAN; CYTOSINE; DNA; DNA NUCLEOTIDYLEXOTRANSFERASE; GUANINE; IMMUNOGLOBULIN; IMMUNOGLOBULIN S; IMMUNOGLOBULIN S GAMMA; IMMUNOGLOBULIN S MU; IMMUNOGLOBULIN SUBCLASS; PEPTIDE; TRYPTOPHYLARGINYLCYSTEINYLTYROSINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BASE PAIRING; CELL ACTIVATION; CONTROLLED STUDY; DNA RECOMBINATION; ENZYME ACTIVITY; ENZYME MECHANISM; GENE EXPRESSION; GENE INDUCTION; GENE INSERTION; GENE LOCATION; GENE MUTATION; GENE SWITCHING; GENETIC RECOMBINATION; GERM LINE; IMMUNOGLOBULIN GENE; MISMATCH REPAIR; MOLECULAR CLONING; MOUSE; MUTATION RATE; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SPLEEN BETA CELL; SPLEEN CELL; TRANSGENE; TRANSGENIC MOUSE;

ANIMALS; B-LYMPHOCYTES; BASE COMPOSITION; BASE SEQUENCE; DNA; DNA NUCLEOTIDYLEXOTRANSFERASE; DNA REPAIR; DNA-BINDING PROTEINS; IMMUNOGLOBULIN SWITCH REGION; LYMPHOCYTE ACTIVATION; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; MUTATION; MUTS HOMOLOG 2 PROTEIN; PROTO-ONCOGENE PROTEINS; RECOMBINANT PROTEINS; RECOMBINATION, GENETIC;

ANIMALIA; INSERTION SEQUENCES; MUS MUSCULUS;

EID: 0242473148     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdg550     Document Type: Article

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