메뉴 건너뛰기




Volumn 40, Issue 3, 2004, Pages 539-551

Regulation of bile acid synthesis: Pathways, nuclear receptors, and mechanisms

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS RECEPTOR; DEXAMETHASONE; HORMONE RECEPTOR STIMULATING AGENT; LIVER X RECEPTOR; LIVER X RECEPTOR AGONIST; PREGNANE X RECEPTOR; PREGNANE X RECEPTOR AGONIST; RIFAMPICIN; UNCLASSIFIED DRUG;

EID: 1242269851     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2003.11.006     Document Type: Review
Times cited : (427)

References (155)
  • 1
    • 0037790917 scopus 로고    scopus 로고
    • The enzymes, regulation, and genetics of bile acid synthesis
    • Russell D.W. The enzymes, regulation, and genetics of bile acid synthesis. Annu Rev Biochem. 72:2003;137-174.
    • (2003) Annu Rev Biochem , vol.72 , pp. 137-174
    • Russell, D.W.1
  • 2
    • 0038649773 scopus 로고    scopus 로고
    • Ursodeoxycholic acid for primary biliary cirrhosis: Treat early to slow progression
    • Paumgartner G. Ursodeoxycholic acid for primary biliary cirrhosis: treat early to slow progression. J Hepatol. 39:2003;112-114.
    • (2003) J Hepatol , vol.39 , pp. 112-114
    • Paumgartner, G.1
  • 3
    • 0036736781 scopus 로고    scopus 로고
    • Do oxysterols control cholesterol homeostasis?
    • Bjorkhem I. Do oxysterols control cholesterol homeostasis? J Clin Invest. 110:2002;725-730.
    • (2002) J Clin Invest , vol.110 , pp. 725-730
    • Bjorkhem, I.1
  • 4
    • 0035860807 scopus 로고    scopus 로고
    • Side chain hydroxylations in bile acid biosynthesis catalyzed by CYP3A are markedly up-regulated in Cyp27-/- mice but not in cerebrotendinous xanthomatosis
    • Honda A., Salen G., Matsuzaki Y., Batta A.K., Xu G., Leitersdorf E., et al. Side chain hydroxylations in bile acid biosynthesis catalyzed by CYP3A are markedly up-regulated in Cyp27-/- mice but not in cerebrotendinous xanthomatosis. J Biol Chem. 276:2001;34579-34585.
    • (2001) J Biol Chem , vol.276 , pp. 34579-34585
    • Honda, A.1    Salen, G.2    Matsuzaki, Y.3    Batta, A.K.4    Xu, G.5    Leitersdorf, E.6
  • 5
    • 0032545281 scopus 로고    scopus 로고
    • CDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolism
    • Lund E.G., Kerr T.A., Sakai J., Li W.P., Russell D.W. cDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolism. J Biol Chem. 273:1998;34316-34327.
    • (1998) J Biol Chem , vol.273 , pp. 34316-34327
    • Lund, E.G.1    Kerr, T.A.2    Sakai, J.3    Li, W.P.4    Russell, D.W.5
  • 6
    • 0023801335 scopus 로고
    • Quantitative importance of the 25-hydroxylation pathway for bile acid biosynthesis in the rat
    • Duane W.C., Bjorkhem I., Hamilton J.N., Mueller S.M. Quantitative importance of the 25-hydroxylation pathway for bile acid biosynthesis in the rat. Hepatology. 8:1988;613-618.
    • (1988) Hepatology , vol.8 , pp. 613-618
    • Duane, W.C.1    Bjorkhem, I.2    Hamilton, J.N.3    Mueller, S.M.4
  • 7
    • 0033594903 scopus 로고    scopus 로고
    • CDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain
    • Lund E.G., Guileyardo J.M., Russell D.W. cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain. Proc Natl Acad Sci USA. 96:1999;7238-7243.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 7238-7243
    • Lund, E.G.1    Guileyardo, J.M.2    Russell, D.W.3
  • 8
    • 0038265008 scopus 로고    scopus 로고
    • Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover
    • Lund E.G., Xie C., Kotti T., Turley S.D., Dietschy J.M., Russell D.W. Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover. J Biol Chem. 278:2003;22980-22988.
    • (2003) J Biol Chem , vol.278 , pp. 22980-22988
    • Lund, E.G.1    Xie, C.2    Kotti, T.3    Turley, S.D.4    Dietschy, J.M.5    Russell, D.W.6
  • 9
    • 0034595650 scopus 로고    scopus 로고
    • Expression cloning of an oxysterol 7α-hydroxylase selective for 24- hydroxycholesterol
    • Li-Hawkins J., Lund E.G., Bronson A.D., Russell D.W. Expression cloning of an oxysterol 7α-hydroxylase selective for 24- hydroxycholesterol. J Biol Chem. 275:2000;16543-16549.
    • (2000) J Biol Chem , vol.275 , pp. 16543-16549
    • Li-Hawkins, J.1    Lund, E.G.2    Bronson, A.D.3    Russell, D.W.4
  • 10
    • 8944255200 scopus 로고
    • I.M. Arias, J.L. Boyer, N. Fausto, W.B. Jakoby, D. Schachter, & D.A. Shafritz. New York: Raven Press
    • Carey M.C., Duane W.C. Arias I.M., Boyer J.L., Fausto N., Jakoby W.B., Schachter D., Shafritz D.A. The liver: biology and pathology. 1994;719-768 Raven Press, New York.
    • (1994) The Liver: Biology and Pathology , pp. 719-768
    • Carey, M.C.1    Duane, W.C.2
  • 11
    • 0033611305 scopus 로고    scopus 로고
    • The continuing importance of bile acids in liver and intestinal disease
    • Hofmann A.F. The continuing importance of bile acids in liver and intestinal disease. Arch Intern Med. 159:1999;2647-2658.
    • (1999) Arch Intern Med , vol.159 , pp. 2647-2658
    • Hofmann, A.F.1
  • 12
    • 0036668184 scopus 로고    scopus 로고
    • Bile acid regulation of gene expression: Roles of nuclear hormone receptors
    • Chiang J.Y. Bile acid regulation of gene expression: roles of nuclear hormone receptors. Endocr Rev. 23:2002;443-463.
    • (2002) Endocr Rev , vol.23 , pp. 443-463
    • Chiang, J.Y.1
  • 13
    • 0037369402 scopus 로고    scopus 로고
    • Bile acid regulation of hepatic physiology: III. Bile acids and nuclear receptors
    • Chiang J.Y. Bile acid regulation of hepatic physiology: III. Bile acids and nuclear receptors. Am J Physiol Gastrointest Liver Physiol. 284:2003;G349-G356.
    • (2003) Am J Physiol Gastrointest Liver Physiol , vol.284
    • Chiang, J.Y.1
  • 14
    • 0028278187 scopus 로고
    • Identification and characterization of a putative bile acid responsive element in cholesterol 7α-hydroxylase gene promoter
    • Chiang J.Y.L., Stroup D. Identification and characterization of a putative bile acid responsive element in cholesterol 7α-hydroxylase gene promoter. J Biol Chem. 269:1994;17502-17507.
    • (1994) J Biol Chem , vol.269 , pp. 17502-17507
    • Chiang, J.Y.L.1    Stroup, D.2
  • 15
    • 0000778664 scopus 로고    scopus 로고
    • Regulation of bile acid synthesis
    • Chiang J.Y.L. Regulation of bile acid synthesis. Front Biosci. 3:1998;D176-D193.
    • (1998) Front Biosci , vol.3
    • Chiang, J.Y.L.1
  • 18
    • 0033617520 scopus 로고    scopus 로고
    • Orphan nuclear receptors: Shifting endocrinology into reverse
    • Kliewer S.A., Lehmann J.M., Wilson T.M. Orphan nuclear receptors: shifting endocrinology into reverse. Science. 284:1999;757-760.
    • (1999) Science , vol.284 , pp. 757-760
    • Kliewer, S.A.1    Lehmann, J.M.2    Wilson, T.M.3
  • 19
    • 0035976638 scopus 로고    scopus 로고
    • Nuclear receptors and lipid physiology: Opening the X-files
    • Chawla A., Repa J.J., Evans R.M., Mangelsdorf D.J. Nuclear receptors and lipid physiology: opening the X-files. Science. 294:2001;1866-1870.
    • (2001) Science , vol.294 , pp. 1866-1870
    • Chawla, A.1    Repa, J.J.2    Evans, R.M.3    Mangelsdorf, D.J.4
  • 20
    • 0033305499 scopus 로고    scopus 로고
    • Orphan nuclear receptors: From gene to function
    • Giguere V. Orphan nuclear receptors: from gene to function. Endocr Rev. 20:1999;689-725.
    • (1999) Endocr Rev , vol.20 , pp. 689-725
    • Giguere, V.1
  • 21
    • 0035851148 scopus 로고    scopus 로고
    • Orphan nuclear receptors: The exotics of xenobiotics
    • Xie W., Evans R.M. Orphan nuclear receptors: the exotics of xenobiotics. J Biol Chem. 276:2001;37739-37742.
    • (2001) J Biol Chem , vol.276 , pp. 37739-37742
    • Xie, W.1    Evans, R.M.2
  • 24
    • 0033026760 scopus 로고    scopus 로고
    • Endogenous bile acids are ligands for the nuclear receptor FXR/BAR
    • Wang H., Chen J., Hollister K., Sowers L.C., Forman B.M. Endogenous bile acids are ligands for the nuclear receptor FXR/BAR. Mol Cell. 3:1999;543-553.
    • (1999) Mol Cell , vol.3 , pp. 543-553
    • Wang, H.1    Chen, J.2    Hollister, K.3    Sowers, L.C.4    Forman, B.M.5
  • 28
    • 0035853057 scopus 로고    scopus 로고
    • An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids
    • Xie W., Radominska-Pandya A., Shi Y., Simon C.M., Nelson M.C., Ong E.S., et al. An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids. Proc Natl Acad Sci USA. 98:2001;3375-3380.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 3375-3380
    • Xie, W.1    Radominska-Pandya, A.2    Shi, Y.3    Simon, C.M.4    Nelson, M.C.5    Ong, E.S.6
  • 30
    • 0030885520 scopus 로고    scopus 로고
    • The orphan nuclear receptor LXRα is positively and negatively regulated by distinct products of mevalonate metabolism
    • Forman B.M., Ruan B., Chen J., Schroepfer G.J., Evans R.M. The orphan nuclear receptor LXRα is positively and negatively regulated by distinct products of mevalonate metabolism. Proc Natl Acad Sci USA. 94:1997;10588-10593.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 10588-10593
    • Forman, B.M.1    Ruan, B.2    Chen, J.3    Schroepfer, G.J.4    Evans, R.M.5
  • 32
    • 0033854882 scopus 로고    scopus 로고
    • Selective activation of liver X receptor alpha by 6alpha-hydroxy bile acids and analogs
    • Song C., Hiipakka R.A., Liao S. Selective activation of liver X receptor alpha by 6alpha-hydroxy bile acids and analogs. Steroids. 65:2000;423-427.
    • (2000) Steroids , vol.65 , pp. 423-427
    • Song, C.1    Hiipakka, R.A.2    Liao, S.3
  • 33
    • 0037119454 scopus 로고    scopus 로고
    • Cholesterol and bile acids regulate xenosensor signaling in drug- mediated induction of cytochromes P450
    • Handschin C., Podvinec M., Amherd R., Looser R., Ourlin J.C., Meyer U.A. Cholesterol and bile acids regulate xenosensor signaling in drug- mediated induction of cytochromes P450. J Biol Chem. 277:2002;29561-29567.
    • (2002) J Biol Chem , vol.277 , pp. 29561-29567
    • Handschin, C.1    Podvinec, M.2    Amherd, R.3    Looser, R.4    Ourlin, J.C.5    Meyer, U.A.6
  • 34
    • 0025811870 scopus 로고
    • The different tissue transcription patterns of genes for HNF1, C/EBP, HNF3, and HNF4 protein factors that govern liver-specific transcription
    • Xanthopoulos K.G., Prezioso V.R., Chen W.S., Sladek F.M., Cortese R., Darnell J.E. The different tissue transcription patterns of genes for HNF1, C/EBP, HNF3, and HNF4 protein factors that govern liver-specific transcription. Proc Natl Acad Sci USA. 88:1991;3807-3811.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 3807-3811
    • Xanthopoulos, K.G.1    Prezioso, V.R.2    Chen, W.S.3    Sladek, F.M.4    Cortese, R.5    Darnell, J.E.6
  • 35
    • 0035141324 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis
    • Hayhurst G.P., Lee Y.H., Lambert G., Ward J.M., Gonzalez F.J. Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis. Mol Cell Biol. 21:2001;1393-1403.
    • (2001) Mol Cell Biol , vol.21 , pp. 1393-1403
    • Hayhurst, G.P.1    Lee, Y.H.2    Lambert, G.3    Ward, J.M.4    Gonzalez, F.J.5
  • 36
    • 0025804452 scopus 로고
    • Regulation of the apolipoprotein AI gene by ARP-1, a novel member of the steroid receptor superfamily
    • Ladias J.A.A., Karathanasis S.K. Regulation of the apolipoprotein AI gene by ARP-1, a novel member of the steroid receptor superfamily. Science. 251:1991;561-565.
    • (1991) Science , vol.251 , pp. 561-565
    • Ladias, J.A.A.1    Karathanasis, S.K.2
  • 37
    • 0026636624 scopus 로고
    • Transcriptional regulation of human apolipoprotein genes Apo B, Apo CIII, and apo AII by member of the steroid hormone receptor superfamily HNF-4, ARP-1, EAR-2 and EAR-3
    • Ladias J.A.A., Hadzopoulou-Cladaras M., Kardassis D., Cardot P., Cheng J., Zannis V., et al. Transcriptional regulation of human apolipoprotein genes Apo B, Apo CIII, and apo AII by member of the steroid hormone receptor superfamily HNF-4, ARP-1, EAR-2 and EAR-3. J Biol Chem. 267:1992;15849-15860.
    • (1992) J Biol Chem , vol.267 , pp. 15849-15860
    • Ladias, J.A.A.1    Hadzopoulou-Cladaras, M.2    Kardassis, D.3    Cardot, P.4    Cheng, J.5    Zannis, V.6
  • 38
    • 0033305213 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors: Nuclear control of metabolism
    • Desvergne B., Wahli W. Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocr Rev. 20:1999;649-688.
    • (1999) Endocr Rev , vol.20 , pp. 649-688
    • Desvergne, B.1    Wahli, W.2
  • 39
    • 0037900979 scopus 로고    scopus 로고
    • Minireview: Lipid metabolism, metabolic diseases, and peroxisome proliferator-activated receptors
    • Lee C.H., Olson P., Evans R.M. Minireview: lipid metabolism, metabolic diseases, and peroxisome proliferator-activated receptors. Endocrinology. 144:2003;2201-2207.
    • (2003) Endocrinology , vol.144 , pp. 2201-2207
    • Lee, C.H.1    Olson, P.2    Evans, R.M.3
  • 41
    • 0030870025 scopus 로고    scopus 로고
    • Identification of a bile acid response element in the cholesterol 7α-hydroxylase gene (CYP7A)
    • Stroup D., Crestani M., Chiang J.Y.L. Identification of a bile acid response element in the cholesterol 7α-hydroxylase gene (CYP7A). Am J Physiol. 273:1997;G508-G517.
    • (1997) Am J Physiol , vol.273
    • Stroup, D.1    Crestani, M.2    Chiang, J.Y.L.3
  • 42
    • 14444285707 scopus 로고    scopus 로고
    • Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway
    • Lehmann J.M., Kliewer S.A., Moore L.B., Smith-Oliver T.A., Oliver B.B., Su J.-L., et al. Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway. J Biol Chem. 272:1997;3137-3140.
    • (1997) J Biol Chem , vol.272 , pp. 3137-3140
    • Lehmann, J.M.1    Kliewer, S.A.2    Moore, L.B.3    Smith-Oliver, T.A.4    Oliver, B.B.5    Su, J.-L.6
  • 43
    • 0013199471 scopus 로고    scopus 로고
    • Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXRα
    • Peet D.J., Turley S.D., Ma W., Janowski B.A., Lobaccaro J.M., Hammer R.E., et al. Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXRα Cell. 93:1998;693-704.
    • (1998) Cell , vol.93 , pp. 693-704
    • Peet, D.J.1    Turley, S.D.2    Ma, W.3    Janowski, B.A.4    Lobaccaro, J.M.5    Hammer, R.E.6
  • 44
    • 0035834868 scopus 로고    scopus 로고
    • Regulation of cholesterol 7α-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRα)
    • Chiang J.Y., Kimmel R., Stroup D. Regulation of cholesterol 7α-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRα). Gene. 262:2001;257-265.
    • (2001) Gene , vol.262 , pp. 257-265
    • Chiang, J.Y.1    Kimmel, R.2    Stroup, D.3
  • 45
    • 0037036417 scopus 로고    scopus 로고
    • Dietary cholesterol fails to stimulate the human cholesterol 7α-hydroxylase gene (CYP7A1) in transgenic mice
    • Agellon L.B., Drover V.A., Cheema S.K., Gbaguidi G.F., Walsh A. Dietary cholesterol fails to stimulate the human cholesterol 7α-hydroxylase gene (CYP7A1) in transgenic mice. J Biol Chem. 277:2002;20131-20134.
    • (2002) J Biol Chem , vol.277 , pp. 20131-20134
    • Agellon, L.B.1    Drover, V.A.2    Cheema, S.K.3    Gbaguidi, G.F.4    Walsh, A.5
  • 46
    • 0031751631 scopus 로고    scopus 로고
    • Transcriptional activation of the cholesterol 7α-hydroxylase gene (CYP7A) by nuclear hormone receptors
    • Crestani M., Sadeghpour A., Stroup D., Gali G., Chiang J.Y.L. Transcriptional activation of the cholesterol 7α-hydroxylase gene (CYP7A) by nuclear hormone receptors. J Lipid Res. 39:1998;2192-2200.
    • (1998) J Lipid Res , vol.39 , pp. 2192-2200
    • Crestani, M.1    Sadeghpour, A.2    Stroup, D.3    Gali, G.4    Chiang, J.Y.L.5
  • 47
    • 0033954261 scopus 로고    scopus 로고
    • HNF4 and OUP-TFII interact to modulate transcription of the cholesterol 7α-hydroxylase gene (CYP7A)
    • Stroup D., Chiang J.Y.L. HNF4 and OUP-TFII interact to modulate transcription of the cholesterol 7α-hydroxylase gene (CYP7A). J Lipid Res. 41:2000;1-11.
    • (2000) J Lipid Res , vol.41 , pp. 1-11
    • Stroup, D.1    Chiang, J.Y.L.2
  • 48
    • 0034646603 scopus 로고    scopus 로고
    • Weinberger C and Stroup D, FXR responds to bile acids and represses cholesterol 7α-hydroxylase gene (CYP7A1) transcription
    • Chiang J.Y.L., Kimmel R. Weinberger C and Stroup D, FXR responds to bile acids and represses cholesterol 7α-hydroxylase gene (CYP7A1) transcription. J Biol Chem. 275:2000;10918-10924.
    • (2000) J Biol Chem , vol.275 , pp. 10918-10924
    • Chiang, J.Y.L.1    Kimmel, R.2
  • 49
    • 0033636789 scopus 로고    scopus 로고
    • Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors
    • Lu T.T., Makishima M., Repa J.J., Schoonjans K., Kerr T.A., Auwerx J., et al. Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors. Mol Cell. 6:2000;507-515.
    • (2000) Mol Cell , vol.6 , pp. 507-515
    • Lu, T.T.1    Makishima, M.2    Repa, J.J.3    Schoonjans, K.4    Kerr, T.A.5    Auwerx, J.6
  • 50
    • 0033637121 scopus 로고    scopus 로고
    • A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis
    • Goodwin B., Jones S.A., Price R.R., Watson M.A., McKee D.D., Moore L.B., et al. A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis. Mol Cell. 6:2000;517-526.
    • (2000) Mol Cell , vol.6 , pp. 517-526
    • Goodwin, B.1    Jones, S.A.2    Price, R.R.3    Watson, M.A.4    McKee, D.D.5    Moore, L.B.6
  • 51
    • 0033536005 scopus 로고    scopus 로고
    • CPF: An orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7α-hydroxylase gene
    • Nitta M., Ku S., Brown C., Okamoto A.Y., Shan B. CPF: An orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7α-hydroxylase gene. Proc Natl Acad Sci USA. 96:1999;6660-6665.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 6660-6665
    • Nitta, M.1    Ku, S.2    Brown, C.3    Okamoto, A.Y.4    Shan, B.5
  • 52
    • 0035851188 scopus 로고    scopus 로고
    • Orphan nuclear receptors as eLiXiRs and FiXeRs of sterol metabolism
    • Lu T.T., Repa J.J., Mangelsdorf D.J. Orphan nuclear receptors as eLiXiRs and FiXeRs of sterol metabolism. J Biol Chem. 276:2001;37735-37738.
    • (2001) J Biol Chem , vol.276 , pp. 37735-37738
    • Lu, T.T.1    Repa, J.J.2    Mangelsdorf, D.J.3
  • 53
    • 0025264171 scopus 로고
    • Regulation of cholesterol 7α-hydroxylase in the liver: Purification of cholesterol 7α-hydroxylase and the immunochemical evidence for the induction of cholesterol 7α-hydroxylase by cholestyramine and circadian rhythm
    • Chiang J.Y.L., Miller W.F., Lin G.M. Regulation of cholesterol 7α-hydroxylase in the liver: purification of cholesterol 7α-hydroxylase and the immunochemical evidence for the induction of cholesterol 7α-hydroxylase by cholestyramine and circadian rhythm. J Biol Chem. 265:1990;3889-3897.
    • (1990) J Biol Chem , vol.265 , pp. 3889-3897
    • Chiang, J.Y.L.1    Miller, W.F.2    Lin, G.M.3
  • 54
    • 0025353861 scopus 로고
    • Regulation of cholesterol 7α-hydroxylase in the liver: CDNA cloning, sequencing and regulation of cholesterol 7α-hydroxylase mRNA
    • Li Y.C., Wang D.P., Chiang J.Y.L. Regulation of cholesterol 7α-hydroxylase in the liver: cDNA cloning, sequencing and regulation of cholesterol 7α-hydroxylase mRNA. J Biol Chem. 265:1990;12012-12019.
    • (1990) J Biol Chem , vol.265 , pp. 12012-12019
    • Li, Y.C.1    Wang, D.P.2    Chiang, J.Y.L.3
  • 55
    • 0025366699 scopus 로고
    • Rat liver cholesterol 7α-hydroxylase. Pretranslational regulation for circadian rhythm
    • Noshiro M., Nishimoto M., Okuda K. Rat liver cholesterol 7α-hydroxylase. Pretranslational regulation for circadian rhythm. J Biol Chem. 265:1990;10036-10041.
    • (1990) J Biol Chem , vol.265 , pp. 10036-10041
    • Noshiro, M.1    Nishimoto, M.2    Okuda, K.3
  • 56
    • 0027428137 scopus 로고
    • Circadian transcription of the cholesterol 7α-hydroxylase gene may involve the liver-enriched bZIP protein DBP
    • Lavery D.J., Schibler U. Circadian transcription of the cholesterol 7α-hydroxylase gene may involve the liver-enriched bZIP protein DBP. Genes Dev. 7:1993;1871-1884.
    • (1993) Genes Dev , vol.7 , pp. 1871-1884
    • Lavery, D.J.1    Schibler, U.2
  • 57
    • 0029089791 scopus 로고
    • The rat hepatic leukemia factor (HLF) gene encodes two transcriptional activators with distinct circadian rhythms, tissue distributions and target preferrences
    • Falvey E., Fleury-Olela F., Schibler U. The rat hepatic leukemia factor (HLF) gene encodes two transcriptional activators with distinct circadian rhythms, tissue distributions and target preferrences. Eur Mol Biol Org J. 14:1995;4307-4317.
    • (1995) Eur Mol Biol Org J , vol.14 , pp. 4307-4317
    • Falvey, E.1    Fleury-Olela, F.2    Schibler, U.3
  • 58
    • 0030710087 scopus 로고    scopus 로고
    • Modulation of circadian expression of D-site binding protein by the schedule of parenteral nutrition in rat liver
    • Ogawa A., Yano M., Tsujimasa T., Morimoto T., Morita S., Taniguchi M., et al. Modulation of circadian expression of D-site binding protein by the schedule of parenteral nutrition in rat liver. Hepatology. 26:1997;1580-1586.
    • (1997) Hepatology , vol.26 , pp. 1580-1586
    • Ogawa, A.1    Yano, M.2    Tsujimasa, T.3    Morimoto, T.4    Morita, S.5    Taniguchi, M.6
  • 59
    • 0029017486 scopus 로고
    • Different hepatocytes express the cholesterol 7α-hydroxylase gene during its circadian modulation in vivo
    • Berkowitz C.M., Shen C.S., Bilir B.M., Guibert E., Gumucio J.J. Different hepatocytes express the cholesterol 7α-hydroxylase gene during its circadian modulation in vivo. Hepatology. 21:1995;1658-1667.
    • (1995) Hepatology , vol.21 , pp. 1658-1667
    • Berkowitz, C.M.1    Shen, C.S.2    Bilir, B.M.3    Guibert, E.4    Gumucio, J.J.5
  • 60
    • 0035059442 scopus 로고    scopus 로고
    • Restricted feeding entrains liver clock without participation of the suprachiasmatic nucleus
    • Hara R., Wan K., Wakamatsu H., Aida R., Moriya T., Akiyama M., et al. Restricted feeding entrains liver clock without participation of the suprachiasmatic nucleus. Genes Cells. 6:2001;269-278.
    • (2001) Genes Cells , vol.6 , pp. 269-278
    • Hara, R.1    Wan, K.2    Wakamatsu, H.3    Aida, R.4    Moriya, T.5    Akiyama, M.6
  • 61
    • 0033637383 scopus 로고    scopus 로고
    • Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus
    • Damiola F., Le Minh N., Preitner N., Kornmann B., Fleury-Olela F., Schibler U. Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus. Genes Dev. 14:2000;2950-2961.
    • (2000) Genes Dev , vol.14 , pp. 2950-2961
    • Damiola, F.1    Le Minh, N.2    Preitner, N.3    Kornmann, B.4    Fleury-Olela, F.5    Schibler, U.6
  • 62
    • 0141866661 scopus 로고    scopus 로고
    • Coordinated control of cholesterol catabolism to bile acids and of gluconeogenesis via a novel mechanism of transcription regulation linked to the fasted-to-fed cycle
    • De Fabiani E., Mitro N., Gilardi F., Caruso D., Galli G., Crestani M. Coordinated control of cholesterol catabolism to bile acids and of gluconeogenesis via a novel mechanism of transcription regulation linked to the fasted-to-fed cycle. J Biol Chem. 278:2003;39124-39132.
    • (2003) J Biol Chem , vol.278 , pp. 39124-39132
    • De Fabiani, E.1    Mitro, N.2    Gilardi, F.3    Caruso, D.4    Galli, G.5    Crestani, M.6
  • 63
    • 0037326196 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma coactivator 1 α (PGC-1 α): Transcriptional coactivator and metabolic regulator
    • Puigserver P., Spiegelman B.M. Peroxisome proliferator-activated receptor-gamma coactivator 1 α (PGC-1 α): transcriptional coactivator and metabolic regulator. Endocr Rev. 24:2003;78-90.
    • (2003) Endocr Rev , vol.24 , pp. 78-90
    • Puigserver, P.1    Spiegelman, B.M.2
  • 64
    • 0035855858 scopus 로고    scopus 로고
    • Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1
    • Yoon J.C., Puigserver P., Chen G., Donovan J., Wu Z., Rhee J., et al. Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Nature. 413:2001;131-138.
    • (2001) Nature , vol.413 , pp. 131-138
    • Yoon, J.C.1    Puigserver, P.2    Chen, G.3    Donovan, J.4    Wu, Z.5    Rhee, J.6
  • 65
    • 0242349197 scopus 로고    scopus 로고
    • Regulation of hepatic fasting response by PPARγ coactivator-1alpha (PGC-1): Requirement for hepatocyte nuclear factor 4α in gluconeogenesis
    • Rhee J., Inoue Y., Yoon J.C., Puigserver P., Fan M., Gonzalez F.J., et al. Regulation of hepatic fasting response by PPARγ coactivator-1alpha (PGC-1): requirement for hepatocyte nuclear factor 4α in gluconeogenesis. Proc Natl Acad Sci USA. 100:2003;4012-4017.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 4012-4017
    • Rhee, J.1    Inoue, Y.2    Yoon, J.C.3    Puigserver, P.4    Fan, M.5    Gonzalez, F.J.6
  • 66
    • 0028965012 scopus 로고
    • Insulin suppresses bile acid synthesis in cultured rat hepatocytes by down-regulation of cholesterol 7α-hydroxylase and sterol 27-hydroxylase gene transcription
    • Twisk J., Hoekman M.F.M., Lehmann E.M., Meijer P., Mager W.H., Princen H.M.G. Insulin suppresses bile acid synthesis in cultured rat hepatocytes by down-regulation of cholesterol 7α-hydroxylase and sterol 27-hydroxylase gene transcription. Hepatology. 21:1995;501-510.
    • (1995) Hepatology , vol.21 , pp. 501-510
    • Twisk, J.1    Hoekman, M.F.M.2    Lehmann, E.M.3    Meijer, P.4    Mager, W.H.5    Princen, H.M.G.6
  • 67
    • 0034177803 scopus 로고    scopus 로고
    • Identification and characterization of cis-acting elements conferring insulin responsiveness on hamster cholesterol 7α-hydroxylase gene promoter
    • De Fabiani E., Crestani M., Marrapodi M., Pinelli A., Golfieri V., Galli G. Identification and characterization of cis-acting elements conferring insulin responsiveness on hamster cholesterol 7α-hydroxylase gene promoter. Biochem J. 347:2000;147-154.
    • (2000) Biochem J , vol.347 , pp. 147-154
    • De Fabiani, E.1    Crestani, M.2    Marrapodi, M.3    Pinelli, A.4    Golfieri, V.5    Galli, G.6
  • 68
    • 0038187621 scopus 로고    scopus 로고
    • Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1α interaction
    • Puigserver P., Rhee J., Donovan J., Walkey C.J., Yoon J.C., Oriente F., et al. Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1α interaction. Nature. 423:2003;550-555.
    • (2003) Nature , vol.423 , pp. 550-555
    • Puigserver, P.1    Rhee, J.2    Donovan, J.3    Walkey, C.J.4    Yoon, J.C.5    Oriente, F.6
  • 69
    • 0033999108 scopus 로고    scopus 로고
    • Peroxisome proliferators down-regulate the expression of the human cholesterol 7α-hydroxylase gene (CYP7A1)
    • Marrapodi M., Chiang J.Y.L. Peroxisome proliferators down-regulate the expression of the human cholesterol 7α-hydroxylase gene (CYP7A1). J Lipid Res. 41:2000;514-520.
    • (2000) J Lipid Res , vol.41 , pp. 514-520
    • Marrapodi, M.1    Chiang, J.Y.L.2
  • 70
    • 0029877596 scopus 로고    scopus 로고
    • Endotoxinand TNF IL-1 decrease cholesterol 7α-hydroxylase mRNA levels and activity
    • Feingold K.R., Spady D.K., Pollock A.S., Moser A.H., Grunfeld C. Endotoxinand TNF IL-1 decrease cholesterol 7α-hydroxylase mRNA levels and activity. J Lipid Res. 37:1996;223-228.
    • (1996) J Lipid Res , vol.37 , pp. 223-228
    • Feingold, K.R.1    Spady, D.K.2    Pollock, A.S.3    Moser, A.H.4    Grunfeld, C.5
  • 71
    • 0029113729 scopus 로고
    • Discordant regulation of proteins of cholesterol metabolism during the acute phase response
    • Feingold K.R., Pollock A.S., Moser A.H., Shigenaga J.K., Grunfeld C. Discordant regulation of proteins of cholesterol metabolism during the acute phase response. J Lipid Res. 36:1995;1474-1482.
    • (1995) J Lipid Res , vol.36 , pp. 1474-1482
    • Feingold, K.R.1    Pollock, A.S.2    Moser, A.H.3    Shigenaga, J.K.4    Grunfeld, C.5
  • 72
    • 0029666289 scopus 로고    scopus 로고
    • Disruption of cholesterol 7α-hydroxylase gene in mice: I. Postnatal lethality reversed by bile acid and vitamin supplementation
    • Ishibashi S., Schwartz M., Frykman P.K., Hertz J., Russell D.W. Disruption of cholesterol 7α-hydroxylase gene in mice: I. Postnatal lethality reversed by bile acid and vitamin supplementation. J Biol Chem. 271:1996;18017-18023.
    • (1996) J Biol Chem , vol.271 , pp. 18017-18023
    • Ishibashi, S.1    Schwartz, M.2    Frykman, P.K.3    Hertz, J.4    Russell, D.W.5
  • 73
    • 85047684249 scopus 로고    scopus 로고
    • Human cholesterol 7α-hydroxylase (CYP7A1) deficiency has a hypercholesterolemic phenotype
    • Pullinger C.R., Eng C., Salen G., Shefer S., Batta A.K., Erickson S.K., et al. Human cholesterol 7α-hydroxylase (CYP7A1) deficiency has a hypercholesterolemic phenotype. J Clin Invest. 110:2002;109-117.
    • (2002) J Clin Invest , vol.110 , pp. 109-117
    • Pullinger, C.R.1    Eng, C.2    Salen, G.3    Shefer, S.4    Batta, A.K.5    Erickson, S.K.6
  • 75
    • 0032866276 scopus 로고    scopus 로고
    • Structure, evolution, and liver-specific expression of sterol 12α-hydroxylase P450 (CYP8B)
    • Ishida H., Kuruta Y., Gotoh O., Yamashita C., Yoshida Y., Noshiro M. Structure, evolution, and liver-specific expression of sterol 12α-hydroxylase P450 (CYP8B). J Biochem (Tokyo). 126:1999;19-25.
    • (1999) J Biochem (Tokyo) , vol.126 , pp. 19-25
    • Ishida, H.1    Kuruta, Y.2    Gotoh, O.3    Yamashita, C.4    Yoshida, Y.5    Noshiro, M.6
  • 76
    • 0034666324 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor α(PPARα) regulates bile acid biosynthesis
    • Hunt M.C., Yang Y.Z., Eggertsen G., Carneheim C.M., Gafvels M., Einarsson C., et al. The peroxisome proliferator-activated receptor α(PPARα) regulates bile acid biosynthesis. J Biol Chem. 275:2000;28947-28953.
    • (2000) J Biol Chem , vol.275 , pp. 28947-28953
    • Hunt, M.C.1    Yang, Y.Z.2    Eggertsen, G.3    Carneheim, C.M.4    Gafvels, M.5    Einarsson, C.6
  • 77
    • 0034625419 scopus 로고    scopus 로고
    • α1-Fetoprotein transcription factor is required for the expression of sterol 12α-hydroxylase, the specific enzyme for cholic acid synthesis. Potential role in the bile acid-mediated regulation of gene transcription
    • del Castillo-Olivares A., Gil G. α1-Fetoprotein transcription factor is required for the expression of sterol 12α-hydroxylase, the specific enzyme for cholic acid synthesis. Potential role in the bile acid-mediated regulation of gene transcription. J Biol Chem. 275:2000;17793-17799.
    • (2000) J Biol Chem , vol.275 , pp. 17793-17799
    • Del Castillo-Olivares, A.1    Gil, G.2
  • 78
    • 0035834771 scopus 로고    scopus 로고
    • Transcriptional regulation of the human sterol 12α-hydroxylase gene (CYP8B1): Roles of hepatocyte nuclear factor 4α (HNF4α) in mediating bile acid repression
    • Zhang M., Chiang J.Y. Transcriptional regulation of the human sterol 12α-hydroxylase gene (CYP8B1): roles of hepatocyte nuclear factor 4α (HNF4α) in mediating bile acid repression. J Biol Chem. 276:2001;41690-41699.
    • (2001) J Biol Chem , vol.276 , pp. 41690-41699
    • Zhang, M.1    Chiang, J.Y.2
  • 79
    • 0037071854 scopus 로고    scopus 로고
    • On the mechanism of bile acid inhibition of rat sterol 12α- hydroxylase gene (CYP8B1) transcription: Roles of alpha-fetoprotein transcription factor and hepatocyte nuclear factor 4α
    • Yang Y., Zhang M., Eggertsen G., Chiang J.Y. On the mechanism of bile acid inhibition of rat sterol 12α- hydroxylase gene (CYP8B1) transcription: roles of alpha-fetoprotein transcription factor and hepatocyte nuclear factor 4α Biochim Biophys Acta. 1583:2002;63-73.
    • (2002) Biochim Biophys Acta , vol.1583 , pp. 63-73
    • Yang, Y.1    Zhang, M.2    Eggertsen, G.3    Chiang, J.Y.4
  • 80
    • 0036801432 scopus 로고    scopus 로고
    • Cholic acid mediates negative feedback regulation of bile acid synthesis in mice
    • Li-Hawkins J., Gafvels M., Olin M., Lund E.G., Andersson U., Schuster G., et al. Cholic acid mediates negative feedback regulation of bile acid synthesis in mice. J Clin Invest. 110:2002;1191-1200.
    • (2002) J Clin Invest , vol.110 , pp. 1191-1200
    • Li-Hawkins, J.1    Gafvels, M.2    Olin, M.3    Lund, E.G.4    Andersson, U.5    Schuster, G.6
  • 83
    • 0031576814 scopus 로고    scopus 로고
    • Localization of sterol 27-hydroxylase immuno-reactivity in human atherosclerotic plaques
    • Crisby M., Nilsson J., Kostulas V., Bjorkhem I., Diczfalusy U. Localization of sterol 27-hydroxylase immuno-reactivity in human atherosclerotic plaques. Biochim Biophys Acta. 1344:1997;278-285.
    • (1997) Biochim Biophys Acta , vol.1344 , pp. 278-285
    • Crisby, M.1    Nilsson, J.2    Kostulas, V.3    Bjorkhem, I.4    Diczfalusy, U.5
  • 84
    • 0028068796 scopus 로고
    • Atherosclerosis and sterol 27-hydroxylase: Evidence for a role of this enzyme in elimination of cholesterol from human macrophages
    • Bjorkhem I., Andersson O., Diczfalusy U., Sevastik B., Xiu R.-J., Duan C., et al. Atherosclerosis and sterol 27-hydroxylase: evidence for a role of this enzyme in elimination of cholesterol from human macrophages. Proc Natl Acad Sci USA. 91:1994;8592-8596.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 8592-8596
    • Bjorkhem, I.1    Andersson, O.2    Diczfalusy, U.3    Sevastik, B.4    Xiu, R.-J.5    Duan, C.6
  • 85
    • 0028989206 scopus 로고
    • 7α-Hydroxylation of 25-hydroxycholesterol and 27- hydroxycholesterol in human fibroblasts
    • Zhang J., Larrson O., Sjovall J. 7α-Hydroxylation of 25-hydroxycholesterol and 27-hydroxycholesterol in human fibroblasts. Biochim Biophys Acta. 1995:1995;353-359.
    • (1995) Biochim Biophys Acta , vol.1995 , pp. 353-359
    • Zhang, J.1    Larrson, O.2    Sjovall, J.3
  • 86
    • 77956841570 scopus 로고
    • Mechanism of bile acid biosynthesis in mammalian liver
    • H. Danielsson, & J. Sjovall. Amsterdam: Elsevier
    • Bjorkhem I. Mechanism of bile acid biosynthesis in mammalian liver. Danielsson H., Sjovall J. Steroid and bile acid. 1985;231-277 Elsevier, Amsterdam.
    • (1985) Steroid and Bile Acid , pp. 231-277
    • Bjorkhem, I.1
  • 87
    • 0343953577 scopus 로고    scopus 로고
    • Sterol 27-hydroxylase deficiency: A rare cause of xanthomas in normocholesterolemic humans
    • Bjorkhem I., Leitersdorf I. Sterol 27-hydroxylase deficiency: a rare cause of xanthomas in normocholesterolemic humans. Trends Endocrinol Metab. 11:2000;180-183.
    • (2000) Trends Endocrinol Metab , vol.11 , pp. 180-183
    • Bjorkhem, I.1    Leitersdorf, I.2
  • 88
    • 0018886395 scopus 로고
    • Cerebrotendinous xanthomatosis: A defect in mitochondrial 26- hydroxylation required for normal biosynthesis of cholic acid
    • Oftebro H., Bjorkhem I., Skrede S., Schreiner A., Pederson J.I. Cerebrotendinous xanthomatosis: a defect in mitochondrial 26- hydroxylation required for normal biosynthesis of cholic acid. J Clin Invest. 65:1980;1418-1430.
    • (1980) J Clin Invest , vol.65 , pp. 1418-1430
    • Oftebro, H.1    Bjorkhem, I.2    Skrede, S.3    Schreiner, A.4    Pederson, J.I.5
  • 89
    • 0027208973 scopus 로고
    • Frameshift and splice-junction mutations in the sterol 27-hydroxylase gene cause cerebrotendinous xanthomatosis in Jews of Moroccan origin I
    • Leitersdorf E., Reshef A., Meiner V., Levitzki R., Schwartz S.P., Dann E.J., et al. Frameshift and splice-junction mutations in the sterol 27-hydroxylase gene cause cerebrotendinous xanthomatosis in Jews of Moroccan origin I. Clin Invest. 91:1993;2488-2496.
    • (1993) Clin Invest , vol.91 , pp. 2488-2496
    • Leitersdorf, E.1    Reshef, A.2    Meiner, V.3    Levitzki, R.4    Schwartz, S.P.5    Dann, E.J.6
  • 90
    • 0032511035 scopus 로고    scopus 로고
    • Markedly reduced bile acid synthesis but maintained levels of cholesterol and vitamin D metabolites in mice with disrupted sterol 27- hydroxylase gene
    • Rosen H., Reshef A., Maeda N., Lippoldt A., Shpizen S., Triger L., et al. Markedly reduced bile acid synthesis but maintained levels of cholesterol and vitamin D metabolites in mice with disrupted sterol 27- hydroxylase gene. J Biol Chem. 273:1998;14805-14812.
    • (1998) J Biol Chem , vol.273 , pp. 14805-14812
    • Rosen, H.1    Reshef, A.2    Maeda, N.3    Lippoldt, A.4    Shpizen, S.5    Triger, L.6
  • 91
    • 0037422578 scopus 로고    scopus 로고
    • Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor
    • Goodwin B., Gauthier K.C., Umetani M., Watson M.A., Lochansky M.I., Collins J.L., et al. Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor. Proc Natl Acad Sci USA. 100:2003;223-228.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 223-228
    • Goodwin, B.1    Gauthier, K.C.2    Umetani, M.3    Watson, M.A.4    Lochansky, M.I.5    Collins, J.L.6
  • 92
    • 0037417994 scopus 로고    scopus 로고
    • Identification of an endogenous ligand that activates pregnane X receptor-mediated sterol clearance
    • Dussault I., Yoo H.D., Lin M., Wang E., Fan M., Batta A.K., et al. Identification of an endogenous ligand that activates pregnane X receptor-mediated sterol clearance. Proc Natl Acad Sci USA. 100:2003;833-838.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 833-838
    • Dussault, I.1    Yoo, H.D.2    Lin, M.3    Wang, E.4    Fan, M.5    Batta, A.K.6
  • 93
    • 0034671509 scopus 로고    scopus 로고
    • Disruption of th sterol 27-hydroxylase gene in mice results in hepatomegaly and hypertriglycridemia: Reversal by cholic acid feeding
    • Repa J.J., Lund E.G., Horton J.D., Leitersdorf E., Russell D.W., Dietschy J.M., et al. Disruption of th sterol 27-hydroxylase gene in mice results in hepatomegaly and hypertriglycridemia: Reversal by cholic acid feeding. J Biol Chem. 275:2000;39685-39692.
    • (2000) J Biol Chem , vol.275 , pp. 39685-39692
    • Repa, J.J.1    Lund, E.G.2    Horton, J.D.3    Leitersdorf, E.4    Russell, D.W.5    Dietschy, J.M.6
  • 95
    • 15444346370 scopus 로고    scopus 로고
    • Regulation of classic and alternative bile acid synthesis in hypercholesterolemic rabbits: Effects of cholesterol feeding and bile acid depletion
    • Xu G., Salen G., Shefer S., Tint G.S., Nguyen L.B., Parker T.T., et al. Regulation of classic and alternative bile acid synthesis in hypercholesterolemic rabbits: effects of cholesterol feeding and bile acid depletion. J Lipid Res. 39:1998;1608-1615.
    • (1998) J Lipid Res , vol.39 , pp. 1608-1615
    • Xu, G.1    Salen, G.2    Shefer, S.3    Tint, G.S.4    Nguyen, L.B.5    Parker, T.T.6
  • 96
    • 0035839606 scopus 로고    scopus 로고
    • In vivo and in vitro regulation of sterol 27-hydroxylase in the liver during the acute phase response. Potential role of hepatocyte nuclear factor-1
    • Memon R.A., Moser A.H., Shigenaga J.K., Grunfeld C., Feingold K.R. In vivo and in vitro regulation of sterol 27-hydroxylase in the liver during the acute phase response. Potential role of hepatocyte nuclear factor-1. J Biol Chem. 276:2001;30118-30126.
    • (2001) J Biol Chem , vol.276 , pp. 30118-30126
    • Memon, R.A.1    Moser, A.H.2    Shigenaga, J.K.3    Grunfeld, C.4    Feingold, K.R.5
  • 97
    • 12644253822 scopus 로고    scopus 로고
    • Cyp7b, a novel brain cytochrome P450, catalyzes the synthesis of neurosteroids 7α-hydroxy dehydroepiandrosterone and 7α- hydroxypregnenolone
    • Rose K.A., Stapleton G., Dott K., Kieny M.P., Best R., Schwarz M., et al. Cyp7b, a novel brain cytochrome P450, catalyzes the synthesis of neurosteroids 7α-hydroxy dehydroepiandrosterone and 7α-hydroxypregnenolone. Proc Natl Acad Sci USA. 94:1997;4925-4930.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 4925-4930
    • Rose, K.A.1    Stapleton, G.2    Dott, K.3    Kieny, M.P.4    Best, R.5    Schwarz, M.6
  • 98
    • 0034595445 scopus 로고    scopus 로고
    • Disruption of the oxysterol 7alpha -hydroxylase gene in mice
    • Li-Hawkins J., Lund E.G., Turley S.D., Russell D.W. Disruption of the oxysterol 7alpha -hydroxylase gene in mice. J Biol Chem. 275:2000;16536-16542.
    • (2000) J Biol Chem , vol.275 , pp. 16536-16542
    • Li-Hawkins, J.1    Lund, E.G.2    Turley, S.D.3    Russell, D.W.4
  • 99
    • 0035968215 scopus 로고    scopus 로고
    • Neurosteroid hydroxylase CYP7B: Vivid reporter activity in dentate gyrus of gene-targeted mice and abolition of a widespread pathway of steroid and oxysterol hydroxylation
    • Rose K., Allan A., Gauldie S., Stapleton G., Dobbie L., Dott K., et al. Neurosteroid hydroxylase CYP7B: vivid reporter activity in dentate gyrus of gene-targeted mice and abolition of a widespread pathway of steroid and oxysterol hydroxylation. J Biol Chem. 276:2001;23937-23944.
    • (2001) J Biol Chem , vol.276 , pp. 23937-23944
    • Rose, K.1    Allan, A.2    Gauldie, S.3    Stapleton, G.4    Dobbie, L.5    Dott, K.6
  • 100
    • 0035962004 scopus 로고    scopus 로고
    • Ontogeny of the neurosteroid enzyme Cyp7b in the mouse
    • Bean R., Seckl J.R., Lathe R., Martin C. Ontogeny of the neurosteroid enzyme Cyp7b in the mouse. Mol Cell Endocrinol. 174:2001;137-144.
    • (2001) Mol Cell Endocrinol , vol.174 , pp. 137-144
    • Bean, R.1    Seckl, J.R.2    Lathe, R.3    Martin, C.4
  • 102
    • 0037109138 scopus 로고    scopus 로고
    • An endocrine pathway in the prostate, ERbeta, AR, 5α-androstane- 3β,17β-diol, and CYP7B1, regulates prostate growth
    • Weihua Z., Lathe R., Warner M., Gustafsson J.A. An endocrine pathway in the prostate, ERbeta, AR, 5α-androstane-3β,17β-diol, and CYP7B1, regulates prostate growth. Proc Natl Acad Sci USA. 99:2002;13589-13594.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 13589-13594
    • Weihua, Z.1    Lathe, R.2    Warner, M.3    Gustafsson, J.A.4
  • 103
    • 0032211865 scopus 로고    scopus 로고
    • Identification of a new inborn error in bile acid synthesis: Mutation of the oxysterol 7α-hydroxylase gene causes severe neonatal liver disease
    • Setchell K.D.R., Schwarz M., O'Connell N.C., Lund E.G., Davis D.L., Lathe R., et al. Identification of a new inborn error in bile acid synthesis: mutation of the oxysterol 7α-hydroxylase gene causes severe neonatal liver disease. J Clin Invest. 102:1998;1690-1703.
    • (1998) J Clin Invest , vol.102 , pp. 1690-1703
    • Setchell, K.D.R.1    Schwarz, M.2    O'Connell, N.C.3    Lund, E.G.4    Davis, D.L.5    Lathe, R.6
  • 104
    • 0034664729 scopus 로고    scopus 로고
    • Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis
    • Sinal C.J., Tohkin M., Miyata M., Ward J.M., Lambert G., Gonzalez F.J. Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis. Cell. 102:2000;731-744.
    • (2000) Cell , vol.102 , pp. 731-744
    • Sinal, C.J.1    Tohkin, M.2    Miyata, M.3    Ward, J.M.4    Lambert, G.5    Gonzalez, F.J.6
  • 105
    • 0035800772 scopus 로고    scopus 로고
    • Human bile salt export pump (BSEP) promoter is transactivated by the farnesoid X receptor/bile acid receptor (FXR/BAR)
    • Ananthanarayanan M., Balasubramanian N.V., Makishima M., Mangelsdorf D.J., Suchy F.J. Human bile salt export pump (BSEP) promoter is transactivated by the farnesoid X receptor/bile acid receptor (FXR/BAR). J Biol Chem. 276:2001;28857-28865.
    • (2001) J Biol Chem , vol.276 , pp. 28857-28865
    • Ananthanarayanan, M.1    Balasubramanian, N.V.2    Makishima, M.3    Mangelsdorf, D.J.4    Suchy, F.J.5
  • 106
    • 0037169551 scopus 로고    scopus 로고
    • Regulation of Multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane x receptor, farnesoid x-activated receptor, and constitutive androstane receptor
    • Kast H.R., Goodwin B., Tarr P.T., Jones S.A., Anisfeld A.M., Stoltz C.M., et al. Regulation of Multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane x receptor, farnesoid x-activated receptor, and constitutive androstane receptor. J Biol Chem. 277:2002;2908-2915.
    • (2002) J Biol Chem , vol.277 , pp. 2908-2915
    • Kast, H.R.1    Goodwin, B.2    Tarr, P.T.3    Jones, S.A.4    Anisfeld, A.M.5    Stoltz, C.M.6
  • 107
    • 0036733630 scopus 로고    scopus 로고
    • Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol
    • Yu L., Li-Hawkins J., Hammer R.E., Berge K.E., Horton J.D., Cohen J.C., et al. Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol. J Clin Invest. 110:2002;671-680.
    • (2002) J Clin Invest , vol.110 , pp. 671-680
    • Yu, L.1    Li-Hawkins, J.2    Hammer, R.E.3    Berge, K.E.4    Horton, J.D.5    Cohen, J.C.6
  • 108
    • 0028039878 scopus 로고
    • Expression cloning and characterization of the hamster ileal sodium- dependent bile acid transporter
    • Wong M.H., Oelkers P., Craddock A.L., Dawson P.A. Expression cloning and characterization of the hamster ileal sodium- dependent bile acid transporter. J Biol Chem. 269:1994;1340-1347.
    • (1994) J Biol Chem , vol.269 , pp. 1340-1347
    • Wong, M.H.1    Oelkers, P.2    Craddock, A.L.3    Dawson, P.A.4
  • 109
    • 0033570028 scopus 로고    scopus 로고
    • Identification of a bile acid-responsive element in the human ileal bile acid-binding protein gene. Involvement of the farnesoid x receptor/9-cis- retinoic acid receptor heterodimer
    • Grober J., Zaghini I., Fujii H., Jones S.A., Kliewer S.A., Willson T.M., et al. Identification of a bile acid-responsive element in the human ileal bile acid-binding protein gene. Involvement of the farnesoid x receptor/9-cis- retinoic acid receptor heterodimer. J Biol Chem. 274:1999;29749-29754.
    • (1999) J Biol Chem , vol.274 , pp. 29749-29754
    • Grober, J.1    Zaghini, I.2    Fujii, H.3    Jones, S.A.4    Kliewer, S.A.5    Willson, T.M.6
  • 110
    • 0034950514 scopus 로고    scopus 로고
    • The orphan nuclear receptor, shp, mediates bile acid-induced inhibition of the rat bile acid transporter, ntcp
    • Denson L.A., Sturm E., Echevarria W., Zimmerman T.L., Makishima M., Mangelsdorf D.J., et al. The orphan nuclear receptor, shp, mediates bile acid-induced inhibition of the rat bile acid transporter, ntcp. Gastroenterology. 121:2001;140-147.
    • (2001) Gastroenterology , vol.121 , pp. 140-147
    • Denson, L.A.1    Sturm, E.2    Echevarria, W.3    Zimmerman, T.L.4    Makishima, M.5    Mangelsdorf, D.J.6
  • 111
    • 0042130513 scopus 로고    scopus 로고
    • A gugulipid: Natural cholesterol-lowering agent
    • Urizar N.L., Moore D.D. A gugulipid: natural cholesterol-lowering agent. Annu Rev Nutr. 2003.
    • (2003) Annu Rev Nutr
    • Urizar, N.L.1    Moore, D.D.2
  • 112
    • 0037205046 scopus 로고    scopus 로고
    • A natural product that lowers cholesterol as an antagonist ligand for FXR
    • Urizar N.L., Liverman A.B., Dodds D.T., Silva F.V., Ordentlich P., Yan Y., et al. A natural product that lowers cholesterol as an antagonist ligand for FXR. Science. 296:2002;1703-1706.
    • (2002) Science , vol.296 , pp. 1703-1706
    • Urizar, N.L.1    Liverman, A.B.2    Dodds, D.T.3    Silva, F.V.4    Ordentlich, P.5    Yan, Y.6
  • 113
    • 0003295132 scopus 로고    scopus 로고
    • Guggulsterone is an FXR antagonist in coactivator association assays but acts to enhance transcription of bile salt export pump
    • Cui J., Huang L., Zhao A., Lew J.L., Yu J., Sahoo S., et al. Guggulsterone is an FXR antagonist in coactivator association assays but acts to enhance transcription of bile salt export pump. J Biol Chem. 278:2003;10214-10220.
    • (2003) J Biol Chem , vol.278 , pp. 10214-10220
    • Cui, J.1    Huang, L.2    Zhao, A.3    Lew, J.L.4    Yu, J.5    Sahoo, S.6
  • 114
    • 0037466407 scopus 로고    scopus 로고
    • Guggulsterone antagonizes farnesoid X receptor induction of bile salt export pump but activates pregnane X receptor to inhibit cholesterol 7α-hydroxylase gene
    • Owsley E., Chiang J.Y. Guggulsterone antagonizes farnesoid X receptor induction of bile salt export pump but activates pregnane X receptor to inhibit cholesterol 7α-hydroxylase gene. Biochem Biophys Res Commun. 304:2003;191-195.
    • (2003) Biochem Biophys Res Commun , vol.304 , pp. 191-195
    • Owsley, E.1    Chiang, J.Y.2
  • 115
    • 85047685018 scopus 로고    scopus 로고
    • The hypolipidemic natural product guggulsterone acts as an antagonist of the bile acid receptor
    • Wu J., Xia C., Meier J., Li S., Hu X., Lala D.S. The hypolipidemic natural product guggulsterone acts as an antagonist of the bile acid receptor. Mol Endocrinol. 16:2002;1590-1597.
    • (2002) Mol Endocrinol , vol.16 , pp. 1590-1597
    • Wu, J.1    Xia, C.2    Meier, J.3    Li, S.4    Hu, X.5    Lala, D.S.6
  • 117
    • 0034671526 scopus 로고    scopus 로고
    • The farnesoid X-activated receptor mediates bile acid activation of phospholipid transfer protein gene expression
    • Urizar N.L., Dowhan D.H., Moore D.D. The farnesoid X-activated receptor mediates bile acid activation of phospholipid transfer protein gene expression. J Biol Chem. 275:2000;39313-39317.
    • (2000) J Biol Chem , vol.275 , pp. 39313-39317
    • Urizar, N.L.1    Dowhan, D.H.2    Moore, D.D.3
  • 118
    • 0037131347 scopus 로고    scopus 로고
    • Phospholipid transfer protein is regulated by liver X receptors in vivo
    • Cao G., Beyer T.P., Yang X.P., Schmidt R.J., Zhang Y., Bensch W.R., et al. Phospholipid transfer protein is regulated by liver X receptors in vivo. J Biol Chem. 277:2002;39561-39565.
    • (2002) J Biol Chem , vol.277 , pp. 39561-39565
    • Cao, G.1    Beyer, T.P.2    Yang, X.P.3    Schmidt, R.J.4    Zhang, Y.5    Bensch, W.R.6
  • 119
    • 0034791544 scopus 로고    scopus 로고
    • Farnesoid x-activated receptor induces apolipoprotein c-II transcription: A molecular mechanism linking plasma triglyceride levels to bile acids
    • Kast H.R., Nguyen C.M., Sinal C.J., Jones S.A., Laffitte B.A., Reue K., et al. Farnesoid x-activated receptor induces apolipoprotein c-II transcription: a molecular mechanism linking plasma triglyceride levels to bile acids. Mol Endocrinol. 15:2001;1720-1728.
    • (2001) Mol Endocrinol , vol.15 , pp. 1720-1728
    • Kast, H.R.1    Nguyen, C.M.2    Sinal, C.J.3    Jones, S.A.4    Laffitte, B.A.5    Reue, K.6
  • 120
    • 0036915379 scopus 로고    scopus 로고
    • Identification of PLTP as an LXR target gene and apoE as an FXR target gene reveals overlapping targets for the two nuclear receptors
    • Mak P.A., Kast-Woelbern H.R., Anisfeld A.M., Edwards P.A. Identification of PLTP as an LXR target gene and apoE as an FXR target gene reveals overlapping targets for the two nuclear receptors. J Lipid Res. 43:2002;2037-2041.
    • (2002) J Lipid Res , vol.43 , pp. 2037-2041
    • Mak, P.A.1    Kast-Woelbern, H.R.2    Anisfeld, A.M.3    Edwards, P.A.4
  • 123
    • 0035900749 scopus 로고    scopus 로고
    • Regulation of lipoprotein lipase by the oxysterol receptors, LXRalpha and LXRbeta
    • Zhang Y., Repa J.J., Gauthier K., Mangelsdorf D.J. Regulation of lipoprotein lipase by the oxysterol receptors, LXRalpha and LXRbeta. J Biol Chem. 276:2001;43018-43024.
    • (2001) J Biol Chem , vol.276 , pp. 43018-43024
    • Zhang, Y.1    Repa, J.J.2    Gauthier, K.3    Mangelsdorf, D.J.4
  • 124
    • 1242288520 scopus 로고    scopus 로고
    • Sterol upregulation of human CETP expression in vitro and in transgenic mice by an LXR element
    • Luo Y., Tall A.R. Sterol upregulation of human CETP expression in vitro and in transgenic mice by an LXR element. J Clin Invest. 276:2000;24767-24773.
    • (2000) J Clin Invest , vol.276 , pp. 24767-24773
    • Luo, Y.1    Tall, A.R.2
  • 126
    • 0036218724 scopus 로고    scopus 로고
    • Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element
    • Claudel T., Sturm E., Duez H., Torra I.P., Sirvent A., Kosykh V., et al. Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element. J Clin Invest. 109:2002;961-971.
    • (2002) J Clin Invest , vol.109 , pp. 961-971
    • Claudel, T.1    Sturm, E.2    Duez, H.3    Torra, I.P.4    Sirvent, A.5    Kosykh, V.6
  • 127
    • 0034623288 scopus 로고    scopus 로고
    • Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor
    • Costet P., Luo Y., Wang N., Tall A.R. Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor. J Biol Chem. 275:2000;28240-28245.
    • (2000) J Biol Chem , vol.275 , pp. 28240-28245
    • Costet, P.1    Luo, Y.2    Wang, N.3    Tall, A.R.4
  • 128
    • 0032813809 scopus 로고    scopus 로고
    • The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease
    • Bodzioch M., Orso E., Klucken J., Langmann T., Bottcher A., Diederich W., et al. The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease. Nat Genet. 22:1999;347-351.
    • (1999) Nat Genet , vol.22 , pp. 347-351
    • Bodzioch, M.1    Orso, E.2    Klucken, J.3    Langmann, T.4    Bottcher, A.5    Diederich, W.6
  • 129
    • 0037199994 scopus 로고    scopus 로고
    • Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta
    • Mak P.A., Laffitte B.A., Desrumaux C., Joseph S.B., Curtiss L.K., Mangelsdorf D.J., et al. Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta. J Biol Chem. 277:2002;31900-31908.
    • (2002) J Biol Chem , vol.277 , pp. 31900-31908
    • Mak, P.A.1    Laffitte, B.A.2    Desrumaux, C.3    Joseph, S.B.4    Curtiss, L.K.5    Mangelsdorf, D.J.6
  • 130
    • 17744376173 scopus 로고    scopus 로고
    • A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis
    • Chawla A., Boisvert W.A., Lee C.H., Laffitte B.A., Barak Y., Joseph S.B., et al. A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis. Mol Cell. 7:2001;161-171.
    • (2001) Mol Cell , vol.7 , pp. 161-171
    • Chawla, A.1    Boisvert, W.A.2    Lee, C.H.3    Laffitte, B.A.4    Barak, Y.5    Joseph, S.B.6
  • 131
    • 0034284918 scopus 로고    scopus 로고
    • Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers
    • Repa J.J., Turley S.D., Lobaccaro J.A., Medina J., Li L., Lustig K., et al. Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers. Science. 289:2000;1524-1529.
    • (2000) Science , vol.289 , pp. 1524-1529
    • Repa, J.J.1    Turley, S.D.2    Lobaccaro, J.A.3    Medina, J.4    Li, L.5    Lustig, K.6
  • 132
    • 0037072809 scopus 로고    scopus 로고
    • Increased hepatobiliary and fecal cholesterol excretion upon activation of the liver X receptor is independent of ABCA1
    • Plosch T., Kok T., Bloks V.W., Smit M.J., Havinga R., Chimini G., et al. Increased hepatobiliary and fecal cholesterol excretion upon activation of the liver X receptor is independent of ABCA1. J Biol Chem. 277:2002;33870-33877.
    • (2002) J Biol Chem , vol.277 , pp. 33870-33877
    • Plosch, T.1    Kok, T.2    Bloks, V.W.3    Smit, M.J.4    Havinga, R.5    Chimini, G.6
  • 133
    • 0035158733 scopus 로고    scopus 로고
    • Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption
    • Lee M.H., Lu K., Hazard S., Yu H., Shulenin S., Hidaka H., et al. Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption. Nat Genet. 27:2001;79-83.
    • (2001) Nat Genet , vol.27 , pp. 79-83
    • Lee, M.H.1    Lu, K.2    Hazard, S.3    Yu, H.4    Shulenin, S.5    Hidaka, H.6
  • 134
    • 17744390348 scopus 로고    scopus 로고
    • Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters
    • Berge K.E., Tian H., Graf G.A., Yu L., Grishin N.V., Schultz J., et al. Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters. Science. 290:2000;1771-1775.
    • (2000) Science , vol.290 , pp. 1771-1775
    • Berge, K.E.1    Tian, H.2    Graf, G.A.3    Yu, L.4    Grishin, N.V.5    Schultz, J.6
  • 135
    • 0037503924 scopus 로고    scopus 로고
    • Liver x receptor signaling pathways in cardiovascular disease
    • Tontonoz P., Mangelsdorf D.J. Liver x receptor signaling pathways in cardiovascular disease. Mol Endocrinol. 17:2003;985-993.
    • (2003) Mol Endocrinol , vol.17 , pp. 985-993
    • Tontonoz, P.1    Mangelsdorf, D.J.2
  • 138
    • 0035812707 scopus 로고    scopus 로고
    • An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing
    • Pennacchio L.A., Olivier M., Hubacek J.A., Cohen J.C., Cox D.R., Fruchart J.C., et al. An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing. Science. 294:2001;169-173.
    • (2001) Science , vol.294 , pp. 169-173
    • Pennacchio, L.A.1    Olivier, M.2    Hubacek, J.A.3    Cohen, J.C.4    Cox, D.R.5    Fruchart, J.C.6
  • 139
    • 0038491484 scopus 로고    scopus 로고
    • The human apolipoprotein AV gene is regulated by peroxisome proliferator-activated receptor α and contains a novel farnesoid X-activated receptor response element
    • Prieur X., Coste H., Rodriguez J.C. The human apolipoprotein AV gene is regulated by peroxisome proliferator-activated receptor α and contains a novel farnesoid X-activated receptor response element. J Biol Chem. 278:2003;25468-25480.
    • (2003) J Biol Chem , vol.278 , pp. 25468-25480
    • Prieur, X.1    Coste, H.2    Rodriguez, J.C.3
  • 140
    • 0034669025 scopus 로고    scopus 로고
    • Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ
    • Repa J.J., Liang G., Ou J., Bashmakov Y., Lobaccaro J.M., Shimomura I., et al. Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ Genes Dev. 14:2000;2819-2830.
    • (2000) Genes Dev , vol.14 , pp. 2819-2830
    • Repa, J.J.1    Liang, G.2    Ou, J.3    Bashmakov, Y.4    Lobaccaro, J.M.5    Shimomura, I.6
  • 141
    • 0037623752 scopus 로고    scopus 로고
    • Liver x receptor agonists as potential therapeutic agents for dyslipidemia and atherosclerosis
    • Lund E.G., Menke J.G., Sparrow C.P. Liver x receptor agonists as potential therapeutic agents for dyslipidemia and atherosclerosis. Arterioscler Thromb Vasc Biol. 23:2003;1169-1177.
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , pp. 1169-1177
    • Lund, E.G.1    Menke, J.G.2    Sparrow, C.P.3
  • 142
    • 0015923566 scopus 로고
    • Effects of a potent catatoxic steroid, 16 -cyanopregnenolone, on microsomal metabolism of steroid hormones, sterols and bile acids in rats
    • Einarsson K., Gustafsson J.A. Effects of a potent catatoxic steroid, 16 -cyanopregnenolone, on microsomal metabolism of steroid hormones, sterols and bile acids in rats. Eur J Biochem. 32:1973;197-206.
    • (1973) Eur J Biochem , vol.32 , pp. 197-206
    • Einarsson, K.1    Gustafsson, J.A.2
  • 143
    • 0015944816 scopus 로고
    • Effect of 16α-cyanopregnenolone on the hydroxylation of lithocholic acid by rat liver microsomes
    • Einarsson K., Gustafsson J.A. Effect of 16α-cyanopregnenolone on the hydroxylation of lithocholic acid by rat liver microsomes. Biochem Pharmacol. 23:1974;9-12.
    • (1974) Biochem Pharmacol , vol.23 , pp. 9-12
    • Einarsson, K.1    Gustafsson, J.A.2
  • 144
    • 0036838580 scopus 로고    scopus 로고
    • Rifampicin and treatment of cholestatic pruritus
    • Hofmann A.F. Rifampicin and treatment of cholestatic pruritus. Gut. 51:2002;756-757.
    • (2002) Gut , vol.51 , pp. 756-757
    • Hofmann, A.F.1
  • 145
    • 0036179358 scopus 로고    scopus 로고
    • Hepatitis and liver dysfunction with rifampicin therapy for pruritus in primary biliary cirrhosis
    • Prince M.I., Burt A.D., Jones D.E. Hepatitis and liver dysfunction with rifampicin therapy for pruritus in primary biliary cirrhosis. Gut. 50:2002;436-439.
    • (2002) Gut , vol.50 , pp. 436-439
    • Prince, M.I.1    Burt, A.D.2    Jones, D.E.3
  • 146
    • 0037965630 scopus 로고    scopus 로고
    • Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue
    • Laffitte B.A., Chao L.C., Li J., Walczak R., Hummasti S., Joseph S.B., et al. Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue. Proc Natl Acad Sci USA. 100:2003;5419-5424.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 5419-5424
    • Laffitte, B.A.1    Chao, L.C.2    Li, J.3    Walczak, R.4    Hummasti, S.5    Joseph, S.B.6
  • 147
    • 18444377348 scopus 로고    scopus 로고
    • Redundant pathways for negative feedback regulation of bile acid production
    • Wang L., Lee Y.K., Bundman D., Han Y., Thevananther S., Kim C.S., et al. Redundant pathways for negative feedback regulation of bile acid production. Dev Cell. 2:2002;721-731.
    • (2002) Dev Cell , vol.2 , pp. 721-731
    • Wang, L.1    Lee, Y.K.2    Bundman, D.3    Han, Y.4    Thevananther, S.5    Kim, C.S.6
  • 148
    • 0036086509 scopus 로고    scopus 로고
    • Loss of nuclear receptor shp impairs but does not eliminate negative feedback regulation of bile acid synthesis
    • Kerr T.A., Saeki S., Schneider M., Schaefer K., Berdy S., Redder T., et al. Loss of nuclear receptor shp impairs but does not eliminate negative feedback regulation of bile acid synthesis. Dev Cell. 2:2002;713-720.
    • (2002) Dev Cell , vol.2 , pp. 713-720
    • Kerr, T.A.1    Saeki, S.2    Schneider, M.3    Schaefer, K.4    Berdy, S.5    Redder, T.6
  • 149
    • 0028979936 scopus 로고
    • Repression of cholesterol 7α-hydroxylase transcription by bile acids is mediated through protein kinase C in primary cultures of rat hepatocytes
    • Stravitz R.T., Vlahcevic Z.R., Gurley E.C., Hylemons P.B. Repression of cholesterol 7α-hydroxylase transcription by bile acids is mediated through protein kinase C in primary cultures of rat hepatocytes. J Lipid Res. 36:1995;1359-1368.
    • (1995) J Lipid Res , vol.36 , pp. 1359-1368
    • Stravitz, R.T.1    Vlahcevic, Z.R.2    Gurley, E.C.3    Hylemons, P.B.4
  • 150
    • 0029792502 scopus 로고    scopus 로고
    • Hepatocellular protein kinase C activation by bile acids: Implications for regulation of cholesterol 7α-hydroxylase
    • Stravitz R.T., Rao Y.P., Vlahcevic Z.R., Gurley E.C., Jarvis W.D., Hylemon P.B. Hepatocellular protein kinase C activation by bile acids: implications for regulation of cholesterol 7α-hydroxylase. Am J Physiol. 34:1996;G293-G303.
    • (1996) Am J Physiol , vol.34
    • Stravitz, R.T.1    Rao, Y.P.2    Vlahcevic, Z.R.3    Gurley, E.C.4    Jarvis, W.D.5    Hylemon, P.B.6
  • 151
    • 0034698145 scopus 로고    scopus 로고
    • Bile acid induction of cytokine expression by macrophages correlates with repression of hepatic cholesterol 7α-hydroxylase
    • Miyake J.H., Wang S.L., Davis R.A. Bile acid induction of cytokine expression by macrophages correlates with repression of hepatic cholesterol 7α-hydroxylase. J Biol Chem. 275:2000;21805-21808.
    • (2000) J Biol Chem , vol.275 , pp. 21805-21808
    • Miyake, J.H.1    Wang, S.L.2    Davis, R.A.3
  • 152
    • 0035903105 scopus 로고    scopus 로고
    • The negative effects of bile acids and tumor necrosis factorα on the transcription of cholesterol 7α-hydroxylase gene (CYP7A1) converge to hepatic nuclear factor-4. A novel mechanism of feedback regulation of bile acid synthesis mediated by nuclear receptors
    • De Fabiani E., Mitro N., Anzulovich A.C., Pinelli A., Galli G., Crestani M. The negative effects of bile acids and tumor necrosis factorα on the transcription of cholesterol 7α-hydroxylase gene (CYP7A1) converge to hepatic nuclear factor-4. A novel mechanism of feedback regulation of bile acid synthesis mediated by nuclear receptors. J Biol Chem. 276:2001;30708-30716.
    • (2001) J Biol Chem , vol.276 , pp. 30708-30716
    • De Fabiani, E.1    Mitro, N.2    Anzulovich, A.C.3    Pinelli, A.4    Galli, G.5    Crestani, M.6
  • 153
    • 0033636892 scopus 로고    scopus 로고
    • Acetylation regulates transcription factor activity at multiple levels
    • Soutoglou E., Katrakili N., Talianidis I. Acetylation regulates transcription factor activity at multiple levels. Mol Cell. 5:2000;745-751.
    • (2000) Mol Cell , vol.5 , pp. 745-751
    • Soutoglou, E.1    Katrakili, N.2    Talianidis, I.3
  • 154
    • 0037040550 scopus 로고    scopus 로고
    • Coordination of PIC assembly and chromatin remodeling during differentiation-induced gene activation
    • Soutoglou E., Talianidis I. Coordination of PIC assembly and chromatin remodeling during differentiation-induced gene activation. Science. 295:2002;1901-1904.
    • (2002) Science , vol.295 , pp. 1901-1904
    • Soutoglou, E.1    Talianidis, I.2
  • 155
    • 0037663483 scopus 로고    scopus 로고
    • Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis
    • Holt J.A., Luo G., Billin A.N., Bisi J., McNeill Y.Y., Kozarsky K.F., et al. Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis. Genes Dev. 17:2003;1581-1591.
    • (2003) Genes Dev , vol.17 , pp. 1581-1591
    • Holt, J.A.1    Luo, G.2    Billin, A.N.3    Bisi, J.4    McNeill, Y.Y.5    Kozarsky, K.F.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.