Identification of PLTP as an LXR target gene and apoE as an FXR target gene reveals overlapping targets for the two nuclear receptors

Journal of Lipid Research

Volumn 43, Issue 12, 2002, Pages 2037-2041

  Mak, Puiying A ^a   Kast Woelbern, Heidi R ^a   Anisfeld, Andrew M ^a   Edwards, Peter A ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Foam cells; Hepatocytes; Liver X receptor; Macrophages; Phospholipid transfer protein; Retinoid X receptor

Indexed keywords

APOLIPOPROTEIN C2; APOLIPOPROTEIN E; FARNESOID X RECEPTOR; GENE PRODUCT; LIVER X RECEPTOR; PHOSPHOLIPID TRANSFER PROTEIN; RECEPTOR; RETINOID X RECEPTOR; UNCLASSIFIED DRUG; CARRIER PROTEIN; CELL RECEPTOR; DNA BINDING PROTEIN; FARNESOID X-ACTIVATED RECEPTOR; MEMBRANE PROTEIN; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; DNA RESPONSIVE ELEMENT; GENE IDENTIFICATION; GENE TARGETING; HUMAN; HUMAN CELL; LIGAND BINDING; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; RECEPTOR GENE; ANIMAL; GENETICS; METABOLISM;

ANIMALS; APOLIPOPROTEINS E; CARRIER PROTEINS; DNA-BINDING PROTEINS; HUMANS; MACROPHAGES; MEMBRANE PROTEINS; MICE; PHOSPHOLIPID TRANSFER PROTEINS; PROMOTER REGIONS (GENETICS); RECEPTORS, CYTOPLASMIC AND NUCLEAR; TRANSCRIPTION FACTORS;

EID: 0036915379     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: 10.1194/jlr.C200014-JLR200     Document Type: Article

References (20)

1. Bruce, C., R. A. Chouinard, Jr., and A. R. Tall. 1998. Plasma lipid transfer proteins, high-density lipoproteins, and reverse cholesterol transport. Annu. Rev. Nutr. 18: 297-330.
2. van Tol, A. 2002. Phospholipid transfer protein. Curr. Opin. Lipidol. 13: 135-139.
3. Albera, J.J., G. Wolfbauer, M. C. Cheung, J. R. Day, A. F. Ching, S. Lok, and A. Y. Tu. 1995. Functional expression of human and mouse plasma phospholipid transfer protein: Effect of recombinam and plasma PLTP on HDL subspecies. Biochim. Biophys. Acta. 1258: 27-34.
4. Laffitte, B. A., H. R. Kast, C. M. Nguyen, A. M. Zavacki, D. D. Moore, and P. A. Edwards. 2000. Identification of the DNA binding specificity and potential target genes for the farnesoid X-activated receptor. J. Biol. Chem. 275: 10638-10647.
5. Urizar, N. L., D. H. Dowhan, and D. D. Moore. 2000. The larnesoid X-activated receptor mediates bile acid activation of phospholipid transfer protein gene expression. J. Biol. Chem. 275: 39313-39317.
6. Kast, H. R., C. M. Nguyen, C. J. Sinai, S. A. Jones, B. A. Laffitte, K. Reue, F. J. Gonzalez, T. M. Willson, and P. A. Edwards. 2001. Farnesoid x-activated receptor induces apolipoprotein C-II transcription: A molecular mechanism linking plasma triglyceride levels to bile acids. Mol. Endocrinol. 15: 1720-1728.
7. Mak. P. A., B. A. Laffitte, C. Desrumaux, S. B. Joseph, L. K. Curtiss, D. J. Mangelsdorf, P. Tontonoz, and P. A. Edwards. 2002. Regulated expression of the ApoE/C-I/G-IV/C-II gene cluster in murine and human macrophages; A critical role for the nuclear receptors LXRalpha and LXRbeta. J. Biol. Chem. 277: 31900- 31908.
8. Laffitte, B. A., J. J. Repa, S. B. Joseph, D. C. Wilpitz, H. R. Kast, D. J. Mangelsdorf, and P. Tontonoz. 2001. LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes. Proc. Natl. Acad. Sci. USA. 98: 507-512.
9. Tabor, D. E., J. B. Kim, B. M. Spiegelman, and P. A. Edwards. 1998. Transcriptional activation of the stearoyl-CoA desaturase 2 gene by sterol regulatory element-binding protein/adipocyte determination and differentiation factor 1. J. Biol. Chem. 273: 22052-22058.
10. Kast, H. R., B. Goodwin, P. T. Tarr, S. A. Jones, A. M. Anisfeld, C. M. Stoltz, P. Tontonoz, S. Kliewer, T. M. Willson, and P. A. Edwards. 2002. Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor. J. Biol. Chem. 277: 2908-2915.
11. Colotta, F., G. Peri, A. Villa, and A. Mantovani. 1984. Rapid killing of actinomycin D-treated tumor cells by human mononuclear cells. I. Effectors belong to the monocyte-macrophage lineage. J. Immunol. 132: 936-944.
12. Joseph, S. B., B. A. Laffitte, P. H. Patel, M. A. Watson, K. E. Matsukuma, R. Walczak, J. L. Collins, T. F. Osborne, and P. Tontonoz. 2002. Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by LXRs. J. Biol. Chem. 277: 11019-11025.
13. Edwards, P. A., H. R. Kast, and A. M. Anisfeld. 2002. BAREing in all. The adoption of LXR and FXR and their roles in lipid homeostasis. J. Lipid Res. 43: 2-12.
14. Cao, G., T. P. Beyer, X. P. Yang, R. J. Schmidt, Y. Zhang, W. R. Bensch, R. F. Kauffman, H. Gao, T. P. Ryan, Y. Liang, P. I. Eacho, and X. C. Jiang. 2002. Phospholipid transfer protein is regulated by liver X receptors in vivo. J. Biol. Chem. 277: 39561-39565.
15. Tu, A. Y., and J. J. Albers. 2001. Functional analysis of the transcriptional activity of the mouse phospholipid transfer protein gene. Biochem. Biophys. Res. Commun. 287: 921-926.
16. Simonet, W. S., N. Bucay, S. J. Lauer, and J. M. Taylor. 1993. A far-downstream hepatocyte-specific control region directs expression of the linked human apolipoprotein E and C-I genes in transgenic mice. J. Biol. Chem. 268: 8221-8229.
17. Shachter, N. S., Y. Zhn, A. Walsh, J. L. Breslow, and J. D. Smith. 1993. Localization of a liver-specific enhancer in the apolipoprotein E/C-I/C-II gene locus. J. Lipid Res. 34: 1699-1707.
18. Simonet, W. S., N. Bucay, R. E. Pitas, S. J. Lauer, and J. M. Taylor. 1991. Multiple tissue-specific elements control the apolipoprotein E/C-I gene locus in transgenic mice. J. Biol. Chem. 266: 8651-8654.
19. Allan, C. M., S. Taylor, and J. M. Taylor. 1997. Two hepatic enhancers, HCR.1 and HCR.2, coordinate the liver expression of the entire human apolipoprotein E/C-I/C-IV/C-II gene cluster. J. Biol. Chem. 272: 29113-29119.
20. Zhang, Y., J. J. Repa, K. Gauthier, and D. J. Mangelsdorf. 2001. Regulation of lipoprotein lipase by the oxysterol receptors. LXRalpha and LXRbeta. J. Biol Chem. 276: 43018-43024.