Identification of a bile acid response element in the cholesterol 7α- hydroxylase gene CYP7A

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 273, Issue 2 36-2, 1997, Pages

  Stroup, Diane ^a   Crestani, Maurizio ^a   Chiang, John Y L ^a  

^a NORTHEAST OHIO MEDICAL UNIVERSITY   (United States)

Author keywords

Bile acid feedback; Cytochrome P 450; Hep G2 cells; Transcriptional regulation; Transient transfection assay

Indexed keywords

BETA GALACTOSIDASE; BILE ACID; CHOLESTEROL 7ALPHA MONOOXYGENASE; DNA; LUCIFERASE; TAUROCHENODEOXYCHOLIC ACID; TAUROCHOLIC ACID; TAURODEOXYCHOLIC ACID; TAUROURSODEOXYCHOLIC ACID;

ARTICLE; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; GENE MUTATION; HEPATOMA CELL; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE;

EID: 0030870025     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.1997.273.2.g508     Document Type: Article

References (19)

1. Ausubel, F. M., R. Brent, R. E. Kingston, D. D. Moore, J. A. Smith, J. G. Seidman, and K. Struhl. Current Protocols in Molecular Biology. New York: Wiley Interscience, 1987.
2. Bjorkhem, I., U. Andersson, E. Sudjama-Sugiaman, G. Eggertsen, and P. Hylemon. Studies of the link between HMG-CoA reductase and cholesterol 7α-hydroxylase in lymphfistula rats: evidence for both transcriptional and post-transcriptional mechanisms for down-regulation of the two enzymes by bile acids. J. Lipid Res. 34: 1497-1503, 1993.
3. Bouscarel, B., S. Ceryak, T. W. Gettys, H. Fromm, and F. Noonan. Alteration of cAMP-mediated hormonal responsiveness by bile acids in cells of nonhepatic origin. Am. J. Physiol. 268 (Gastrointest. Liver Physiol. 31): G908-G916, 1995.
4. Boyer, J. L., B. Hagenbuch, M. Ananthanarayana, F. Suchy, B. Steiger, and P. J. Meier. Phylogenic and ontogenetic expression of hepatocellular bile acid transport. Proc. Natl. Acad. Sci. USA 90: 435-438, 1993.
5. Chiang, J. Y. L., and D. Stroup. Identification of a liver nuclear protein factor responsive to bile acid inhibition of cholesterol 7α-hydroxylase gene. J. Biol. Chem. 269: 17502-17507, 1994.
6. Chiang, J. Y. L., and Z. R. Vlahcevic. The regulation of cholesterol conversion to bile acids. Adv. Mol. Cell Biol. 14: 269-316, 1996.
7. Crestani, M., G. Galli, and J. Y. L. Chiang. Genomic cloning, sequencing and analysis of hamster cholesterol 7α-hydroxylase gene (CYP7). Arch. Biochem. Biophys. 306: 451-460, 1993.
8. Crestani, M., W. G. Karam, and J. Y. L. Chiang. Effects of bile acids and steroid/thyroid hormones on the expression of cholesterol 7α-hydroxylase mRNA and the CYP7 gene in Hep G2 cells. Biochem. Biophys. Res. Commun. 198: 546-553, 1994.
9. Crestani, M., A. Sadeghpour, D. Stroup, G. Galli, and J. Y. L. Chiang. The opposing effects of retinoic acid and phorbol esters converge to a common response element in the promoter of the rat cholesterol 7α-hydroxylase gene (CYP7A). Biochem. Biophys. Res. Commun. 225: 585-592, 1996.
10. Crestani, M., D. Stroup, and J. Y. L. Chiang. Hormonal regulation of the cholesterol 7α-hydroxylase gene (CYP7). J. Lipid Res. 36: 2419-2432, 1995.
11. Dent, C. D., and D. S. Latchman. Transcription Factors: A Practical Approach, edited by D. S. Latchman. Oxford: IRL, 1993, p. 10-12.
12. Hirano, F., H. Tanaka, Y. Makino, K. Okamoto, M. Inaba, T. Miura, and I. Makino. Regulation of the major histocompatibility complex class mRNA expression by bile acids in cultured human hepatoma cells. Biochem. Biophys. Res. Commun. 208: 935-942, 1995.
13. Hoekman, M. F. M., J. M. J. Rientjes, J. Twisk, R. J. Planta, H. M. G. Princen, and W. H. Mager. Transcriptional regulation of the gene encoding cholesterol 7α-hydroxylase in the rat. Gene 130: 217-223, 1993.
14. Huang, X. P., X. T. Fan, J. F. Desjeux, and M. Castagna. Bile acids, non-phorbol ester type tumor promoters, stimulate the phosphorylation of protein kinase C substrate in human platelets and colon cell line HT29. Int. J. Cancer 52: 444-450, 1992.
15. Javitt, N. B. Bile acid synthesis from cholesterol: regulatory and auxiliary pathways. FASEB J. 8: 1308-1311, 1994.
16. Kullak-Ublick, G.-A., U. Beuers, and G. Paumgartner. Molecular and functional characterization of bile acid transport in human hepatoblastoma Hep G2 cells. Hepatology 23: 1053-1060, 1996.
17. Li, Y. C., D. P. Wang, and J. Y. L. Chiang. Regulation of cholesterol 7α-hydroxylase in the liver: cDNA cloning, sequencing and regulation of cholesterol 7α-hydroxylase mRNA. J. Biol. Chem. 265: 12012-12019, 1990.
18. Mangelsdorf, D. J., C. Thummel, M. Beato, P. Herrlich, G. Schutz, K. Umesono, B. Blumberg, P. Kastner, M. Mark, P. Chambon, and R. M. Evans. The nuclear receptor superfamily: the second decade. Cell 83: 835-839, 1995.
19. Nes, W. R., and M. L. McKean. Biochemistry of Steroids and Other Isopentenoids. Baltimore, MD: University Park, 1977, p. 76-77.