Guggulsterone is a farnesoid X receptor antagonist in coactivator association assays but acts to enhance transcription of bile salt export pump

Journal of Biological Chemistry

Volumn 278, Issue 12, 2003, Pages 10214-10220

  Cui, Jisong ^a   Huang, Li ^c   Zhao, Annie ^c   Lew, Jane L ^c   Yu, Jinghua ^c   Sahoo, Soumya ^a   Meinke, Peter T ^a   Royo, Inmaculada ^b   Peláez, Fernando ^b   Wright, Samuel D ^c  

^a MERCK RESEARCH LABORATORIES   (United States)

^b Medical affairs Merck sharp and Dohme ltd   (Spain)

^c RY80W 107 ^*

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; LIPIDS; ORGANIC ACIDS; RNA;

ANTAGONIST LIGANDS;

BIOASSAY;

BILE SALT EXPORT PUMP; BINDING PROTEIN; CARRIER PROTEIN; CELL NUCLEUS RECEPTOR; CHENODEOXYCHOLIC ACID; CHOLESTEROL 7ALPHA MONOOXYGENASE; FARNESOID X RECEPTOR ANTAGONIST; GUGGULSTERONE; HIGH DENSITY LIPOPROTEIN; INTESTINAL BILE ACID BINDING PROTEIN; LUCIFERASE; MESSENGER RNA; OXYGENASE; RECEPTOR BLOCKING AGENT; RECEPTOR SUBTYPE; STEROL 12ALPHA HYDROXYLASE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; ABC TRANSPORTER; ABCB11 PROTEIN, HUMAN; ABCB11 PROTEIN, RAT; BILE ACID; CELL RECEPTOR; DNA BINDING PROTEIN; FARNESOID X RECEPTOR; FARNESOID X-ACTIVATED RECEPTOR; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; ISOPROTEIN; PREGNA 4,17 DIENE 3,16 DIONE; PREGNA-4,17-DIENE-3,16-DIONE; PREGNANE DERIVATIVE; TRANSCRIPTION FACTOR;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE ACTIVATION; GENE EXPRESSION REGULATION; GENE INDUCTION; GENE TARGETING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; LIPOPROTEIN BLOOD LEVEL; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; RAT; REPORTER GENE; TRIACYLGLYCEROL BLOOD LEVEL; ANIMAL; BLOOD; CELL CULTURE; DRUG ANTAGONISM; DRUG EFFECT; FISCHER 344 RAT; GENETICS; METABOLISM;

ANIMALIA; COMMIPHORA; COMMIPHORA MUKUL; MARTES PENNANTI;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BILE ACIDS AND SALTS; CHOLESTEROL, HDL; DNA-BINDING PROTEINS; HUMANS; MALE; PREGNENEDIONES; PROMOTER REGIONS (GENETICS); PROTEIN ISOFORMS; RATS; RATS, INBRED F344; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRIGLYCERIDES; TUMOR CELLS, CULTURED;

EID: 0003295132     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M209323200     Document Type: Article

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