Bile acid regulation of hepatic physiology III. Bile acids and nuclear receptors

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 284, Issue 3 47-3, 2003, Pages

  Chiang, John Y L ^a  

^a Northeastern Ohio Medical University   (United States)

Author keywords

Cholesterol 7 hydroxylase cytochrome P 450; Cholesterol homeostasis; Farnesoid X receptor; Gene regulation; Liver orphan receptor

Indexed keywords

BILE ACID; CELL NUCLEUS RECEPTOR; CHOLESTEROL;

CARDIOVASCULAR DISEASE; GENE MUTATION; HOMEOSTASIS; HUMAN; INTESTINE ABSORPTION; LIPID ABSORPTION; LIPID TRANSPORT; LIVER DISEASE; LIVER FUNCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR GENE; RECEPTOR UPREGULATION; REGULATOR GENE; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; STEROL EXCRETION;

EID: 0037369402     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.00417.2002     Document Type: Review

References (37)

1. Agellon LB, Drover VA, Cheema SK, Gbaguidi GF, and Walsh A. Dietary cholesterol fails to stimulate the human cholesterol 7α-hydroxylase gene (CYP7A1) in transgenic mice. J Biol Chem 277: 20131-20134, 2002.
2. Chiang JY. Bile acid regulation of gene expression: roles of nuclear hormone receptors. Endocr Rev 23: 443-463, 2002.
3. Chiang JY, Kimmel R, and Stroup D. Regulation of cholesterol 7α-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRα). Gene 262: 257-265, 2001.
4. Chiang JYL. Regulation of bile acid synthesis. Front Biosci 3: D176-D193, 1998.
5. Chiang JYL, Kimmel R, Weinberger C, and Stroup D. FXR responds to bile acids and represses cholesterol 7α-hydroxylase gene (CYP7A1) transcription. J Biol Chem 275: 10918-10924, 2000.
6. Chiang JYL, Miller WF, and Lin GM. Regulation of cholesterol 7α-hydroxylase in the liver: purification of cholesterol 7α-hydroxylase and the immunochemical evidence for the induction of cholesterol 7α-hydroxylase by cholestyramine and circadian rhythm. J Biol Chem 265: 3889-3897, 1990.
7. Chiang JYL and Stroup D. Identification and characterization of a putative bile acid responsive element in cholesterol 7α-hydroxylase gene promoter. J Biol Chem 269: 17502-17507, 1994.
8. Del Castillo-Olivares A and Gil G. Suppression of sterol 12α-hydroxylase transcription by the short heterodimer partner: insights into the repression mechanism. Nucleic Acids Res 29: 4035-4042, 2001.
9. Del Castillo-Olivares A and Gil G. Differential effects of sterol regulatory binding proteins 1 and 2 on sterol 12α-hydroxylase SREBP-2 suppresses the sterol 12 α-hydroxylase promoter. J Biol Chem 277: 6750-6757, 2002.
10. De Fabiani E, Mitro N, Anzulovich AC, Pinelli A, Galli G, and Crestani M. The negative effects of bile acids and tumor necrosis factor α on the transcription of cholesterol 7α-hydroxylase gene (CYP7A1) converge to hepatic nuclear factor-4. A novel mechanism of feedback regulation of bile acid synthesis mediated by nuclear receptors. J Biol Chem 276: 30708-30716, 2001.
11. Goodwin B, Jones SA, Price RR, Watson MA, McKee DD, Moore LB, Galardi C, Wilson JG, Lewis MC, Roth ME, Maloney PR, Willson TM, and Kliewer SA. A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis. Mol Cell 6: 517-526, 2000.
12. Ishibashi S, Schwartz M, Frykman PK, Hertz J, and Russell DW. Disruption of cholesterol 7α-hydroxylase gene in mice: I. Postnatal lethality reversed by bile acid and vitamin supplementation. J Biol Chem 271: 18017-18023, 1996.
13. Kerr TA, Saeki S, Schneider M, Schaefer K, Berdy S, Redder T, Shan B, Russell DW, and Schwarz M. Loss of nuclear receptor SHP impairs but does not eliminate negative feedback regulation of bile acid synthesis. Dev Cell 2: 713-720, 2002.
14. Leitersdorf E, Safadi R, Meiner V, Reshef A, Bjorkhem I, Friedlander Y, Morkos S, and Berginer VM. Cerebrotendinous xanthomatosis in the Israeli Druze: molecular genetics and phenotypic characteristics. Am J Hum Genet 55: 907-915, 1994.
15. Li YC, Wang DP, and Chiang JYL. Regulation of cholesterol 7α-hydroxylase in the liver: cDNA cloning, sequencing and regulation of cholesterol 7α-hydroxylase mRNA. J Biol Chem 265: 12012-12019, 1990.
16. Li-Hawkins J, Lund EG, Turley SD, and Russell DW. Disruption of the oxysterol 7α-hydroxylase gene in mice. J Biol Chem 275: 16536-16542, 2000.
17. Lu TT, Makishima M, Repa JJ, Schoonjans K, Kerr TA, Auwerx J, and Mangelsdorf DJ. Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors. Mol Cell 6: 507-515, 2000.
18. Makishima M, Lu TT, Xie W, Whitfield GK, Domoto H, Evans RM, Haussler MR, and Mangelsdorf DJ. Vitamin D receptor as an intestinal bile acid sensor. Science 296: 1313-1316, 2002.
19. Makishima M, Okamoto AY, Repa JJ, Tu H, Learned RM, Luk A, Hull MV, Lustig KD, Mangelsdorf DJ, and Shan B. Identification of a nuclear receptor for bile acids. Science 284: 1362-1365, 1999.
20. Miyake JH, Duong-Polk XT, Taylor JM, Du EZ, Castellani LW, Lusis AJ, and Davis RA. Transgenic expression of cholesterol 7α-hydroxylase prevents atherosclerosis in C57BL/6J mice. Arterioscler Thromb Vasc Biol 22: 121-126, 2002.
21. Miyake JH, Wang SL, and Davis RA. Bile acid induction of cytokine expression by macrophages correlates with repression of hepatic cholesterol 7α-hydroxylase. J Biol Chem 275: 21805-21808, 2000.
22. Parks DJ, Blanchard SG, Bledsoe RK, Chandra G, Consler TG, Kliewer SA, Stimmel JB, Willson TM, Zavacki AM, Moore DD, and Lehmann JM. Bile acids: natural ligands for an orphan nuclear receptor. Science 284: 1365-1368, 1999.
23. Peet DJ, Turley SD, Ma W, Janowski BA, Lobaccaro JM, Hammer RE, and Mangelsdorf DJ. Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXRα. Cell 93: 693-704, 1998.
24. Pullinger CR, Eng C, Salen G, Shefer S, Batta AK, Erickson SK, Verhagen A, Rivera CR, Mulvihill SJ, Malloy MJ, and Kane JP. Human cholesterol 7α-hydroxylase (CYP7A1) deficiency has a hypercholesterolemic phenotype. J Clin Invest 110: 109-117, 2002.
25. Rosen H, Reshef A, Maeda N, Lippoldt A, Shpizen S, Triger L, Eggertsen G, Bjorkhem I, and Leitersdorf E. Markedly reduced bile acid synthesis but maintained levels of cholesterol and vitamin D metabolites in mice with disrupted sterol 27-hydroxylase gene. J Biol Chem 273: 14805-14812, 1998.
26. Schuetz EG, Strom S, Yasuda K, Lecureur V, Assem M, Brimer C, Lamba J, Kim RB, Ramachandran V, Komoroski BJ, Venktaramanan R, Cai H, Sinal CJ, Gonzalez FJ, and Schuetz JD. Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450. J Biol Chem 276: 39411-39418, 2001.
27. Setchell KDR, Schwarz M, O'Connell NC, Lund EG, Davis DL, Lathe R, Thompson HR, Weslie TR, Sokol RJ, and Russell DW. Identification of a new inborn error in bile acid synthesis involving 7α-hydroxylation - a cause of severe liver disease. J Clin Invest 102: 1690-1703, 1998.
28. Staudinger JL, Goodwin B, Jones SA, Hawkins-Brown D, MacKenzie KI, LaTour A, Liu Y, Klaassen CD, Brown KK, Reinhard J, Willson TM, Koller BH, and Kliewer SA. The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity. Proc Natl Acad Sci USA 98: 3369-3374, 2001.
29. Stravitz RT, Rao YP, Vlahcevic ZR, Gurley EC, Jarvis WD, and Hylemon PB. Hepatocellular protein kinase C activation by bile acids: implications for regulation of cholesterol 7α-hydroxylase. Am J Physiol Gastrointest Liver Physiol 271: G293-G303, 1996.
30. Stroup D and Chiang JYL. HNF4 and COUP-TFII interact to modulate transcription of the cholesterol 7α-hydroxylase gene (CYP7A). J Lipid Res 41: 1-11, 2000.
31. Stroup D, Crestani M, and Chiang JYL. Identification of a bile acid response element in the cholesterol 7α-hydroxylase gene (CYP7A). Am J Physiol Gastrointest Liver Physiol 273: G508-G517, 1997.
32. Urizar NL, Liverman AB, Dodds DT, Silva FV, Ordentlich P, Yan Y, Gonzalez FJ, Heyman RA, Mangelsdorf DJ, and Moore DD. A natural product that lowers cholesterol as an antagonist ligand for FXR. Science 296: 1703-1706, 2002.
33. Wang L, Lee YK, Bundman D, Han Y, Thevananther S, Kim CS, Chua SS, Wei P, Heyman RA, Karin M, and Moore DD. Redundant pathways for negative feedback regulation of bile acid production. Dev Cell 2: 721-731, 2002.
34. Wang H, Chen J, Hollister K, Sowers LC, and Forman BM. Endogenous bile acids are ligands for the nuclear receptor FXR/BAR. Mol Cell 3: 543-553, 1999.
35. Xie W, Radominska-Pandya A, Shi Y, Simon CM, Nelson MC, Ong ES, Waxman DJ, and Evans RM. An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids. Proc Natl Acad Sci USA 98: 3375-3380, 2001.
36. Yang Y, Zhang M, Eggertsen G, and Chiang JY. On the mechanism of bile acid inhibition of rat sterol 12α-hydroxylase gene (CYP8B1) transcription: roles of α-fetoprotein transcription factor and hepatocyte nuclear factor 4α. Biochim Biophys Acta 1583: 63-73, 2002.
37. Zhang M and Chiang JY. Transcriptional regulation of the human sterol 12α-hydroxylase gene (CYP8B1): roles of hepatocyte nuclear factor 4α (HNF-4α) in mediating bile acid repression. J Biol Chem 276: 41690-41699, 2001.