Cholesterol and bile acids regulate xenosensor signaling in drug-mediated induction of cytochromes P450

Journal of Biological Chemistry

Volumn 277, Issue 33, 2002, Pages 29561-29567

  Handschin, Christoph ^a   Podvinec, Michael ^a   Amherd, Remo ^a,b   Looser, Renate ^a   Ourlin, Jean Claude ^a,c   Meyer, Urs A ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

^b MyoContract   (Switzerland)

^c CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSENSORS; CARBOXYLIC ACIDS; CYTOLOGY; DRUG DOSAGE; ENZYME KINETICS; METABOLISM;

BILE ACIDS; CHICKEN XENOBIOTIC RECEPTOR (CXR); XENOBIOTICS; XENOSENSOR;

CHOLESTEROL;

ANDROGEN RECEPTOR; BILE ACID; CELL NUCLEUS RECEPTOR; CHOLESTEROL; CHOLESTEROL 7ALPHA MONOOXYGENASE; CYTOCHROME P450; CYTOCHROME P450 2B6; CYTOCHROME P450 3A4; OXYSTEROL; PREGNANE X RECEPTOR; PROTEIN ANDROSTANE RECEPTOR; PROTEIN CHICKEN XENOBIOTIC RECEPTOR; UNCLASSIFIED DRUG; AVIAN PROTEIN; CELL RECEPTOR; CXR PROTEIN, CHICKEN; PHENOBARBITAL; PRIMER DNA; RETINOIC ACID RECEPTOR; XENOBIOTIC AGENT;

ARTICLE; DRUG METABOLISM; ENZYME ACTIVATION; LIPID METABOLISM; PRIORITY JOURNAL; PROTEIN INDUCTION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; ANIMAL; BIOSYNTHESIS; CELL LINE; DRUG EFFECT; ENHANCER REGION; ENZYME INDUCTION; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE;

ANIMALS; AVIAN PROTEINS; BASE SEQUENCE; BILE ACIDS AND SALTS; CELL LINE; CHOLESTEROL; CYTOCHROME P-450 ENZYME SYSTEM; DNA PRIMERS; ENHANCER ELEMENTS (GENETICS); ENZYME INDUCTION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; MOLECULAR SEQUENCE DATA; PHENOBARBITAL; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, RETINOIC ACID; SIGNAL TRANSDUCTION; XENOBIOTICS;

EID: 0037119454     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M202739200     Document Type: Article

References (59)

1. Waxman, D. J., and Azaroff, L. (1992) Biochem. J. 281, 577-592
2. Nelson, D. R. (1999) Arch. Biochem. Biophys. 369, 1-10
3. Repa, J. J., and Mangelsdorf, D. J. (2000) Annu. Ren. Cell Dev. Biol. 16, 459-481
4. Honkakoski, P., and Negishi, M. (2000) Biochem. J. 347, 321-337
5. Waxman, D. J. (1999) Arch. Biochem. Biophys. 369, 11-23
6. Savas, U., Griffin, K. J., and Johnson, E. F. (1999) Mol. Pharmacol. 56, 851-857
7. Goodwin, B., Jones, S. A., Price, R. R., Watson, M. A., McKee, D. D., Moore, L. B., Galardi, C., Wilson, J. G., Lewis, M. C., Roth, M. E., Maloney, P. R., Willson, T. M., and Kliewer, S. A. (2000) Mol. Cell 6, 517-526
8. Lu, T. T., Makishima, M., Repa, J. J., Schoonjans, K., Kerr, T. A., Auwerx, J., and Mangelsdorf, D. J. (2000) Mol. Cell 6, 507-515
9. Handschin, C., Podvinec, M., and Meyer, U. A. (2000) Proc. Natl. Acad. Sci. U.S.A. 97, 10769-10774
10. Xie, W., Banvick, J. L., Simon, C. M., Pierce, A. M., Safe, S., Blumberg, B., Guzelian, P. S., and Evans, R. M. (2000) Genes Dev. 14, 3014-3023
11. Wei, P., Zhang, J., Egan-Hafley, M., Liang, S., and Moore, D. D. (2000) Nature 407, 920-923
12. Xie, W., Barwick, J. L., Downes, M., Blumberg, B., Simon, C. M., Nelson, M. C., Neuschwander-Tetri, B. A., Brunt, E. M., Guzelian, P. S., and Evans, R. M. (2000) Nature 406, 435-439
13. Staudinger, J. L., Goodwin, B., Jones, S. A., Hawkins-Brown, D., MacKenzie, K. I., LaTour, A., Liu, Y., Haassen, C. D., Brown, K. K., Reinhard, J., Willson, T. M., Koller, B. H., and Kliewer, S. A. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 3369-3374
14. Handschin, C., and Meyer, U. A. (2000) J. Biol. Chem. 275, 13362-13369
15. Handschin, C., Podvinec, M., Looser, R., Amherd, R., and Meyer, U. A. (2001) Mol. Pharmacol. 60, 681-689
16. Handschin, C., Podvinec, M., Stöckli, J., Hoffmann, K, and Meyer, U. A. (2001) Mol. Endocrinol. 15, 1571-1585
17. Xie, W., Radominska-Pandya, A., Shi, Y., Simon, C. M., Nelson, M. C., Ong, E. S., Waxman, D. J., and Evans, R. M. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 3375-3380
18. Goodwin, B., Hodgson, E., and Liddle, C. (1999) Mol. Pharmacol. 56, 1329-1339
19. Kocarek, T. A., Kraniak, J. M., and Reddy, A. B. (1998) Mol. Pharmacol. 54, 474-484
20. Kocarek, T. A., and Reddy, A. B. (1998) Biochem. Pharmacol 55, 1435-1443
21. Kocarek, T. A., Schuetz, E. G., and Guzelian, P. S. (1993) Toxicol. Appl. Pharmacol. 120, 298-307
22. Ourlin, J. C., Handschin, C., Kaufmann, M., and Meyer, U. A. (2002) Biochem. Biophys. Res. Commun. 291, 378-384
23. Setchell, K. D., Rodrigues, C. M., Clerici, C., Solinas, A., Morelli, A., Gartung, C., and Boyer, J. (1997) Gastroenterology 112, 226-235
24. Fischer, S., Beuers, U., Spengler, U., Zwiebel, F. M., and Koebe, H. G. (1996) Clin. Chim. Acta 251, 173-186
25. Jones, S. A., Moore, L. B., Shenk, J. L., Wisely, G. B., Hamilton, G. A., McKee, D. D., Tomkinson, N. C., LeCluyse, E. L., Lambert, M. H., Willson, T. M., Kliewer, S. A., and Moore, J. T. (2000) Mol. Endocrinol. 14, 27-39
26. Forman, B. M., Ruan, B., Chen, J., Schroepfer, G. J., Jr., and Evans, R. M. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 10588-10593
27. Gan, X., Kaplan, R., Menke, J. G., MacNaul, K., Chen, Y., Sparrow, C. P., Zhou, G., Wright, S. D., and Cai, T. Q. (2001) J. Biol. Chem. 276, 48702-48708
28. Mangelsdorf, D. J., and Evans, R. M. (1995) Cell 83, 841-850
29. Araya, Z., and Wikvall, K (1999) Biochim. Biophys. Acta 1438, 47-54
30. Furster, C., and Wikvall, K. (1999) Biochim. Biophys. Acta 1437, 46-52
31. Song, C., Hiipakka, R. A., and Liao, S. (2000) Steroids 65, 423-427
32. Sueyoshi, T., Kawamoto, T., Zelko, I., Honkakoski, P., and Negishi, M. (1999) J. Biol. Chem. 274, 6043-6046
33. Chawla, A., Repa, J. J., Evans, R. M., and Mangelsdorf, D. J. (2001) Science 294, 1866-1870
34. Chiang, J. Y., Kimmel, R., and Stroup, D. (2001) Gene (Amst.) 262, 257-265
35. Schuetz, E. G., Strom, S., Yasuda, K., Lecureur, V., Assem, M., Brimer, C., Lamba, J., Kim, R. B., Ramachandran, V., Komoroski, B. J., Venkataramanan, R., Cai, H., Sinal, C. J., Gonzalez, F. J., and Schuetz, J. D. (2001) J. Biol. Chem. 276, 39411-39418
36. Sugatani, J., Kojima, H., Ueda, A., Kakizaki, S., Yoshinari, K, Gong, Q. H., Owens, I. S., Negishi, M., and Sueyoshi, T. (2001) Hepatology 33, 1232-1238
37. Synold, T. W., Dussault, I., and Forman, B. M. (2001) Nat. Med. 7, 584-590
38. Plewka, A., and Kaminski, M. (1996) Exp. Toxicol. Pathol. 48, 249-253
39. Watanabe, M., Nakura, H., Tateishi, T., Tanaka, H., Kumai, T., and Kobayashi, S. (1996) Med. SCI. Res. 24, 257-259
40. Andersson, M., Ericsson, J., Appelkvist, E. L., Schedin, S., Chojnacki, T., and Dallner, G. (1994) Biochim. Biophys. Acta 1214, 79-87
41. Sudjana-Sugiaman, E., Eggertsen, G., and Bjorkhem, I. (1994) J. Lipid Res. 35, 319-327
42. Blouin, R. A., Bandyopadhyay, A. M., Chaudhary, I., Robertson, L. W., Gemzik, B., and Parkinson, A. (1993) Aren. Biochem. Biophys. 303, 313-320
43. Thomas, K. D. (1984) Isr. J. Med. Sci. 20, 240-241
44. Eins, J. M., Lojo, S., Del Rio, M. C., Novo, I., Bravo, M., Pavon, P., and Castro-Gago, M. (1995) Neurology 45, 1155-1157
45. Aynaci, F. M., Orhan, F., Orem, A., Yildirmis, S., and Gedik, Y. (2001) J. Child Neurol. 16, 367-369
46. Schwaninger, M., Ringleb, P., Annecke, A., Winter, R., Kohl, B., Werle, E., Fiehn, W., Rieser, P. A., and Walter-Sack, I. (2000) J. Neurol. 247, 687-690
47. Verrotti, A., Domizio, S., Angelozzi, B., Sabatino, G., Morgese, G., and Chiarelli, F. (1997) J. Paediatr. Child Health 33, 242-245
48. Yilmaz, E., Dosan, Y., Gurgoze, M. K., and Gungor, S. (2001) Acta Neurol. Belg. 101, 217-220
49. Penzak, S. R., and Chuck, S. K. (2000) Scand. J. Infect. Dis. 32, 111-123
50. Dussault, I., Lin, M., Hollister, K., Wang, E. H., Synold, T. W., and Forman, B. M. (2001) J. Biol. Chem. 276, 33309-33312
51. Back, P. (1987) Pharmacol. Ther. 33, 153-155
52. Summerfield, J. A., Billing, B. H., and Shackleton, C. H. (1976) Biochem. J. 154, 507-516
53. Wietholtz, H., Marschall, H. U., Sjovall, J., and Matem, S. (1996) J. Hepatol. 24, 713-718
54. Cancado, E. L., Leitao, R. M., Carrilho, F. J., and Laudanna, A. A. (1998) Am. J. Gastroenterol. 93, 1510-1517
55. Chawla, A., Saez, E., and Evans, R. M. (2000) Cell 103, 1-4
56. Repa, J. J., Turley, S. D., Lobaccaro, J. A., Medina, J., Li, L., Lustig, K., Shan, B., Heyman, R. A., Dietschy, J. M., and Mangelsdorf, D. J. (2000) Science 289, 1524-1529
57. Venkateswaran, A., Repa, J. J., Lobaccaro, J. M., Bronson, A., Mangelsdorf, D. J., and Edwards, P. A. (2000) J. Biol. Chem. 275, 14700-14707
58. Sehayek, E., Ono, J. G., Duncan, E. M., Batta, A. K., Salen, G., Shefer, S., Neguyen, L. B., Yang, K., Lipkin, M., and Breslow, J. L. (2001) J. Lipid Res. 42, 1250-1256
59. Blumberg, B., and Evans, R. M. (1998) Genes Dev. 12, 3149-3155