Side Chain Hydroxylations in Bile Acid Biosynthesis Catalyzed by CYP3A Are Markedly Up-regulated in Cyp27-/- Mice but Not in Cerebrotendinous Xanthomatosis

Journal of Biological Chemistry

Volumn 276, Issue 37, 2001, Pages 34579-34585

  Honda, Akira ^a   Salen, Gerald ^b,c   Matsuzaki, Yasushi ^a   Batta, Ashok K ^b   Xu, Guorong ^b,c   Leitersdorf, Eran ^d   Tint, G Stephen ^b,c   Erickson, Sandra K ^e   Tanaka, Naomi ^a   Shefer, Sarah ^b  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD; ENZYMES; GASTROENTEROLOGY; HORMONES; HYDROXYLATION; MUTAGENESIS;

BILE ACID;

BIOSYNTHESIS;

5BETA CHOLESTANE 3ALPHA,7ALPHA,12ALPHA TRIOL 25 HYDROXYLASE; 5BETA CHOLESTANE 3ALPHA,7ALPHA,12ALPHA,25 TETROL 23 HYDROXYLASE; 5BETA CHOLESTANE 3ALPHA,7ALPHA,12ALPHA,25 TETROL 24 HYDROXYLASE; 5BETA CHOLESTANE 3ALPHA,7ALPHA,12ALPHA,25 TETROL 27 HYDROXYLASE; BILE ACID; CHOLESTANETRIOL 26 MONOOXYGENASE; CHOLIC ACID; CYTOCHROME P450 3A; CYTOCHROME P450 3A4; OXYGENASE; STEROL 27 HYDROXYLASE; TROLEANDOMYCIN; UNCLASSIFIED DRUG; CYP27A1 PROTEIN, HUMAN; CYP27A1 PROTEIN, MOUSE; CYP3A PROTEIN, HUMAN; CYP3A4 PROTEIN, HUMAN; CYTOCHROME P450; ETHANOLAMINE DERIVATIVE; MIXED FUNCTION OXIDASE; NITRATE; STEROID MONOOXYGENASE; TROLNITRATE;

ADULT; ANIMAL TISSUE; ARTICLE; BILE ACID SYNTHESIS; CASE REPORT; CATALYSIS; CEREBROTENDINOUS XANTHOMATOSIS; DOSE RESPONSE; ENZYME ACTIVITY; HUMAN; HUMAN TISSUE; HYDROXYLATION; LIVER MICROSOME; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; UPREGULATION; ANIMAL; BIOSYNTHESIS; GENETICS; METABOLISM; MIDDLE AGED; MOUSE MUTANT; MUTATION; PHYSIOLOGY;

ANIMALIA; STAPHYLOCOCCUS PHAGE 3A;

ANIMALS; BILE ACIDS AND SALTS; CATALYSIS; CYTOCHROME P-450 CYP27A1; CYTOCHROME P-450 ENZYME SYSTEM; ETHANOLAMINES; HUMANS; HYDROXYLATION; MALE; MICE; MICE, KNOCKOUT; MICROSOMES, LIVER; MIDDLE AGED; MIXED FUNCTION OXYGENASES; MUTATION; NITRATES; STEROID HYDROXYLASES; TROLEANDOMYCIN; UP-REGULATION; XANTHOMATOSIS, CEREBROTENDINOUS;

EID: 0035860807     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M103025200     Document Type: Article

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