Cyp7b, a novel brain cytochrome P450, catalyzes the synthesis of neurosteroids 7α-hydroxy dehydroepiandrosterone and 7α-hydroxy pregnenolone

Proceedings of the National Academy of Sciences of the United States of America

Volumn 94, Issue 10, 1997, Pages 4925-4930

  Rose, Ken A ^a   Stapleton, Genevieve ^a,f   Dott, Karin ^b   Kieny, Marie Paule ^b   Best, Ruth ^c   Schwarz, Margrit ^d   Russell, David W ^d   Björkhem, Ingemar ^e   Seckl, Jonathan ^c   Lathe, Richard ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b TRANSGENE S A   (France)

^c WESTERN GENERAL HOSPITAL   (United Kingdom)

^d UNIVERSITY OF TEXAS AT DALLAS   (United States)

^e KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^f UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

25 HYDROXYCHOLESTEROL; ANDROSTANOLONE; CORTICOSTERONE; CYTOCHROME P450; CYTOCHROME P450 CYP7B; ESTRADIOL; PREGNENOLONE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TESTOSTERONE; UNCLASSIFIED DRUG; VIRUS VECTOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; ENZYME ANALYSIS; HORMONE PROTEIN COMPLEX; HYDROXYLATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REACTION ANALYSIS; STEROID METABOLISM;

17-ALPHA-HYDROXYPREGNENOLONE; ANIMALS; BRAIN; CYTOCHROME P-450 ENZYME SYSTEM; DEHYDROEPIANDROSTERONE; DNA, COMPLEMENTARY; GENETIC VECTORS; HELA CELLS; HIPPOCAMPUS; HUMANS; KINETICS; MICE; RATS; RECOMBINANT PROTEINS; STEROID HYDROXYLASES; SUBSTRATE SPECIFICITY; TRANSFECTION; VACCINIA VIRUS;

EID: 12644253822     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.94.10.4925     Document Type: Article

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