The negative effects of bile acids and tumor necrosis factor-α on the transcription of cholesterol 7α-hydroxylase gene (CYP7A1) converge to hepatic nuclear factor-4: A novel mechanism of feedback regulation of bile acid synthesis mediated by nuclear receptors

Journal of Biological Chemistry

Volumn 276, Issue 33, 2001, Pages 30708-30716

  De Fabiani, Emma ^c   Mitro, Nico ^c   Anzulovich, Ana Cecilia ^a   Pinelli, Alessandra ^c   Galli, Giovanni ^c   Crestani, Maurizio ^b  

^a UNIVERSIDAD NACIONAL DE SAN LUIS   (Argentina)

^b UNIVERSITY OF MILAN   (Italy)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; BODY FLUIDS; CELLS; ENZYMES; GENES; TUMORS;

STRESS SIGNALS;

BIOCHEMISTRY;

BILE ACID; BILE ACID RESPONSE ELEMENT; CELL NUCLEUS RECEPTOR; CHENODEOXYCHOLIC ACID; GALANIN; GALANIN 4 HEPATIC NUCLEAR FACTOR 4 FUSION PROTEIN; HEPATIC NUCLEAR FACTOR 4; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; NUCLEAR FACTOR; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE KINASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; BASIC HELIX LOOP HELIX LEUCINE ZIPPER TRANSCRIPTION FACTOR; CHOLESTEROL 7ALPHA MONOOXYGENASE; DNA BINDING PROTEIN; HEPATOCYTE NUCLEAR FACTOR 4; MAP3K1 PROTEIN, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE 1; MLX PROTEIN, HUMAN; PHOSPHOPROTEIN; PROTEIN SERINE THREONINE KINASE; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; BILE ACID SYNTHESIS; CELL STRAIN HEPG2; CHOLESTEROL 7ALPHA HYDROXYLASE GENE; CONSENSUS SEQUENCE; CONTROLLED STUDY; FEEDBACK SYSTEM; GENE; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; SIGNAL TRANSDUCTION; STRESS; TRANSACTIVATION; TRANSCRIPTION REGULATION; BIOSYNTHESIS; CELL CULTURE; DNA RESPONSIVE ELEMENT; DRUG EFFECT; GENETIC TRANSCRIPTION; GENETICS; PHYSIOLOGY;

ANIMALIA;

BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; BILE ACIDS AND SALTS; CELLS, CULTURED; CHOLESTEROL 7-ALPHA-HYDROXYLASE; DNA-BINDING PROTEINS; FEEDBACK; HEPATOCYTE NUCLEAR FACTOR 4; HUMANS; MAP KINASE KINASE KINASE 1; PHOSPHOPROTEINS; PROTEIN-SERINE-THREONINE KINASES; RESPONSE ELEMENTS; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0035903105     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M103270200     Document Type: Article

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