Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover

Journal of Biological Chemistry

Volumn 278, Issue 25, 2003, Pages 22980-22988

  Lund, Erik G ^a,b   Xie, Chonglun ^a   Kotti, Tiina ^a   Turley, Stephen D ^a   Dietschy, John M ^a   Russell, David W ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL CULTURE; BIOCHEMISTRY; BIOSYNTHESIS; BRAIN; CHOLESTEROL; ENZYME KINETICS; METABOLISM; TISSUE;

LIVER;

GENES;

24 HYDROXYCHOLESTEROL; CHOLESTEROL; CHOLESTEROL 24 HYDROXYLASE; CYTOCHROME P450; OXYGENASE; OXYSTEROL; UNCLASSIFIED DRUG;

ARTICLE; BILE ACID METABOLISM; BILE ACID SYNTHESIS; BRAIN; CHOLESTEROL METABOLISM; CHOLESTEROL SYNTHESIS; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; EMBRYO; KNOCKOUT GENE; KNOCKOUT MOUSE; LIVER; MOUSE; MUTANT; NONHUMAN; PRIORITY JOURNAL; STEADY STATE; WILD TYPE;

ALLELES; ANIMALS; BETA-GALACTOSIDASE; BRAIN; CHOLESTEROL; CHOLESTEROL, DIETARY; EMBRYONIC AND FETAL DEVELOPMENT; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; KINETICS; LIVER; MICE; MICE, KNOCKOUT; RESTRICTION MAPPING; RNA, MESSENGER; STEROID HYDROXYLASES; TRANSCRIPTION, GENETIC;

ANIMALIA;

EID: 0038265008     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M303415200     Document Type: Article

References (52)

1. Russell, D. W. (2003) Annu. Rev. Biochem. 72, 137-174
2. Fielding, C. J., and Fielding, P. E. (1995) J. Lipid Res. 36, 211-228
3. Lutjohann, D., Breuer, O., Ahlborg, G., Nennesmo, I., Siden, A., Diczfalusy, U., and Bjorkhem, I. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 9799-9804
4. Bjorkhem, I., Lutjohann, D., Breuer, O., Sakinis, A., and Wennmalm, A. (1997) J. Biol. Chem. 272, 30178-30184
5. Meaney, S., Bodin, K., Diczfalusy, U., and Bjorkhem, I. (2002) J. Lipid Res. 43, 2130-2135
6. Bjorkhem, I. (2002) J. Clin. Invest. 110, 725-730
7. Bretillon, L., Lutjohann, D., Stahle, L., Widhe, T., Bindl, L., Eggertsen, G., Diczfalusy, U., and Bjorkhem, I. (2000) J. Lipid Res. 41, 840-845
8. Bjorkhem, I., Andersson, U., Ellis, E., Alvelius, G., Ellegard, L., Diczfalusy, U., Sjovall, J., and Einarsson, C. (2001) J. Biol. Chem. 276, 37004-37010
9. Li-Hawkins, J., Lund, E. G., Bronson, A. D., and Russell, D. W., (2000) J. Biol. Chem. 275, 16543-16549
10. Bjorkhem, I., Lutjohann, D., Diczfalusy, U., Stahle, L., Ahlborg, G., and Wahren, J. (1998) J. Lipid Res. 39, 1594-1600
11. Wilson, J. D. (1970) J. Clin. Invest. 49, 655-665
12. Xie, Z., Burns, D. K., Turley, S. D., and Dietschy, J. M. (2000) J. Neuropathol. Exp. Neurol. 59, 1106-1117
13. Mahley, R. W., and Rall, S. C., Jr. (2000) Annu. Rev. Genom. Hum. Genet. 1, 507-537
14. de Chaves, E. I. P., Rusinol, A. E., Vance, D. E., Campenot, R. B., and Vance, J. E. (1997) J. Biol. Chem. 272, 30766-30773
15. Mauch, D. H., Nagler, K., Schumacher, S., Goritz, C., Muller, E.-C., Otto, A., and Pfrieger, F. W. (2001) Science 294, 1354-1357
16. Xu, G., Servatius, R. J., Shefer, S., Tint, G. S., O'Brien, W. T., Batta, A. K., and Salen, G. (1998) Metabolism 47, 878-882
17. Bodovitz, S., and Klein, W. L. (1996) J. Biol. Chem. 271, 4436-4440
18. Howland, D. S., Trusko, S. P., Savage, M. J., Reaume, A. G., Lang, D. M., Hirsch, J. D., Maeda, N., Siman, R., Greenberg, B. D., Scott, R. W., and Flood, D. G. (1998) J. Biol. Chem. 273, 16576-16582
19. Simons, M., Keller, P., De Strooper, B., Beyreuther, K., Dotti, C. G., and Simons, K. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 6460-6464
20. Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., and Pericak-Vance, M. A. (1993) Science 261, 921-923
21. Holtzman, D. M., Bales, K. R., Tenkova, T., Fagan, A. M., Parsadanian, M., Sartorius, L. J., Mackey, B., Olney, J., McKeel, D., Wozniak, D., and Paul, S. M. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 2892-2897
22. Janowski, B. A., Willy, P. J., Devi, T. R., Falck, J. R., and Mangelsdorf, D. J. (1996) Nature 383, 728-731
23. Lehmann, J. M., Kliewer, S. T., Moore, L. B., Smith-Oliver, T. A., Oliver, B. B., Su, J., Sundseth, S. S., Winegar, D. A., Blanchard, D. E., Spencer, T. A., and Willson, T. M. (1997) J. Biol. Chem. 272, 3137-3140
24. Forman, B. M., Ruan, B., Chen, J., Schroepfer, G. J., Jr., and Evans, R. M. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 10588-10593
25. Chawla, A., Repa, J. J., Evans, R. M., and Mangelsdorf, D. J. (2001) Science 294, 1866-1870
26. Lund, E. G., Guileyardo, J. M., and Russell, D. W. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 7238-7243
27. Nelson, D. R., Koymans, L., Kamataki, T., Stegeman, J. J., Feyereisen, R., Waxman, D. J., Waterman, M. R., Gotoh, O., Coon, M. J., Estabrook, R. W., Gunsalus, I. C., and Nebert, D. W. (1996) Pharmacogenetics 6, 1-42
28. Sambrook, J., and Russell, D. W. (2000) Molecular Cloning: A Laboratory Manual., 3rd Ed. 3 vols., Cold Spring Harbor Laboratory Press, Plainview, NY
29. Callahan, C. A., and Thomas, J. B. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 5972-5976
30. Mansour, S. L., Thomas, K. R., and Capecchi, M. R. (1988) Nature 336, 348-352
31. Hogan, B., Beddington, R., Costantini, F., and Lacy, E. (1995) Manipulating the Mouse Embryo, 2nd Ed., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
32. Bayer, S. A., and Altman, J. (1991) Neocortical Development, Raven Press, New York
33. Lawson, A. M., and Setchell, K. D. R. (1988) in The Bile Acids: Chemistry, Physiology, and Metabolism (Setchell, K. D. R., Kritchevsky, D., and Nair, P. P., eds) Vol. 4, pp. 167-267, Plenum Press, New York
34. Kaluzny, M. A., Duncan, L. A., Merritt, M. V., and Epps, D. E. (1985) J. Lipid Res. 26, 135-140
35. Dzeletovic, S., Breuer, O., Lund, E., and Diczfalusy, U. (1995) Anal. Biochem. 225, 73-80
36. Lund, E. G., Kerr, T. A., Sakai, J., Li, W.-P., and Russell, D. W. (1998) J. Biol. Chem. 273, 34316-34348
37. Osono, Y., Woollett, L. A., Herz, J., and Dietschy, J. M. (1995) J. Clin. Invest. 95, 1124-1132
38. Schwarz, M., Russell, D. W., Dietschy, J. M., and Turley, S. D. (1998) J. Lipid Res. 39, 1833-1843
39. Jeske, D. J., and Dietschy, J. D. (1980) J. Lipid Res. 21, 364-376
40. Dietschy, J. M., and Spady, D. K. (1984) J. Lipid Res. 25, 1469-1476
41. Turley, S. D., Daggy, B. P., and Dietschy, J. M. (1994) Gastroenterology 107, 444-452
42. Mombaerts, P., Wang, F., Dulac, C., Chao, S. K., Nemes, A., Mendelsohn, M., Edmondson, J., and Axel, R. (1996) Cell 15, 675-686
43. Repa, J. J., Lund, E. G., Horton, J. D., Leitersdorf, E., Russell, D. W., Dietschy, J. M., and Turley, S. D. (2000) J. Biol. Chem. 275, 39685-39692
44. Lund, E., Bjorkhem, I., Furster, C., and Wikvall, K. (1993) Biochim. Biophys. Acta 1166, 177-182
45. Bjorkhem, I., Diczfalusy, U., and Lutjohann, D. (1999) Curr. Opin. Lipidol. 10, 161-165
46. Herz, J., and Bock, H. H. (2002) Annu. Rev. Biochem. 71, 405-434
47. Anderson, R. G., and Jacobson, K. (2002) Science 296, 1821-1825
48. Kandel, E. R. (1991) in Principles of Neural Science (Kandel, E. R., Schwartz, J. H., and Jessell, T. M., eds) 3rd Ed., pp. 18-32, Appleton & Lange, Norwalk
49. Kelly, J. P. (1991) in Principles of Neural Science (Kandel, E. R., Schwartz, J. H., and Jessell, T. M., eds) 3rd Ed., pp. 283-295, Appleton & Lange, Norwalk
50. Peet, D. J., Turley, S. D., Ma, W., Janowski, B. A., Lobaccaro, J.-M. A., Hammer, R. E., and Mangelsdorf, D. J. (1998) Cell 93, 693-704
51. Alberti, S., Schuster, G., Parini, P., Feltkamp, D., Diczfalusy, U., Rudling, M., Angelin, B., Bjorkhem, I., Pettersson, S., and Gustafsson, J.-A. (2001) J. Clin. Invest. 107, 565-573
52. Wang, L., Schuster, G. U., Hultenby, K., Zhang, Q., Andersson, S., and Gustafsson, J.-A. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 13873-13883