Transcriptional activation of the cholesterol 7α-hydroxylase gene (CYP7A) by nuclear hormone receptors

Journal of Lipid Research

Volumn 39, Issue 11, 1998, Pages 2192-2200

  Crestani, Maurizio ^a   Sadeghpour, Azita ^a   Stroup, Diane ^a   Galli, Giovanni ^b   Chiang, John Y L ^a  

^a Northeastern Ohio Medical University   (United States)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

Bile acid response element; Bile acid synthesis; Cholesterol 7 hydroxylase; Cytochrome P450; Gene transcription and regulation; Nuclear hormone receptor

Indexed keywords

BILE ACID; CELL NUCLEUS RECEPTOR; CHICKEN OVALBUMIN UPSTREAM PROMOTER TRANSCRIPTION FACTOR; CHOLESTEROL 7ALPHA MONOOXYGENASE; CYTOCHROME P450 CYP7A; CYTOCHROME P450 ISOENZYME; HEPATOCYTE NUCLEAR FACTOR 3; HEPATOCYTE NUCLEAR FACTOR 4; HORMONE RECEPTOR; NUCLEAR FACTOR; RETINOIC ACID; RETINOIC ACID RECEPTOR; RETINOID X RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; ATHEROSCLEROSIS; BILE ACID SYNTHESIS; CHOLELITHIASIS; CHOLESTASIS; CHOLESTEROL METABOLISM; CONTROLLED STUDY; DIABETES MELLITUS; ELECTROPHORETIC MOBILITY; ENZYME ACTIVATION; FEEDBACK SYSTEM; GENETIC TRANSFECTION; HORMONE RECEPTOR INTERACTION; HORMONE RESPONSIVE ELEMENT; HUMAN; HUMAN CELL; LIVER CELL; NUCLEOTIDE REPEAT; PRIORITY JOURNAL; PROMOTER REGION; RECEPTOR BINDING; REPORTER GENE; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; TRANSCRIPTION REGULATION;

ANIMALS; BASE SEQUENCE; BILE ACIDS AND SALTS; CHOLESTEROL 7-ALPHA-HYDROXYLASE; COUP TRANSCRIPTION FACTOR II; COUP TRANSCRIPTION FACTORS; DNA; DNA-BINDING PROTEINS; GENES, REPORTER; HEPATOCYTE NUCLEAR FACTOR 4; HORMONES; LUCIFERASES; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; OLIGONUCLEOTIDE PROBES; PHOSPHOPROTEINS; PROMOTER REGIONS (GENETICS); RATS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, RETINOIC ACID; RECEPTORS, STEROID; REPETITIVE SEQUENCES, NUCLEIC ACID; RETINOID X RECEPTORS; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED;

EID: 0031751631     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Russell, D. W., and K. D. R. Setchell. 1992. Bile acid biosynthesis. Biochemistry. 31: 4737-4749.
2. Chiang, J. Y. L., and Z. R. Vlahcevic. 1996. The regulation of cholesterol conversion to bile acids. In Advances in Molecular and Cell Biology. JAI Press, Inc., Greenwich, London. 269-316.
3. Li, Y. C., D. P. Wang, and J. Y. L. Chiang. 1990. Regulation of cholesterol 7α-hydroxylase in the liver. J. Biol. Chem. 265: 12012-12019.
4. Hylemon, P. B., E. C. Gurley, R. T. Stravitz, J. S. Litz, W. M. Pandak, J. Y. L. Chiang, and Z. R. Vlahcevic. 1992. Hormonal regulation of cholesterol 7α-hydroxylase mRNA levels and transcriptional activity in primary rat hepatocyte cultures. J. Biol. Chem. 267: 16866-16871.
5. Pandak, W. M., Y. C. Li, J. Y. L. Chiang, E. J. Studer, E. C. Gurley, D. M. Heuman, Z. R. Vlahcevic, and P. B. Hylemon. 1991. Regulation of cholesterol 7α-hydroxylase mRNA and transcriptional activity by taurocholate and cholesterol in the chronic biliary diverted rat. J. Biol. Chem. 266: 3416-3421.
6. Stravitz, R. T., P. B. Hylemon, D. M. Heuman, L. R. Hagey, C. D. Schteingart, H-T. Ton-Nu, A. F. Hoffman, and Z. R. Vlahcevic. 1993. Transcriptional regulation of cholesterol 7α-hydroxylase mRNA by conjugated bile acids in primary cultures of rat hepatocytes. J. Biol. Chem. 268: 13987-13993.
7. Crestani, M., D. Stroup, and J. Y. L. Chiang. 1995. Hormonal regulation of the cholesterol 7α-hydroxylase gene (CYP7). J. Lipid. Res. 36:2419-2432.
8. Wang, D-P., D. Stroup, M. Marrapodi, M. Crestani, G. Galli, and J. Y. L. Chiang. 1996. Transcriptional regulation of the human cholesterol 7α-hydroxylase gene (CYP7A) in HepG2 cells. J. Lipid Res. 37: 1831-1841.
9. Ness, G. C. 1994. Developmental regulation of the expression of genes encoding proteins involved in cholesterol homeostasis. Am. J. Med. Genet. 50: 355-357.
10. Smith, J. L., S. R. Lear, and S. K. Erickson. 1995. Developmental expression of elements of hepatic cholesterol metabolism in the rat. J. Lipid Res. 36: 641-652.
11. Lavery, D. J., and U. Schibler. 1993. Circadian transcription of the cholesterol 7α-hydroxylase gene may involve the liver-enriched bZIP protein DBP. Genes & Dev. 7: 1871-1884.
12. Lee, Y-H., J. A. Alberta, F. J. Gonzalez, and D. J. Waxman. 1994. Multiple, functional DBP sites on the promoter of the cholesterol 7α-hydroxylase P450 gene, CYP7. J. Biol. Chem. 269: 14681-14689.
13. Molowa, D. T., W. S. Chen, G. M. Cimis, and C. P. Tan. 1992. Transcriptional regulation of the human cholesterol 7α-hydroxylase gene. Biochemistry. 31: 2539-2544.
14. Cooper, A. D., J. Chen, M. J. Botelho-Yetkinler, Y. Cao, T. Taniguchi, and B. Levy-Wilson. 1997. Characterization of hepatic-specific regulatory elements in the promoter region of the human cholesterol 7α-hydroxylase gene. J. Biol. Chem. 272: 3444-3452.
15. Chiang, J. Y. L., and D. Stroup. 1994. Identification of a putative bile acid-responsive element in cholesterol 7α-hydroxylase gene promoter. J. Biol. Chem. 269: 17502-17507.
16. Crestani, M., A. Sadeghpour, D. Stroup, G. Galli, and J. Y. L. Chiang. 1996. The opposing effects of retinoic acid and phorbol esters converge to a common response element in the promoter of the rat cholesterol 7α-hydroxylase gene (CYP7A). Biochem. Biophys. Res. Commun. 225: 585-592.
17. Stroup, D., M. Crestani, and J. Y. L. Chiang. 1997. Identification of a bile acid response element in the cholesterol 7α-hydroxylase gene (CYP7A). Am. J. Physiol., 273: G508-G517.
18. Stroup, D., M. Crestani, and J. Y. L. Chiang. 1997. Orphan receptor chicken ovalbumin upstream promoter transcription factor II (COUP-TFII) and retinoid X receptor activate and bind the rat cholesterol 7α-hydroxylase gene (CYP7A). J. Biol. Chem. 272: 9833-9839.
19. Lehmann, J. M., S. A. Kliewer, L. B. Moore, T. A. Smith-Oliver, B. B. Oliver, J-L. Su, S. S. Sundseth, D. A. Winegar, D. E. Blanchard, T. A. Spencer, and T. M. Wilson. 1997. Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway. J. Biol. Chem. 272: 3137-3140.
20. Kastner, P., M. Mark, and P. Chambon. 1995. Nonsteroid nuclear receptors: what are genetic studies telling us about their role in real life. Cell. 83: 859-869.
21. Chambon, P. 1996. A decade of molecular biology of retinoic acid receptors. FASEB J. 10: 940-954.
22. Pereira, F. A., Y. Qiu, M-J. Tsai, and S. Y. Tsai. 1995. Chicken ovalbumin upstream promoter transcription factor (COUP-TF): expression during mouse embryogenesis. J. Steroid Biochem. Mol. Biol. 53: 503-508.
23. Barik, S. 1993. PCR Protocols: Current Methods and Applications. B. A. White, editor. Humana Press, Totowa, NJ. 277-286.
24. Dent, C. D., and D. S. Latchman. 1993. In Transcription Factors: a Practical Approach. D. S. Latchman, editor. IRL Press at Oxford University Press, New York, NY. 1-26.
25. Ogbourne, S., and T. M. Antalis. 1998. Transcriptional control and the role of silencers in transcriptional regulation in eukaryotes. Biochem. J. 331: 1-14.
26. Mangelsdorf, D. J., K. Umesono, and R. M. Evans. 1994. The Retinoids: Biology, Chemistry and Medicine. M. B. Sporn, A. B. Roberts, and D. S. Goodman, editors. 2nd ed. Raven Press Ltd, New York. 319-349.
27. Rigaud, G., J. Roux, R. Pictet, and T. Grange. 1991. In vivo footprinting of rat TAT gene: dynamic interplay between the glucocorticoid receptor and a liver-specific factor. Cell. 67: 977-986.
28. Harnish, D. C., S. Malik, E. Kilbourne, R. Costa, and S. K. Karathanasis. 1996. Control of apolipoprotein A-I gene expression through synergistic interactions between hepatocyte nuclear factors 3 and 4. J. Biol. Chem. 271: 13621-13628.
29. Jiang, G., L. Nepomuceno, K. Hopkins, and F. M. Sladek. 1995. Exclusive homodimerization of the orphan receptor hepatocyte nuclear factor 4 defines a new subclass of nuclear receptors. Mol. Cell. Biol. 15: 5131-5143.
30. Ktistaki, E., and I. Talianidis. 1997. Chicken ovalbumin upstream promoter transcription factors act as auxiliary cofactors for hepatocyte nuclear factor 4 and enhance hepatic gene expression. Mol. Cell. Biol. 17: 2790-2797.
31. Malik, S., and S. Karathanasis. 1995. Transcriptional activation by the orphan nuclear receptor ARP-1. Nucleic Acids Res. 23: 1536-1543.
32. Malik, S., and S. K. Karathanasis. 1996. TFIIB-directed transcriptional activation by the orphan nuclear receptor hepatocyte nuclear factor 4. Mol. Cell. Biol. 16: 1824-1831.
33. Cooney, A. J., S. Y. Tsai, B. W. O'Malley, and M-J. Tsai. 1992. Chicken ovalbumin upstream promoter transcription factor (COUP-TF) dimers bind to different GGTCA response elements, allowing COUP-TF to repress hormonal induction of the vitamin D3, thyroid hormone, and retinoic acid receptors. Mol. Cell. Biol. 12: 4153-4163.
34. Yoshida, E., S. Aratani, H. Itou, M. Miyagishi, M. Takiguchi, T. Osumu, K. Murakami, and A. Fukamizu. 1997. Functional association between CBP and HNF4 in trans-activation. Biochem. Biophys. Res. Commun. 241: 664-669.
35. Sladek, F. M. 1994. Hepatocyte Nuclear Factor 4 (HNF4). In Liver Gene Expression. F. Tronche, and M. Yaniv, editors. R. G. Landes Co., Austin, TX. 207-230.
36. Machleder, D., B. Ivandic, C., Welch, L. Castellani, K. Reue, and A. J. Lusis. 1997. Complex genetic control of HDL levels in mice in response to an atherogenic diet. J. Clin. Invest. 99: 1406-1419.
37. Dueland, S., D. France, S-L. Wang, J. D. Trawick, and R. A. Davis. 1997. Cholesterol 7α-hydroxylase influences the expression of hepatic apoA-I in two inbred mouse strains displaying different susceptabilities to atherosclerosis and in hepatoma cells. J. Lipid Res. 38: 1445-1453.
38. Yamagata, K., N. Oda, P. J. Kaisaki, S. Menzel, H. Furuta, M. Vaxillaire, L. Southam, R. D. Cox, G. M. Lathrop, V. V. Boriraj, X. Chen, N. J. Cox, Y. Oda, H. Yano, M. M. LeBeau, S. Yamada, H. Nishigori, J. Takeda, S. S. Fajans, A. T. Hattersley, N. Iwasaki, T. Hanson, O. Pedersen, K. S. Polonsky, R. C. Turner, G. Velho, J-C. Chevre, P. Froguel, and G. I. Bell. 1996. Mutations in the hepatocyte nuclear factor-1α gene in maturity-onset diabetes of the young (MODY3). Nature. 384: 455-458.
39. Yamagata, K., H. Furuta, N. Oda, P. J. Kaisaki, S. Menzel, N. J. Cox, S. S. Fajans, S. Signorini, M. Stoffel, and G. I. Bell. 1996. Mutations in the hepatocyte nuclear factor-4α gene in maturity-onset diabetes of the young (MODY1). Nature. 384: 458-460.
40. Hani, E. B., L. Suaud, P. Boutin, I-C. Chevre, E. Durand, A. Phillippi, F. Demenais, N. Vionnet, H. Furuta, G. Velho, G. I. Bell, B. Laine, and P. Froguel. 1998. A missense mutation in hepatocyte nuclear factors-4α, resulting in a reduced transactivation activity, in human late-onset non-insulin-depedent diabetes mellitus. J. Clin. Invest. 101: 521-526.
41. Hertz, R., J. Magenheim, I. Berman, and J. Bar-Tana. 1998. Fatty acyl-CoA thioesters are ligands of hepatic nuclear factor-4α. Nature. 392: 512-516.
42. 2 is a ligand for the adipocyte determination factor PPARγ. Cell. 83: 803-812.
43. Forman, B. M., J. Chen, and R. M. Evans. 1997. Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ. Proc. Natl. Acad. Sci. USA. 94: 4312-4317.
44. Stravitz, R. T., Y-I. Rao, Z. R. Vlahcevic, E. C. Gurley, W. D. Jarvis, and P. B. Hylemon. 1996. Hepatocellular protein kinase C activation by bile acids: implications for regulation of cholesterol 7α-hydroxylase. Am. J. Physiol. 271: G293-G303.
45. Chiang, J. Y. L. 1998. Regulation of bile acid synthesis. Front. Biosci. 3: 176-193.