Disruption of the oxysterol 7α-hydroxylase gene in mice

Journal of Biological Chemistry

Volumn 275, Issue 22, 2000, Pages 16536-16542

  Li Hawkins, Jia ^a   Lund, Erik G ^a   Turley, Stephen D ^a   Russell, David W ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

25 HYDROXYCHOLESTEROL; 26 HYDROXYCHOLESTEROL; BILE ACID; OXYGENASE; OXYSTEROL; OXYSTEROL 7ALPHA HYDROXYLASE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; CHOLESTEROL; CYTOCHROME P450; OXYSTEROL 7 ALPHA HYDROXYLASE; OXYSTEROL 7-ALPHA-HYDROXYLASE; STEROID MONOOXYGENASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BILE ACID SYNTHESIS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME SUBSTRATE; FEMALE; IN VIVO STUDY; LIPID METABOLISM; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEX DIFFERENCE; STEROL SYNTHESIS; ANIMAL; BIOSYNTHESIS; GENETICS; KIDNEY; METABOLISM; MOUSE MUTANT; PHENOTYPE;

ANIMALS; CHOLESTEROL; CYTOCHROME P-450 ENZYME SYSTEM; FEMALE; KIDNEY; MALE; MICE; MICE, KNOCKOUT; PHENOTYPE; STEROID HYDROXYLASES;

EID: 0034595445     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M001811200     Document Type: Article

References (33)

1. Schwarz, M., Lund, E. G., and Russell, D. W. (1998) Curr. Opin. Lipidol. 9, 1-6
2. Russell, D. W., and Setchell, K. D. R. (1992) Biochemistry 31, 4737-4749
3. Wang, H., Chen, J., Hollister, K., Sowers, L. C., and Forman, B. M. (1999) Mol. Cell 3, 543-553
4. Makishima, M., Okamoto, A. Y., Repa, J. J., Tu, H., Learned, R. M., Luk, A., Hull, M. V., Lustig, K. D., Mangelsdorf, D. J., and Shan, B. (1999) Science 284, 1362-1365
5. Parks, D. J., Blanchard, S. G., Bledsoe, R. K., Chandra, G., Consler, T. G., Kliewer, S. A., Stimmel, J. B., Willson, T. M., Zavacki, A.-M., Moore, D. D., and Lehmann, J. M. (1999) Science 284, 1365-1368S. A.
6. Janowski, B. A., Willy, P. J., Devi, T. R., Falck, J. R., and Mangelsdorf, D. J. (1996) Nature 383, 728-731
7. Lehmann, J. M., Kliewer, S. A., Moore, L. B., Smith-Oliver, T. A., Oliver, B. B., Su, J.-L., Sundseth, S. S., Winegar, D. A., Blanchard, D. E., Spencer, T. A., and Willson, T. M. (1997) J. Biol. Chem. 272, 3137-3140
8. Forman, B. M., Ruan, B., Chen, J., Schroepfer, G. J., Jr., and Evans, R. M. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 10588-10593
9. Schwarz, M., Russell, D. W., Dietschy, J. M., and Turley, S. D. (1998) J. Lipid Res. 39, 1833-1843
10. Turley, S. D., Schwarz, M., Spady, D. K., and Dietschy, J. M. (1998) Hepatology 28, 1088-1094
11. Peet, D. J., Turley, S. D., Ma, W., Janowski, B. A., Lobaccaro, J.-M. A., Hammer, R. E., and Mangelsdorf, D. J. (1998) Cell 93, 693-704
12. Vlahcevic, Z. R., Jairath, S. K., Heuman, D. M., Stravitz, R. T., Hylemon, P. B., Avadhani, N. G., and Pandak, W. M. (1996) Am. J. Physiol. 270, G646-G652
13. Schwarz, M., Lund, E. G., Lathe, R., Bjorkhem, I., and Russell, D. W. (1997) J. Biol. Chem. 272, 23995-24001
14. Xu, G., Salen, G., Shefer, S., Tint, G. S., Nguyen, L. B., Chen, T. S., and Greenblatt, D. (1999) J. Clin. Invest. 103, 89-95
15. Lammert, F., Wang, D. Q.-H., Paigen, B., and Carey, M. C. (1999) J. Lipid Res. 40, 2080-2090
16. Schwarz, M., Lund, E. G., Setchell, K. D. R., Kayden, H. J., Zerwekh, J. E., Bjorkhem, I., Herz, J., and Russell, D. W. (1996) J. Biol. Chem. 271, 18024-18031
17. Setchell, K. D. R., Schwarz, M., O'Connell, N. C., Lund, E. G., Davis, D. L., Lathe, R., Thompson, H. R., Tyson, R. W., Sokol, R. J., and Russell, D. W. (1998) J. Clin. Invest. 102, 1690-1703
18. Sambrook, J., Fritsch, E. F., and Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
19. Mansour, S. L., Thomas, K. R., and Capecchi, M. R. (1988) Nature 336, 348-352
20. Dzeletovic, S., Breuer, O., Lund, E., and Diczfalusy, U. (1995) Anal. Biochem. 225, 73-80
21. Smith, L. L. (1987) Chem. Phys. Lipids 44, 87-125
22. Mahendroo, M. S., Cala, K. M., and Russell, D. W. (1996) Mol. Endocrinol. 10, 380-392
23. Turley, S. D., Daggy, B. P., and Dietschy, J. M. (1994) Gastroenterology 107, 444-452
24. Rosen, H., Reshef, A., Maeda, N., Lippoldt, A., Shpizen, S., Triger, L., Eggertsen, G., Björkhem, I., and Leitersdorf, E. (1998) J. Biol. Chem. 273, 14805-14812
25. Lund, E., Breuer, O., and Björkhem, I. (1992) J. Biol. Chem. 267, 25092-25097
26. Saucier, S. E., Kandutsch, A. A., Gayen, A. K., Swahn, D. K., and Spencer, T. A. (1989) J. Biol. Chem. 264, 6863-6869
27. Kandutsch, A. A., and Chen, H. W. (1974) J. Biol. Chem. 249, 6057-6061
28. Brown, M. S., and Goldstein, J. L. (1974) J. Biol. Chem. 249, 7306-7314
29. Lund, E. G., Kerr, T. A., Sakai, J., Li, W.-P., and Russell, D. W. (1998) J. Biol. Chem. 273, 34316-34348
30. Taylor, F. R., Saucier, S. E., Shown, E. P., Parish, E. J., and Kandutsch, A. A. (1984) J. Biol. Chem. 259, 12382-12387
31. Dawson, P. A., van der Westhuyzen, D. R., Goldstein, J. L., and Brown, M. S. (1989) J. Biol. Chem. 264, 9046-9052
32. Cases, S., Novak, S., Zheng, Y.-W., Myers, H. M., Lear, S. R., Sande, E., Welch, C. B., Lusis, A. J., Spencer, T. A., Krause, B. R., Erickson, S. K., and Farese, R. V., Jr. (1998) J. Biol. Chem. 273, 26755-26764
33. Li-Hawkins, J., Lund, E. G., Bronson, A. D., and Russell, D. W. (2000) J. Biol. Chem. 275, 16543-16549