cDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolism

Journal of Biological Chemistry

Volumn 273, Issue 51, 1998, Pages 34316-34327

  Lund, Erik G ^a   Kerr, Thomas A ^a   Sakai, Juro ^a   Li, Wei Ping ^a   Russell, David W ^a,b  

^a UNIVERSITY OF TEXAS AT DALLAS   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; COMPLEMENTARY DNA; OXYGENASE; STEROL;

ANIMAL TISSUE; ARTICLE; BIOSYNTHESIS; CHOLESTEROL METABOLISM; DNA SEQUENCE; EMBRYO; ENZYME ACTIVITY; ENZYME REGULATION; HUMAN; HUMAN CELL; HYDROXYLATION; KIDNEY CELL; LIPID METABOLISM; LIVER; MOLECULAR CLONING; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; TRANSGENIC MOUSE;

AMINO ACID SEQUENCE; ANIMALS; BLOTTING, WESTERN; CELL LINE; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 10; CLONING, MOLECULAR; CYTOCHROME P-450 CYP27A1; DNA PRIMERS; DNA, COMPLEMENTARY; HUMANS; KIDNEY; LIVER; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; POLYMERASE CHAIN REACTION; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; STEROID HYDROXYLASES; TRANSFECTION;

EID: 0032545281     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.51.34316     Document Type: Article

References (46)

1. Kandutsch, A. A., and Chen, H. W. (1974) J. Biol. Chem. 249, 6057-6061
2. Brown, M. S., and Goldstein, J. L. (1974) J. Biol. Chem. 249, 7306-7314
3. Björkhem, I., Andersson, O., Diczfalusy, U., Sevastik, B., Xiu, R., Duan, C., and Lund, E. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 8592-8596
4. Babiker, A., Andersson, O., Lund, E., Xiu, R.-J., Deeb, S., Reshef, A., Leitersdorf, E., Diczfalusy, U., and Björkhem, I. (1997) J. Biol. Chem. 272, 26253-26261
5. Lutjohann, D., Breuer, O., Ahlborg, G., Nennesmo, I., Siden, A., Diczfalusy, U., and Björkhem, I. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 9799-9804
6. Schwarz, M., Lund, E. G., and Russell, D. W. (1998) Curr. Opin. Lipidol. 9, 1-6
7. Ishibashi, S., Schwarz, M., Frykman, P. K., Herz, J., and Russell, D. W. (1996) J. Biol. Chem. 271, 18017-18023
8. Janowski, B. A., Willy, P. J., Devi, T. R., Falck, J. R., and Mangelsdorf, D. J. (1996) Nature 383, 728-731
9. Lehmann, J. M., Kliewer, S. T., Moore, L. B., Smith-Oliver, T. A., Oliver, B. B., Su, J.-L., Sundseth, S. S., Winegar, D. A., Blanchard, D. E., Spencer, T. A., and Willson, T. M. (1997) J. Biol. Chem. 272, 3137-3140
10. Russell, D. W., and Setchell, K. D. R. (1992) Biochemistry 31, 4737-4749
11. Peet, D. J., Turley, S. D., Ma, W., Janowski, B. A., Lobaccaro, J.-M. A., Hammer, R. E., and Mangelsdorf, D. J. (1998) Cell 93, 693-704
12. Brown, M. S., and Goldstein, J. L. (1997) Cell 89, 331-340
13. Dzeletovic, S., Breuer, O., Lund, E., and Diczfalusy, U. (1995) Anal. Biochem. 225, 73-80
14. Shimano, H., Horton, J. D., Hammer, R. E., Shimomura, I., Brown, M. S., and Goldstein, J. L. (1996) J. Clin. Invest. 98, 1575-1584
15. Andersson, S., Davis, D. L., Dahlbäck, H., Jörnvall, H., and Russell, D. W. (1989) J Biol. Chem. 264, 8222-8229
16. Stocco, D. M., and Clark, B. J. (1996) Endocr. Rev. 17, 221-244
17. Stapleton, G., Steel, M., Richardson, M., Mason, J. O., Rose, K. A., Morris, R. G. M., and Lathe, R. (1995) J. Biol. Chem. 270, 29739-29745
18. Schwarz, M., Lund, E. G., Lathe, R., Björkhem, I., and Russell, D. W. (1997) J. Biol. Chem. 272, 23995-24001
19. Schneider, R. J., and Shenk, T. (1987) Annu. Rev. Biochem. 56, 317-332
20. Sambrook, J., Fritsch, E. F., and Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
21. Harlow, E., and Lane, D. (1988) Antibodies: A Laboratory Manual, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
22. Hua, X., Sakai, J., Ho, Y. K., Goldstein, J. L., and Brown, M. S. (1995) J. Biol. Chem. 270, 29422-29427
23. Smith, M. (1985) Annu. Rev. Genet. 9, 423-462
24. Heffernan, M., and Dennis, J. W. (1991) Nucleic Acids Res. 19, 85-92
25. Metherall, J. E., Goldstein, J. L., Luskey, K. L., and Brown, M. S. (1989) J. Biol. Chem. 264, 15634-15641
26. Rawson, R. B., Zelenski, N. G., Nijhawan, D., Ye, J., Sakai, J., Kasan, M. Z., Chang, T. Y., Brown, M. S., and Goldstein, J. L. (1997) Mol. Cell 1, 47-57
27. Sakai, J., Duncan, E. A., Rawson, R. B., Hua, X., Brown, M. S., and Goldstein, J. L. (1996) Cell 85, 1037-1046
28. Hua, X., Nohturfft, A., Goldstein, J. L., and Brown, M. S. (1996) Cell 87, 415-426
29. Yang, J., Brown, M. S., Ho, Y. K., and Goldstein, J. L. (1995) J. Biol. Chem. 270, 12152-12161
30. Thigpen, A. E., Silver, R. I., Guileyardo, J. M., Casey, M. L., McConnell, J. D., and Russell, D. W. (1993) J. Clin. Invest. 92, 903-910
31. No, D., Yao, T. P., and Evans, R. M. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 3346-3351
32. Goldstein, J. L., and Brown, M. S. (1973) Proc. Natl. Acad. Sci. U. S. A. 70, 2804-2808
33. Sugawara, T., Lin, D., Holt, J. A., Martin, K. O., Javitt, N. B., Miller, W. L., and Strauss, J. F., Jr. (1995) Biochemistry 34, 12506-12512
34. Kilsdonk, E. P. C., Yancey, P. G., Stoudt, G. W., Bangerter, F. W., Johnson, W. J., Phillips, M. C., and Rothblat, G. H. (1995) J. Biol. Chem. 270, 17250-17256
35. Suzuki, M., Hayakawa, T., Shaw, J. P., Rekik, M., and Harayama, S. (1991) J. Bacteriol. 173, 1690-1695
36. Kok, M., Oldenhuis, R., van der Linden, M. P. G., Raatjes, P., Kingma, J., van Lelyveld, P. H., and Witholt, B. (1989) J. Biol. Chem. 264, 5435-5441
37. Shanklin, J., Whittle, E., and Fox, B. G. (1994) Biochemistry 33, 12787-12794
38. Bard, M., Bruner, D. A., Pierson, C. A., Lees, N. D., Bierman, B., Frye, L., Koegel, C., and Barbuch, R. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 186-190
39. Li, L., and Kaplan, J. (1996) J. Biol. Chem. 271, 16927-16933
40. van Beilen, J. B., Penninga, D., and Witholt, B. (1992) J. Biol. Chem. 267, 9194-9201
41. Fox, B. G., Shanklin, J., Ai, J., Loehr, T. M., and Sanders-Loehr, J. (1994) Biochemistry 33, 12776-12786
42. Uwabe, K., Gahara, Y., Yamada, H., Miyake, T., and Kitamura, T. (1997) Neuroscience 80, 501-509
43. Kandutsch, A. A., and Chen, H. W. (1973) J. Biol. Chem. 248, 8408-8417
44. Osborne, T. F., Goldstein, J. L., and Brown, M. S. (1985) Cell 42, 203-212
45. Sudhof, T. C., Russell, D. W., Brown, M. S., and Goldstein, J. L. (1987) Cell 48, 1061-1069
46. Yanofsky, C., and Crawford, I. P. (1987) in Escherichia coli and Salmonella typhimurium: Cellular and Molecular Biology (Neidhardt, F. C., ed) Vol. 2, pp. 1453-1472, American Society for Microbiology, Washington, D. C.