Threonine 68 phosphorylation by ataxia telangiectasia mutated is required for efficient activation of Chk2 in response to ionizing radiation

Cancer Research

Volumn 60, Issue 21, 2000, Pages 5934-5936

  Ahn, Joon Young ^a   Schwarz, Julie K ^b   Piwnica Worms, Helen ^b   Canman, Christine E ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE CHECKPOINT KINASE; THREONINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ATAXIA TELANGIECTASIA; CONTROLLED STUDY; DNA DAMAGE; EMBRYO; ENZYME ACTIVATION; GENE MUTATION; HUMAN; HUMAN CELL; IONIZING RADIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; PROTEIN TARGETING; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; ANIMALS; CELL CYCLE; CELL CYCLE PROTEINS; DNA-BINDING PROTEINS; ENZYME ACTIVATION; FIBROBLASTS; HUMANS; MICE; MOLECULAR SEQUENCE DATA; NEUROBLASTOMA; PHOSPHORYLATION; PROTEIN KINASES; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; THREONINE; TRANSFECTION; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEINS;

EID: 0034326802     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

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3. ATM: A mediator of multiple responses to genotoxic stress
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5. ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway
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8. ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response
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15. A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase
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21. Loss of atm radiosensitizes multiple p53 null tissues
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23. Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates
24. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
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