An overactivated ATR/CHK1 pathway is responsible for the prolonged G 2 accumulation in irradiated AT cells

Journal of Biological Chemistry

Volumn 278, Issue 33, 2003, Pages 30869-30874

  Wang, Xiang ^a   Khadpe, Jay ^a   Hu, Baocheng ^a   Iliakis, George ^b   Wang, Ya ^a,c  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b UNIVERSITY OF ESSEN MEDICAL SCHOOL   (Germany)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL CULTURE; GENETIC ENGINEERING; IONIZING RADIATION; MUTAGENESIS;

BIOACTIVATION;

BIOCHEMICAL ENGINEERING;

7 HYDROXYSTAUROSPORINE; ATAXIA TELANGIECTASIA MUTATED KINASE; ATM PROTEIN; BROXURIDINE; CAFFEINE; CHECKPOINT KINASE 1; CYCLINE; GLUTATHIONE TRANSFERASE; MESSENGER RNA; PROTEIN; PROTEIN KINASE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE; CELL CYCLE G2 PHASE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME PHOSPHORYLATION; ENZYME PURIFICATION; FIBROBLAST CULTURE; FLOW CYTOMETRY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IONIZING RADIATION; IRRADIATION; PRIORITY JOURNAL; WESTERN BLOTTING;

NASA DISCIPLINE RADIATION HEALTH; NASA PROGRAM BIOMEDICAL RESEARCH AND COUNTERMEASURES; NON-NASA CENTER;

ALKALOIDS; CAFFEINE; CELL CYCLE PROTEINS; CELL LINE, TRANSFORMED; CELL SURVIVAL; ENZYME INHIBITORS; FIBROBLASTS; G2 PHASE; HUMANS; PHOSPHODIESTERASE INHIBITORS; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; RADIATION, IONIZING; RNA, SMALL INTERFERING; STAUROSPORINE;

ANIMALIA;

EID: 0043234465     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M301876200     Document Type: Article

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