53BP1 functions in a ATM-dependent checkpoint pathway that is constitutively activated in human cancer

Nature Cell Biology

Volumn 4, Issue 12, 2002, Pages 998-1002

  DiTullio Jr , Richard A ^a,b   Mochan, Tamara A ^a,b   Venere, Monica ^a,b   Bartkova, Jirina ^c   Sehested, Maxwell ^d   Bartek, Jiri ^c   Halazonetis, Thanos D ^a,b  

^a WISTAR INSTITUTE   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

^d Mental Health Services CPH   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; BINDING PROTEIN; DOUBLE STRANDED DNA; NUCLEAR PROTEIN; PROTEIN P53; RNA; THREONINE;

ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL CYCLE G2 PHASE; CELL NUCLEUS; CONTROLLED STUDY; DNA STRAND BREAKAGE; GENE MUTATION; GROWTH INHIBITION; HUMAN; HUMAN CELL; HUMAN TISSUE; INTERPHASE; LUNG CANCER; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; RADIATION EXPOSURE;

CARRIER PROTEINS; CELL CYCLE; CELL CYCLE PROTEINS; DNA DAMAGE; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, P53; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MUTATION; PHOSPHOPROTEINS; PROTEIN-SERINE-THREONINE KINASES; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEINS;

ATAXIA; ATAXIA TELANGIECTASIA;

EID: 0036902410     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb892     Document Type: Article

References (27)

1. Schultz, L. B., Chehab, N. H., Malikzay, A. & Halazonetis, T. D. J. Cell Biol. 151, 1381-1390 (2000).
2. Rappold, I., Iwabuchi, K., Date, T. & Chen, J. J. Cell Biol. 153, 613-620 (2001).
3. Anderson, L., Henderson, C. & Adachi, Y. Mol. Cell. Biol. 21, 1719-1729 (2001).
4. Xia, Z., Morales, J. C., Dunphy, W. G. & Carpenter, P. B. J. Biol. Chem. 276, 2708-2718 (2001).
5. Shiloh, Y. & Kastan, M. B. Adv. Cancer Res. 83, 209-254 (2001).
6. Weinert, T. A. & Hartwell, L. H. Science 241, 317-322 (1988).
7. Vialard, J. E., Gilbert, C. S., Green, C. M. & Lowndes, N. F. EMBO J. 17, 5679-5688 (1998).
8. Sun, Z., Hsiao, J., Fay, D. S. & Stern, D. F. Science 281, 272-274 (1998).
9. Schwartz, M. F., Duong, J. K., Sun, Z., Morrow, J. S., Pradhan, D. & Stern, D. F. Mol. Cell 9, 1055-1065 (2002).
10. Rogakou, E. P., Pilch, D. R., Orr, A. H., Ivanova, V. S. & Bonner, W. M. J. Biol. Chem. 273, 5858-5868 (1998).
11. Rogakou E. P., Boon, C., Redon, C. & Bonner, W. M. J. Cell Biol. 146, 905-916 (1999).
12. Abraham, R. T. Genes Dev. 15, 2177-2196 (2001).
13. Kim, S. T., Xu, B. & Kastan, M. B. Genes Dev. 16, 560-570 (2002).
14. Yazdi, P. T., Wang Y., Zhao, S., Patel, N., Lee, E. Y. & Qin, J. Genes Dev. 16, 571-582 (2002).
15. Andegeko, Y., Moyal L., Mittelman, L., Tsarfaty I., Shiloh Y. & Rotman, G. J. Biol. Chem. 276, 38224-38230 (2001).
16. Xu, B., Kim, S. T., Lim, D. S. & Kastan, M. B. Mol. Cell. Biol. 22, 1049-1059 (2002).
17. Vogelstein, B., Lane, D. & Levine, A. J. Nature 408, 307-310 (2000).
18. Bartek, J., Falck, J. & Lukas, J. Nature Rev. Mol. Cell, Biol. 2, 877-886 (2001).
19. McGowan, C. H. Bioessays 24, 502-511 (2002).
20. Bell, D. W. et al. Science 286, 2528-2531 (1999).
21. Meijers-Heijboer, H. et al. Nature Genet. 31, 55-59 (2002).
22. Lukas, C. et al. Cancer Res. 61, 4990-4993 (2001).
23. Boulton, S. J. et al. Science 295, 127-131 (2002).
24. Saka, Y., Esashi, F., Matsusaka, T., Mochida, S. & Yanagida, M. Genes Dev. 11, 3387-3400 (1997).
25. Wang, B., Matsuoka, S., Carpenter, P. B. & Elledge, S. J. Science online (cited 3 October 2002) 10.1126-science.1076182 (2002).
26. Bartkova, J et al. Cancer Res. 55, 949-956 (1995).
27. Falck, J., Mailand, N., SyljuÂsen, R. G., Bartek, J. & Lukas, J. Nature 410, 842-847 (2001).