Hypoxia links ATR and p53 through replication arrest

Molecular and Cellular Biology

Volumn 22, Issue 6, 2002, Pages 1834-1843

  Hammond, Ester M ^a   Denko, Nicholas C ^a   Dorie, Mary Jo ^a   Abraham, Robert T ^a   Giaccia, Amato J ^a  

^a STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53;

ARTICLE; CELL CYCLE S PHASE; CELL GROWTH; CELL PROLIFERATION; DNA DAMAGE; HUMAN; HUMAN CELL; HYPOXIA; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY;

CELL CYCLE PROTEINS; CELL DIVISION; CELL HYPOXIA; CELL LINE; CELL NUCLEUS; COBALT; COMET ASSAY; DNA DAMAGE; DNA REPLICATION; ENZYME INHIBITORS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IRON CHELATING AGENTS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; S PHASE; SIGNAL TRANSDUCTION; STRESS; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0036179376     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.22.6.1834-1843.2002     Document Type: Article

References (56)

1. Hypoxia induces p53 accumulation through MDM2 down-regulation and inhibition of E6-mediated degradation
2. Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha
3. Stress signals utilize multiple pathways to stabilize p53
4. Enhanced phosphorylation of p53 by ATM in response to DNA damage
5. ATR disruption leads to chromosomal fragmentation and early embryonic lethality
6. The unique physiology, of solid tumors: Opportunities (and problems) for cancer therapy
7. Aphidicolin and deoxycoformycin cause DNA breaks and cell death in unstimulated human lymphocytes
8. Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia
9. The role of ATM in DNA damage responses and cancer
10. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
11. Phosphorylation of murine p53 at ser-18 regulates the p53 responses to DNA damage
12. Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice
13. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
14. DNA damage measured by the comet assay in head and neck cancer patients treated with tirapazamine
15. The comet assay: A comprehensive review
16. Iron deprivation results in an increase in p53 expression
17. Hypoxia-inducible factor-1 (HIF-1) up-regulates adrenomedullin expression in human tumor cell lines during oxygen deprivation: A possible promotion mechanism of carcinogenesis
18. Selective and synchronous activation of early-S-phase replicons of Ehrlich ascites cells
19. The complexity of p53 modulation: Emerging patterns from divergent signals
20. p53 accumulates but is functionally impaired when DNA synthesis is blocked
21. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
22. 1-phase checkpoint by low-oxygen conditions is independent of p53 status
23. p21(Cip1) and p27(Kip1) regulate cell cycle reentry after hypoxic stress but are not necessary for hypoxia-induced arrest
24. Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts
25. The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse
26. Mdm2 promotes the rapid degradation of p53
27. Intratumoral pO2 predicts survival in advanced cancer of the uterine cervix
28. Aphidicolin prevents mitotic cell division by interfering with the activity of DNA polymerase-alpha
29. The many substrates and functions of ATM
30. Regulation of p53 by hypoxia: Dissociation of transcriptional repression and apoptosis from p53-dependent transactivation
31. Regulation of p53 stability by Mdm2
32. p53, the cellular gatekeeper for growth and division
33. Progressive formation of DNA lesions in cultured Ehrlich ascites tumor cells treated with hydroxyurea
34. Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint
35. Ubiquitination of p53 and p21 is differentially affected by ionizing and UV radiation
36. Multisite phosphorylation and the integration of stress signals at p53
37. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
38. Negative feedback regulation of wild-type p53 biosynthesis
39. Role of ribonucleotide reductase in inhibition of mammalian cell growth by potent iron chelators
40. Heterogeneity in radiation-induced DNA damage and repair in tumor and normal cells measured using the "comet" assay
41. Signaling to p53: Breaking the MDM2-p53 circuit
42. Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha
43. Ribonucleotide reductase-a radical enzyme
44. DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2
45. Hypoxia-selective antitumor agents. 15. Modification of rate of nitroreduction and extent of lysosomal uptake by polysubstitution of 4-(alkylamino)-5-nitroquinoline bioreductive drugs
46. DNA damage induces phosphorylation of the amino terminus of p53
47. Brca2 is required for embryonic cellular proliferation in the mouse
48. DNA replication blockade impairs p53-transactivation
49. Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress
50. Hydroxyurea
51. Targeted disruption of the Rad51 gene leads to lethality in embryonic mice
52. Cellular localisation of the ataxia-telangiectasia (ATM) gene product and discrimination between mutated and normal forms
53. Up-regulation of hypoxia-inducible factor-lalpha is not sufficient for hypoxic/anoxic p53 induction
54. A p53 amino-terminal nuclear export signal inhibited by DNA damage-induced phosphorylation
55. ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1
56. Direct comparison of GAPDH, beta-actin, cyclophilin, and 28S rRNA as internal standards for quantifying RNA levels under hypoxia