Activation of the ATR-mediated DNA damage response by the HIV-1 viral protein R

Journal of Biological Chemistry

Volumn 278, Issue 28, 2003, Pages 25879-25886

  Roshal, Mikhail ^a   Kim, Baek ^a   Zhu, Yonghong ^b   Nghiem, Paul ^c   Planelles, Vicente ^d  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c HARVARD UNIVERSITY   (United States)

^d UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENES; PROTEINS;

CELL CYCLE;

DNA;

ATM PROTEIN; ATR PROTEIN; CHECKPOINT KINASE 1; GENE PRODUCT; HAPTOCORRIN; PROTEIN DERIVATIVE; RNA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VIRUS PROTEIN; VPR PROTEIN;

ARTICLE; CELL CYCLE G2 PHASE; CELL PROLIFERATION; CONTROLLED STUDY; DNA CONTENT; DNA DAMAGE; ENZYME ACTIVATION; GENE VPR; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; TRANSACTIVATION; VIRUS GENE;

ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CAFFEINE; CD4-POSITIVE T-LYMPHOCYTES; CELL CYCLE; CELL CYCLE PROTEINS; CELL DIVISION; CELL LINE, TRANSFORMED; CHROMONES; DNA DAMAGE; DOXORUBICIN; ENZYME INHIBITORS; G2 PHASE; GENE PRODUCTS, VPR; GENES, DOMINANT; GENETIC VECTORS; HELA CELLS; HIV INFECTIONS; HUMANS; IMMUNOBLOTTING; LUCIFERASES; MORPHOLINES; PACLITAXEL; PHOSPHORYLATION; PLASMIDS; PROTEIN-SERINE-THREONINE KINASES; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSFECTION;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; RNA VIRUSES;

EID: 0037830710     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M303948200     Document Type: Article

References (57)

1. Zhou, B. B., and Elledge, S. J. (2000) Nature 408, 433-439
2. Smits, V. A., and Medema, R. H. (2001) Biochim. Biophys. Acta 1519, 1-12
3. Ohi, R., and Gould, K. L. (1999) Curr. Opin. Cell Biol. 11, 267-273
4. Walworth, N. C. (2000) Curr. Opin. Cell Biol. 12, 697-704
5. O'Connell, M. J., Walworth, N. C., and Carr, A. M. (2000) Trends Cell Biol. 10, 296-303
6. Westphal, C. H. (1997) Curr. Biol. 7, 789-792
7. Cliby, W. A., Lewis, K. A., Lilly, K. K., and Kaufmann, S. H. (2002) J. Biol. Chem. 277, 1599-1606
8. Lupardus, P. J., Byun, T., Yee, M. C., Hekmat-Nejad, M., and Cimprich, K. A. (2002) Genes Dev. 16, 2327-2332
9. Zou, L., Cortez, D., and Elledge, S. J. (2002) Genes Dev. 16, 198-208
10. Roos-Mattjus, P., Vroman, B. T., Burtelow, M. A., Rauen, M., Eapen, A. K., and Karnitz, L. M. (2002) J. Biol. Chem. 277, 43809-43812
11. Bao, S., Tibbetts, R. S., Brumbaugh, K. M., Fang, Y., Richardson, D. A., Ali, A., Chen, S. M., Abraham, R. T., and Wang, X. F. (2001) Nature 411, 969-974
12. de Klein, A., Muijtjens, M., van Os, R., Verhoeven, Y., Smit, B., Carr, A. M., Lehmann, A. R., and Hoeijmakers, J. H. (2000) Curr. Biol. 10, 479-482
13. Brown, E. J., and Baltimore, D. (2000) Genes Dev. 14, 397-402
14. Casper, A. M., Nghiem, P., Arlt, M. F., and Glover, T. W. (2002) Cell 111, 779-789
15. Cliby, W. A., Roberts, C. J., Cimprich, K. A., Stringer, C. M., Lamb, J. R., Schreiber, S. L., and Friend, S. H. (1998) EMBO J. 17, 159-169
16. Nghiem, P., Park, P. K., Kim, Y-s., Y., Desai, B. N., and Schreiber, S. L. (2002) J. Biol. Chem. 277, 4428-4434
17. Poggioli, G. J., Keefer, C., Connolly, J. L., Dermody, T. S., and Tyler, K. L. (2000) J. Virol. 74, 9562-9570
18. Davy, C. E., Jackson, D. J., Wang, Q., Raj, K., Masterson, P. J., Fenner, N. F., Southern, S., Cuthill, S., Millar, J. B., and Doorbar, J. (2002) J. Virol. 76, 9806-9818
19. Planelles, V., Jowett, J. B. M., Li, Q. X., Xie, Y., Hahn, B., and Chen, I. S. Y. (1996) J. Virol. 70, 2516-2524
20. Rogel, M. E., Wu, L. I., and Emerman, M. (1995) J. Virol. 69, 882-888
21. Re, F., Braaten, D., Franke, E. K., and Luban, J. (1995) J. Virol. 69, 6859-6864
22. He, J., Choe, S., Walker, R., Di Marzio, P., Morgan, D. O., and Landau, N. R. (1995) J. Virol. 69, 6705-6711
23. Jowett, J. B., Planelles, V., Poon, B., Shah, N. P., Chen, M. L., and Chen, I. S. (1995) J. Virol. 69, 6304-6313
24. Shostak, L. D., Ludlow, J., Fisk, J., Pursell, S., Rimel, B. J., Nguyen, D., Rosenblatt, J. D., and Planelles, V. (1999) Exp. Cell Res. 251, 156-165
25. Stewart, S. A., Poon, B., Jowett, J. B., and Chen, I. S. (1997) J. Virol. 71, 5579-5592
26. Goh, W. C., Rogel, M. E., Kinsey, C. M., Michael, S. F., Fultz, P. N., Nowak, M. A., Hahn, B. H., and Emerman, M. (1998) Nat. Med. 4, 65-71
27. Zhu, Y., Gelbard, H. A., Roshal, M., Pursell, S., Jamieson, B. D., and Planelles, V. (2001) J. Virol. 75, 3791-3801
28. Forget, J., Yao, X. J., Mercier, J., and Cohen, E. A. (1998) J. Mol. Biol. 284, 915-923
29. Hrimech, M., Yao, X. J., Bachand, F., Rougeau, N., and Cohen, E. A. (1999) J. Virol. 73, 4101-4109
30. Poon, B., Jowett, J. B., Stewart, S. A., Armstrong, R. W., Rishton, G. M., and Chen, I. S. (1997) J. Virol. 71, 3961-3971
31. Zhang, S., Pointer, D., Singer, G., Feng, Y., Park, K., and Zhao, L. J. (1998) Gene (Amst.) 212, 157-166
32. Bartz, S. R., Rogel, M. E., and Emerman, M. (1996) J. Virol. 70, 2324-2331
33. Zhu, Y., Feuer, G., Day, S. L., Wrzesinski, S., and Planelles, V. (2001) Mol. Ther. 4, 375-382
34. Wrzesinski, S., Seguin, R., Liu, Y., Domville, S., Planelles, V., Massa, P., Barker, E., Antel, J., and Feuer, G. (2000) AIDS Res. Hum. Retroviruses 16, 1771-1776
35. An, D. S., Morizono, K., Li, Q. X., Mao, S. H., Lu, S., and Chen, I. S. (1999) J. Virol. 73, 7671-7677
36. Akkina, R. K., Walton, R. M., Chen, M. L., Li, Q. X., Planelles, V., and Chen, I. S. (1996) J. Virol. 70, 2581-2585
37. Zhao, H., Watkins, J. L., and Piwnica-Worms, H. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 14795-14800
38. Vlahos, C. J., Matter, W. F., Hui, K. Y., and Brown, R. F. (1994) J. Biol. Chem. 269, 5241-5248
39. Smith, G. C., Divecha, N., Lakin, N. D., and Jackson, S. P. (1999) Biochem. Soc. Symp. 64, 91-104
40. Nghiem, P., Park, P. K., Kim, Y., Vaziri, C., and Schreiber, S. L. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 9092-9097
41. Connor, R. I., Chen, B. K., Choe, S., and Landau, N. R. (1995) Virology 206, 935-944
42. Vanitharani, R., Mahalingam, S., Rafaeli, Y., Singh, S. P., Srinivasan, A., Weiner, D. B., and Ayyavoo, V. (2001) Virology 289, 334-342
43. Elbashir, S. M., Harborth, J., Lendeckel, W., Yalcin, A., Weber, K., and Tuschl, T. (2001) Nature 411, 494-498
44. Lee, R. C., and Ambros, V. (2001) Science 294, 862-864
45. Reinhart, B. J., Slack, F. J., Basson, M., Pasquinelli, A. E., Bettinger, J. C., Rougvie, A. E., Horvitz, H. R., and Ruvkun, G. (2000) Nature 403, 901-906
46. Busby, E. C., Leistritz, D. F., Abraham, R. T., Karnitz, L. M., and Sarkaria, J. N. (2000) Cancer Res. 60, 2108-2112
47. Luo, Y., Rockow-Magnone, S. K., Joseph, M. K., Bradner, J., Butler, C. C., Tahir, S. K., Han, E. K., Ng, S. C., Severin, J. M., Gubbins, E. J., Reilly, R. M., Rueter, A., Simmer, R. L., Holzman, T. F., and Giranda, V. L. (2001) Anticancer Res. 21, 23-28
48. Jordan, M. A. (2002) Curr. Med. Chem. Anti-Canc. Agents 2, 1-17
49. Elder, R. T., Yu, M., Chen, M., Edelson, S., and Zhao, Y. (2000) Virus Res. 68, 161-173
50. Bentley, N. J., Holtzman, D. A., Flaggs, G., Keegan, K. S., DeMaggio, A., Ford, J. C., Hoekstra, M., and Carr, A. M. (1996) EMBO J. 15, 6641-6651
51. Humphrey, J. S., Salim, A., Erdos, M. R., Collins, F. S., Brody, L. C., and Klausner, R. D. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 5820-5825
52. de Noronha, C. M., Sherman, M. P., Lin, H. W., Cavrois, M. V., Moir, R. D., Goldman, R. D., and Greene, W. C. (2001) Science 294, 1105-1108
53. Hekmat-Nejad, M., You, Z., Yee, M. C., Newport, J. W., and Cimprich, K. A. (2000) Curr. Biol. 10, 1565-1573
54. Tibbetts, R. S., Cortez, D., Brumbaugh, K. M., Scully, R., Livingston, D., Elledge, S. J., and Abraham, R. T. (2000) Genes Dev. 14, 2989-3002
55. Guo, Z., Kumagai, A., Wang, S. X., and Dunphy, W. G. (2000) Genes Dev. 14, 2745-2756
56. Masuda, M., Nagai, Y., Oshima, N., Tanaka, K., Murakami, H., Igarashi, H., and Okayama, H. (2000) J. Virol. 74, 2636-2646
57. Elder, R. T., Yu, M., Chen, M., Zhu, X., Yanagida, M., and Zhao, Y. (2001) Virology 287, 359-370