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Volumn 21, Issue 6, 1996, Pages 771-781

Differential activation of ERK, JNK/SAPK and P38/CSBP/RK map kinase family members during the cellular response to arsenite

Author keywords

Arsenite; Free radicals; Mitogen activated protein kinase; Oxidative stress; Ras; Stress response

Indexed keywords

ACETYLCYSTEINE; ARSENIC TRIOXIDE; GROWTH FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; SCAVENGER; SURAMIN;

EID: 0029961252     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/0891-5849(96)00176-1     Document Type: Article
Times cited : (194)

References (53)
  • 1
    • 0028175091 scopus 로고
    • Raf meets Ras: Completing the framework of a signal transduction pathway
    • 1. Avruch, J.; Zhang, X.; Kyriakis, J. M. Raf meets Ras: Completing the framework of a signal transduction pathway. Trends Biochem. Sci. 19:279-283; 1994.
    • (1994) Trends Biochem. Sci. , vol.19 , pp. 279-283
    • Avruch, J.1    Zhang, X.2    Kyriakis, J.M.3
  • 2
    • 0028073283 scopus 로고
    • MAPKs: New JNK expands the group
    • 2. Davis, R. MAPKs: New JNK expands the group. Trends Biochem. Sci. 19:470-473; 1994.
    • (1994) Trends Biochem. Sci. , vol.19 , pp. 470-473
    • Davis, R.1
  • 3
    • 0029011218 scopus 로고
    • The MAPK signaling cascade
    • 3. Seger, R.; Krebs, E. G. The MAPK signaling cascade. FASEB J. 9:726-735; 1995.
    • (1995) FASEB J. , vol.9 , pp. 726-735
    • Seger, R.1    Krebs, E.G.2
  • 5
    • 0027936755 scopus 로고
    • A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells
    • 5. Han, J.; Lee, J. D.; Bibbs, L.; Ulevitch, R. A. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science 265:808-811; 1994.
    • (1994) Science , vol.265 , pp. 808-811
    • Han, J.1    Lee, J.D.2    Bibbs, L.3    Ulevitch, R.A.4
  • 7
    • 0028022750 scopus 로고
    • A novel kinase cascade triggered by stress and heat shock that stimulates MAP-KAP kinase-2 and phosphorylation of the small heat shock proteins
    • 7. Rouse, J.; Cohen, P.; Trigon, S.; Morange, M.; Alonso-Liamazares, A.; Zamanillo, D.; Hunt, T.; Nebreda, A. R. A novel kinase cascade triggered by stress and heat shock that stimulates MAP-KAP kinase-2 and phosphorylation of the small heat shock proteins. Cell 78:1027-1037; 1994.
    • (1994) Cell , vol.78 , pp. 1027-1037
    • Rouse, J.1    Cohen, P.2    Trigon, S.3    Morange, M.4    Alonso-Liamazares, A.5    Zamanillo, D.6    Hunt, T.7    Nebreda, A.R.8
  • 8
    • 0028558986 scopus 로고
    • Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun
    • 8. Sanchez, I.; Hughes, R. T.; Mayer, B. J.; Yee, K.; Woodgett, J. R.; Avruch, J.; Kyriakis, J. M.; Zon, L. I. Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun. Nature 372:794-798; 1994.
    • (1994) Nature , vol.372 , pp. 794-798
    • Sanchez, I.1    Hughes, R.T.2    Mayer, B.J.3    Yee, K.4    Woodgett, J.R.5    Avruch, J.6    Kyriakis, J.M.7    Zon, L.I.8
  • 9
    • 0028935974 scopus 로고
    • Independent human MAP kinase signal transduction pathways defined by MEK and MKK isoforms
    • 9. Dérijard, B.; Raingeaud, J.; Barrett, T.; Wu, I.-H.; Han, J.; Ulevitch, R. J.; Davis, R. J. Independent human MAP kinase signal transduction pathways defined by MEK and MKK isoforms. Science 267:682-685; 1995.
    • (1995) Science , vol.267 , pp. 682-685
    • Dérijard, B.1    Raingeaud, J.2    Barrett, T.3    Wu, I.-H.4    Han, J.5    Ulevitch, R.J.6    Davis, R.J.7
  • 12
    • 0028670788 scopus 로고
    • Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1
    • 12. Yan, M.; Dai, T.; Deak, J. C.; Kyriakis, J. M.; Zon, L. I.; Woodgett, J. R.; Templeton, J. D. Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1. Nature 372:798-800; 1994.
    • (1994) Nature , vol.372 , pp. 798-800
    • Yan, M.1    Dai, T.2    Deak, J.C.3    Kyriakis, J.M.4    Zon, L.I.5    Woodgett, J.R.6    Templeton, J.D.7
  • 13
    • 0023766145 scopus 로고
    • Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II
    • 13. Sturgill, T. W.; Ray, L. B.; Erikson, E.; Maller, J. L. Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II. Nature 334:715-718; 1988.
    • (1988) Nature , vol.334 , pp. 715-718
    • Sturgill, T.W.1    Ray, L.B.2    Erikson, E.3    Maller, J.L.4
  • 14
    • 0026733636 scopus 로고
    • MAPKAP kinase-2: A novel protein kinase activated by mitogen-activated protein kinase
    • 14. Stokoe, D.; Campbell, D. G.; Nakielny, S.; Hidaka, H.; Leevers, S.; Marshall, C.; Cohen, P. MAPKAP kinase-2: A novel protein kinase activated by mitogen-activated protein kinase. EMBO J. 11:3985-3994; 1992.
    • (1992) EMBO J. , vol.11 , pp. 3985-3994
    • Stokoe, D.1    Campbell, D.G.2    Nakielny, S.3    Hidaka, H.4    Leevers, S.5    Marshall, C.6    Cohen, P.7
  • 15
    • 0026523559 scopus 로고
    • Ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK
    • 15. Wood, K. W.; Sarnecki, C.; Roberts, T. M.; Blenis, J. Ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK. Cell 68:1041-1050; 1992.
    • (1992) Cell , vol.68 , pp. 1041-1050
    • Wood, K.W.1    Sarnecki, C.2    Roberts, T.M.3    Blenis, J.4
  • 16
    • 0027165150 scopus 로고
    • The mitogen-activated protein kinase signal transduction pathway
    • 16. Davis, R. J. The mitogen-activated protein kinase signal transduction pathway. J. Biol. Chem. 268:14553-14556; 1993.
    • (1993) J. Biol. Chem. , vol.268 , pp. 14553-14556
    • Davis, R.J.1
  • 17
    • 0027080533 scopus 로고
    • Activating transcription factor-2 DNA-binding activity is stimulated by phosphorylation catalyzed by p42 and p54 microtubule-associated protein kinases
    • 17. Abdel-Hafiz, H. A. M.; Heasley, L. E.; Kyriakis, J. M.; Avruch, J.; Kroll, D. J.; Johnson, G. J.; Hoeffler, J. P. Activating transcription factor-2 DNA-binding activity is stimulated by phosphorylation catalyzed by p42 and p54 microtubule-associated protein kinases. Mol. Endocrinol. 16:2079-2089; 1992.
    • (1992) Mol. Endocrinol. , vol.16 , pp. 2079-2089
    • Abdel-Hafiz, H.A.M.1    Heasley, L.E.2    Kyriakis, J.M.3    Avruch, J.4    Kroll, D.J.5    Johnson, G.J.6    Hoeffler, J.P.7
  • 18
    • 0027423418 scopus 로고
    • Identification of an oncoprotein-and UV-responsive protein kinase that bind and potentiates the c-Jun activation domain
    • 18. Hibi, M.; Lin, A.; Smeal, T.; Minden, A.; Karin, M. Identification of an oncoprotein-and UV-responsive protein kinase that bind and potentiates the c-Jun activation domain. Genes Dev. 7:2135-2148; 1993.
    • (1993) Genes Dev. , vol.7 , pp. 2135-2148
    • Hibi, M.1    Lin, A.2    Smeal, T.3    Minden, A.4    Karin, M.5
  • 19
    • 0028905076 scopus 로고
    • Transcription factor ATF2 regulation by the JNK signal transduction pathway
    • 19. Gupta, S.; Campbell, D.; Dérijard, B.; Davis, R. J. Transcription factor ATF2 regulation by the JNK signal transduction pathway. Science 267:389-393; 1995.
    • (1995) Science , vol.267 , pp. 389-393
    • Gupta, S.1    Campbell, D.2    Dérijard, B.3    Davis, R.J.4
  • 20
    • 0029125757 scopus 로고
    • Integration of MAP Kinase signal transduction pathways at the serum response element
    • 20. Whitmarsh, A. J.; Shore, P.; Sharrocks, A. D.; Davis, R. J. Integration of MAP Kinase signal transduction pathways at the serum response element. Science 269:403-407; 1995.
    • (1995) Science , vol.269 , pp. 403-407
    • Whitmarsh, A.J.1    Shore, P.2    Sharrocks, A.D.3    Davis, R.J.4
  • 21
    • 0028034233 scopus 로고
    • Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5′-cap function
    • 21. Pause, A.; Belsham, G. J.; Gingras, A-C.; Donze, O.; Lin, T.-A.; Lawrence, J. C., Jr.; Sonenburg, N. Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5′-cap function. Nature 371:762-767; 1994.
    • (1994) Nature , vol.371 , pp. 762-767
    • Pause, A.1    Belsham, G.J.2    Gingras, A.-C.3    Donze, O.4    Lin, T.-A.5    Lawrence J.C., Jr.6    Sonenburg, N.7
  • 23
    • 0028329953 scopus 로고
    • JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
    • 23. Dérijard, B.; Hibi, M.; Wu, I.-H.; Barrett, T.; Su, B.; Deng, T.; Karin, M.; Davis, R. J. JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 76:1025-1037; 1994.
    • (1994) Cell , vol.76 , pp. 1025-1037
    • Dérijard, B.1    Hibi, M.2    Wu, I.-H.3    Barrett, T.4    Su, B.5    Deng, T.6    Karin, M.7    Davis, R.J.8
  • 24
    • 0027994002 scopus 로고
    • An osmosensing signal transduction pathway in mammalian cells
    • 24. Galcheva-Gargova, Z.; Dérijard, B.; Wu, I.-H.; Davis, R. J. An osmosensing signal transduction pathway in mammalian cells. Science 265:806-808; 1994.
    • (1994) Science , vol.265 , pp. 806-808
    • Galcheva-Gargova, Z.1    Dérijard, B.2    Wu, I.-H.3    Davis, R.J.4
  • 25
    • 0028935270 scopus 로고
    • Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine
    • 25. Raingeaud, J.; Gupta, S.; Rogers, J. S.; Dickens, M.; Han, J.; Ulevitch, R. J.; Davis, R. J. Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. J. Biol. Chem. 270:7420-7426; 1995.
    • (1995) J. Biol. Chem. , vol.270 , pp. 7420-7426
    • Raingeaud, J.1    Gupta, S.2    Rogers, J.S.3    Dickens, M.4    Han, J.5    Ulevitch, R.J.6    Davis, R.J.7
  • 26
    • 0028926263 scopus 로고
    • Parallel signal processing among mammalian MAPKs
    • 26. Cano, E.; Mahadevan, L. C. Parallel signal processing among mammalian MAPKs. Trends Biochem. Sci. 20:117-122; 1995.
    • (1995) Trends Biochem. Sci. , vol.20 , pp. 117-122
    • Cano, E.1    Mahadevan, L.C.2
  • 27
    • 0029055812 scopus 로고
    • The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway
    • 27. Cosco, O. A.; Chiariello, M.; Yu, J. C.; Teramoto, H.; Crespo, N.; Xu, N.; Miki, T.; Gutkind, J. S. The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell 81:1137-1146; 1995.
    • (1995) Cell , vol.81 , pp. 1137-1146
    • Cosco, O.A.1    Chiariello, M.2    Yu, J.C.3    Teramoto, H.4    Crespo, N.5    Xu, N.6    Miki, T.7    Gutkind, J.S.8
  • 28
    • 0029070887 scopus 로고
    • Selective activation of the JNK signaling cascade and c-jun transcriptional activity by the small GTPases Rac and Cdc42Hs
    • 28. Minden, A.; Lin, A.; Claret, F. X.; Abo, A.; Karin, M. Selective activation of the JNK signaling cascade and c-jun transcriptional activity by the small GTPases Rac and Cdc42Hs. Cell 81:1147-1157; 1995.
    • (1995) Cell , vol.81 , pp. 1147-1157
    • Minden, A.1    Lin, A.2    Claret, F.X.3    Abo, A.4    Karin, M.5
  • 30
    • 0028986629 scopus 로고
    • Tumor necrosis factor a rapidly activates the mitogen-activated protein kinase (MAPK) cascade in a MAPK kinase kinase-dependent, c-Raf-1-independent fashion in mouse macrophages
    • 30. Winston, B. W.; Lange-Carter, C. A.; Gardner, A. M.; Johnson, G. E.; Riches, D. W. H. Tumor necrosis factor a rapidly activates the mitogen-activated protein kinase (MAPK) cascade in a MAPK kinase kinase-dependent, c-Raf-1-independent fashion in mouse macrophages. Proc. Natl. Acad. Sci. USA 92:1614-16; 1995.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 1614-1616
    • Winston, B.W.1    Lange-Carter, C.A.2    Gardner, A.M.3    Johnson, G.E.4    Riches, D.W.H.5
  • 31
    • 0027215820 scopus 로고
    • A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf
    • 31. Lange-Carter, C. A.; Pleiman, C. M.; Gardner, A. M.; Blumer, K. J.; Johnson, G. L. A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf. Science 260:315-319; 1993.
    • (1993) Science , vol.260 , pp. 315-319
    • Lange-Carter, C.A.1    Pleiman, C.M.2    Gardner, A.M.3    Blumer, K.J.4    Johnson, G.L.5
  • 32
    • 0027358722 scopus 로고
    • MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo
    • 32. Sun, H.; Charles, C. H.; Lau, F.; Tonks, N. K. MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo. Cell 75:487-493; 1993.
    • (1993) Cell , vol.75 , pp. 487-493
    • Sun, H.1    Charles, C.H.2    Lau, F.3    Tonks, N.K.4
  • 33
    • 0028125887 scopus 로고
    • Control of MAP kinase activation by the mitogen-induced threonine/tyrosine phosphatase PAC1
    • 33. Ward, Y.; Gupta, S.; Jensen, P.; Wartman, M.; Davis, R. J.; Kelly, K. Control of MAP kinase activation by the mitogen-induced threonine/tyrosine phosphatase PAC1. Nature 367:651-654; 1994.
    • (1994) Nature , vol.367 , pp. 651-654
    • Ward, Y.1    Gupta, S.2    Jensen, P.3    Wartman, M.4    Davis, R.J.5    Kelly, K.6
  • 34
    • 0028924419 scopus 로고
    • Role of mitogen-activated protein kinase phosphatase during the cellular response to genotoxic stress. Inhibition of c-Jun N-terminal kinase activity and AP-1-dependent gene activation
    • 34. Liu, Y.; Gorospe, M.; Yang, C.; Holbrook, N. J. Role of mitogen-activated protein kinase phosphatase during the cellular response to genotoxic stress. Inhibition of c-Jun N-terminal kinase activity and AP-1-dependent gene activation. J. Biol. Chem. 270:8377-8380; 1995.
    • (1995) J. Biol. Chem. , vol.270 , pp. 8377-8380
    • Liu, Y.1    Gorospe, M.2    Yang, C.3    Holbrook, N.J.4
  • 35
    • 0027716596 scopus 로고
    • Inhibition by cAMP of Ras-dependent activation of Raf
    • 35. Cook, S. J.; McCormick, F. Inhibition by cAMP of Ras-dependent activation of Raf. Science 262:1069-1072; 1993.
    • (1993) Science , vol.262 , pp. 1069-1072
    • Cook, S.J.1    McCormick, F.2
  • 37
    • 0026439402 scopus 로고
    • Role of Ras in signal transduction from the nerve growth factor receptor: Relationship to protein kinase C, calcium and cyclic AMP
    • 37. Szeberényi, J.; Erhardt, P.; Cai, H.; Cooper, G. M. Role of Ras in signal transduction from the nerve growth factor receptor: relationship to protein kinase C, calcium and cyclic AMP. Oncogene 7:2105-2113; 1992.
    • (1992) Oncogene , vol.7 , pp. 2105-2113
    • Szeberényi, J.1    Erhardt, P.2    Cai, H.3    Cooper, G.M.4
  • 38
    • 0028089986 scopus 로고
    • Inhibition of Ras-induced DNA synthesis by expression of the phosphatase MKP-1
    • 38. Sun, H.; Tonks, N. K.; Bar-Sagi, D. Inhibition of Ras-induced DNA synthesis by expression of the phosphatase MKP-1. Science 266:285-288; 1994.
    • (1994) Science , vol.266 , pp. 285-288
    • Sun, H.1    Tonks, N.K.2    Bar-Sagi, D.3
  • 39
    • 0025075302 scopus 로고
    • Effect of a dominant inhibitory Ha-ras mutation on neuronal differentiation of PC12 cells
    • 39. Szeberényi, J.; Hong, C.; Cooper, G. M. Effect of a dominant inhibitory Ha-ras mutation on neuronal differentiation of PC12 cells. Mol. Cell. Biol. 10:5324-5332; 1990.
    • (1990) Mol. Cell. Biol. , vol.10 , pp. 5324-5332
    • Szeberényi, J.1    Hong, C.2    Cooper, G.M.3
  • 40
    • 0028078824 scopus 로고
    • A brain serine/threonine protein kinase activated by Cdc42 and Rac1
    • 40. Manser, E.; Leung, T.; Salihuddin, H.; Zhao, Z.; Lim, L. A brain serine/threonine protein kinase activated by Cdc42 and Rac1. Nature 367:40-46; 1994.
    • (1994) Nature , vol.367 , pp. 40-46
    • Manser, E.1    Leung, T.2    Salihuddin, H.3    Zhao, Z.4    Lim, L.5
  • 41
    • 0028074621 scopus 로고
    • Ras-dependent growth factor regulation of MEK kinase in PC12 cells
    • 41. Lange-Carter, C. A.; Johnson, G. L. Ras-dependent growth factor regulation of MEK kinase in PC12 cells. Science 265:1458-1461; 1994.
    • (1994) Science , vol.265 , pp. 1458-1461
    • Lange-Carter, C.A.1    Johnson, G.L.2
  • 42
    • 0023715225 scopus 로고
    • Inhibition of NIH3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP
    • 42. Feig, L.; Cooper, G. Inhibition of NIH3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP. Mol. Cell. Biol. 8:3235-3243; 1988.
    • (1988) Mol. Cell. Biol. , vol.8 , pp. 3235-3243
    • Feig, L.1    Cooper, G.2
  • 43
    • 0025080435 scopus 로고
    • Arsenite and cadmium(II) as probes of glucocorticoid receptor structure and function
    • 43. Simons, S. S., Jr.; Chakraborti, P. K.; Cavanaugh, A. H. Arsenite and cadmium(II) as probes of glucocorticoid receptor structure and function. J. Biol. Chem. 265:1938-1945; 1990.
    • (1990) J. Biol. Chem. , vol.265 , pp. 1938-1945
    • Simons S.S., Jr.1    Chakraborti, P.K.2    Cavanaugh, A.H.3
  • 44
    • 0027298410 scopus 로고
    • Suramin: A novel antineoplastic agent with multiple potential mechanisms of action
    • 44. Stein, C. A. Suramin: A novel antineoplastic agent with multiple potential mechanisms of action. Cancer Res. 53:2239-2248; 1993.
    • (1993) Cancer Res. , vol.53 , pp. 2239-2248
    • Stein, C.A.1
  • 45
    • 0027049804 scopus 로고
    • The mammalian ultraviolet response is triggered by activation of Src tyrosine kinase
    • 45. Devary, Y.; Gottlieb, R. A.; Smeal, T.; Karin, M. The mammalian ultraviolet response is triggered by activation of Src tyrosine kinase. Cell 71:1081-1091; 1992.
    • (1992) Cell , vol.71 , pp. 1081-1091
    • Devary, Y.1    Gottlieb, R.A.2    Smeal, T.3    Karin, M.4
  • 46
    • 0028015872 scopus 로고
    • Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of hsp27
    • 46. Freshney, N. W.; Rawlinson, L.; Guesdon, F.; Jones, E.; Cowley, S.; Hsuan, J.; Saklatvala, J. Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of hsp27. Cell 78:1039-1049; 1994.
    • (1994) Cell , vol.78 , pp. 1039-1049
    • Freshney, N.W.1    Rawlinson, L.2    Guesdon, F.3    Jones, E.4    Cowley, S.5    Hsuan, J.6    Saklatvala, J.7
  • 47
    • 0028988138 scopus 로고
    • SB203580 is a specific inhibitor of MAP kinase homologue which is stimulated by cellular stresses and interleukin-1
    • 47. Cuenda, A.; Rouse, J.; Doza, Y. N.; Meier, R.; Cohen, P.; Gallagher, T. F.; Young, P. R.; Lee, J. C. SB203580 is a specific inhibitor of MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett. 364:229-233; 1995.
    • (1995) FEBS Lett. , vol.364 , pp. 229-233
    • Cuenda, A.1    Rouse, J.2    Doza, Y.N.3    Meier, R.4    Cohen, P.5    Gallagher, T.F.6    Young, P.R.7    Lee, J.C.8
  • 48
    • 0028838012 scopus 로고
    • Dimerization of cell surface receptors in signal transduction
    • 48. Heldin, C.-H. Dimerization of cell surface receptors in signal transduction. Cell 80:213-223; 1995.
    • (1995) Cell , vol.80 , pp. 213-223
    • Heldin, C.-H.1
  • 49
    • 0028307058 scopus 로고
    • Stabilization of an active dimeric form of the epidermal growth factor receptor by introduction of an inter-receptor disulfide bond
    • 49. Sorkin, A.; Lemmon, M. A.; Ullrich, A.; Schlessinger, J. Stabilization of an active dimeric form of the epidermal growth factor receptor by introduction of an inter-receptor disulfide bond. J. Biol Chem. 269:9752-9759; 1994.
    • (1994) J. Biol Chem. , vol.269 , pp. 9752-9759
    • Sorkin, A.1    Lemmon, M.A.2    Ullrich, A.3    Schlessinger, J.4
  • 50
    • 0024505028 scopus 로고
    • A point mutation in the neu oncogene mimics ligand induction of receptor aggregation
    • 50. Weiner, D. B.; Liu, J.; Cohen, J. A.; Williams, W. V.; Greene, M. I. A point mutation in the neu oncogene mimics ligand induction of receptor aggregation. Nature 339:230-231; 1989.
    • (1989) Nature , vol.339 , pp. 230-231
    • Weiner, D.B.1    Liu, J.2    Cohen, J.A.3    Williams, W.V.4    Greene, M.I.5
  • 52
    • 0027194309 scopus 로고
    • Oxidative mechanisms in carcinogenesis
    • 52. Guyton, K. Z.; Kensler, T. W. Oxidative mechanisms in carcinogenesis. Br. Med. Bull. 49:523-544; 1993.
    • (1993) Br. Med. Bull. , vol.49 , pp. 523-544
    • Guyton, K.Z.1    Kensler, T.W.2
  • 53
    • 0028577137 scopus 로고
    • Activation of tyrosine kinase signal pathways by radiation and oxidative stress
    • 53. Schieven, G. L.; Ledbetter, J. A. Activation of tyrosine kinase signal pathways by radiation and oxidative stress. Trends Endocrinol. Metab. 5:383-388; 1994.
    • (1994) Trends Endocrinol. Metab. , vol.5 , pp. 383-388
    • Schieven, G.L.1    Ledbetter, J.A.2


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