Interaction between ATM protein and c-Abl in response to DNA damage

Nature

Volumn 387, Issue 6632, 1997, Pages 520-523

  Shafman, Timothy ^a   Khanna, Kum Kum ^b   Kedar, Padmini ^b   Spring, Kevin ^b   Kozlov, Sergei ^b   Yen, Tim ^c   Hobson, Karen ^b   Gatei, Magtouf ^b   Zhang, Ning ^b   Watters, Dianne ^b   Egerton, Mark ^b   Shiloh, Yosef ^d   Kharbanda, Surender ^a   Kufe, Donald ^a   Lavin, Martin F ^b  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c FOX CHASE CANCER CENTER   (United States)

^d TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN TYROSINE KINASE;

ARTICLE; ATAXIA TELANGIECTASIA; CELL CYCLE; CELL LINE; DNA DAMAGE; ENZYME INDUCTION; GENE MUTATION; IONIZING RADIATION; MEIOSIS; PRIORITY JOURNAL; PROTEIN INDUCTION; RADIATION INJURY; RADIOSENSITIVITY; REGULATORY MECHANISM;

ATAXIA TELANGIECTASIA; CELL CYCLE PROTEINS; CELL LINE; CLONING, MOLECULAR; DNA DAMAGE; DNA-BINDING PROTEINS; ENZYME ACTIVATION; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; PROTEINS; PROTO-ONCOGENE PROTEINS C-ABL; RADIATION, IONIZING; RECOMBINANT FUSION PROTEINS; SACCHAROMYCES CEREVISIAE; SRC HOMOLOGY DOMAINS; TUMOR SUPPRESSOR PROTEINS;

EID: 0030992749     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/387520a0     Document Type: Article

References (26)

1. Savitsky, K. et al. A single ataxia telangiectasia gene with a product similar to PI-3 kinase. Science 268, 1749-1753 (1995).
2. Zakian, V. A. ATM-related genes: what do they tell us about functions of the human gene? Cell 82, 685-687 (1995).
3. Lavin, M. F. et al. Relationship of the ataxia-telangiectasia protein ATM to phosphoinositide 3-kinase. Trends Biochem. Sci. 20, 382-383 (1995).
4. Jackson, S. P. Cancer predisposition. Ataxia-telangiectasia at the crossroads. Current Biol. 5, 1210-1212 (1995).
5. Taylor, A. M. et al. Ataxia telangiectasia: a human mutation with abnormal radiation sensitivity. Nature 274, 484-486 (1975).
6. Chen, P. C., Lavin, M. F., Kidson, C. & Moss, D. Identification of ataxia telangiectasia heterozygotes, a cancer prone population. Nature 258, 427-429 (1975).
7. Paterson, M. C., Anderson, A. K., Smith, B. P. & Smith, P. J. Enhanced radiosensitivity of cultured fibroblasts from ataxia telangiectasia heterozygotes manifested by defective colony-forming ability and reduced DNA repair replication after hypoxic gamma-irradiation. Cancer Res. 39, 3725-3734 (1979).
8. Kastan, M. B. et al. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell 71, 587-597 (1992).
9. Khanna, K. K. & Lavin, M. F. Ionizing radiation and UV induction of p53 protein by different pathways in ataxia-telangiectasia cells. Oncogene 8, 3307-3312 (1993).
10. Khanna, K. K. et al. Nature of G1/S cell cycle checkpoint defect in ataxia-telangiectasia. Oncogene 11, 609-618 (1995).
11. Yuan, Z.-M. et al. Role for c-Abl tyrosine kinase in growth arrest response to DNA damage. Nature 382, 272-274 (1996).
12. Telatar, M. et al. Ataxia-telangiectasia: mutations in ATM cDNA detected by protein-truncation screening. Am. J. Hum. Genet. 59, 40-44 (1996).
13. Uziel, T. et al. Genomic organization of the ATM gene. Genomics 33, 317-320 (1996).
14. Pawson, T. Non-catalytic domains of cytoplasmic protein-tyrosine kinases: regulatory elements in signal transduction. Oncogene 3, 491-495 (1988).
15. Pecker, L. et al. Identification and chromosomal localization of Atm, the mouse homolog of the ataxia-telangiectasia gene. Genomics 35, 39-45 (1996).
16. Kharbanda, S. et al. The stress response to ionizing radiation involves c-Abl-dependent phosphorylation of SHPTP1. Proc. Natl. Acad. Sci. USA 93, 6898-6901 (1996).
17. Kharbanda, S. et al. Activation of the c-Abl tyrosine kinase in the stress response to DNA-damaging agents. Nature 376, 785-788 (1995).
18. Ren, R., Ye, Z.-S. & Baltimore, D. Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding sites. Genes Dev. 8, 783-795 (1994).
19. Shafman, T. et al. Defective induction of stress-activated protein kinase activity in atana-telangiectasia cells exposed to ionizing radiation. Cancer Res. 55, 3242-3245 (1995).
20. Zhang, N. et al. Correction of the ataxia-telangiectasa cellular phenotype with full-length ATM cDNA. Proc. Natl Acad. Sci. USA (in the press).
21. Rudolph, N. S. & Latt, S. A. Flow cytometric analysis of X-ray sensitivity in ataxia telangiectasia. Mutat. Res. 211, 31-41 (1989).
22. Beamish, H. & Lavin, M. F. Radiosensitivity in ataxia-telangiectasia: anomalies in radiation-induced cell cycle delay. Int. J. Radiat. Biol. 65, 175-184 (1994).
23. Frangioni, J. V. & Neel, B. G. Solubilization and purification of enzymatically active glutathione S-transferase (pGEX) fusion proteins. Anal. Biochem. 210, 179-187 (1993).
24. Gilad, S. et al. Ataxia-telangiectasia: founder effect among North African Jews. Hum. Mol. Genet. 5, 2033-2037 (1996).
25. Watters, D. et al. Cellular localisation of the ataxia-telangiectasia (ATM) gene product and discrimination between mutated and normal forms. Oncogene 14, 1911-1921 (1997).
26. Houldsworth, J. & Lavin, M. F. Effect of ionizing radiation on DNA synthesis in ataxia telangiectasia cells. Nucleic Acids Res. 8, 3709-3720 (1980).