DNA-PK activation by ionizing radiation-induced DNA single-strand breaks

International Journal of Radiation Biology

Volumn 75, Issue 5, 1999, Pages 553-561

  Plumb, M A ^a   Smith, G C M ^b   Cunniffe, S M T ^a   Jackson, S P ^b   O'Neill, P ^a  

^a MRC Radiat and Genome Stability U   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COBALT; DOUBLE STRANDED DNA; ENDONUCLEASE; PLASMID DNA; PROTEIN KINASE;

ARTICLE; CONTROLLED STUDY; DNA DETERMINATION; DNA STRAND BREAKAGE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME ISOLATION; ENZYME PURIFICATION; FIBROBLAST; GAMMA IRRADIATION; HELA CELL; HUMAN; HUMAN CELL; IONIZING RADIATION; PRIORITY JOURNAL; RADIATION DOSE;

CELLS, CULTURED; DNA DAMAGE; DNA, SINGLE-STRANDED; DNA-ACTIVATED PROTEIN KINASE; DNA-BINDING PROTEINS; ENZYME ACTIVATION; HUMANS; NUCLEAR PROTEINS; PLASMIDS; PROTEIN-SERINE-THREONINE KINASES;

EID: 0032978973     PISSN: 09553002     EISSN: None     Source Type: Journal    
DOI: 10.1080/095530099140195     Document Type: Article

References (39)

1. AN, S., CHEN, Y., WU, W. and WU, J. M., 1994, Demonstration of a double-stranded DNA-stimulated protein kinase (DNA-PK) inhibitory activity in human HL-60 leukemia cells. Biochemistry, Biophysical Research Communications, 202, 1530-1537.
2. ANDERSON, C. W. and LEES-MILLIR, S. P., 1992, The nuclear serine/threonine protein kinase DNA-PK. Critical Reviews in Eukaryotic Gene Expression, 2, 283-314.
3. BLIER, P. R., GRIFFITH, A. J., CRAFT, J. and HARDIN, J. A., 1993, Binding of Ku protein to DNA. The Journal of Biological Chemistry, 268, 7594-7601.
4. BLISS, T. M. and LANE, D. P., 1997, Ku selectively transfers between DNA molecules with homologous ends. Journal of Biological Chemistry, 272, 5765-5773.
5. BUCHKO, G. W. and WEINFELD, M., 1993, Influence of nitrogen, oxygen, and nitroimidazole radiosensitizers on DNA damage induced by ionizing radiation. Biochemistry, 32, 2186-2193.
6. CARTER, T., VANCUROVA, I., SUN, I., LOU, W. and DELEON, S., 1990, A DNA-activaled protein kinase from HeLa cell nuclei. Molecular and Cellular Biology, 10, 6460-6471.
7. CRITCHLOW, S. E., BOWATER, R. P. and JACKSON, S. P., 1997, Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV. Current Biology, 7, 580-598.
8. DIZDAROGLU, M., 1992, Measurement of radiation-induced damage to DNA at the molecular level. International Journal of Radiation Biology, 61, 175-183.
9. DVIR, A., STEIN, L. Y., CALORE., B. L. and DYNAN, W. S., 1993, Purification and characterization of a template-associated protein kinase that phosphorylates RNA polymerase II. Journal of Biological Chemistry, 268, 10440-10447.
10. FALZON, M., FEWELL, J. W. and KUFF, E. L., 1993, EBP-80, a transcription factor closely resembling the human auto-antigen Ku, recognizes single-to double-strand transitions in DNA. Journal of Biological Chemistry, 268, 10546-10552.
11. FINNIE, N. J., GOTTLIEB, T. M., BLUNT, T., JEGGO, P. A. and JACKSON, S. P., 1995, DNA-dependent protein kinase activity is absent in xrs-6 cells: implications for site-specific recombination and DNA double-strand break repair. Proceedings of the National Academy of Sciences, USA, 92, 320-324.
12. FRIEDBERG, E. C., WALKER, G. C. and SIEDE, W., 1995, DNA Repair and Mutagenesis (Washington: ASM).
13. GOTTLIEB, T. M. and JACKSON, S. P., 1993, The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen. Cell, 72, 131-142.
14. GRAWUNDER, U., WILM, M., WU, X., KULESZA, P., WILSON, T. E., MANN, M. and LIEBER, M. R., 1997, Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells. Nature, 388, 492-495.
15. GROVE, M. and PLUMB, M., 1993, C/EBP, NF-kB, and c-Ets family members and transcriptional regulation of the cell-specific and inducible macrophage inflammatory protein l α immediate-early gene. Molecular and Cellular Biology, 13, 5276-5289.
16. HARTLEY K. O., GELL, D., SMITH, G. C., ZHANG, H., DIVECHA, N., CONNELLY, M. A., ADMON, A., LEES-MILLER, S. P., ANDERSON, C. W. and JACKSON, S. P., 1995, DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product. Cell, 82, 849-856.
17. HENNER, W. D., RODRIGUEZ, L. O., HECHT, S. M. and HASELTINE, W. A., 1983, γ-ray induced deoxyribonucleic acid strand breaks: 3′ glycolate termini. Journal of Biological Chemistry, 258, 711-713.
18. HODGKINS, P. S., FAIRMAN, M. P. and O'NEILL, P., 1996, Rejoining of gamma-radiation-induced single-strand breaks in plasmid DNA by human cell extracts: dependence on the concentration of the hydroxyl radical scavenger, Tris. Radiation Research, 145, 24-30.
19. JACKSON, S. P. and JEGGO, P. A., 1995, DNA double-strand break repair and V(D)J recombination: involvement of DNA-PK. Trends in Biological Sciences, 20, 412-415.
20. JACKSON, S. P., MACDONALD, J. J., LEES-MILLER, S. P. and TJIAN, R., 1990, GC box binding induces phosphorylation of Spl by a DNA-dependent protein kinase. Cell, 53, 155-165.
21. JEGGO, P. A., 1998, DNA repair: PARP another guardian angel? Current Biology, 8, R49-51.
22. LEES-MILLER, S. P., SAKAGUCHI, K., ULLRICH, S. J., APPELLA, E. and ANDERSON, C. W., 1992, Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53. Molecular and Cellular Biology, 12, 5041-5049.
23. LIEBER, M. R., GRAWUNDER, U., WU, X. and YANEVA, M., 1997, Tying loose ends: roles of Ku and DNA-dependent protein kinase in the repair of double-strand breaks. Current Opinions in Genetic Development, 7, 99-104.
24. LINDAHL, T., SATOH, M. S., POIRIER, G. G. and KLUNGLAND, A., 1995, Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks. Trends in Biological Sciences, 20, 405-412.
25. MILLER, R. D., HOGG, J., OZAKI, J. H., GELL, D., JACKSON, S. P. and RIBLET, R., 1995, Gene for the catalytic subunit of mouse DNA-dependent protein kinase maps to the scid locus. Proceedings of the National Academy of Sciences, USA, 92, 10792-10795.
26. MILLIGAN, J. R., AGUILERA, J. A. and WARD, J. F., 1993, Variation of single-strand break yield with scavenger concentration for plasmid DNA irradiated in aqueous solution. Radiation Research, 133, 151-157.
27. MOROZOV, V. E., FALZON, M., ANDERSON, C. W. and KUFF, E. L., 1994, DNA-dependent protein kinase is activated by nicks and larger single-stranded gaps. Journal of Biological Chemistry, 269, 16684-16688.
28. NUSSENZWEIG, A., CHEN, C., DA COSTA SOARES, V., SANCHEZ, M., SOKOL, K., NUSSENZWEIG, M. C. and LI, G. C., 1996, Requirement for Ku80 in growth and immunoglobulin V(D)J recombination. Nature, 382, 551-555.
29. O'NEILL, P. and FIELDEN, M., 1993, Primary Free Radical Processes in DNA. In L. J. Lett and W. K. Sinclair (eds), Advances in Radiation Biology, vol. 17 (San Diego: Academic Press), pp. 53-120.
30. PAILLARD, S. and STRAUSS, F., 1991, Analysis of the mechanism of interaction of simian Ku protein with DNA. Nucleic Acids Research, 19, 5619-5624.
31. POLTORATSKY, V. P., SHI, X., YORK, J. D., LIEBER, M. R. and CARTER, T. H., 1995, Human DNA-activated protein kinase (DNA-PK) is homologous to phosphatidylinositol kinases. Journal of Immunology, 155, 4529-4533.
32. PRICE, A., 1993, The repair of ionising radiation-induced damage to DNA. Seminars in Cancer Biology, 4, 61-71.
33. SAMBROOK, J., FRITSCH, E. F. and MANIATIS, T., 1989, Molecular Cloning: A Laboratory Manual, 2nd edn (Cold Spring Harbor: Cold Spring Harbor Laboratory Press).
34. SATOH, M. S. and LINDAHL, T., 1992, Role of poly(ADP-ribose) formation in DNA repair. Nature, 356, 356-358.
35. SY, D., SAVOYE, C., BEGUSOVA, M., MICHALIK, V., CHARLIER, M. and SPOTHEIM-MAURIZOT, M., 1997, Sequence-dependent variations of DNA structure modulate radiation-induced strand breakage. International Journal of Radiation Biology, 72, 147-155.
36. WEINFELD, M, CHAUDHRY, M. A., D'AMOURS, D., PELLETIER, J. D., POIRIER, G. G., POVIRK, L. P. and LEES-MILLER, S. P., 1997, Interaction of DNA-dependent protein kinase and poly(ADP-ribose) polymerase with radiation-induced DNA strand breaks. Radiation Research, 148, 22-28.
37. YANEVA, M., KOWALEWSKI, T. and LIEBER, M. R., 1997, Interaction of DNA-dependent protein kinase with DNA and with Ku: biochemical and atomic-force microscopy studies. EMBO Journal, 16, 5098-5112.
38. YAVUZER, U., SMITH, G. C. M., BLISS, T., WERNER, D. and JACKSON, S. P., 1998, DNA end-independent activation of DNA-PK mediated via association with the DNA-binding protein CID. Genes and Development, 12, 2188-2199.
39. ZHU, C., BOGUE, M. A., LIM, D.-S., HASTY, P. and ROTH, D. B., 1996, Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates. Cell, 86, 379-389.