Transiently transfected and stably integrated HIV-1 LTR responds differentially to the silencing activity of the Kruppel-associated box (KRAB) transcriptional repressor domain

Journal of Medical Virology

Volumn 58, Issue 3, 1999, Pages 264-272

  Rossi, Cristina ^a   Gibellini, Davide ^b   Barbanti Brodano, Giuseppe ^a   Betti, Monica ^a   Boarini, Chiara ^a   Pengue, Gina ^c   Lania, Luigi ^c   Caputo, Antonella ^a  

^a UNIVERSITY OF FERRARA   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

HIV 1 replication; HIV 1 Tat mutants; Kruppel associated box

Indexed keywords

ARTICLE; CONTROLLED STUDY; FUSION GENE; GENE SILENCING; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; LONG TERMINAL REPEAT; NONHUMAN; PROTEIN DOMAIN; TRANSACTIVATION; TRANSCRIPTION REGULATION; VIRUS EXPRESSION; VIRUS GENOME; VIRUS REPLICATION; VIRUS TRANSCRIPTION;

ANIMALS; CELL LINE; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, VIRAL; GENE PRODUCTS, TAT; HELA CELLS; HIV LONG TERMINAL REPEAT; HUMANS; JURKAT CELLS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MUTATION; RECOMBINANT FUSION PROTEINS; REPRESSOR PROTEINS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION; VIRUS INTEGRATION; ZINC FINGERS;

EID: 0032997376     PISSN: 01466615     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9071(199907)58:3<264::AID-JMV12>3.0.CO;2-V     Document Type: Article

References (38)

1. Alberts AS, Geneste O, Treisman R. 1998. Activation of SRF-regulated chromosomal templates by Rho-family GTPases requires a signal that also induces H4 hyperacetylation. Cell 92: 475-487.
2. Balboni PG, Bozzini R, Zucchini S, Marconi PC, Grossi MP, Caputo A, Manservigi R, Barbanti-Brodano G. 1993. Inhibition of HIV reactivation from latency by a tat transdominant negative mutant. J Med Virol 41:289-295.
3. Bellefroid EJ, Poncelet DA, Lecocq PJ, Revelant O, Martial JA. 1991. The evolutionary conserved Krüppel-associated box domain defines a subfamily of eukaryotic multifingered proteins. Proc Natl Acad Sci USA 88:3608-3612.
4. Caputo A, Grossi MP, Rossi C, Campioni D, Balboni PG, Corallini A, Barbanti-Brodano G. 1995. The tat gene and protein of the human immunodeficiency virus type 1. Microbiologica 18:87-110.
5. Caputo A, Grossi MP, Bozzini R, Rossi C, Betti M, Marconi PC, Barbanti-Brodano G, Balboni PG. 1996. Inhibition of HIV-1 replication and reactivation from latency by tat transdominant negative mutants in the cysteine rich region. Gene Ther 3:235-245.
6. Caputo A, Rossi C, Bozzini R, Betti M, Grossi MP, Barbanti-Brodano G, Balboni PG. 1997. Studies on the effect of the combined expression of anti-tat and anti-rev genes on HIV-1 replication. Gene Ther 4:288-295.
7. Chang HK, Gallo RC, Ensoli B. 1995. Regulation of cellular gene expression and function by the human immunodeficiency virus type 1 Tat protein. J Biomed Sci 2:189-202.
8. Corallini A, Campioni D, Rossi C, Albini A, Possati L, Rusnati M, Gazzanelli G, Benelli R, Masiello L, Sparacciari V, Presta M, Mannello F, Fontanini G, Barbanti-Brodano G. 1996. Promotion of tumor metastases and induction of angiogenesis by native HIV-1 Tat protein from BK virus/tat transgenic mice. AIDS 10:701-710.
9. Davis LG, Dibner MD, Battey JF. 1986. Basic methods in molecular biology. New York: Elsevier.
10. De Luca P, Majello B, Lania L. 1998. Retinoblastoma protein tethered to promoter DNA represses TBP-mediated transcription. J Cell Biochem 70:281-287.
11. el Kharroubi A, Verdin E. 1994. Protein-DNA interactions within DNase I-hypersensitive sites located downstream of the HIV-1 promoter. J Biol Chem 269:19916-19924.
12. Friedman JR, Fredericks WJ, Jensen DE, Speicher DW, Huang X-P, Neilson EG, Raucher FJ. 1996. KAP-1, a novel corepressor for the highly conserved KRAB repression domain. Genes Dev 10:2067-2078.
13. Gonsky R, Knauf JA, Elisei R, Wang JW, Su S, Fagin JA. 1997. Identification of rapid turnover transcripts over-expressed in thyroid cancer cell lines: use of a targeted differential RNA display method to select for mRNA subsets. Nucleic Acids Res 25:3823-3831.
14. Jeong SW, Stein A. 1994a. DNA sequence affects nucleosome ordering on replicating plasmids in transfected COS-1 cells and in vitro. J Biol Chem 269:2197-2205.
15. Jeong SW, Stein A. 1994b. Micrococcal nuclease digestion of nuclei reveals extended nucleosome ladders having anomalous DNA lengths for chromatin assembled on non-replicating plasmids in transfected cells. Nucleic Acids Res 22:370-375.
16. Jones KA, Peterlin BM. 1994. Control of RNA initiation and elongation at the HIV-1 promoter. Ann Rev Biochem 63:717-738.
17. Kim S-S, Chen Y-M, O'Leary E, Witzgall R, Vidai M, Bonventre J. 1996. A novel member of the RING family, KRIP-1, associates with the KRAB-A transcriptional repressor domain of zinc finger proteins. Proc Natl Acad Sci USA 93:15299-15304.
18. Le Douarin B, Nielsen AN, Gamier J-M, Ichinose H, Jeanmougin F, Losson R, Chambon P. 1996. A possible involvement of TIF1α and TIF1β in the epigenetic control of transcription by nuclear receptors. EMBO J 15:6701-6715.
19. Margolin JF, Friedman JR, Meyer WKH, Vissing H, Thiensen HJ, Rauscher FJ. 1994. Krüppel-associated boxes are potent transcriptional repressor domains. Proc Natl Acad Sci USA 91:4509-4513.
20. Miller AD, Rosman GJ. 1989. Improved retroviral vectors for gene transfer and expression. Biotechniques 7:980-990.
21. Moosmann P, Georgiev OB, Bourquin JP, Schaffner W. 1996. Transcriptional repression by RING finger protein TIF1b that interacts with the KRAB repressor domain of KOX1. Nucleic Acids Res 24: 4859-4867.
22. Moosmann P, Georgiev O, Thiesen HJ, Hagmann M, Schaffner W. 1997. Silencing of RNA polymerase II and III-dependent transcription by the KRAB protein domain of KOX1, a Kruppel-type zinc finger factor. Biol Chem 378:669-677.
23. Myers G, Hahn BH, Mellors JW, Korber B, Jeang KT, Me Cutchan FE, Pavlakis GN. 1995. Human retroviruses and AIDS. A compilation and analysis of nucleic acid and aminoacid sequences. Theoretical Biology and Biophysics. Los Alamos, NM. Section IIA-61-66.
24. Norton PA, Coffin JM. 1985. Bacterial β-galactosidase as a marker of Rous sarcoma virus gene expression and replication. Mol Cell Biol 5:281-290.
25. Paranjape SM, Kamakaka TT, Kadonaga JT. 1994. Role of chromatin structure in the regulation of transcription by RNA polymerase II. Annu Rev Biochem 63:265-297.
26. Pengue G, Calabrò V, Cannada Bartoli P, Pagliuca A, Lania L. 1994. Repression of transcriptional activity at a distance by the evolutionary conserved KRAB domain present in a subfamily of zinc finger proteins. Nucleic Acids Res 22:2908-2914.
27. Pengue G, Caputo A, Rossi C, Barbanti-Brodano G, Lania L. 1995. Transcriptional silencing of HIV-1 long terminal repeat-driven gene expression by the Krüppel-associated box repressor domain targeted to the transactivating response element. J Virol 69:6577-6580.
28. Pengue G, Lania L. 1996. Krüppel-associated box-mediated repression of RNA polymerase II promoters is influenced by the arrangement of basal promoter elements. Proc Natl Acad Sci USA 93: 1015-1020.
29. Pomerantz JL, Sharp PA, Pabo CO. 1995. Structure-based design of transcriptional factors. Science 267:93-96.
30. Rauscher FJ. 1998. Targeting cellular and viral promoters with engineered transcriptional repressers: a potential strategy for silencing integrated proviruses. 1998 Meeting of the Institute of Human Virology (August 23-29). Baltimore, MD. Abstract 66.59.
31. Rossi C, Balboni PG, Betti M, Marconi PC, Bozzini R, Grossi MP, Barbanti-Brodano G, Caputo A. 1997. Inhibition of HIV-1 replication by a Tat transdominant negative mutant in human peripheral blood lymphocytes from healthy donors and HIV-1-infected patients. Gene Ther 4:1261-1269.
32. Sheridan PL, Mayall TP, Verdin E, Jones KA. 1997. Histone acetyl-transferases regulate HIV-1 enhancer activity in vitro. Genes Dev 11:3327-3340.
33. Snedecor GW, Cochran WG. 1968. In: Statistical methods, 7th ed., Ames IA, editor. Iowa State University Press.
34. Sodroski J, Patarca R, Rosen C, Wong-Staal F, Haseltine WA. 1985. Localization of the trans-activating region on the genome of human T-cell lymphotropic virus type III. Science 229:74-77.
35. Thiesen HJ. 1996. From repression domains to designer zinc finger proteins: a novel strategy of intracellular immunization against HIV. Gene Expr 5:229-243.
36. Van Lint C, Emiliani S, Ott M, Verdin E. 1996. Transcriptional activation and chromatin remodeling of the HIV-1 promoter in response to histone acetylation. EMBO J 15:1112-1120.
37. Verdin E, Paras P, Jr, Van Lint C. 1993. Chromatin disruption in the promoter of human immunodeficiency virus type 1 during transcriptional activation. EMBO J 12:3249-3259.
38. Witzgall R, O'Leary E, Leaf A, Önaldi D, Bonventre J. 1994. The Krüppel-associated box-A (KRAB-A) domain of zinc finger proteins mediates transcriptional repression. Proc Natl Acad Sci USA 91: 4514-4518.