Generation of conditional mutants in higher eukaryotes by switching between the expression of two genes

Proceedings of the National Academy of Sciences of the United States of America

Volumn 96, Issue 3, 1999, Pages 1013-1018

  Baron, Udo ^a   Schnappinger, Dirk ^b   Helbl, Vera ^b   Gossen, Manfred ^c   Hillen, Wolfgang ^b   Bujard, Hermann ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA;

ARTICLE; DNA BINDING; EUKARYOTE; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE MUTATION; GENE SWITCHING; GENE THERAPY; HELA CELL; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL;

BACTERIAL PROTEINS; DNA-BINDING PROTEINS; DOXORUBICIN; GENE EXPRESSION REGULATION, BACTERIAL; GENES, SWITCH; HELA CELLS; HUMANS; PHENOTYPE; PROMOTER REGIONS (GENETICS); RECOMBINANT FUSION PROTEINS; TETRACYCLINE; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; TRANSFECTION;

EUKARYOTA;

EID: 0033514374     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.96.3.1013     Document Type: Article

References (29)

1. Gossen, M. & Bujard, H. (1992) Proc. Natl. Acad. Sci. USA 89, 5547-5551.
2. Gossen, M., Freundlieb, S., Bender, G., Müller, G., Hillen, W. & Bujard, H. (1995) Science 268, 1766-1769.
3. Freundlieb, S., Baron, U., Bonin, A., Gossen, M. & Bujard, H. (1997) Methods Enzymol. 283, 159-172.
4. Camacho-Vanegas, O., Mannucci, L. & Amaldi, F. (1998) In Vitro Cell Dev. Biol. Anim. 34, 14-15.
5. Garí, E., Piedrafita, L., Aldea, M. & Herrero, E. (1997) Yeast 13, 837-848.
6. Girard, F., Bello, B., Laemmli, U. & Gehring, W. J. (1998) EMBO J. 17, 2079-2085.
7. Weinmann, P., Gossen, M., Hillen, W., Bujard, H. & Gatz, C. (1994) Plant J. 5, 559-569.
8. Zeidler, M., Gatz, C., Hartmann, E. & Hughes, J. (1996) Plant Mol. Biol. 30, 199-205.
9. Kistner, A., Gossen, M., Zimmermann, F., Jerecic, J., Ullmer, C., Lübbert, H. & Bujard, H. (1996) Proc. Natl. Acad. Sci. USA 93, 10933-10938.
10. Efrat, S., Fusco-DeMane, D., Lemberg, H., Emran, O. A. & Wang, X. (1995) Proc. Natl. Acad. Sci. USA 92, 3576-3580.
11. Ewald, D., Li, M., Efrat, S., Auer, G., Wall, R. J., Furth, P. A. & Hennighausen, L. (1996) Science 273, 1384-1386.
12. Mayford, M., Bach, M. E., Huang, Y., Wang, L., Hawkins, R. & Kandel, E. (1996) Science 274, 1678-1683.
13. Kolster, K., Kistner, A., Baron, U., Freundlieb, S., Gossen, M. & Bujard, H. (1998) Transgenic Techniques, in press.
14. Fishman, G. I., Kaplan, M. L. & Buttrick, P. M. (1994) J. Clin. Invest. 93, 1864-1868.
15. Baron, U., Gossen, M. & Bujard, H. (1997) Nucleic Acids Res. 25, 2723-2729.
16. Resnitzky, D., Gossen, M., Bujard, H. & Reed, S. I. (1994) Mol. Cell. Biol. 14, 1669-1679.
17. Southern, P. J. & Berg, P. (1982) J. Mol. Appl. Genet. 1, 327-341.
18. Harlow, E. & Lane, D. (1988) Antibodies: A Laboratory Manual (Cold Spring Harbor Lab. Press, Plainview, NY).
19. Baumeister, R., Helbl, V. & Hillen, W. (1992) J. Mol. Biol. 226, 1257-1270.
20. Helbl, V., Berens, C. & Hillen, W. (1995) J. Mol. Biol. 245, 538-548.
21. Helbl, V., Tiebel, B. & Hillen, W. (1998) J. Mol. Biol. 276, 319-324.
22. Helbl, V. & Hillen, W. (1998) J. Mol. Biol. 276, 313-318.
23. Bonin, A., Gossen, M. & Bujard, H. (1994) Gene 141, 75-77.
24. Hillen, W. & Berens, C. (1994) Annu. Rev. Microbiol. 48, 345-369.
25. Hinrichs, W., Kisker, C., Duvel, M., Muller, A., Tovar, K., Hillen, W. & Saenger, W. (1994) Science 264, 418-420.
26. Altschmied, L., Baumeister, R., Pfleiderer, K. & Hillen, W. (1988) EMBO J. 7, 4011-4017.
27. Baron, U. (1998) Ph.D. thesis (Univ. Heidelberg).
28. Kringsten, A. M., Rossi, F. M. V., Hofmann, A. & Blau, H. N. (1998) Proc. Natl. Acad. Sci. USA 95, 13670-13675.
29. Freundlieb, S., Schirra, Ch. & Bujard, H. (1999) J. Gene Medicine, in press.