메뉴 건너뛰기




Volumn 201, Issue 8, 1998, Pages 1153-1162

Oxygen sensing, hypoxia-inducible factor-1 and the regulation of mammalian gene expression

Author keywords

Erythropoietin; Hypoxia inducible factor 1; Oxygen; Redox; Transcription

Indexed keywords

DNA BINDING PROTEIN; HIF1A PROTEIN, HUMAN; HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; NUCLEAR PROTEIN; OXYGEN; TRANSCRIPTION FACTOR;

EID: 0032053169     PISSN: 00220949     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (324)

References (67)
  • 1
    • 0025080230 scopus 로고
    • Growth regulation of the vascular system: Evidence for a metabolic hypothesis
    • ADAIR, T. H., GAY, W. J. AND MONTANI, J.-P. (1990). Growth regulation of the vascular system: evidence for a metabolic hypothesis. Am. J. Physiol. 259, 393-404.
    • (1990) Am. J. Physiol. , vol.259 , pp. 393-404
    • Adair, T.H.1    Gay, W.J.2    Montani, J.-P.3
  • 3
    • 0026049416 scopus 로고
    • Enhancer element at the 3′-flanking region controls transcriptional response to hypoxia in the human erythropoietin gene
    • BECK, I., RAMIREZ, S., WEINMANN, R. AND CARO, J. (1991). Enhancer element at the 3′-flanking region controls transcriptional response to hypoxia in the human erythropoietin gene. J. biol. Chem. 266, 15563-15566.
    • (1991) J. Biol. Chem. , vol.266 , pp. 15563-15566
    • Beck, I.1    Ramirez, S.2    Weinmann, R.3    Caro, J.4
  • 4
    • 0026494916 scopus 로고
    • Hypoxic induction of the human erythropoietin gene: Cooperation between the promoter and enhancer, each of which contains steroid receptor response elements
    • BLANCHARD, K. L., ACQUAVIVA, A. M., GALSON, D. L. AND BUNN, H. F. (1992). Hypoxic induction of the human erythropoietin gene: cooperation between the promoter and enhancer, each of which contains steroid receptor response elements. Molec. cell. Biol. 12, 5373-5385.
    • (1992) Molec. Cell. Biol. , vol.12 , pp. 5373-5385
    • Blanchard, K.L.1    Acquaviva, A.M.2    Galson, D.L.3    Bunn, H.F.4
  • 5
    • 0028972768 scopus 로고
    • Cell-specificity and signaling pathway of endothelin-1 gene regulation by hypoxia
    • BODI, I., BISHOPRIC, N. H., DISCHER, D. J., WU, X. AND WEBSTER, K. A. (1995). Cell-specificity and signaling pathway of endothelin-1 gene regulation by hypoxia. Cardiovasc. Res. 30, 975-984.
    • (1995) Cardiovasc. Res. , vol.30 , pp. 975-984
    • Bodi, I.1    Bishopric, N.H.2    Discher, D.J.3    Wu, X.4    Webster, K.A.5
  • 6
    • 0029842459 scopus 로고    scopus 로고
    • Oxygen sensing and molecular adaptation to hypoxia
    • BUNN, H. F. AND POYTON, R. O. (1996). Oxygen sensing and molecular adaptation to hypoxia. Physiol. Rev. 76, 839-885.
    • (1996) Physiol. Rev. , vol.76 , pp. 839-885
    • Bunn, H.F.1    Poyton, R.O.2
  • 8
    • 0026577610 scopus 로고
    • Regulation of tyrosine hydroxylase gene expression in the rat carotid body by hypoxia
    • CZYZYK-KRZESKA, M. F., BAYLISS, D. A., LAWSON, E. E. AND MILLHORN, D. E. (1992). Regulation of tyrosine hydroxylase gene expression in the rat carotid body by hypoxia. J. Neurochem. 58, 1538-1546.
    • (1992) J. Neurochem. , vol.58 , pp. 1538-1546
    • Czyzyk-Krzeska, M.F.1    Bayliss, D.A.2    Lawson, E.E.3    Millhorn, D.E.4
  • 9
    • 0030045543 scopus 로고
    • Isoenzyme specific regulation of genes involved in energy metabolism by hypoxia, cobalt and desferrioxamine: Similarities with the regulation of erythropoietin
    • EBERT, B. L., GLEADLE, J. M., O'ROURKE, J. F., BARTLETT, S. M., POULTON, J. AND RATCLIFFE, P. J. (1995). Isoenzyme specific regulation of genes involved in energy metabolism by hypoxia, cobalt and desferrioxamine: similarities with the regulation of erythropoietin. Biochem. J. 313, 809-814.
    • (1995) Biochem. J. , vol.313 , pp. 809-814
    • Ebert, B.L.1    Gleadle, J.M.2    O'Rourke, J.F.3    Bartlett, S.M.4    Poulton, J.5    Ratcliffe, P.J.6
  • 10
    • 0027970536 scopus 로고
    • Role of hydrogen peroxide in hypoxia-induced erythropoietin production
    • FANDREY, J., FREDE, S. AND JELKMANN, W. (1994). Role of hydrogen peroxide in hypoxia-induced erythropoietin production. Biochem. J. 303, 507-510.
    • (1994) Biochem. J. , vol.303 , pp. 507-510
    • Fandrey, J.1    Frede, S.2    Jelkmann, W.3
  • 11
    • 0028359320 scopus 로고
    • Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactute dehydrogenase a genes: Similarities with the erythropoeitin 3′ enhancer
    • FIRTH, J. D., EBERT, B. L., PUGH, C. W. AND RATCLIFFE, P. J. (1994). Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactute dehydrogenase A genes: similarities with the erythropoeitin 3′ enhancer. Proc. natn. Acad. Sci. U.S.A. 91, 6496-6500.
    • (1994) Proc. Natn. Acad. Sci. U.S.A. , vol.91 , pp. 6496-6500
    • Firth, J.D.1    Ebert, B.L.2    Pugh, C.W.3    Ratcliffe, P.J.4
  • 12
    • 0029101515 scopus 로고
    • Hypoxic regulation of lactate dehydrogcnase A: Interaction between hypoxia inducible factor 1 and cyclic AMP response elements
    • FIRTH, J. D., EBERT, B. L. AND RATCLIFFE, P. J. (1995). Hypoxic regulation of lactate dehydrogcnase A: interaction between hypoxia inducible factor 1 and cyclic AMP response elements. J. biol. Chem. 270, 21021-21027.
    • (1995) J. Biol. Chem. , vol.270 , pp. 21021-21027
    • Firth, J.D.1    Ebert, B.L.2    Ratcliffe, P.J.3
  • 13
    • 0028967752 scopus 로고
    • The orphan receptor hepatic nuclear factor 4 functions as a transcriptional activator for tissue- Specific and hypoxia-specific erythropoietin gene expression and is antagonized by EAR3/COUP-TFI
    • GALSON, D. L., TSUCHIYA, T., TENDLER, D. S., HUANG, E., REN, Y., OGURA, T. AND BUNN, H. F. (1995). The orphan receptor hepatic nuclear factor 4 functions as a transcriptional activator for tissue-specific and hypoxia-specific erythropoietin gene expression and is antagonized by EAR3/COUP-TFI. Molec. cell. Biol. 15, 2135-2144.
    • (1995) Molec. Cell. Biol. , vol.15 , pp. 2135-2144
    • Galson, D.L.1    Tsuchiya, T.2    Tendler, D.S.3    Huang, E.4    Ren, Y.5    Ogura, T.6    Bunn, H.F.7
  • 14
    • 0028843411 scopus 로고
    • Regulation of angiogenic growth factor expression by hypoxia, transition metals and chelating agents
    • GLEADLE, J. M., EBERT, B. L., FIRTH, J. D. AND RATCLIFFE, P. J. (1995a). Regulation of angiogenic growth factor expression by hypoxia, transition metals and chelating agents. Am. J. Physiol. 268, C1362-C1368.
    • (1995) Am. J. Physiol. , vol.268
    • Gleadle, J.M.1    Ebert, B.L.2    Firth, J.D.3    Ratcliffe, P.J.4
  • 15
    • 0028844810 scopus 로고
    • Diphenylene iodonium inhibits the induction of erythropoietin and other mammalian genes by hypoxia: Implications for the mechanism of oxygen sensing
    • GLEADLE, J. M., EBERT, B. L. AND RATCLIFFE, P. J. (1995b). Diphenylene iodonium inhibits the induction of erythropoietin and other mammalian genes by hypoxia: implications for the mechanism of oxygen sensing. Eur. J. Biochem. 234, 92-99.
    • (1995) Eur. J. Biochem. , vol.234 , pp. 92-99
    • Gleadle, J.M.1    Ebert, B.L.2    Ratcliffe, P.J.3
  • 16
    • 0024273450 scopus 로고
    • Regulation of the erythropoietin gene: Evidence that the oxygen sensor is a heme protein
    • GOLDBERG, M. A., DUNNING, S. P. AND BUNN, H. F. (1988). Regulation of the erythropoietin gene: evidence that the oxygen sensor is a heme protein. Science 242, 1412-1415.
    • (1988) Science , vol.242 , pp. 1412-1415
    • Goldberg, M.A.1    Dunning, S.P.2    Bunn, H.F.3
  • 17
    • 0025972125 scopus 로고
    • Erythropoietin mRNA levels are governed by both the rate of gene transcription and posttranscriptional events
    • GOLDBERG, M. A., GAUT, C. C. AND BUNN, H. F. (1991). Erythropoietin mRNA levels are governed by both the rate of gene transcription and posttranscriptional events. Blood 77, 271-277.
    • (1991) Blood , vol.77 , pp. 271-277
    • Goldberg, M.A.1    Gaut, C.C.2    Bunn, H.F.3
  • 19
    • 0028095127 scopus 로고
    • Similarities between the oxygen-sensing mechanisms regulating the expression of vascular endothelial growth factor and erythropoietin
    • GOLDBERG, M. A. AND SCHNEIDER, T. J. (1994). Similarities between the oxygen-sensing mechanisms regulating the expression of vascular endothelial growth factor and erythropoietin. J. biol. Chem. 269, 4355-4359.
    • (1994) J. Biol. Chem. , vol.269 , pp. 4355-4359
    • Goldberg, M.A.1    Schneider, T.J.2
  • 20
    • 0028053910 scopus 로고
    • Carotid body chemoreceptors: From natural stimuli to sensory discharges
    • GONZALEZ, C., ALMARAZ, L., OBESO, A. AND RIGUAL, R. (1994). Carotid body chemoreceptors: from natural stimuli to sensory discharges. Physiol. Rev. 74, 829-877.
    • (1994) Physiol. Rev. , vol.74 , pp. 829-877
    • Gonzalez, C.1    Almaraz, L.2    Obeso, A.3    Rigual, R.4
  • 21
    • 1842309184 scopus 로고
    • Single-step selection of clones of a mouse hepatoma line deficient in aryl hydrocarbon hydroxylase
    • HANKINSON, O. (1979). Single-step selection of clones of a mouse hepatoma line deficient in aryl hydrocarbon hydroxylase. Proc. natn. Acad. Sci. U.S.A. 76, 373-376.
    • (1979) Proc. Natn. Acad. Sci. U.S.A. , vol.76 , pp. 373-376
    • Hankinson, O.1
  • 22
    • 0025765508 scopus 로고
    • Modulation by oxygen of the glucagon-dependent activation of the phosphoenolpyruvate carboxykinase gene in rat hepatocyte cultures
    • HELLKAMP, J., CHRIST, B., BASTIAN, H. AND JUNGERMANN, K. (1991). Modulation by oxygen of the glucagon-dependent activation of the phosphoenolpyruvate carboxykinase gene in rat hepatocyte cultures. Eur. J. Biochem. 198, 635-639.
    • (1991) Eur. J. Biochem. , vol.198 , pp. 635-639
    • Hellkamp, J.1    Christ, B.2    Bastian, H.3    Jungermann, K.4
  • 24
    • 0030887045 scopus 로고    scopus 로고
    • Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway
    • HOGENESCH, J. B., CHAN, W. K., JACKIW, V. H., BROWN, R. C., GU, Y.-Z., PRAY-GRANT, M., PERDEW, G. H. AND BRADFIELD, C. A. (1997). Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway. J. biol. Chem. 272, 8581-8593.
    • (1997) J. Biol. Chem. , vol.272 , pp. 8581-8593
    • Hogenesch, J.B.1    Chan, W.K.2    Jackiw, V.H.3    Brown, R.C.4    Gu, Y.-Z.5    Pray-Grant, M.6    Perdew, G.H.7    Bradfield, C.A.8
  • 25
    • 0029753008 scopus 로고    scopus 로고
    • Activation of hypoxia-inducible transcription factor depends primarily on redox-sensitive stabilization of its α subunit
    • HUANG, L. E., ARANY, Z., LIVINGSTON, D. M. AND BUNN, H. F. (1996). Activation of hypoxia-inducible transcription factor depends primarily on redox-sensitive stabilization of its α subunit. J. biol. Chem. 271, 32253-32259.
    • (1996) J. Biol. Chem. , vol.271 , pp. 32253-32259
    • Huang, L.E.1    Arany, Z.2    Livingston, D.M.3    Bunn, H.F.4
  • 26
    • 0027184569 scopus 로고
    • PAS is a dimerization domain common to Drosophila period and several transcription factors
    • HUANG, Z. J., EDERY, I. AND ROSBASH, M. (1993). PAS is a dimerization domain common to Drosophila period and several transcription factors. Nature 364, 259-262.
    • (1993) Nature , vol.364 , pp. 259-262
    • Huang, Z.J.1    Edery, I.2    Rosbash, M.3
  • 27
    • 0029944965 scopus 로고    scopus 로고
    • Dimerization, DNA binding and transactivation properties of hypoxia-inducible factor 1
    • JIANG, B.-H., RUE, E., WANG, G. L., ROE, R. AND SEMENZA, G. L. (1996). Dimerization, DNA binding and transactivation properties of hypoxia-inducible factor 1. J. biol. Chem. 271, 17771-17778.
    • (1996) J. Biol. Chem. , vol.271 , pp. 17771-17778
    • Jiang, B.-H.1    Rue, E.2    Wang, G.L.3    Roe, R.4    Semenza, G.L.5
  • 28
    • 0028985793 scopus 로고
    • Zonation of metabolism and gene expression in liver
    • JUNGERMANN, K. (1995). Zonation of metabolism and gene expression in liver. Histochemistry 103, 81-91.
    • (1995) Histochemistry , vol.103 , pp. 81-91
    • Jungermann, K.1
  • 29
    • 0027228302 scopus 로고
    • A ferro-heme protein senses oxygen levels, which modulate the glucagon-dependent activation of the phosphoenolpyruvate carboxykinase gene in rat hepatocyte cultures
    • KIETZMANN, T., SCHMIDT, H., UNTHAN, F. K., PROBST, I. AND JUNGERMANN, K. (1993). A ferro-heme protein senses oxygen levels, which modulate the glucagon-dependent activation of the phosphoenolpyruvate carboxykinase gene in rat hepatocyte cultures. Biochem. biophys. Res. Commun. 195, 792-798.
    • (1993) Biochem. Biophys. Res. Commun. , vol.195 , pp. 792-798
    • Kietzmann, T.1    Schmidt, H.2    Unthan, F.K.3    Probst, I.4    Jungermann, K.5
  • 30
    • 0025050735 scopus 로고
    • Oxygen tension regulates the expression of the platelet-derived growth factor-β chain gene in human endothelial cells
    • KOUREMBANAS, S., HANNAN, R. L. AND FALLER, D. V. (1990). Oxygen tension regulates the expression of the platelet-derived growth factor-β chain gene in human endothelial cells. J. clin. Invest. 86, 670-674.
    • (1990) J. Clin. Invest. , vol.86 , pp. 670-674
    • Kourembanas, S.1    Hannan, R.L.2    Faller, D.V.3
  • 31
    • 0031041377 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia
    • LEE, P. J., JIANG, B.-H., CHIN, B. Y., IYER, N. V., ALAM, J., SEMENZA, G. L. AND CHOI, A. M. K. (1997). Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia. J. biol. Chem. 272, 5375-5381.
    • (1997) J. Biol. Chem. , vol.272 , pp. 5375-5381
    • Lee, P.J.1    Jiang, B.-H.2    Chin, B.Y.3    Iyer, N.V.4    Alam, J.5    Semenza, G.L.6    Choi, A.M.K.7
  • 33
    • 0027959825 scopus 로고
    • Hypoxia and cobalt stimulate lactate dehydrogenase (LDH) activity in vascular smooth muscle cells
    • MARTI, H. H., JUNG, H. H., PFEILSCHIFTER, J. AND BAUER, C. (1994). Hypoxia and cobalt stimulate lactate dehydrogenase (LDH) activity in vascular smooth muscle cells. Pflügers Arch. 429, 216-222.
    • (1994) Pflügers Arch. , vol.429 , pp. 216-222
    • Marti, H.H.1    Jung, H.H.2    Pfeilschifter, J.3    Bauer, C.4
  • 35
    • 0027461553 scopus 로고
    • Inducible operation of the erythropoietin 3′ enhancer in multiple cell lines: Evidence for a widespread oxygen sensing mechanism
    • MAXWELL, P. H., PUGH, C. W. AND RATCLIFFE, P. J. (1993). Inducible operation of the erythropoietin 3′ enhancer in multiple cell lines: evidence for a widespread oxygen sensing mechanism. Proc. natn. Acad. Sci. U.S.A. 90, 2423-2427.
    • (1993) Proc. Natn. Acad. Sci. U.S.A. , vol.90 , pp. 2423-2427
    • Maxwell, P.H.1    Pugh, C.W.2    Ratcliffe, P.J.3
  • 36
    • 0029681850 scopus 로고    scopus 로고
    • Oncogenic transformation and hypoxia synergistically act to modulate vascular endothelial growth factor expression
    • MAZURE, N. M., CHEN, E. Y., YEH, P., LADEROUTE, K. R. AND GIACCIA, A. J. (1996). Oncogenic transformation and hypoxia synergistically act to modulate vascular endothelial growth factor expression. Cancer Res. 56, 3436-3440.
    • (1996) Cancer Res. , vol.56 , pp. 3436-3440
    • Mazure, N.M.1    Chen, E.Y.2    Yeh, P.3    Laderoute, K.R.4    Giaccia, A.J.5
  • 37
    • 0027938194 scopus 로고
    • Hypoxia inhibits expression of eNOS via transcriptional and posttranscriptional mechanisms
    • MCQUILLAN, L. P., LEUNG, G. K., MARSDEN, P. A., KOSTYK, S. K. AND KOUREMBANAS, S. (1994). Hypoxia inhibits expression of eNOS via transcriptional and posttranscriptional mechanisms. Am. J. Physiol. 267, H1921-H1927.
    • (1994) Am. J. Physiol. , vol.267
    • Mcquillan, L.P.1    Leung, G.K.2    Marsden, P.A.3    Kostyk, S.K.4    Kourembanas, S.5
  • 38
    • 0028786601 scopus 로고
    • A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter
    • MELILLO, G., MUSSO, T., SICA, A., TAYLOR, L. S., COX, G. W. AND VARESIO, L. (1995). A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter. J. exp. Med. 182, 1683-1693.
    • (1995) J. Exp. Med. , vol.182 , pp. 1683-1693
    • Melillo, G.1    Musso, T.2    Sica, A.3    Taylor, L.S.4    Cox, G.W.5    Varesio, L.6
  • 39
    • 0029891739 scopus 로고    scopus 로고
    • Drosophila melanogaster SL2 cells contain a hypoxically inducible DNa binding complex which recognises mammalian HIF-1 binding sites
    • NAGAO, M., EBERT, B. L., RATCLIFFE, P. J. AND PUGH, C. W. (1996). Drosophila melanogaster SL2 cells contain a hypoxically inducible DNA binding complex which recognises mammalian HIF-1 binding sites. FEBS Lett. 387, 161-166.
    • (1996) FEBS Lett. , vol.387 , pp. 161-166
    • Nagao, M.1    Ebert, B.L.2    Ratcliffe, P.J.3    Pugh, C.W.4
  • 40
    • 0030012683 scopus 로고    scopus 로고
    • The Drosophila melanogaster similar bHLH-PAS gene encodes a protein related to human hypoxia-inducible factor 1α and Drosophila single-minded
    • in Press
    • NAMBU, J. R., CHEN, W., HU, S. AND CREWS, S. T. (1996). The Drosophila melanogaster similar bHLH-PAS gene encodes a protein related to human hypoxia-inducible factor 1α and Drosophila single-minded. Gene (in press).
    • (1996) Gene
    • Nambu, J.R.1    Chen, W.2    Hu, S.3    Crews, S.T.4
  • 41
    • 0015302188 scopus 로고
    • The effect of inhibitors of energy metabolism on erythropoietin production
    • NECAS, E. AND NEUWIRT, J. (1972). The effect of inhibitors of energy metabolism on erythropoietin production. J. Lab. clin. Med. 79, 388-396.
    • (1972) J. Lab. Clin. Med. , vol.79 , pp. 388-396
    • Necas, E.1    Neuwirt, J.2
  • 42
    • 0027479814 scopus 로고
    • Studies on the inhibitory mechanism of iodonium compounds with special reference to neutrophil NADPH oxidase
    • O'DONNELL, V. B., TEW, D. G., JONES, O. T. G. AND ENGLAND, P. J. (1993). Studies on the inhibitory mechanism of iodonium compounds with special reference to neutrophil NADPH oxidase. Biochem. J. 290, 41-49.
    • (1993) Biochem. J. , vol.290 , pp. 41-49
    • O'Donnell, V.B.1    Tew, D.G.2    Jones, O.T.G.3    England, P.J.4
  • 43
    • 0029858079 scopus 로고    scopus 로고
    • Identification of hypoxically inducible mRNAs in Hela cells using differential display PCR
    • O'ROURKE, J. F., PUGH, C. W., BARTLETT, S. M. AND RATCLIFFE, P. J. (1996). Identification of hypoxically inducible mRNAs in Hela cells using differential display PCR. Eur. J. Biochem. 241, 403-410.
    • (1996) Eur. J. Biochem. , vol.241 , pp. 403-410
    • O'Rourke, J.F.1    Pugh, C.W.2    Bartlett, S.M.3    Ratcliffe, P.J.4
  • 44
    • 0026446102 scopus 로고
    • Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo
    • PLATE, K. H., BREIER, G., WEICH, H. A. AND RISAU, W. (1992). Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo. Nature 359, 845-848.
    • (1992) Nature , vol.359 , pp. 845-848
    • Plate, K.H.1    Breier, G.2    Weich, H.A.3    Risau, W.4
  • 45
    • 0028279870 scopus 로고
    • Characterisation of functional domains within the mouse erythropoietin 3′ enhancer conveying oxygen-regulated responses in different cell lines
    • PUGH, C. W., EBERT, B. L., EBRAHIM, O. AND RATCLIFFE, P. J. (1994). Characterisation of functional domains within the mouse erythropoietin 3′ enhancer conveying oxygen-regulated responses in different cell lines. Biochim. biophys. Acta 1217, 297-306.
    • (1994) Biochim. Biophys. Acta , vol.1217 , pp. 297-306
    • Pugh, C.W.1    Ebert, B.L.2    Ebrahim, O.3    Ratcliffe, P.J.4
  • 46
    • 0030937718 scopus 로고    scopus 로고
    • Activation of hypoxia inducible factor-1; Definition of regulatory domains within the α subunit
    • PUGH, C. W., O'ROURKE, J. F., NAGAO, M., GLEADLE, J. M. AND RATCLIFFE, P. J. (1997). Activation of hypoxia inducible factor-1; Definition of regulatory domains within the α subunit. J. biol. Chem. 272, 11205-11214.
    • (1997) J. Biol. Chem. , vol.272 , pp. 11205-11214
    • Pugh, C.W.1    O'Rourke, J.F.2    Nagao, M.3    Gleadle, J.M.4    Ratcliffe, P.J.5
  • 47
    • 0025885693 scopus 로고
    • Functional analysis of an oxygen-related transcriptional enhancer lying 3′ to the mouse erythropoietin gene
    • PUGH, C. W., TAN, C. C., JONES, R. W. AND RATCLIFFE, P. J. (1991). Functional analysis of an oxygen-related transcriptional enhancer lying 3′ to the mouse erythropoietin gene. Proc. natn. Acad. Sci. U.S.A. 88, 10553-10557.
    • (1991) Proc. Natn. Acad. Sci. U.S.A. , vol.88 , pp. 10553-10557
    • Pugh, C.W.1    Tan, C.C.2    Jones, R.W.3    Ratcliffe, P.J.4
  • 48
    • 0027377576 scopus 로고
    • Molecular biology of erythropoietin
    • RATCLIFFE, P. J. (1993). Molecular biology of erythropoietin. Kidney Int. 44, 887-904.
    • (1993) Kidney Int. , vol.44 , pp. 887-904
    • Ratcliffe, P.J.1
  • 49
    • 0026625037 scopus 로고
    • Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNa binding form of the Ah receptor
    • REYES, H., REISZ-PORSZASZ, S. AND HANKINSON, O. (1992). Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor. Science 256, 1193-1195.
    • (1992) Science , vol.256 , pp. 1193-1195
    • Reyes, H.1    Reisz-Porszasz, S.2    Hankinson, O.3
  • 50
    • 0030792094 scopus 로고    scopus 로고
    • Oxygen-regulated transferrin expression is mediated by hypoxia-inducible factor-1
    • in press
    • ROLFS, A., KVIETIKOVA, I., GASSMANN, M. AND WENGER, R. H. (1997). Oxygen-regulated transferrin expression is mediated by hypoxia-inducible factor-1. J. biol. Chem. (in press).
    • (1997) J. Biol. Chem.
    • Rolfs, A.1    Kvietikova, I.2    Gassmann, M.3    Wenger, R.H.4
  • 51
    • 0029864024 scopus 로고    scopus 로고
    • Divergent regulation of vascular endothelial growth factor and of erythropoietin gene expression in vivo
    • SANDNER, P., GESS, B., WOLF, K. AND KURTZ, A. (1996). Divergent regulation of vascular endothelial growth factor and of erythropoietin gene expression in vivo. Pflügers Arch. 431, 905-912.
    • (1996) Pflügers Arch. , vol.431 , pp. 905-912
    • Sandner, P.1    Gess, B.2    Wolf, K.3    Kurtz, A.4
  • 52
    • 0030460724 scopus 로고    scopus 로고
    • Hypoxia response elements in the aldolase A, enolase 1 and lactate dehydrogenase a gene promoters contain essential binding sites for hypoxia-inducible factor 1
    • SEMENZA, G. L., JIAN, B.-H., LEUNG, S. W., PASSANTINO, R., CONCORDET, J.-P., MAIRE, P. AND GIALLONGO, A. (1996). Hypoxia response elements in the aldolase A, enolase 1 and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1. J. biol. Chem. 271, 32529-32537.
    • (1996) J. Biol. Chem. , vol.271 , pp. 32529-32537
    • Semenza, G.L.1    Jian, B.-H.2    Leung, S.W.3    Passantino, R.4    Concordet, J.-P.5    Maire, P.6    Giallongo, A.7
  • 53
    • 0026075610 scopus 로고
    • Hypoxia-inducible nuclear factors bind to an enhancer element located 3′ to the human erythropoietin gene
    • SEMENZA, G. L., NEJFELT, M. K., CHI, S. M. AND ANTONARAKIS, S. E. (1991). Hypoxia-inducible nuclear factors bind to an enhancer element located 3′ to the human erythropoietin gene. Proc. natn. Acad. Sci. U.S.A. 88, 5680-5684.
    • (1991) Proc. Natn. Acad. Sci. U.S.A. , vol.88 , pp. 5680-5684
    • Semenza, G.L.1    Nejfelt, M.K.2    Chi, S.M.3    Antonarakis, S.E.4
  • 54
    • 0028068606 scopus 로고
    • Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1
    • SEMENZA, G. L., ROTH, P. H., FANG, H.-M. AND WANG, G. L. (1994). Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1. J. biol. Chem. 269, 23757-23763.
    • (1994) J. Biol. Chem. , vol.269 , pp. 23757-23763
    • Semenza, G.L.1    Roth, P.H.2    Fang, H.-M.3    Wang, G.L.4
  • 55
    • 0026468180 scopus 로고
    • A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
    • SEMENZA, G. L. AND WANG, G. L. (1992). A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Molec. cell. Biol. 12, 5447-5454.
    • (1992) Molec. Cell. Biol. , vol.12 , pp. 5447-5454
    • Semenza, G.L.1    Wang, G.L.2
  • 56
    • 0026485002 scopus 로고
    • Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
    • SHWEIKI, D., ITIN, A., SOFFER, D. AND KESHET, E. (1992). Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 359, 843-845.
    • (1992) Nature , vol.359 , pp. 843-845
    • Shweiki, D.1    Itin, A.2    Soffer, D.3    Keshet, E.4
  • 57
    • 0031020884 scopus 로고    scopus 로고
    • Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells
    • TIAN, H., MCKNIGHT, S. L. AND RUSSELL, D. W. (1997). Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. Genes Dev. 11, 72-82.
    • (1997) Genes Dev. , vol.11 , pp. 72-82
    • Tian, H.1    Mcknight, S.L.2    Russell, D.W.3
  • 59
    • 0027136260 scopus 로고
    • Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNA-binding activity: Implications for models of hypoxia signal transduction
    • WANG, G. L. AND SEMENZA, G. L. (1993a). Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction. Blood 82, 3610-3615.
    • (1993) Blood , vol.82 , pp. 3610-3615
    • Wang, G.L.1    Semenza, G.L.2
  • 60
    • 0027210562 scopus 로고
    • General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia
    • WANG, G. L. AND SEMENZA, G. L. (1993b). General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia. Proc. natn. Acad. Sci. U.S.A. 90, 4304-4308.
    • (1993) Proc. Natn. Acad. Sci. U.S.A. , vol.90 , pp. 4304-4308
    • Wang, G.L.1    Semenza, G.L.2
  • 61
    • 0026566197 scopus 로고
    • Variations in function and design: Testing symmorphosis in the respiratory system
    • WEIBEL, E. R., TAYLOR, C. R. AND HOPPELER, H. (1992). Variations in function and design: Testing symmorphosis in the respiratory system. Respir. Physiol. 87, 325-348.
    • (1992) Respir. Physiol. , vol.87 , pp. 325-348
    • Weibel, E.R.1    Taylor, C.R.2    Hoppeler, H.3
  • 62
    • 0028916976 scopus 로고
    • The mechanisms of acute hypoxic pulmonary vasoconstriction: The tale of two channels
    • WEIR, E. K. AND ARCHER, S. L. (1995). The mechanisms of acute hypoxic pulmonary vasoconstriction: the tale of two channels. FASEB J. 9, 183-189.
    • (1995) FASEB J. , vol.9 , pp. 183-189
    • Weir, E.K.1    Archer, S.L.2
  • 63
    • 0029982422 scopus 로고    scopus 로고
    • Nucleotide sequence, chromosomal assignment and mRNA expression of mouse hypoxia-inducible factor-1α
    • WENGER, R. H., ROLFS, A., MARTI, H. H., GUÉNET, J.-L. AND GASSMANN, M. (1996). Nucleotide sequence, chromosomal assignment and mRNA expression of mouse hypoxia-inducible factor-1α. Biochem. biophys. Res. Commun. 223, 54-59.
    • (1996) Biochem. Biophys. Res. Commun. , vol.223 , pp. 54-59
    • Wenger, R.H.1    Rolfs, A.2    Marti, H.H.3    Guénet, J.-L.4    Gassmann, M.5
  • 64
    • 0030583293 scopus 로고    scopus 로고
    • In vivo expression of mRNAs encoding hypoxia-inducible factor 1
    • WIENER, C. M., BOOTH, G. AND SEMENZA, G. L. (1996). In vivo expression of mRNAs encoding hypoxia-inducible factor 1. Biochem. biophys. Res. Commun. 225, 485-188.
    • (1996) Biochem. Biophys. Res. Commun. , vol.225 , pp. 485-1188
    • Wiener, C.M.1    Booth, G.2    Semenza, G.L.3
  • 65
    • 0030025172 scopus 로고    scopus 로고
    • Trachealess encodes a bHLH-PAS protein that is an inducer of tracheal cell fates in Drosophila
    • WILK, R., WEIZMAN, I. AND SHILO, B.-Z. (1996). trachealess encodes a bHLH-PAS protein that is an inducer of tracheal cell fates in Drosophila. Genes Dev. 10, 93-102.
    • (1996) Genes Dev. , vol.10 , pp. 93-102
    • Wilk, R.1    Weizman, I.2    Shilo, B.-Z.3
  • 66
    • 0029888061 scopus 로고    scopus 로고
    • The role of aryl hydrocarbon receptor nuclear translocator (ARNT) in hypoxic induction of gene expression: Studies in ARNT deficient cells
    • WOOD, S. M., GLEADLE, J. M., PUGH, C. W., HANKINSON, O. AND RATCLIFFE, P. J. (1996). The role of aryl hydrocarbon receptor nuclear translocator (ARNT) in hypoxic induction of gene expression: studies in ARNT deficient cells. J. biol. Chem. 271, 15117-15123.
    • (1996) J. Biol. Chem. , vol.271 , pp. 15117-15123
    • Wood, S.M.1    Gleadle, J.M.2    Pugh, C.W.3    Hankinson, O.4    Ratcliffe, P.J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.