A regulatory network for the efficient control of transgene expression

Journal of Gene Medicine

Volumn 2, Issue 2, 2000, Pages 107-116

  Imhof, Markus O ^a   Chatellard, Philippe ^a   Mermod, Nicolas ^a,b  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

^b EPFL   (Switzerland)

Author keywords

Diphtheria toxin A; Erythropoietin; Tetracycline repressor; Transgene regulation

Indexed keywords

EUKARYOTA; MAMMALIA;

DIPHTHERIA TOXIN; DOXYCYCLINE; ERYTHROPOIETIN; GAL VP16; GAL-VP16; HYBRID PROTEIN; REPRESSOR PROTEIN; TRANSACTIVATOR PROTEIN;

ANIMAL; ARTICLE; CELL LINE; GENE EXPRESSION REGULATION; GENE TRANSFER; GENETIC TRANSFECTION; GENETICS; METABOLISM; MOUSE; PROMOTER REGION;

ANIMALS; CELL LINE; DIPHTHERIA TOXIN; DOXYCYCLINE; ERYTHROPOIETIN; GENE EXPRESSION REGULATION; GENE TRANSFER TECHNIQUES; MICE; PROMOTER REGIONS (GENETICS); RECOMBINANT FUSION PROTEINS; REPRESSOR PROTEINS; TRANS-ACTIVATORS; TRANSFECTION;

EID: 0034151831     PISSN: 1099498X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1521-2254(200003/04)2:2<107::aid-jgm91>3.0.co;2-e     Document Type: Article

References (32)

1. Allgood VE, Eastman EM. Chimeric receptors as gene switches. Curr Opin Biotechnol 1997; 8: 474-479.
2. Saez E, No D, West A, Evans RM. Inducible gene expression in mammalian cells and transgenic mice. Curr Opin Biotechnol 1997; 8: 608-616.
3. Russel M. Inducible mammalian expression systems. In Gene Expression Systems, Fernandez JM, Hoeffler JP (eds). San Diego: Academic Press, 1999; 235-257.
4. Joshi N, Miller DQ. Doxycycline revisited. Arch Intern Med 1997; 157: 1421-1428.
5. Gossen M, Freundlieb S, Bender G, Müller G, Hillen W, Bujard H. Transcriptional activation by tetracyclines in mammalian cells. Science 1995; 268: 1766-1769.
6. Ackland-Berglund CE, Leib DA. Efficacity of tetracycline-controlled gene expression is influenced by the cell type. Biotechniques 1995; 18: 196-200.
7. Rossi FMV, Guicherit OM, Spicher A, Kringstein AM, Fatyol K, Blakely BT, Blau HM. Tetracycline-regulatable factors with distinct dimerization domains allow reversible growth inhibition by p16. Wat Genet 1998; 20: 389-393.
8. Baron U, Schnappinger D, Helbl V, Gossen M, Hillen W, Bujard H. Generation of conditional mutants in higher eukaryotes by switching between the expression of two genes. Proc Natl Acad Sci USA 1999; 96: 1013-1018.
9. Forster K, Helbl V, Lederer T, Urlinger S, Wittenburg N, Hillen W. Tetracycline-inducible expression systems with reduced basal activity in mammalian cells. Nucleic Acids Res 1999; 27: 708-710.
10. Freundlieb S, Schirra-Müller C, Bujard H. A tetracycline controlled activation/repression system with increased potential for gene transfer into mammalian cells. J Gene Med 1999; 1: 4-12.
11. Blau HM, Rossi FMV. Tet B or not tet B: advances in tetracycline-inducible gene expression. Proc Natl Acad Sci USA 1999; 96: 797-799.
12. Sadowski I, Ptashne M. A vector for expressing GAL4 (1-147) fusions in mammalian cells. Nucleic Acids Res 1989; 17: 7539.
13. Klucher KM, Gerlach MJ, Daley GQ. A novel method to isolate cells with conditional gene expression using fluorescence activated cell sorting (FACS). Nucleic Acids Res 1997; 25: 4858-4860.
14. MacGregor GR, Caskey CT. Construction of plasmids that express E. coli=DF-galactosidase in mammalian cells. Nucleic Acids Res 1989; 17: 2365.
15. Fiering SN, Roederer M, Nolan GP, Micklem DR, Parks DR, Herzenberg LA. Improved FACS-Gal: flow cytometric analysis and sorting of viable eukaryotic cells expressing reporter gene constructs. Cytometry 1991; 12: 291-301.
16. Margolin JF, Friedman JR, Meyer WK-H, Vissing H, Thiesen H-J, Rauscher III FJ. Kr=FCppel-associated boxes are potent transcriptional repression domains. Proc Natl Acad Sci USA 1994; 91: 4509-4513.
17. Deuschle U, Meyer WK-H, Thiesen H-J. Tetracycline-reversible silencing of eukaryotic promoters. Mol Cell Biol 1995; 15: 1907-1914.
18. Baniahmad A, Leng X, Burris TP, Tsai SY, Tsai M-J, O'Malley BW. The t4 activation domain of the thyroid hormone receptor is required for release of a putative corepressor(s) necessary for transcriptional silencing. Mol Cell Biol 1995; 15: 76-86.
19. Fisher AL, Ohsako S, Caudy M. The WRPW motif on the hairy-related basic helix-loop-helix repressor proteins acts as a 4-amino-acid transcription repression and protein-protein interaction domain. Mol Cell Biol 1996; 16: 2670-2677.
20. Kaufmann J, Smale ST. Direct recognition of initiator elements by a component of the transcription factor IID complex. Genes Dev 1994; 8: 821-829.
21. Sadowski I, Ma J, Triezenberg S, Ptashne M. GAL4-VP16 is an unusually potent transcriptional activator. Nature 1988; 335: 563-564.
22. Evans GA. Dissecting mouse development with toxigenics. Genes Dev 1989; 3: 259-263.
23. Yamaizumi M, Mekada E, Uchida T, Okada Y. One molecule of Diphtheria toxin fragment A introduced into a cell can kill the cell. Cell 1978; 15: 245-250.
24. Gossen M, Bujard H. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc Natl Acad Sci USA 1992; 89: 5547-5551.
25. Friedrich G, Soriano P. Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice. Genes Dev 1991; 5: 1513-1523.
26. Roelant CH, Burns DA, Scheirer W. Accelerating the pace of Iuciferase reporter gene assays. Biotechniques 1996; 20: 914-917.
27. Lee P, Morley G, Huang Q, Fischer A, Seiler S, Homer JW, Factor S, Vaidya D, Jalife J, Fishman GI. Conditional lineage ablation to model human disease. Proc Natl Acad Sci USA 1998; 95: 11371-11376.
28. Yuh C-H, Bolouri H, Davidson EH. Genomic cis-regulatory logic: experimental and computational analysis of a sea urchin gene. Science 1998; 279: 1896-1902.
29. Gray S, Levine M. Transcriptional repression in development. Curr Opin Cell Biol 1996; 8: 358-364.
30. Bohl D, Naffakh N, Heard JM. Long-term control of erythropoietin secretion by doxycycline in mice transplanted with engineered primary myoblasts. Nat Med 1997; 3: 299-305.
31. Régulier E, Schneider BL, Déglon N, Beuzard Y, Aebischer P. Continuous delivery of human and mouse erythropoietin in mice by genetically engineered polymer encapsulated myoblasts. Gene Ther 1998; 5: 1014-1022.
32. Baron U, Gossen M, Bujard H. Tetracycline-controlled transcription in eukaryotes: novel transactivators with graded transactivation potential. Nucleic Acids Res 1997; 25: 2723-2729.