Retroviral delivery and tetracycline-dependent expression of IL-1β-converting enzyme (ICE) in a rat glioma model provides controlled induction of apoptotic death in tumor cells

Cancer Research

Volumn 56, Issue 23, 1996, Pages 5423-5427

  Yu, John S ^a   Sena Esteves, Miguel ^a   Paulus, Werner ^a   Breakefield, Xandra O ^a   Reeves, Steven A ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE PROTEINASE; GALACTOSIDASE; INTERLEUKIN 1BETA CONVERTING ENZYME; VIRUS VECTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GLIOMA; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; RAT;

ANIMALS; APOPTOSIS; BRAIN NEOPLASMS; CASPASE 1; CORPUS STRIATUM; CYSTEINE ENDOPEPTIDASES; ENZYME INDUCTION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE THERAPY; GENES, REPORTER; GENETIC VECTORS; GLIOSARCOMA; MALE; MOLONEY MURINE LEUKEMIA VIRUS; NEOPLASM TRANSPLANTATION; PROMOTER REGIONS (GENETICS); RATS; TETRACYCLINE; TRANSFECTION;

EID: 0030467622     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Thornberry, N. A., Bull, H G., Calaycay, J R., Chapman, K. T., Howard, A. D., Kostura, M. J., Miller, D. K., Molineaux, S. M., Weidner, J. R., Aunins, J., Elliston, K. O , Ayala, J M., Casano, F J , Chin, J , Ding, G J-F., Egger, L. A., Gaffney, E P., Limjuco, G., Palyha, O. C., Raju, S. M., Rolando, A. M., Salley, J. P., Yamin, T-T., Lee, T D., Shively, J E., MacCross, M., Mumford, R A , Schmidt, J. A , and Tocci, M. J. A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes. Nature (Lond), 356: 768-774, 1992.
2. Cerretti, D P, Kozlosky, C. J., Mosley, B., Nelson, N , Van Ness, K., Greenstreet, T. A., March, C. J., Kronheim, S R , Druck, T , Cannizzaro, L. A , Huebner, K., and Black, R. A. Molecular cloning of the interleukin-1 beta converting enzyme. Science (Washington DC), 256: 97-100, 1992
3. Yuan, J., Shaham, S , Ledoux, S., Ellis, H M , and Horvitz, H. R The C. elegans cell death gene ced-3 encodes a protein similar to mammalian inlerleukin-1 beta-converting enzyme. Cell, 75. 641-652, 1993.
4. Miura, M , Zhu, H., Rotello, R , Hartwieg, E. A., and Yuan, J. Induction of apoptosis in fibroblasts by IL-1 beta-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3. Cell, 75: 653-660, 1993.
5. Thompson, C B. Apoptosis in the pathogenesis and treatment of disease. Science (Washington DC), 267: 1456-1462, 1995
6. Loeffler, J. S Radiotherapy in managing malignant gliomas current role and future directions Adv. Oncol., 8: 14-20, 1992
7. Kyritsis, A. P , and Levin, V. A. Chemotherapeutic approaches to the treatment of malignant gliomas. Adv Oncol , 8: 9-13, 1992.
8. Paulus, W , Baur, I , Boyce, F. M., Breakefield, X. O., and Reeves, S. A. Self-contained, tetracycline-regulated retroviral vector system for gene delivery to mammalian cells J Virol., 70. 62-67, 1996
9. Gossen, M., and Bujard, H. Tight control of gene expression in mammalian cells by tetracycline- responsive promoters Proc. Natl. Acad. Sci. USA, 89: 5547-5551, 1992
10. Morgenstern, J. P., and Land, H. Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line. Nucleic Acids Res , 18: 3587-3596, 1990.
11. Pear, W. S., Nolan, G P., Scott, M. L., and Baltimore, D. Production of high-titer helper-free retroviruses by transient transfection. Proc. Natl. Acad. Sci. USA, 90: 8392-8396, 1993.
12. Rosenthal, N. Identification of regulatory elements of cloned genes with functional assays. Methods Enzymol , 152: 704-720, 1987
13. Price, J., Turner, D , and Cepko, C. Lineage analysis in the vertebrate nervous system by retrovirus-mediated gene transfer. Proc. Natl Acad. Sci USA, 84: 156-160, 1987
14. Fishman, G. I., Kaplan, M. L , and Buttrick, P. M. Tetracycline-regulated cardiac gene expression in vivo. J. Clin Invest , 93: 1864-1868, 1994.
15. Kobayashi, N., Allen, N , Clendenon, N. R., and Ko, L. W An improved rat brain-tumor model J. Neurosurg., 53: 808-815, 1980.
16. Hoffman, B , and Liebermann, D. A. Molecular controls of apoptosis: differentiation/ growth arrest primary response genes, proto-oncogenes, and rumor suppressor genes as positive & negative modulators. Oncogene, 9: 1807-1812, 1994.
17. Short, M. P., Choi, B C , Lee, J K., Malick, A., Breakefield, X O., and Martuza, R. L Gene delivery to glioma cells in rat brain by grafting of a retrovirus packaging cell line. J. Neurosci Res., 27: 427-439, 1990
18. Lowe, S. W., Schmitt, E. M., Smith, S. W., Osborne, B. A., and Jacks, T. p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature (Lond.), 362: 847-849, 1993.
19. Lowe, S W., Ruley, H. E , Jacks, T., and Housman, D. E. p53-dependent apoptosis modulates the cytotoxicity of anticancer agents Cell, 74: 957-967, 1993.
20. Freeman, S. M., Abboud, C. N., Whartenby, K. A., Packman, C H , Koeplin, D S , Moolten, F. L , and Abraham, G. N. The "bystander effect" tumor regression when a fraction of the tumor mass is genetically modified. Cancer Res., 53: 5274-5283, 1993.
21. Louis, D N. The p53 gene and protein in human brain tumors. J. Neuropathol. & Exp. Neurol., 53: 11-21, 1994.
22. Asai, A , Miyagi, Y., Sugiyama, A., Gamanuma, M., Hong, S H., Takamoto, S., Nomura, K., Matsutani, M., Takakura, K., and Kuchino, Y. Negative effects of wild-type p53 and s-Myc on cellular growth and tumorigenicity of glioma cells. Implication of the tumor suppressor genes for gene therapy J. Neuro-Oncol , 19: 259-268, 1994.
23. Kondo, S , Barna, B P, Morimura, T., Takeuchi, J., and Barnett, G H Cisplatin induces expression of interleukin 1β converting enzyme in murine and human glioma cells during apoptosis regardless of their p53 status Annual Congress of Neurological Surgeons, San Francisco, CA, 1995.