Redesigning an FKBP-ligand interface to generate chemical dimerizers with novel specificity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 95, Issue 18, 1998, Pages 10437-10442

  Clackson, Tim ^a   Yang, Wu ^a   Rozamus, Leonard W ^a   Hatada, Marcos ^a   Amara, Jane F ^a   Rollins, Carl T ^a   Stevenson, Lauren F ^a,b   Magari, Shannon R ^a,c   Wood, Susan A ^a   Courage, Nancy L ^a   Lu, Xiaode ^a   Cerasoli Jr , Franklin ^a   Gilman, Michael ^a   Holt, Dennis A ^a  

^a ARIAD PHARMACEUTICALS INC   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL CANCER CENTER   (United States)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AP 1903; HYBRID PROTEIN; LIGAND; MUTANT PROTEIN; PHENYLALANINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; DIMERIZATION; INTRAVENOUS DRUG ADMINISTRATION; LIGAND BINDING; MALE; MOUSE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DETERMINATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FOLDING; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; ANIMALS; CARRIER PROTEINS; CELL LINE; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; DNA-BINDING PROTEINS; FAS LIGAND PROTEIN; HEAT-SHOCK PROTEINS; LIGANDS; MALE; MEMBRANE GLYCOPROTEINS; MICE; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; SIGNAL TRANSDUCTION; TACROLIMUS BINDING PROTEINS;

ANIMALIA;

EID: 13144276290     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.95.18.10437     Document Type: Article

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