Induction of apoptosis in neoplastic cells by depletion of vitamin B12

Cell Death and Differentiation

Volumn 4, Issue 3, 1997, Pages 233-241

  Walker, P Roy ^a   Smith, Brandon ^a   Carson, Christine ^a   LeBlanc, Julie ^a   Sikorska, Marianna ^a   Woodhouse, Clive S ^b   Morgan, A Charles ^b,c  

^a NATIONAL RESEARCH COUNCIL CANADA   (Canada)

^b Receptagen Corporation   (United States)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Growth blocker; K562; Methionine synthase; Transcobalamin

Indexed keywords

ANTIMITOTIC AGENT; CYANOCOBALAMIN; DEOXYRIBONUCLEOTIDE; METHIONINE SYNTHASE; NITROUS OXIDE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL KINETICS; CELL PROLIFERATION; CONTROLLED STUDY; CYANOCOBALAMIN DEFICIENCY; DNA REPLICATION; DNA SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; METABOLITE; MITOSIS INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR CELL;

ANIMALIA;

EID: 0030994543     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4400225     Document Type: Article

References (31)

1. Abels J, Kroes ACM, Ermens AAM, van Kapel J, Schoester M, Spijkes LJM and Lindemans J (1990) Anti-leukemic Potential of Methyl-Cobalamin Inactivation by Nitrous Oxide. American Journal of Hematology 34. 128 - 131
2. Amagasaki T, Green R and Jacobsen DW (1990) Expression of Transcobalamin II receptors by Human Leukemia K-562 and HL-60 cells Blood 78: 1380 - 1386
3. Banks RGS. Henderson RJ and Pratt JM (1968) Reactions of Gases in Solution. Part III. Some Reactions ot Nitrous Oxide with Transition-metal Complexes Journal Chemical Society (A) 2886 - 2889
4. Chanarin I (1982) The Effects of Nitrous Oxide on Cobalamins, Folates and on Related Events CRC Critical Reviews in Toxicology 10: 179 - 213
5. Chanarin I. Deacon R, Lumb M, Muir M and Perry J (1985) Coabalamin-Folate Interrelations: A Critical Review. Blood 66: 479 - 489
6. Christensen B, Refsum H, Garras A and Ueland PM (1992) Homocysteine Remethylation during Nitrous Oxide Exposure of Cells Cultured in Media Containing Various Concentrations of Folates Journal of Pharmacology and Experimental Therapeutics 261: 1096 - 1105
7. Christensen B and Ueland PM (1993) Methionine Synthase Inactivation by Nitrous Oxide during Methionine Loading of Normal Human Fibroblasts Homocysteine Remethylation as Determinant of Enzyme Inactivation and Homocysteine Export Journal of Pharmacology and Experimental Therapeutics 267: 1298 - 1303
8. Deacon R, Lumb M, Perry J, Chanarin I, Minty B, Halsey M and Nunn J (1980) Inactivation of Methionine Synthase by Nitrous Oxide. European Journal of Biochemistry 104: 419 - 422
9. Eastwood DW, Green CD, Lambdin MA and Gardner R (1963) Effects of Nitrous Oxide on the White Cell Count in Leukemia. New England Journal of Medicine 268 297 - 299
10. Ermens AAM, Vink N, Schoester M, van Lom K1 Lindemans J and Abels J (1989) Nitrous Oxide Selectively Reduces the Proliferation of the Malignant Cells in Experimental Rat Leukemia Cancer Letters 45: 123 - 128
11. Fisher DE (1994) Apoptosis in cancer therapy: Crossing the threshold. Cell 78: 539 - 542
12. 12 by Human Lymphocytes and the Relationships to the Cell Cycle Journal of Laboratory and Clinical Medicine 103: 70 - 81
13. Hickman JA. Potten CS, Merritt AJ and Fisher TC (1994) Apoptosis and cancer chemotherapy Philos Trans. R. Soc. Lond [Biol] 345: 319 - 325
14. Ikeda K, Aosaki T, Furukawa Y, Ohta M, Kano Y, Tsuboyama A, Sakamoto S, Muira Y, Sakuraya K, Fuke N and Kubota T (1989) Antileukmic effect of Nitrous Oxide in a Patient with Chronic Myelogenous Leukemia American Journal of Hematology 30 114
15. James SJ, Basnakian AG and Miller BJ (1994) in vitro folate deficiency induces deoxynucleotide pool imbalance. apoptosis and mutagenesis in chinese hamster ovary cells. Cancer Research 54: 5075 - 5080
16. Kerr JFR, Winterford CM and Harmon BV (1994) Apoptosis - Its Significance in Cancer and Cancer Therapy Cancer 73: 2013 - 2026
17. Kondo H, Osborne ML, Kolhouse JF, Binder MJ, Podell ER, Utley CS, Abrams RS and Allen RH (1981) Nitrous Oxide has Multiple Deleterious Effects on Cobalamin Metabolism and Causes Decreases in Activities of Both Mammalian Cobalamin-dependent Enzymes in Rats. Journal of Clinical Investigation 67 1270 - 1283
18. Kondo H, Iseka T, Iwasa S, Okuda K, Kanazawa S and Ohto M (1989) Cobalamin-dependent Replication of L1210 Leukemia Cells and Effects of Cobalamin Analogues. Acta Haematologia 81: 61 - 69
19. Koury MJ and Home DW (1994) Apoptosis mediates and thymidine prevents erythroblast destruction in folate deficiency anemia. Proceedings of the National Academy of Sciences of the United 91: 4067 - 4071
20. Lassen HCA and Knstensen HS (1959) Remission in Chronic Myeloid Leukemia Following Prolonged Nitrous Oxide Inhalation. Danish Medical Bulletin 6: 252 - 254
21. Lindemaris J, Kroes AC, van Geel J, van Kapel J, Schoester M and Abels J (1989) Uptake of Transcobalamin II-bound Cobalamin by HL-60 cells: Effects of Differentiation Induction. Experimental Cell Research 184: 449 - 460
22. McLean GR, Quadros EV, Rothenberg SP, Morgan AC, Schrader JW and Ziltener HJ (1996) Antibodies to transcobalamin II block in vitro proliferation of leukemic cells. Blood in Press
23. Parbrook GD (1967) Experimental Studies into the Effects of Nitrous Oxide on Tumour Cell Growth. British Journal of Anaesthesiology 39: 549 - 553
24. Pathare PM, Wilbur DS, Heusser S, Quadras EV, McLoughlin P and Morgan AC (1996) Synthesis of cobalamin-biotin conjugates that vary in the position of cobalamin coupling. Evaluation of cobalamin denvative binding to transcobalamin II. Bioconjugate Chem 7: 217 - 232
25. Quadros EV, Rotheriberg SP and McLoughlin PM (1996) Characterisation of monoclonal antibodies to epitopes of Transcobalamin II. Biochem. Biophys. Res. Commun 222: 149 - 154
26. Walker PR, Kokileva L, Leblanc J and SikorskaM (1993) Detection of the initial stages of DNA fragmentation in apoptosis. Biotechniques 15: 1032 - 1041
27. Walker PR, Pandey S and Sikorska M (1995) Degradation of Chromatin in Apoptosis. Cell Death Differ. 2: 97 - 104
28. Walker PR, Smith C, Youdale T, Leblanc J, Whitfield JF and Sikorska M (1991) Topoisomerase II-reactive chemotherapeutic drugs induce apoptosis in thymocytes. Cancer Res. 51: 1078 - 1085
29. Weaver VM, Carson CE, Walker PR, Chaly N, Lach B, Raymond Y, Brown DL and Sikorska M (1996) Degradation of Nuclear Matrix and DNA Cleavage in Apoptotic Thymocytes J Cell Sci. 109: 45 - 56
30. 12-deficient HL60 cells. Eur. J. Hematol. 50: 127 - 132
31. Yoshioka A. Tanaka S, Hiraoka O, Koyama Y, Hirota Y and Wataya Y (1987) Deoxyribonucleosie-triphosphate inbalance death: deoxyadenosine-induced dNTp imbalance and DNA double strand breaks in mouse FM3A cells and the mechanism of cell death. Biochem. Biophys. Res Commun 146 258 - 264