-
1
-
-
0027501690
-
Control of gene activity in higher eukaryotic cells by prokaryotic regulatory elements
-
Gossen, M., Bonin, A. & Bujard, H Control of gene activity in higher eukaryotic cells by prokaryotic regulatory elements. Trends Biol. Sci. 18, 471-475 (1993).
-
(1993)
Trends Biol. Sci.
, vol.18
, pp. 471-475
-
-
Gossen, M.1
Bonin, A.2
Bujard, H.3
-
2
-
-
0029883166
-
Creating conditional mutants in mammals
-
Spencer, D.M Creating conditional mutants in mammals Trends Genet. 12, 181-187 (1996).
-
(1996)
Trends Genet.
, vol.12
, pp. 181-187
-
-
Spencer, D.M.1
-
3
-
-
0023683667
-
How eukaryotic transcriptional activators work
-
Ptashne, M. How eukaryotic transcriptional activators work. Nature 335, 683-689 (1988)
-
(1988)
Nature
, vol.335
, pp. 683-689
-
-
Ptashne, M.1
-
4
-
-
0022328481
-
A eukaryotic transcriptional activator bearing the DNA specificity of a prokaryotic repressor
-
Brent, R. & Ptashne, M. A eukaryotic transcriptional activator bearing the DNA specificity of a prokaryotic repressor. Cell 43, 729-736 (1985).
-
(1985)
Cell
, vol.43
, pp. 729-736
-
-
Brent, R.1
Ptashne, M.2
-
5
-
-
0022551258
-
Functional dissection of a eukaryotic transcriptional activator protein, GCN4 of yeast
-
Hope, I.A. & Struhl, K Functional dissection of a eukaryotic transcriptional activator protein, GCN4 of yeast. Cell 46, 885-894 (1986).
-
(1986)
Cell
, vol.46
, pp. 885-894
-
-
Hope, I.A.1
Struhl, K.2
-
6
-
-
0024406857
-
A novel genetic system to detect protein-protein interactions
-
Fields, S. & Song, O.-K. A novel genetic system to detect protein-protein interactions. Nature 340, 245-246 (1989)
-
(1989)
Nature
, vol.340
, pp. 245-246
-
-
Fields, S.1
Song, O.-K.2
-
7
-
-
0027756895
-
Controlling signal transduction with synthetic ligands
-
Spencer, D M., Wandless, T.J., Schreiber, S.L. & Crabtree, G.R Controlling signal transduction with synthetic ligands. Science 262, 1019-1024 (1993).
-
(1993)
Science
, vol.262
, pp. 1019-1024
-
-
Spencer, D.M.1
Wandless, T.J.2
Schreiber, S.L.3
Crabtree, G.R.4
-
8
-
-
0028533869
-
Proximity versus allostery: The role of regulated protein dimerization in biology
-
Austin, D.J , Crabtree, G.R. & Schreiber, S.L. Proximity versus allostery: The role of regulated protein dimerization in biology. Chem. Biol. 1, 131-136 (1994).
-
(1994)
Chem. Biol.
, vol.1
, pp. 131-136
-
-
Austin, D.J.1
Crabtree, G.R.2
Schreiber, S.L.3
-
9
-
-
0028533803
-
Mechanistic studies of a signaling pathway activated by the organic dimerizer FK1012
-
Pruschy, M.N. et al. Mechanistic studies of a signaling pathway activated by the organic dimerizer FK1012 Chem. Biol 1, 163-172 (1994).
-
(1994)
Chem. Biol
, vol.1
, pp. 163-172
-
-
Pruschy, M.N.1
-
10
-
-
0028845027
-
A general strategy for producing conditional alleles of Src-like tyrosine kinases
-
Spencer, D M., Graef, I., Austin, D J., Schreiber, S.L. & Crabtree, G.R. A general strategy for producing conditional alleles of Src-like tyrosine kinases. Proc. Natl. Acad. Sci. USA 92, 9805-9809 (1995).
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 9805-9809
-
-
Spencer, D.M.1
Graef, I.2
Austin, D.J.3
Schreiber, S.L.4
Crabtree, G.R.5
-
11
-
-
0028832658
-
Signal transduction in T lymphocytes using a conditional allele of Sos
-
Holsinger, L.J., Spencer, D.M , Austin, D.J., Schreiber, S.L. & Crabtree, G.R. Signal transduction in T lymphocytes using a conditional allele of Sos Proc. Natl. Acad. Sci. USA 92, 9810-9814 (1995).
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 9810-9814
-
-
Holsinger, L.J.1
Spencer, D.M.2
Austin, D.J.3
Schreiber, S.L.4
Crabtree, G.R.5
-
12
-
-
0030013607
-
Controlling protein association and subcellular localization with a synthetic ligand that induces heterodimerization of proteins
-
Belshaw, P.J , Ho, S.N , Crabtree, G.R & Schreiber, S.L. Controlling protein association and subcellular localization with a synthetic ligand that induces heterodimerization of proteins. Proc Natl. Acad. Sci. USA 93, 4604-4607 (1996).
-
(1996)
Proc Natl. Acad. Sci. USA
, vol.93
, pp. 4604-4607
-
-
Belshaw, P.J.1
Ho, S.N.2
Crabtree, G.R.3
Schreiber, S.L.4
-
13
-
-
9544233830
-
Controlling transcription with synthetic ligands
-
in the press
-
Ho, S N., Biggar, S.R., Spencer, D M., Schreiber, S.L & Crabtree, G.R Controlling transcription with synthetic ligands. Nature (in the press).
-
Nature
-
-
Ho, S.N.1
Biggar, S.R.2
Spencer, D.M.3
Schreiber, S.L.4
Crabtree, G.R.5
-
14
-
-
0025647885
-
Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin
-
Bierer, B.E. et al. Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin Proc. Natl. Acad. Sci. USA 87, 9231-9235 (1990)
-
(1990)
Proc. Natl. Acad. Sci. USA
, vol.87
, pp. 9231-9235
-
-
Bierer, B.E.1
-
15
-
-
0028360374
-
A mammalian protein targeted by G1-arresting rapamycin-receptor complex
-
Brown, E.J. et al. A mammalian protein targeted by G1-arresting rapamycin-receptor complex. Nature 369, 756-758 (1994).
-
(1994)
Nature
, vol.369
, pp. 756-758
-
-
Brown, E.J.1
-
16
-
-
0028598672
-
RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex
-
Chiu, M I , Katz, H. & Berlin, V. RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex Proc. Natl. Acad. Sci. USA 91, 12574-12578 (1994).
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 12574-12578
-
-
Chiu, M.I.1
Katz, H.2
Berlin, V.3
-
17
-
-
0028239893
-
RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs
-
Sabatini, D.M , Erdjument-Bromage, H., Lui, M., Tempst, P. & Snyder, S H RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs. Cell 78, 35-43 (1994)
-
(1994)
Cell
, vol.78
, pp. 35-43
-
-
Sabatini, D.M.1
Erdjument-Bromage, H.2
Lui, M.3
Tempst, P.4
Snyder, S.H.5
-
18
-
-
0028950217
-
Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells
-
Sabers, C.J. et al. Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells J. Biol. Chem. 270, 815-822 (1995)
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 815-822
-
-
Sabers, C.J.1
-
19
-
-
0028561918
-
Interaction between FKBP12-rapamycin and TOR involves a conserved serine residue
-
Stan, R. et al. Interaction between FKBP12-rapamycin and TOR involves a conserved serine residue J Biol. Chem. 269, 32037-32030 (1994).
-
(1994)
J Biol. Chem.
, vol.269
, pp. 32037-132030
-
-
Stan, R.1
-
20
-
-
0025902276
-
Preclinical evaluation of a new potent immunosuppressive agent, rapamycin
-
Kahan, B., Chang, J & Sehgal, S. Preclinical evaluation of a new potent immunosuppressive agent, rapamycin. Transplantation 52, 185-191 (1991).
-
(1991)
Transplantation
, vol.52
, pp. 185-191
-
-
Kahan, B.1
Chang, J.2
Sehgal, S.3
-
21
-
-
0025734876
-
Inhibition of T and B lymphocyte proliferation by rapamycin
-
Kay, J., Kromwel, L., Doe, S. & Denyer, M Inhibition of T and B lymphocyte proliferation by rapamycin. Immunology 72, 544-549 (1991)
-
(1991)
Immunology
, vol.72
, pp. 544-549
-
-
Kay, J.1
Kromwel, L.2
Doe, S.3
Denyer, M.4
-
22
-
-
0026024078
-
Rapamycin, apotent immunosuppressive drug for vascularized heart, kidney, and small bowel transplantation in the rat
-
Stepkowski, S., Chen, H., Daloze, P & Kahan, B. Rapamycin, apotent immunosuppressive drug for vascularized heart, kidney, and small bowel transplantation in the rat. Transplantation 51, 22-26 (1991)
-
(1991)
Transplantation
, vol.51
, pp. 22-26
-
-
Stepkowski, S.1
Chen, H.2
Daloze, P.3
Kahan, B.4
-
23
-
-
0028948325
-
Structure-based design of transcription factors
-
Pomerantz, J L., Sharp, P.A. & Pabo, C O Structure-based design of transcription factors. Science 267, 93-96 (1995)
-
(1995)
Science
, vol.267
, pp. 93-96
-
-
Pomerantz, J.L.1
Sharp, P.A.2
Pabo, C.O.3
-
24
-
-
0025943986
-
The p65 subunit is responsible for the strong transcription activating potential of NF-κB
-
Schmitz, M.L & Baeurle, P.A. The p65 subunit is responsible for the strong transcription activating potential of NF-κB EMBO J. 10, 3805-3817 (1991).
-
(1991)
EMBO J.
, vol.10
, pp. 3805-3817
-
-
Schmitz, M.L.1
Baeurle, P.A.2
-
25
-
-
0029055145
-
Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue
-
Chen, J., Zheng, X F , Brown, E J. & Schreiber, S.L. Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue. Proc Natl Acad. Sci USA 92, 4947-4951 (1995).
-
(1995)
Proc Natl Acad. Sci USA
, vol.92
, pp. 4947-4951
-
-
Chen, J.1
Zheng, X.F.2
Brown, E.J.3
Schreiber, S.L.4
-
26
-
-
0028153271
-
Long-term production and delivery of human growth hormone
-
Heartlein, M.W. et al. Long-term production and delivery of human growth hormone. Proc. Natl. Acad Sci USA 91, 10967-10971 (1994).
-
(1994)
Proc. Natl. Acad Sci USA
, vol.91
, pp. 10967-10971
-
-
Heartlein, M.W.1
-
27
-
-
13344261952
-
T-cell mediated rejection of gene-modified HIV-specific cytotoxic T lymphocytes in HIV-infected patients
-
Riddell, S.R et al. T-cell mediated rejection of gene-modified HIV-specific cytotoxic T lymphocytes in HIV-infected patients. Nature Med. 2, 216-223 (1996).
-
(1996)
Nature Med.
, vol.2
, pp. 216-223
-
-
Riddell, S.R.1
-
28
-
-
0028773294
-
Antigenic peptide binding by class I and class II histocompatibility proteins
-
Stern, L J. & Wiley, D.C. Antigenic peptide binding by class I and class II histocompatibility proteins. Structure 2, 245-251 (1994)
-
(1994)
Structure
, vol.2
, pp. 245-251
-
-
Stern, L.J.1
Wiley, D.C.2
-
29
-
-
0029329592
-
Structure-activity studies of rapamycin analogs: Evidence that the C-7 methoxy is part of the effector domain and positioned at the FKBP12/FRAP interface
-
Luengo, J.I. et al. Structure-activity studies of rapamycin analogs: Evidence that the C-7 methoxy is part of the effector domain and positioned at the FKBP12/FRAP interface. Chem. Biol. 2, 471-481 (1995)
-
(1995)
Chem. Biol.
, vol.2
, pp. 471-481
-
-
Luengo, J.I.1
-
30
-
-
33748226936
-
Rational design of orthogonal receptor-ligand combinations
-
Belshaw, P.J., Schoepfer, J., Liu, K., Morrison, K & Schreiber, S.L. Rational design of orthogonal receptor-ligand combinations. Angew. Chem. Int. Ed. Eng. 34, 2129-2132 (1995).
-
(1995)
Angew. Chem. Int. Ed. Eng.
, vol.34
, pp. 2129-2132
-
-
Belshaw, P.J.1
Schoepfer, J.2
Liu, K.3
Morrison, K.4
Schreiber, S.L.5
-
31
-
-
0029842109
-
Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP
-
Choi, J., Chen, J., Schreiber, S L & Clardy, J. Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP Science 273, 239-242 (1996).
-
(1996)
Science
, vol.273
, pp. 239-242
-
-
Choi, J.1
Chen, J.2
Schreiber, S.L.3
Clardy, J.4
-
32
-
-
0026629418
-
Expression cloning of a novel zinc-finger protein that binds to the c-fos serum response element
-
Attar, R.M. & Gilman, M Z. Expression cloning of a novel zinc-finger protein that binds to the c-fos serum response element Mol. Cell. Biol. 12, 2432-2443 (1992).
-
(1992)
Mol. Cell. Biol.
, vol.12
, pp. 2432-2443
-
-
Attar, R.M.1
Gilman, M.Z.2
-
33
-
-
0025061678
-
Molecular cloning and overexpression of the human FK506-binding protein FKBP
-
Standaert, R.F., Galat, A., Verdine, G.L & Schreiber, S.L. Molecular cloning and overexpression of the human FK506-binding protein FKBP. Nature 346, 671-674 (1990).
-
(1990)
Nature
, vol.346
, pp. 671-674
-
-
Standaert, R.F.1
Galat, A.2
Verdine, G.L.3
Schreiber, S.L.4
-
34
-
-
0022371467
-
A very strong enhancer is located upstream of an immediate early gene of human cytomegalovirus
-
Boshart, M. et al. A very strong enhancer is located upstream of an immediate early gene of human cytomegalovirus. Cell 41, 521-530 (1985)
-
(1985)
Cell
, vol.41
, pp. 521-530
-
-
Boshart, M.1
-
35
-
-
0023022087
-
Promoter region of interleukin-2 gene undergoes chromatin structure changes and confers inducibility on chloramphenicol acetyltransferase gene during activation of T cells
-
Siebenlist, U et al. Promoter region of interleukin-2 gene undergoes chromatin structure changes and confers inducibility on chloramphenicol acetyltransferase gene during activation of T cells Mol. Cell. Biol. 6, 3042-3049 (1986).
-
(1986)
Mol. Cell. Biol.
, vol.6
, pp. 3042-3049
-
-
Siebenlist, U.1
-
36
-
-
0023028241
-
Human growth hormone as a reporter gene in regulation studies employing transient gene expression
-
Selden, R.F., Burke-Howie, K., Rowe, M.E., Goodman, H M. & Moore, D.D Human growth hormone as a reporter gene in regulation studies employing transient gene expression. Mol. Cell. Biol. 6, 3173-3179 (1986).
-
(1986)
Mol. Cell. Biol.
, vol.6
, pp. 3173-3179
-
-
Selden, R.F.1
Burke-Howie, K.2
Rowe, M.E.3
Goodman, H.M.4
Moore, D.D.5
-
37
-
-
0025352187
-
Advanced mammalian gene transfer: High titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line
-
Morgenstern, J P. & Land, H. Advanced mammalian gene transfer: High titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line. Nucleic Acids Res. 18, 3587-3596 (1990).
-
(1990)
Nucleic Acids Res.
, vol.18
, pp. 3587-3596
-
-
Morgenstern, J.P.1
Land, H.2
-
38
-
-
0025959660
-
BCR first exon sequences specifically activate BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemias
-
Muller, A.J. et al. BCR first exon sequences specifically activate BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemias Mol. Cell. Biol. 11, 1785-1792 (1991).
-
(1991)
Mol. Cell. Biol.
, vol.11
, pp. 1785-1792
-
-
Muller, A.J.1
-
39
-
-
0027236954
-
Production of high-titer helper-free retroviruses by transient transfection
-
Pear, W S , Nolan, G.P., Scott, M.L & Baltimore, D. Production of high-titer helper-free retroviruses by transient transfection Proc. Natl. Acad. Sci. USA 90, 8392-8396 (1993).
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 8392-8396
-
-
Pear, W.S.1
Nolan, G.P.2
Scott, M.L.3
Baltimore, D.4
|