메뉴 건너뛰기




Volumn 10, Issue 2, 1999, Pages 271-280

Toward autologous ex vivo gene therapy for the central nervous system with human adult astrocytes

Author keywords

[No Author keywords available]

Indexed keywords

DOXYCYCLINE; LEVODOPA; TETRACYCLINE; TYROSINE 3 MONOOXYGENASE; VIRUS VECTOR;

EID: 0033585426     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/10430349950019057     Document Type: Article
Times cited : (43)

References (50)
  • 2
    • 0026650485 scopus 로고
    • Astrocyte cultures from human embryonic brain: Characterization and modulation of surface molecules by inflammatory cytokines
    • ALOISI, F., BORSELLINO, G., SAMOGGIA, P., TESTA, U., CHELUCCI, C., RUSSO, G., PESCHLE, C., and LEVI, G. (1992). Astrocyte cultures from human embryonic brain: Characterization and modulation of surface molecules by inflammatory cytokines. J. Neurosci. Res. 32, 494-506.
    • (1992) J. Neurosci. Res. , vol.32 , pp. 494-506
    • Aloisi, F.1    Borsellino, G.2    Samoggia, P.3    Testa, U.4    Chelucci, C.5    Russo, G.6    Peschle, C.7    Levi, G.8
  • 3
    • 0027427950 scopus 로고
    • Transplantation of cultured type 1 astrocyte cell suspensions into young, adult and aged rat cortex: Cell migration and survival
    • ANDERSSON, C., TYTELL, M., and BRUNSO-BECHTLOD, J. (1993). Transplantation of cultured type 1 astrocyte cell suspensions into young, adult and aged rat cortex: Cell migration and survival. Int. J. Dev. Neurosci. 11, 555-568.
    • (1993) Int. J. Dev. Neurosci. , vol.11 , pp. 555-568
    • Andersson, C.1    Tytell, M.2    Brunso-Bechtlod, J.3
  • 4
    • 0028867747 scopus 로고
    • Regeneration in the adult mammalian CNS: Guided by development
    • AUBERT, I., RIDET, J.L., and GAGE, F.H. (1995). Regeneration in the adult mammalian CNS: Guided by development. Curr. Opin. Neurobiol. 5, 625-635.
    • (1995) Curr. Opin. Neurobiol. , vol.5 , pp. 625-635
    • Aubert, I.1    Ridet, J.L.2    Gage, F.H.3
  • 6
    • 0030795798 scopus 로고    scopus 로고
    • Intrastrial injection of an adenoviral vector expressing GDNF prevents dopaminergic neuron degeneration and behavioral impairment in a rat model of Parkinson's disease
    • BILANG-BLEUEL, A., REVAH, F., COLIN, P., LOCQUET, I., ROBERT, J.J., MALLET, J., and HORELLOU, P. (1997). Intrastrial injection of an adenoviral vector expressing GDNF prevents dopaminergic neuron degeneration and behavioral impairment in a rat model of Parkinson's disease. Proc. Natl. Acad. Sci. U.S.A. 94, 8818-8823.
    • (1997) Proc. Natl. Acad. Sci. U.S.A. , vol.94 , pp. 8818-8823
    • Bilang-Bleuel, A.1    Revah, F.2    Colin, P.3    Locquet, I.4    Robert, J.J.5    Mallet, J.6    Horellou, P.7
  • 7
    • 0025871897 scopus 로고
    • Migration of xenogenic astrocytes in myelinated tracts: A novel probe for immune responses in white matter
    • BOOSS, J., SOLLY, K.S., COLLINS, P.V., and JACQUE, C. (1991). Migration of xenogenic astrocytes in myelinated tracts: A novel probe for immune responses in white matter. Acta Neuropathol. 82, 172-177.
    • (1991) Acta Neuropathol. , vol.82 , pp. 172-177
    • Booss, J.1    Solly, K.S.2    Collins, P.V.3    Jacque, C.4
  • 8
    • 0028307929 scopus 로고
    • Retinal ganglion cell survival is promoted by genetically modified astrocytes designed to secrete brain-derived neurotrophic factor (BDNF)
    • CASTILLO, B., JR., DEL CERRO, M., BREAKEFIELD, X.O., FRIM, D.M., BARNSTABLE, C.J., DEAN, D.O., and BOHN, M.C. (1994). Retinal ganglion cell survival is promoted by genetically modified astrocytes designed to secrete brain-derived neurotrophic factor (BDNF). Brain Res. 647, 30-37.
    • (1994) Brain Res. , vol.647 , pp. 30-37
    • Castillo Jr., B.1    Del Cerro, M.2    Breakefield, X.O.3    Frim, D.M.4    Barnstable, C.J.5    Dean, D.O.6    Bohn, M.C.7
  • 9
    • 0029780040 scopus 로고    scopus 로고
    • Intracerebral tetracycline-dependent regulation of gene expression in grafts of neural precursors
    • CORTI, O., HORELLOU, P., COLIN, P., CATTANEO, E., and MALLET, J. (1996). Intracerebral tetracycline-dependent regulation of gene expression in grafts of neural precursors. NeuroReport 7, 1655-1659.
    • (1996) NeuroReport , vol.7 , pp. 1655-1659
    • Corti, O.1    Horellou, P.2    Colin, P.3    Cattaneo, E.4    Mallet, J.5
  • 10
    • 0025947311 scopus 로고
    • The use of genetically altered astrocytes to provide nerve growth factor (NGF) to adrenal chromaffin cell grafted into the striatum
    • CUNNINGHAM, L.A., HANSEN, J.T., SHORT, M.P., and BOHN, M.C. (1991). The use of genetically altered astrocytes to provide nerve growth factor (NGF) to adrenal chromaffin cell grafted into the striatum. Brain Res. 561, 192-202.
    • (1991) Brain Res. , vol.561 , pp. 192-202
    • Cunningham, L.A.1    Hansen, J.T.2    Short, M.P.3    Bohn, M.C.4
  • 11
    • 0028015728 scopus 로고
    • Nerve growth factor released by transgenic astrocytes enhanced the function of adrenal chromaffin cell grafts in a rat model of Parkinson's disease
    • CUNNINGHAM, L.A., SHORT, M.P., BREAKEFIELD, X.O., and BOHN, M.C. (1994). Nerve growth factor released by transgenic astrocytes enhanced the function of adrenal chromaffin cell grafts in a rat model of Parkinson's disease. Brain Res. 558, 219-223.
    • (1994) Brain Res. , vol.558 , pp. 219-223
    • Cunningham, L.A.1    Short, M.P.2    Breakefield, X.O.3    Bohn, M.C.4
  • 12
    • 0030664107 scopus 로고    scopus 로고
    • Neural precursor cells: Applications for the study and repair of the central nervous system
    • FISHER, L.J. (1997). Neural precursor cells: Applications for the study and repair of the central nervous system. Neurobiol. Dis. 4, 1-22.
    • (1997) Neurobiol. Dis. , vol.4 , pp. 1-22
    • Fisher, L.J.1
  • 13
    • 0027325738 scopus 로고
    • Grafting in the mammalian central nervous system
    • FISHER, L.J., and GAGE, F.H. (1993). Grafting in the mammalian central nervous system. Physiol. Rev. 73, 583-616.
    • (1993) Physiol. Rev. , vol.73 , pp. 583-616
    • Fisher, L.J.1    Gage, F.H.2
  • 14
    • 0025963275 scopus 로고
    • Survival and function of intrastriatally grafted fibroblasts genetically modified to produce L-DOPA
    • FISHER, L.J., JINNAH, H.A., KALE, L.C., HIGGINS, G.A., and GAGE, F.H. (1991). Survival and function of intrastriatally grafted fibroblasts genetically modified to produce L-DOPA. Neuron 6, 371-380.
    • (1991) Neuron , vol.6 , pp. 371-380
    • Fisher, L.J.1    Jinnah, H.A.2    Kale, L.C.3    Higgins, G.A.4    Gage, F.H.5
  • 15
    • 0029931197 scopus 로고    scopus 로고
    • Brain cell type specificity and gliosis-induced activation of the human cytomegalovirus immediate-early promoter in transgenic mice
    • FRITSCHY, J.M., BRANDNER, S., AGUZZI, A., KOEDOOD, M., LUSCHER, B., and MITCHELL, P.J. (1996). Brain cell type specificity and gliosis-induced activation of the human cytomegalovirus immediate-early promoter in transgenic mice. J. Neurosci. 16, 2275-82.
    • (1996) J. Neurosci. , vol.16 , pp. 2275-2282
    • Fritschy, J.M.1    Brandner, S.2    Aguzzi, A.3    Koedood, M.4    Luscher, B.5    Mitchell, P.J.6
  • 16
    • 0028908299 scopus 로고
    • Isolation, characterization and use of stem cells from the CNS
    • GAGE, F.H., RAY, J., and FISHER, L.J. (1995). Isolation, characterization and use of stem cells from the CNS. Annu. Rev. Neurosci. 18, 159-192.
    • (1995) Annu. Rev. Neurosci. , vol.18 , pp. 159-192
    • Gage, F.H.1    Ray, J.2    Fisher, L.J.3
  • 18
    • 0026720075 scopus 로고
    • Tight control of gene expression in mammalian cells by tetracycline-responsive promoters
    • GOSSEN, M., and BUJARD, H. (1992). Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc. Natl. Acad. Sci. U.S.A. 89, 5547-5551.
    • (1992) Proc. Natl. Acad. Sci. U.S.A. , vol.89 , pp. 5547-5551
    • Gossen, M.1    Bujard, H.2
  • 19
    • 0029022369 scopus 로고
    • Transcriptional activation by tetracyclines in mammalian cells
    • GOSSEN, M., FREUNDLIEB, S., BENDER, G., MULLER, G., HILLEN, W., and BUJARD, H. (1995). Transcriptional activation by tetracyclines in mammalian cells. Science 268, 1766-1769.
    • (1995) Science , vol.268 , pp. 1766-1769
    • Gossen, M.1    Freundlieb, S.2    Bender, G.3    Muller, G.4    Hillen, W.5    Bujard, H.6
  • 20
    • 0025119186 scopus 로고
    • In vivo release of DOPA and dopamine from genetically engineered cells grafted to the denervated striatum
    • HORELLOU, P., BRUNDIN, P., KALEN, P., MALLET, J., and BJÖRKLUND, A. (1990a). In vivo release of DOPA and dopamine from genetically engineered cells grafted to the denervated striatum. Neuron 5, 393-402.
    • (1990) Neuron , vol.5 , pp. 393-402
    • Horellou, P.1    Brundin, P.2    Kalen, P.3    Mallet, J.4    Björklund, A.5
  • 21
    • 0025186862 scopus 로고
    • Behavioral effect of engineered cells that synthesize L-dopa or dopamine after grafting into the rat neostriatum
    • HORELLOU, P., MARLIER, L., PRIVAT, A., and MALLET, J. (1990b). Behavioral effect of engineered cells that synthesize L-dopa or dopamine after grafting into the rat neostriatum. Eur. J. Neurosci. 2, 116-119.
    • (1990) Eur. J. Neurosci. , vol.2 , pp. 116-119
    • Horellou, P.1    Marlier, L.2    Privat, A.3    Mallet, J.4
  • 22
    • 0028606905 scopus 로고
    • Direct intracerebral gene transfer of an adenoviral vector expressing tyrosine hydroxylase in a rat model of Parkinson's disease
    • HORELLOU, P., VIGNE, E., CASTEL, M.N., BARNEOUD, P., COLIN, P., PERRICAUDET, M., DELAERE, P., and MALLET, J. (1994). Direct intracerebral gene transfer of an adenoviral vector expressing tyrosine hydroxylase in a rat model of Parkinson's disease. NeuroReport 6, 49-53.
    • (1994) NeuroReport , vol.6 , pp. 49-53
    • Horellou, P.1    Vigne, E.2    Castel, M.N.3    Barneoud, P.4    Colin, P.5    Perricaudet, M.6    Delaere, P.7    Mallet, J.8
  • 23
    • 0026661365 scopus 로고
    • Comparative migration and development of astroglial and oligodendroglial cell populations from a brain xenograft
    • JACQUE, C., QUINONERO, J., COLLINS, P.V., VILLARROYA, H., and SUARD, I. (1992). Comparative migration and development of astroglial and oligodendroglial cell populations from a brain xenograft. J. Neurosci. 12, 3098-3106.
    • (1992) J. Neurosci. , vol.12 , pp. 3098-3106
    • Jacque, C.1    Quinonero, J.2    Collins, P.V.3    Villarroya, H.4    Suard, I.5
  • 24
    • 0027375492 scopus 로고
    • Decarboxylation of L-dopa by cultured mouse astrocytes
    • JUORIO, A.V., LI, X.M., WALZ, W., and PATERSON, I.A. (1993). Decarboxylation of L-dopa by cultured mouse astrocytes. Brain Res. 626, 306-309.
    • (1993) Brain Res. , vol.626 , pp. 306-309
    • Juorio, A.V.1    Li, X.M.2    Walz, W.3    Paterson, I.A.4
  • 26
    • 0027233350 scopus 로고
    • Genetically modified primary astrocytes as cellular vehicles for gene therapy in the brain
    • LA GAMMA, E.F., WIESINGER, G., LENN, N.J., and STRECKER, R.E. (1993). Genetically modified primary astrocytes as cellular vehicles for gene therapy in the brain. Cell Transplant. 2, 207-214.
    • (1993) Cell Transplant. , vol.2 , pp. 207-214
    • La Gamma, E.F.1    Wiesinger, G.2    Lenn, N.J.3    Strecker, R.E.4
  • 27
    • 0030221516 scopus 로고    scopus 로고
    • An adenovirus vector encoding tyrosine hydroxylase activity may enter human CNS cells in primary dissociated cultures
    • LEVALLOIS, C., MALLET, J., and PRIVAT, A. (1996). An adenovirus vector encoding tyrosine hydroxylase activity may enter human CNS cells in primary dissociated cultures. Int. J. Dev. Neurosci. 14, 613-619.
    • (1996) Int. J. Dev. Neurosci. , vol.14 , pp. 613-619
    • Levallois, C.1    Mallet, J.2    Privat, A.3
  • 28
    • 0030816512 scopus 로고    scopus 로고
    • Human fetal astrocytes as an ex vivo gene therapy vehicle for delivering biologically active nerve growth factor
    • LIN, Q., CUNNINGHAM, L.A., EPSTEIN, L.G., PECHAN, P.A., SHORT, M.P., FLEET C., and BOHN, M.C. (1997). Human fetal astrocytes as an ex vivo gene therapy vehicle for delivering biologically active nerve growth factor. Hum. Gene Ther. 8, 331-339.
    • (1997) Hum. Gene Ther. , vol.8 , pp. 331-339
    • Lin, Q.1    Cunningham, L.A.2    Epstein, L.G.3    Pechan, P.A.4    Short, M.P.5    Fleet, C.6    Bohn, M.C.7
  • 29
    • 0029973056 scopus 로고    scopus 로고
    • Generation of DOPA-producing astrocytes by retroviral transduction of the human tyrosine hydroxylase gene: In vitro characterization and in vivo effects in the rat Parkinson model
    • LUNDBERG, C., HORELLOU, P., MALLET, J., and BJÖRKLUND, A. (1996). Generation of DOPA-producing astrocytes by retroviral transduction of the human tyrosine hydroxylase gene: In vitro characterization and in vivo effects in the rat Parkinson model. Exp. Neurol. 139, 39-53.
    • (1996) Exp. Neurol. , vol.139 , pp. 39-53
    • Lundberg, C.1    Horellou, P.2    Mallet, J.3    Björklund, A.4
  • 30
    • 0031016270 scopus 로고    scopus 로고
    • Differential toxicity of ganciclovir for rat neurons and astrocytes in primary culture following adenovirus-mediated transfer of the HSVtk gene
    • MARON, A., HAVAUX, N., LE ROUX, A., KNOOPS, B., PERRICAUDET, M., and OCTAVE, J.N. (1997). Differential toxicity of ganciclovir for rat neurons and astrocytes in primary culture following adenovirus-mediated transfer of the HSVtk gene. Gene Ther. 4, 25-31.
    • (1997) Gene Ther. , vol.4 , pp. 25-31
    • Maron, A.1    Havaux, N.2    Le Roux, A.3    Knoops, B.4    Perricaudet, M.5    Octave, J.N.6
  • 31
    • 0030838238 scopus 로고    scopus 로고
    • Immortalized neural progenitor cells for CNS gene transfer and repair
    • MARTINEZ-SERRANO, A., and BJORKLUND, A. (1997). Immortalized neural progenitor cells for CNS gene transfer and repair. Trends Neurosci. 20, 530-538.
    • (1997) Trends Neurosci. , vol.20 , pp. 530-538
    • Martinez-Serrano, A.1    Bjorklund, A.2
  • 32
    • 0029807527 scopus 로고    scopus 로고
    • Control of memory formation through regulated expression of a CAMKII transgene
    • MAYFORD, M., BACH, M.E., HUANG, Y.Y., WANG, L., HAWKINS, R.D., and KANDEL, E.R. (1996). Control of memory formation through regulated expression of a CAMKII transgene. Science 274, 1678-1683.
    • (1996) Science , vol.274 , pp. 1678-1683
    • Mayford, M.1    Bach, M.E.2    Huang, Y.Y.3    Wang, L.4    Hawkins, R.D.5    Kandel, E.R.6
  • 33
    • 0029361951 scopus 로고
    • Media components influence viral gene expression assays in human fetal astrocyte cultures
    • McCARTHY, M., WOOD, C., FEDOSEYEVA, L., and WHITTEMORE, S.C. (1995). Media components influence viral gene expression assays in human fetal astrocyte cultures. J. Neurovirol. 1, 275-285.
    • (1995) J. Neurovirol. , vol.1 , pp. 275-285
    • McCarthy, M.1    Wood, C.2    Fedoseyeva, L.3    Whittemore, S.C.4
  • 34
    • 0030996011 scopus 로고    scopus 로고
    • Progress in transcriptionally targeted and regulatable vectors for genetic therapy
    • MILLER, N., and WHELAN, J. (1997). Progress in transcriptionally targeted and regulatable vectors for genetic therapy. Hum. Gene Ther. 8, 803-815.
    • (1997) Hum. Gene Ther. , vol.8 , pp. 803-815
    • Miller, N.1    Whelan, J.2
  • 35
    • 0030041034 scopus 로고    scopus 로고
    • Fetal nigral transplantation as a therapy for Parkinson's disease
    • OLANOW, C., KORDOWER, J.H., and FREEMAN, T.B. (1996). Fetal nigral transplantation as a therapy for Parkinson's disease. Trends Neurosci. 19, 102-109.
    • (1996) Trends Neurosci. , vol.19 , pp. 102-109
    • Olanow, C.1    Kordower, J.H.2    Freeman, T.B.3
  • 36
    • 0027563903 scopus 로고
    • Appearance of GFAP-positive cells in adult human brain cultures spontaneously decelerated in growth
    • PERZELOVA, A., and MARES, V. (1993). Appearance of GFAP-positive cells in adult human brain cultures spontaneously decelerated in growth. Glia 7, 237-244.
    • (1993) Glia , vol.7 , pp. 237-244
    • Perzelova, A.1    Mares, V.2
  • 37
    • 0028970469 scopus 로고
    • The fate of human glial cells following transplantation in normal rodents and rodent models of neurodegenerative disease
    • PUNDT, L.L., KONDOH, T., and LOW, W.C. (1995). The fate of human glial cells following transplantation in normal rodents and rodent models of neurodegenerative disease. Brain Res. 695, 25-36.
    • (1995) Brain Res. , vol.695 , pp. 25-36
    • Pundt, L.L.1    Kondoh, T.2    Low, W.C.3
  • 39
    • 0030697366 scopus 로고    scopus 로고
    • Reactive astrocytes: Cellular and molecular cues to biological function
    • RIDET, J.L., MALHOTRA, S.K., PRIVAT, A., and GAGE, F.H. (1997). Reactive astrocytes: Cellular and molecular cues to biological function. Trends Neurosci. 20, 570-577.
    • (1997) Trends Neurosci. , vol.20 , pp. 570-577
    • Ridet, J.L.1    Malhotra, S.K.2    Privat, A.3    Gage, F.H.4
  • 41
    • 0028861802 scopus 로고
    • Transplantation to the rat brain of human neural progenitors that were genetically modified using adenovirus
    • SABATE, O., HORELLOU, P., VIGNE, E., COLIN, P., PERRICAUDET, M., BUCCARON, M.H., and MALLET, J. (1995). Transplantation to the rat brain of human neural progenitors that were genetically modified using adenovirus. Nature Genet. 9, 256-260.
    • (1995) Nature Genet. , vol.9 , pp. 256-260
    • Sabate, O.1    Horellou, P.2    Vigne, E.3    Colin, P.4    Perricaudet, M.5    Buccaron, M.H.6    Mallet, J.7
  • 42
    • 0030681310 scopus 로고    scopus 로고
    • Inducible gene expression in mammalian cells and transgenic mice
    • SAEZ, E., NO., D., WEST, A., and EVANS, R.M. (1997). Inducible gene expression in mammalian cells and transgenic mice. Curr. Opin. Biotechnol. 8, 608-616.
    • (1997) Curr. Opin. Biotechnol. , vol.8 , pp. 608-616
    • Saez, E.1    No, D.2    West, A.3    Evans, R.M.4
  • 43
    • 0031306059 scopus 로고    scopus 로고
    • Growth factor regulation of cell growth and proliferation in the nervous system
    • STACHOWIAK, M.K., MOFFETT, J., MAHER, P., TUCHOLSKI, J., and STACHOWIAK, E.K. (1997). Growth factor regulation of cell growth and proliferation in the nervous system. Mol. Neurobiol. 15, 257-283.
    • (1997) Mol. Neurobiol. , vol.15 , pp. 257-283
    • Stachowiak, M.K.1    Moffett, J.2    Maher, P.3    Tucholski, J.4    Stachowiak, E.K.5
  • 44
    • 0025132453 scopus 로고
    • An improved staining method for rat microglial cells using the lectin from Griffonia simplicifolia (GSA I-B4)
    • STREIT, W.J. (1990). An improved staining method for rat microglial cells using the lectin from Griffonia simplicifolia (GSA I-B4). J. Histochem. Cytochem. 38, 1683-1686.
    • (1990) J. Histochem. Cytochem. , vol.38 , pp. 1683-1686
    • Streit, W.J.1
  • 45
    • 0030766409 scopus 로고    scopus 로고
    • Cell vehicles for gene transfer to the brain
    • TAYLOR, R. (1997). Cell vehicles for gene transfer to the brain. Neuromusc. Dis. 7, 343-351.
    • (1997) Neuromusc. Dis. , vol.7 , pp. 343-351
    • Taylor, R.1
  • 47
    • 0025734387 scopus 로고
    • Gamma-interferon promotes proliferation of adult human astrocytes in vitro and reactive gliosis in the adult mouse brain in vivo
    • YONG, V.W., MOUMDJIAN, R., YONG, F.P., RUIJS, T.C.G., FREEDMAN, M.S., CASHMAN, N., and ANTEL, J.P. (1991). Gamma-interferon promotes proliferation of adult human astrocytes in vitro and reactive gliosis in the adult mouse brain in vivo. Proc. Natl. Acad. Sci. U.S.A. 88, 7016-7020.
    • (1991) Proc. Natl. Acad. Sci. U.S.A. , vol.88 , pp. 7016-7020
    • Yong, V.W.1    Moumdjian, R.2    Yong, F.P.3    Ruijs, T.C.G.4    Freedman, M.S.5    Cashman, N.6    Antel, J.P.7
  • 48
    • 0027024539 scopus 로고
    • Differential proliferative response of human and mouse astrocytes to gamma-interferon
    • YONG, V.W., TEJADA-BERGES, T., GOODYER, C.G., ANTEL, J.P., and YONG, F.P. (1992). Differential proliferative response of human and mouse astrocytes to gamma-interferon. Glia 6, 269-280.
    • (1992) Glia , vol.6 , pp. 269-280
    • Yong, V.W.1    Tejada-Berges, T.2    Goodyer, C.G.3    Antel, J.P.4    Yong, F.P.5
  • 49
    • 0029134980 scopus 로고
    • Astrocytes retrovirally transduced with BDNF elicit behavioral improvement in a rat model of Parkinson's disease
    • YOSHIMOTO, Y., LIN, Q., COLLIER, T., FRIM, D., BREAKEFIELD, X.O., and BOHN, M.C. (1995). Astrocytes retrovirally transduced with BDNF elicit behavioral improvement in a rat model of Parkinson's disease. Brain Res. 691, 25-36.
    • (1995) Brain Res. , vol.691 , pp. 25-36
    • Yoshimoto, Y.1    Lin, Q.2    Collier, T.3    Frim, D.4    Breakefield, X.O.5    Bohn, M.C.6
  • 50
    • 0030467622 scopus 로고    scopus 로고
    • Retroviral delivery and tetracycline-dependent expression of IL-1beta-converting enzyme (ICE) in a rat glioma model provides controlled induction of apoptotic death in tumor cells
    • YU, J.S., SENA-ESTEVES, M., PAULUS, W., BREAKEFIELD, X.O., and REEVES, S.A. (1996). Retroviral delivery and tetracycline-dependent expression of IL-1beta-converting enzyme (ICE) in a rat glioma model provides controlled induction of apoptotic death in tumor cells. Cancer Res. 56, 5423-5427.
    • (1996) Cancer Res. , vol.56 , pp. 5423-5427
    • Yu, J.S.1    Sena-Esteves, M.2    Paulus, W.3    Breakefield, X.O.4    Reeves, S.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.