Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 20, 1996, Pages 10933-10938

  Kistner, Andreas ^a   Gossen, Manfred ^a,c   Zimmermann, Frank ^a   Jerecic, Jasna ^a   Ullmer, Christoph ^b   Lübbert, Hermann ^b   Bujard, Hermann ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b Sandoz Pharma Ltd   (Switzerland)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

genetic switch; kinetics of induction; liver specific control; tet system

Indexed keywords

ANIMAL TISSUE; ARTICLE; GENE EXPRESSION REGULATION; GENE TARGETING; GENETIC ANALYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; TISSUE SPECIFICITY; TRANSCRIPTION REGULATION;

ANIMALS; CYTOMEGALOVIRUS; DOXYCYCLINE; GENE EXPRESSION REGULATION; GENETIC ENGINEERING; IN SITU HYBRIDIZATION; LIVER; MICE; MICE, TRANSGENIC; PROMOTER REGIONS (GENETICS); RNA, MESSENGER; TISSUE DISTRIBUTION; TRANS-ACTIVATION (GENETICS);

ANIMALIA; MUS MUSCULUS;

EID: 0029763587     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.20.10933     Document Type: Article

References (27)

1. Thomas, K. R. & Capecchi, M. R. (1987) Cell 51, 503-512.
2. Sternberg, N. & Hamilton, D. (1981) J. Mol. Biol. 150, 467-486.
3. Byrne, G. & Ruddle, F. H. (1989) Proc. Natl. Acad. Sci. USA 86, 5473-5477.
4. Lakso, M., Sauer, B., Mosinger, B., Jr., Lee, E. J., Manning, R. W., Yu, S. H., Mulder, K. L. & Westphal, H. (1992) Proc. Natl. Acad. Sci. USA 89, 6232-6236.
5. Gu, H., Zou, Y. R. & Rajewsky, K. (1993) Cell 73, 1155-1164.
6. Gu, H., Marth, I. D., Orban, P. C., Mossann, H. & Rajewsky, K. (1994) Science 265, 103-106.
7. Gossen, M. & Bujard, H. (1992) Proc. Natl. Acad. Sci. USA 89, 5547-5551.
8. Gossen, M., Freundlieb, S., Bender, G., Müller, G., Hillen, W. & Bujard, H. (1995) Science 268, 1766-1769.
9. Weinmann, P., Gossen, M., Hillen, W., Bujard, H. & Gatz, C. (1994) Plant J. 5, 559-569.
10. Furth, P. A., Onge, L. St., Böger, H., Gruss, P., Gossen, M., Kistner, A., Bujard, H. & Hennighausen, L. (1994) Proc. Natl. Acad. Sci. USA 91, 9302-9306.
11. Passman, R. S. & Fishman, G. I. (1994) J. Clin. Invest. 94, 2421-2425.
12. Efrat, S., Fusco-DeMane, D., Lemberg, H., Emran, O. A. & Wang, X. (1995) Proc. Natl. Acad. Sci. USA 92, 3576-3580.
13. Talbot, D., Descombes, P. & Schibler, U. (1994) Nucleic Acids Res. 22, 756-766.
14. Hogan, B., Constantini, F. & Lacy, E. (1995) Manipulating the Mouse Embryo: A Laboratory Manual (Cold Spring Harbor Lab. Press, Plainview, NY), 2nd Ed.
15. Sambrook, J., Fritsch, E. F. & Maniatis, T (1989) Molecular Cloning: A Laboratory Manual (Cold Spring Harbor Lab. Press, Plainview, NY), 2nd Ed.
16. Bradford, M. M. (1976) Anal. Biochem. 72, 248-254.
17. Shockett, P., Difilippantonio, M., Hellman, N. & Schatz, D. G. (1995) Proc. Natl. Acad. Sci. USA 92, 6522-6526.
18. Arias, I. M., Jakoby, W. B., Papper, H., Schachter, D. & Shafritz, D. A. (1987) The Liver: Biology and Pathobiology (Raven, New York), 2nd Ed.
19. Wisden, W., Morris, B. J. & Hunt, S. P. (1991) in Molecular Neurobiology: A Practical Approach, eds. Chad, J. & Wheal, H. (Oxford Univ. Press, New York), Vol. 2, pp. 205-225.
20. Boshart, M., Weber, F., Jahn, G., Dorsch-Häsler, K., Fleckenstein, B. & Schaffner, W. (1985) Cell 41, 521-530.
21. Kistner, A. (1996) Ph.D. thesis (Universität Heidelberg, Heidelberg, Germany).
22. Furth, P. A., Hennighausen, K., Baker, C., Beatty, B. & Woychick, R. (1991) Nucleic Acids Res. 19, 6205-6208.
23. Yin, D. X., Zhu, L. & Schimke, R. T. (1996) Anal. Biochem. 235, 195-201.
24. Dhawan, J., Rando, T. A., Elson, S. L., Bujard, H. & Blau, H. (1995) Somatic Cell Mol. Genet. 21, 233-240.
25. Chrast-Balz, J. & Hooft van Huijsduijnen, R. (1996) Nucleic Acids Res. 24, 2900-2904.
26. Hennighausen, L., Wall, R. J., Tillmann, W., Li, M. & Furth, P. (1995) J. Cell. Biochem. 59, 1-10.
27. Baskar, J. F., Smith, P. P., Gajahan, N., Ray, A. J., Hoffman, S., Peffer, N., Tenney, D. J., Coleberg-Poley, A. M., Ghazal, P. & Nelson, J. A. (1996) J. Virol. 70, 3207-3214.