A mathematical model of caspase function in apoptosis

Nature Biotechnology

Volumn 18, Issue 7, 2000, Pages 768-774

  Fussenegger, Martin ^a   Bailey, James E ^a   Varner, Jeffrey ^b  

^a ETH ZURICH   (Switzerland)

^b University of Minnesota ^*  (United States)

Author keywords

Apoptosis; Caspases; Mechanistic mathematical models

Indexed keywords

CASPASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME MECHANISM; MATHEMATICAL MODEL; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN DEGRADATION; SUICIDE GENE; XENOPUS LAEVIS;

ANTIGENS, CD95; APOPTOSIS; ARABIDOPSIS PROTEINS; BCL-X PROTEIN; CASPASE 8; CASPASE 9; CASPASES; COMPUTER SIMULATION; ENZYME ACTIVATION; FATTY ACID DESATURASES; GENES, P53; HUMANS; KINETICS; MODELS, BIOLOGICAL; MODELS, THEORETICAL; MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-BCL-2;

ANIMALIA; XENOPUS LAEVIS;

EID: 0033925842     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/77589     Document Type: Article

References (37)

1. Evan, G., & Littlewood, T. A matter of life and cell death. Science 281, 1317-1722 (1998).
2. Thompson, C.B. Apoptosis in the pathogenesis and treatment of disease. Science 267, 1456-1462 (1995).
3. Haass, C. Apoptosis. Dead end for neurodegeneration? Nature 399, 204-207 (1999).
4. Ashkenazi, A. & Dixit, V.M. Death receptors: signaling and modulation. Science 281, 1305-1308 (1998).
5. Adams, J.M. & Cory, S. The Bcl-2 protein family: arbiters of cell survival. Science 281, 1322-1326 (1998).
6. Thomberry, N.A., & Lazebnik, Y. Caspases: enemies within. Science 281, 1312-1316 (1998).
7. Green, D.R., & Reed, J.C. Mitochondria and apoptosis. Science 281, 1309-1312 (1998).
8. Smith, C.A., Farrah, T. & Goodwin, R.G. The TNF receptor superfamily of cellular and viral proteins: activation, costimulation, and death. Cell 76, 969-962 (1994).
9. Tartaglia, LA, Ayres, T.M., Wong, G.H. & Goeddel, D.V. A novel domain within the 55 kd TNF receptor signals cell death. Cell 74, 845-853 (1993).
10. Nagata, S. Apoptosis by death factor. Cell 88, 355-365 (1997).
11. Huang, B., Eberstadt, M., Olejniczak, E.T., Meadows, P.P. & Fesik, S.W. NMR structure and mutagenesis of the Fas (APO-1/CD95) death domain. Nature 384, 638-641 (1996).
12. Chinnaiyan, A.M., O'Rourke, K., Tewari, M. & Dixit, V.M. FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell 81, 505-512 (1995).
13. Boldin, M.P. et al. A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motil related to the death domain. J. Biol. Chem. 270, 7795-7798 (1995).
14. Boldin, M.P. et al. Self-association of the "death domains" of the p55 tumor necrosis factor (TNF) receptor and Fas/APO1 prompts signaling for TNF and Fas/AP01 effects. J. Biol. Chem. 270, 387-391 (1995).
15. Muzio, M., Stockwell, B.R., Stennicke, H.R., Salvesen, G.S. & Dixit, V.M. An induced proximity model for caspase-8 activation. J. Biol. Chem. 273, 2926-2930 (1998).
16. Salvesen, G.S. & Dixit, V.M. Caspase activation: the induced-proximity model. Proc. Natl. Acad. Sci. USA 96, 10964-10967 (1999).
17. Li, P. et al. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91, 479-489 (1997).
18. Yang, J. et al. Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science 275, 1129-1132 (1997).
19. Kluck, P.M., Bossy-Wetzel, E., Green, D.R. & Newmeyer, D.D. The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science 275, 1132-1136 (1997).
20. Simpson, N.H., Singh, R.P., Perani, A., Goldenzon, C. & Al-Rubeai, M. In hybridoma cultures, deprivation of any single amino acid leads to apoptotic death, which is suppressed by the expression of the bcl-2 gene. Biotecnol. Bioeng. 59, 90-98 (1998).
21. Goswami, J., Sinskey, A.J., Steller, H., Stephanopoulos, G.N. & Wang, D.I. Apoptosis in batch cultures of Chinese hamster ovary cells. Biotechnol. Bioeng. 62, 632-640 (1999).
22. Sanfeliu, A. & Stephanopoulos, G. Effect of glutamine limitation on the death of attached Chinese hamster ovary cells. Biotechnol. Bioeng. 64, 46-53 (1999).
23. Deveraux, Q.L., Takahashi, R., Salvesen, G.S. & Reed, J.C X-linked IAP is a direct inhibitor of cell-death proteases. Nature 388, 300-304 (1997).
24. Deveraux, Q.L. et al. IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases. EMBO J. 17, 2215-2223 (1998).
25. Seshagiri, S. & Miller, L.K. Baculovirus inhibitors of apoptosis (IAPs) block activation of Sf-caspase-1. Proc. Natl. Acad. Sci. USA 94, 13606-13611 (1997).
26. Irmler, M. et al. Inhibition of death receptor signals by cellular FLIP. Nature 388, 125-126 (1997).
27. Shu, H.B., Halpin, D.R. & Goeddel, D.V. Casper is a FADD- and caspase-related inducer of apoptosis. Immunity 6, 751-763 (1997).
28. Koseki, T., Inohara, N., Chen, S. &Nunez, G. ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases. Proc. Natl. Acad. Sci. USA 95, 5156-5160 (1998).
29. Amarante-Mendes, G.P. et al, Anti-apoptotic oncogenes prevent caspase-dependent and independent commitment for cell death. Cell Death Differ. 5, 298-306 (1998).
30. Reed, J.C. Double identity for proteins of the Bcl-2 family. Nature 387, 773-776 (1997).
31. Newton, K. & Strasser, A. The Bcl-2 family and cell death regulation. Curr. Opin. Genet. Dev. 8, 68-75 (1998).
32. Hsu, Y.T., Wolter, K.G. & Youle, R.J. Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis. Proc. Natl. Acad. Sci. USA 94, 3668-3672 (1997).
33. Miyashita, T. & Reed, J.C. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80, 293-299 (1995).
34. Zhang, J., Cado, D., Chen, A., Kabra, N.H. & Winoto, A. Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1. Nature 392, 296-300 (1998).
35. Yeh, W.C. et al. FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis. Science 279, 1954-1958 (1998).
36. Ona, V.O. et al. Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease. Nature 399, 263-267 (1999).
37. Davidson, F.F. & Steller, H. Blocking apoptosis prevents blindness in Drosophila retinal degeneration mutants. Nature 391, 587-591 (1998).