A gene therapy approach to regulated delivery of erythropoietin as a function of oxygen tension

Human Gene Therapy

Volumn 8, Issue 16, 1997, Pages 1881-1889

  Rinsch, Christopher ^a   Régulier, Etienne ^a   Déglon, Nicole ^a   Dalle, Bruno ^b   Beuzard, Yves ^b   Aebischer, Patrick ^a,c  

^a University of Lausanne Medical Center   (Switzerland)

^b SAINT LOUIS HOSPITAL   (France)

^c LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; ERYTHROPOIETIN; PHOSPHOGLYCERATE KINASE;

ANEMIA; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ARTIFICIAL MEMBRANE; CELL LINE; CONTROLLED STUDY; ENCAPSULATION; GENE TARGETING; GENE THERAPY; GENETIC ENGINEERING; HUMAN; HYPOXIA; MOUSE; NONHUMAN; OXYGEN TENSION; PHYSIOLOGY; PROMOTER REGION; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALIA; MURINAE; TRIXIS;

EID: 0030690936     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.1997.8.16-1881     Document Type: Article

References (5)

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2. AEBISCHER, P., and LYSAGHT, M.J. (1995). Immunoisolation and cellular xenotransplantation. Xeno 3, 43-48.
3. AEBISCHER, P., SCHLUEP, M., DEGLON, N., JOSEPH, J.-M., HIRT, L., HEYD, B., GODDARD, M., HAMMANG, J.P., ZURN, A.D., KATO, A.C., REGLI, F., and BAETGE, E.E. (1996). Intrathecal delivery of CNTF using encapsulated genetically modified xenogeneic cells in amyotrophic lateral sclerosis patients. Nature Med. 2, 696-699.
4. BLANCHARD, K.L., ACQUAVIVA, A.M., GALSON, D.L., and BUNN, H.F. (1992). Hypoxie induction of the human erythropoietin gene: cooperation between the promoter and enhancer, each of which contains steroid receptor response elements. Mol. Cell. Biol. 12, 5373-5385.
5. BOHL, D., NAFFAKH, N., and HEARD, J.-M. (1997). Long-term control of erythropoietin secretion by doxycycline in mice transplanted with engineered primary myoblasts. Nature Med. 3, 299-305.