Models and mechanisms of O-O bond activation by cytochrome P450: A critical assessment of the potential role of multiple active intermediates in oxidative catalysis

European Journal of Biochemistry

Volumn 271, Issue 22, 2004, Pages 4335-4360

  Hlavica, Peter ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

(Hydro)peroxo iron; Iron oxene; O2 activation; P450; P450 biomimics

Indexed keywords

BIOMIMETIC MATERIAL; BLEOMYCIN IRON; CYTOCHROME P450; HEMOPROTEIN; HYDROCARBON; HYDROGEN; HYDROPEROXOIRON; IRON DERIVATIVE; IRON OXENE; IRON OXIDE; METAL CHELATE; METALLOPORPHYRIN; MICROPEROXIDASE 8; OXENOID; OXIDIZING AGENT; OXYGEN; THREONINE; UNCLASSIFIED DRUG;

BIOTRANSFORMATION; CATALYSIS; CHEMICAL BOND; CHEMICAL MODEL; CHEMICAL STRUCTURE; COMPARATIVE STUDY; DENSITY FUNCTIONAL THEORY; ENZYME ACTIVE SITE; ENZYME KINETICS; ENZYME MECHANISM; ENZYME SUBSTRATE; GENETIC ENGINEERING; HYDROXYLATION; ISOTOPE PARTITIONING; MOLECULAR MECHANICS; MOLECULAR MODEL; MUTAGENESIS; OXIDATION; PRIORITY JOURNAL; PROTEIN MODIFICATION; REVIEW;

ANIMALS; CATALYSIS; CYTOCHROME P-450 ENZYME SYSTEM; FERRIC COMPOUNDS; HEME; HEMIN; HUMANS; HYDROXYLATION; IRON; MODELS, MOLECULAR; OXIDATION-REDUCTION; OXYGEN; THERMODYNAMICS;

EID: 9744265664     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1432-1033.2004.04380.x     Document Type: Review

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