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Volumn 29, Issue 7, 1996, Pages 322-330

Bleomycins: A Structural Model for Specificity, Binding, and Double Strand Cleavage

Author keywords

[No Author keywords available]

Indexed keywords


EID: 0002746148     PISSN: 00014842     EISSN: None     Source Type: Journal    
DOI: 10.1021/ar9501333     Document Type: Article
Times cited : (217)

References (120)
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    • Umezawa, H.1
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    • and references therein
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    • Dunitz, J. D., Hemmerich, P., Jørgensen, C. K., Reiner, D., Goodenough, J. B., Ibers, J. A., Neilands, J. B., Williams, R. J. P., Eds.; Springer-Verlag: New York
    • Umezawa, H.; Takita, T. In Structure and Bonding; Dunitz, J. D., Hemmerich, P., Jørgensen, C. K., Reiner, D., Goodenough, J. B., Ibers, J. A., Neilands, J. B., Williams, R. J. P., Eds.; Springer-Verlag: New York, 1980; Vol. 40, pp 73-99.
    • (1980) Structure and Bonding , vol.40 , pp. 73-99
    • Umezawa, H.1    Takita, T.2
  • 38
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    • Ph.D. Thesis, University of Maryland, College Park, MD
    • (b) Zhang, G. Ph.D. Thesis, University of Maryland, College Park, MD, 1993.
    • (1993)
    • Zhang, G.1
  • 71
    • 0004878969 scopus 로고
    • Eichhorn, G. L., Marzilli, L. G., Eds.; Elsevier Biomedical: New York
    • (b) Dabrowiak, J. C. In Advanced Inorganic Biochemistry; Eichhorn, G. L., Marzilli, L. G., Eds.; Elsevier Biomedical: New York, 1982; Vol. 4, pp 69-113.
    • (1982) Advanced Inorganic Biochemistry , vol.4 , pp. 69-113
    • Dabrowiak, J.C.1
  • 77
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    • note
    • (a) Pseudotetrapeptide A includes A, P, H, and V moieties of BLM in Figure 1; PMA is 2-[[N-(aminoethyl)amino]methyl]-4-[N-[2-(4-imidazolyl)ethyl]carbamoyl]-5- bromopyrimidine.
  • 78
    • 85081464457 scopus 로고    scopus 로고
    • note
    • (b) Although neither of these compounds possesses a carbamoyl ligand, these studies substantiate the feasibility of the primary amine as an axial ligand to the cobalt. In addition, to our knowledge, no crystallographic examples have been reported in which a carbamoyl group serves as an axial ligand to cobalt.
  • 101
    • 0002624342 scopus 로고
    • 13C line widths is also observed with ZnBLM. In light of this work and recent crystallographic evidence of a trigonal-bipyramidal structure of a ZnBLM model compound (Kurosaki, H.; Hayashi, K.; Ishikawa, Y.; Goto, M. Chem. Lett. 1995, 8, 691-692), the ligand coordination and exchange behavior in ZnBLM need to be reinvestigated.
    • (1995) Chem. Lett. , vol.8 , pp. 691-692
    • Kurosaki, H.1    Hayashi, K.2    Ishikawa, Y.3    Goto, M.4
  • 102
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    • note
    • 26e The reasons for the differences observed when III interacts with different oligonucleotides remain to be explained.
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    • Ph.D. Thesis, Massachusetts Institute of Technology. Cambridge, MA
    • (c) Absalon, M. J. Ph.D. Thesis, Massachusetts Institute of Technology. Cambridge, MA, 1994.
    • (1994)
    • Absalon, M.J.1
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    • 85081468896 scopus 로고    scopus 로고
    • note
    • 58a With the binding mode shown in Figure 5, a single molecule of BLM could not catalyze this cleavage.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.