Understanding the role of the essential Asp251 in cytochrome P450cam using site-directed mutagenesis, crystallography, and kinetic solvent isotope effect

Biochemistry

Volumn 37, Issue 26, 1998, Pages 9211-9219

  Vidakovic, Momcilo ^a   Sligar, Stephen G ^a   Li, Huiying ^b   Poulos, Thomas L ^b  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC ACID; CARBOXYLIC ACID DERIVATIVE; CYTOCHROME P450; IRON; OXYGEN;

ARTICLE; BINDING SITE; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ANALYSIS; GENE MUTATION; PRIORITY JOURNAL; PROTEIN METABOLISM; PROTON TRANSPORT; SITE DIRECTED MUTAGENESIS;

ASPARAGINE; ASPARTIC ACID; CAMPHOR 5-MONOOXYGENASE; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; DEUTERIUM OXIDE; ELECTRON TRANSPORT; FREEZING; HYDROGEN-ION CONCENTRATION; KINETICS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTONS; SOLVENTS;

PROTIUM;

EID: 0032581042     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi980189f     Document Type: Article

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