Crystal structure of naphthalene dioxygenase: Side-on binding of dioxygen to iron

Science

Volumn 299, Issue 5609, 2003, Pages 1039-1042

  Karlsson, Andreas ^a   Parales, Juanito V ^b   Parales, Rebecca E ^b   Gibson, David T ^b   Eklund, Hans ^a   Ramaswamy, S ^c  

^a SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^b UNIVERSITY OF IOWA   (United States)

^c UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CHEMICAL BONDS; CRYSTAL STRUCTURE; IRON; OXYGEN; SPECTROSCOPIC ANALYSIS; STEREOCHEMISTRY;

SIDE-ON BINDING;

ENZYMES;

BACTERIAL ENZYME; IRON; NAPHTHALENE DIOXYGENASE; OXYGEN; UNCLASSIFIED DRUG;

CRYSTAL STRUCTURE; IRON; NAPHTHALENE; OXYGEN;

ARTICLE; CALCULATION; CATALYSIS; CHEMICAL BINDING; COMPLEX FORMATION; CRYSTAL STRUCTURE; ELECTRON SPIN RESONANCE; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS; SPECTROSCOPY; STEREOSPECIFICITY; X RAY CRYSTALLOGRAPHY;

BINDING SITES; CATALYSIS; CHEMISTRY, PHYSICAL; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; HYDROXYLATION; INDOLES; IRON; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MULTIENZYME COMPLEXES; NAPHTHALENES; OXIDATION-REDUCTION; OXYGEN; OXYGENASES; PROTEIN CONFORMATION; PROTONS; PSEUDOMONAS; STEREOISOMERISM;

BACTERIA (MICROORGANISMS); NEGIBACTERIA; PSEUDOMONAS;

EID: 0347264753     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1078020     Document Type: Article

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32. We thank J. Hajdu and his group at Uppsala for help in carrying out several experiments; M. Niebergall for helpful tips; several synchrotron stations and beam lines for help with data collection (European Synchrotron Radiation Facility, Grenoble, Max Lab, Lund, and Industrial Macromolecular Crystallography Association-Collaborative Access Team, Advanced Photon Source); and J. Lipscomb for helpful discussions. Supported by the Swedish Research Council for Environment, Agricultural Science, and Spatial Planning (H.E. and S.R.), the Swedish Research Council (H.E.), and U.S. Public Health Service grants GM62904 (S.R.) and GM29909 (D.T.G.).