How Does Product Isotope Effect Prove the Operation of a Two-State "Rebound" Mechanism in C-H Hydroxylation by Cytochrome P450?

Journal of the American Chemical Society

Volumn 125, Issue 43, 2003, Pages 13024-13025

  Kumar, Devesh ^a   De Visser, Samuël P ^a   Shaik, Sason ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; ISOTOPE; RADICAL;

ARTICLE; COMPLEX FORMATION; DENSITY FUNCTIONAL THEORY; HYDROGEN BOND; HYDROXYLATION; REBOUND;

CYCLOPROPANES; CYTOCHROME P-450 ENZYME SYSTEM; DEUTERIUM; DEUTERIUM EXCHANGE MEASUREMENT; FERRIC COMPOUNDS; HYDROGEN PEROXIDE; HYDROXYLATION; KINETICS; THERMODYNAMICS;

EID: 0142244914     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja036906x     Document Type: Article

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