Radical Clock Substrates, Their C-H Hydroxylation Mechanism by Cytochrome P450, and Other Reactivity Patterns: What Does Theory Reveal about the Clocks' Behavior?

Journal of the American Chemical Society

Volumn 126, Issue 6, 2004, Pages 1907-1920

  Kumar, Devesh ^a   De Visser, Samuël P ^a   Sharma, Pankaz K ^a   Cohen, Shimrit ^a   Shaik, Sason ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC COMPOUNDS; COMPUTATIONAL METHODS; HYDROXYLATION; METABOLISM; METHANE;

CARBOCATIONS; DEUTERATION; METABOLIC SWITCHING;

ENZYMES;

2 PHENYLISOPROPYLCYCLOPROPANE; 2 PHENYLMETHYLCYCLOPROPANE; ALCOHOL; ALKYL GROUP; CARBOCATION; CARBON; CATION; CYCLOPROPANE DERIVATIVE; CYTOCHROME P450; DEUTERIUM; HYDROGEN; ISOTOPE; METHANE; METHYL GROUP; PHENYL GROUP; RADICAL; UNCLASSIFIED DRUG;

ARTICLE; CALCULATION; CHEMOREACTIVITY; DEHYDROGENATION; ENERGY TRANSFER; EXPERIMENT; HYDROGEN ABSTRACTION; HYDROXYLATION; ISOTOPE EFFECT; PREDICTION; REACTION ANALYSIS; THEORY;

EID: 1242291810     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja039439s     Document Type: Article

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