Microperoxidase/H2O2-catalyzed aromatic hydroxylation proceeds by a cytochrome-P-450-type oxygen-transfer reaction mechanism

European Journal of Biochemistry

Volumn 240, Issue 1, 1996, Pages 232-238

  Osman, Ahmed M ^a  

^a WAGENINGEN UNIVERSITY   (Netherlands)

Author keywords

Aromatic hydroxylation; Microperoxidase 8; Oxygen transfer; Reaction mechanism

Indexed keywords

ANILINE DERIVATIVE; CYTOCHROME P450 ISOENZYME; PHENOL DERIVATIVE; 4 AMINOPHENOL; 4-AMINOPHENOL; AMINOPHENOL DERIVATIVE; ANILINE; ASCORBIC ACID; CYTOCHROME C; CYTOCHROME P450; HYDROGEN PEROXIDE; HYDROXYL RADICAL; OXYGEN; PEROXIDASE; SUPEROXIDE;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; HYDROXYLATION; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; REACTION ANALYSIS; ANIMAL; HEART MITOCHONDRION; HORSE; KINETICS; MASS FRAGMENTOGRAPHY; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PH;

AMINOPHENOLS; ANILINE COMPOUNDS; ANIMALS; ASCORBIC ACID; CYTOCHROME C GROUP; CYTOCHROME P-450 ENZYME SYSTEM; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HORSES; HYDROGEN PEROXIDE; HYDROGEN-ION CONCENTRATION; HYDROXYL RADICAL; HYDROXYLATION; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MITOCHONDRIA, HEART; OXYGEN ISOTOPES; PEROXIDASES; SUPEROXIDES;

EID: 0029664872     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1432-1033.1996.0232h.x     Document Type: Article

References (3)

1. Aron, J., Baldwin, D. A., Marques, M. M., Pratt, J. M. & Adams, P. A. (1986) Hemes and hemoproteins. 1. Preparation and analysis of the heme-containing octapeptide (microperoxidase-8) and identification of the monomeric form in aqueous solution, J. Inorg. Biochem. 27, 227-243.
2. 2 by peroxidases: kinetic studies on a model system, FEBS Lett. 183, 309-312.
3. Baldwin, D. A., Marques, M. M. & Pratt, J. M. (1987) Hemes and hemoproteins. 5 : Kinetics of the peroxidatic activity of microperoxidase8: model for the peroxidase enzymes, J. Inorg. Biochem. 30, 203-217.