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Volumn 118, Issue 6, 1996, Pages 1281-1294

Solution structure of Co·Bleomycin A2 green complexed with d(CCAGGCCTGG)

Author keywords

[No Author keywords available]

Indexed keywords

BLEOMYCIN A2 COBALT; BLEOMYCIN DERIVATIVE; UNCLASSIFIED DRUG;

EID: 0029670556     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja952497w     Document Type: Article
Times cited : (117)

References (68)
  • 2
    • 0000166202 scopus 로고
    • Cassady, J. M., Douros, J., Eds.; Academic Press, Inc.: New York
    • (b) Umezawa, H. In Anticancer agents based on natural product models: Cassady, J. M., Douros, J., Eds.; Academic Press, Inc.: New York, 1980; Vol. 16, pp 147-166.
    • (1980) Anticancer Agents Based on Natural Product Models , vol.16 , pp. 147-166
    • Umezawa, H.1
  • 33
    • 13344263581 scopus 로고    scopus 로고
    • note
    • 2O ligand has replaced the hydroperoxide ligand) demonstrate that it binds 1 in an analogous fashion to CoBLM A2 green. The exchangeable proton, however, at 8.89 ppm is absent.
  • 46
    • 13344265115 scopus 로고    scopus 로고
    • note
    • 7 (Figure 7c).
  • 49
    • 13344256671 scopus 로고    scopus 로고
    • note
    • (a) Although the penultimate thiazolium ring as a whole is partially stacked between the bases of C6 and C7, the B-H5′ proton is positioned almost directly below the base of C6, which causes the upfield chemical shift change (0.61 ppm) due to the ring current effect. The B-H5 proton is completely stacked between G14 and G15 (Figure 9) and thus experiences even larger upfield chemical shift change (0.91 ppm). (b) The bithiazole tail is sufficiently flexible in the free CoBLM A2 green such that the orientation of the thiazolium rings relative to one another is not discernible.
  • 58
    • 13344271788 scopus 로고
    • Ph.D. Thesis, University of Maryland
    • Zhang, G. Ph.D. Thesis, University of Maryland, 1993.
    • (1993)
    • Zhang, G.1
  • 59
    • 13344252664 scopus 로고    scopus 로고
    • note
    • The H bond distance is between the proton and the H bond acceptor atom in all cases. The H bond angle is determined by the donor atom, the hydrogen, and the acceptor atom.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.