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Journal of the American Chemical Society

Volumn 124, Issue 21, 2002, Pages 6020-6027

Revisiting the mechanism of P450 enzymes with the radical clocks norcarane and spiro[2,5]octane

(5) Auclair, Karine a Hu, Zhengbo a Little, Dorothy M a Ortiz de Montellano, Paul R b Groves, John T a

a PRINCETON UNIVERSITY (United States)

b UNIVERSITY OF CALIFORNIA (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RADICAL REARRANGEMENT;

BACTERIA; ENZYMES; HYDROXYLATION; OXIDATION;

HYDROCARBONS;

ALKANE DERIVATIVE; CYTOCHROME P450; CYTOCHROME P450 2B1; CYTOCHROME P450 2E1; NORCARANE; OCTANE; SPIRO[2.5]OCTANE; UNCLASSIFIED DRUG;

ARTICLE; DISSOCIATION; DRUG MECHANISM; DRUG STRUCTURE; ENZYME MECHANISM; HYDROXYLATION; MOLECULAR CLOCK; OXIDATION; REACTION ANALYSIS; REBOUND;

ANIMALS; BICYCLO COMPOUNDS; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; HYDROXYLATION; ISOENZYMES; KINETICS; OCTANES; OXIDATION-REDUCTION; RATS; SPIRO COMPOUNDS; TERPENES;

EID: 0037140738 PISSN: 00027863 EISSN: None Source Type: Journal
DOI: 10.1021/ja025608h Document Type: Article

Times cited : (147)

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