Kinetic isotope effects implicate two electrophilic oxidants in cytochrome P450-catalyzed hydroxylations

Journal of the American Chemical Society

Volumn 125, Issue 20, 2003, Pages 6064-6065

  Newcomb, Martin ^a,b   Aebisher, David ^a,b   Shen, Runnan ^a,b   Chandrasena, R Esala P ^a,b   Hollenberg, Paul F ^a,b   Coon, Minor J ^a,b  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; IRON; ISOTOPE; OXIDIZING AGENT; OXYGEN;

ARTICLE; CATALYSIS; CHEMICAL REACTION; CHEMICAL STRUCTURE; CHIRALITY; ENANTIOMER; ENZYME MECHANISM; ENZYME SUBSTRATE; EPOXIDATION; GAS CHROMATOGRAPHY; HYDROXYLATION; KINETICS; OXIDATION; PROTEIN FAMILY; PROTON TRANSPORT; REACTION ANALYSIS;

ALCOHOLS; CATALYSIS; CYTOCHROME P-450 ENZYME SYSTEM; DEUTERIUM; HYDROXYLATION; KINETICS; OXIDANTS;

EID: 0038288845     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0343858     Document Type: Article

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