-
1
-
-
84958539762
-
IL-10 in humans: lessons from the gut, IL-10/IL-10 receptor deficiencies, and IL-10 polymorphisms
-
Engelhardt, K.R., Grimbacher, B., IL-10 in humans: lessons from the gut, IL-10/IL-10 receptor deficiencies, and IL-10 polymorphisms. Curr. Top. Microbiol. Immunol. 380 (2014), 1–18.
-
(2014)
Curr. Top. Microbiol. Immunol.
, vol.380
, pp. 1-18
-
-
Engelhardt, K.R.1
Grimbacher, B.2
-
2
-
-
84958528789
-
The regulation of IL-10 expression
-
Gabrysova, L., et al. The regulation of IL-10 expression. Curr. Top. Microbiol. Immunol. 380 (2014), 157–190.
-
(2014)
Curr. Top. Microbiol. Immunol.
, vol.380
, pp. 157-190
-
-
Gabrysova, L.1
-
3
-
-
0035062021
-
Interleukin-10 and the interleukin-10 receptor
-
Moore, K.W., et al. Interleukin-10 and the interleukin-10 receptor. Annu. Rev. Immunol. 19 (2001), 683–765.
-
(2001)
Annu. Rev. Immunol.
, vol.19
, pp. 683-765
-
-
Moore, K.W.1
-
4
-
-
47249134619
-
Strategies for use of IL-10 or its antagonists in human disease
-
O'Garra, A., et al. Strategies for use of IL-10 or its antagonists in human disease. Immunol. Rev. 223 (2008), 114–131.
-
(2008)
Immunol. Rev.
, vol.223
, pp. 114-131
-
-
O'Garra, A.1
-
5
-
-
79953048089
-
Regulation and functions of the IL-10 family of cytokines in inflammation and disease
-
Ouyang, W., et al. Regulation and functions of the IL-10 family of cytokines in inflammation and disease. Annu. Rev. Immunol. 29 (2011), 71–109.
-
(2011)
Annu. Rev. Immunol.
, vol.29
, pp. 71-109
-
-
Ouyang, W.1
-
6
-
-
77649184739
-
The regulation of IL-10 production by immune cells
-
Saraiva, M., O'Garra, A., The regulation of IL-10 production by immune cells. Nat. Rev. Immunol. 10:3 (2010), 170–181.
-
(2010)
Nat. Rev. Immunol.
, vol.10
, Issue.3
, pp. 170-181
-
-
Saraiva, M.1
O'Garra, A.2
-
7
-
-
85060906306
-
Targeting IL-10 family cytokines for the treatment of human diseases
-
Wang, X., et al. Targeting IL-10 family cytokines for the treatment of human diseases. Cold Spring Harb. Perspect. Biol., 11(2), 2019.
-
(2019)
Cold Spring Harb. Perspect. Biol.
, vol.11
, Issue.2
-
-
Wang, X.1
-
8
-
-
0027521572
-
Interleukin-10-deficient mice develop chronic enterocolitis
-
Kuhn, R., et al. Interleukin-10-deficient mice develop chronic enterocolitis. Cell 75:2 (1993), 263–274.
-
(1993)
Cell
, vol.75
, Issue.2
, pp. 263-274
-
-
Kuhn, R.1
-
9
-
-
44449096726
-
IL-10: the master regulator of immunity to infection
-
Couper, K.N., Blount, D.G., Riley, E.M., IL-10: the master regulator of immunity to infection. J. Immunol. 180:9 (2008), 5771–5777.
-
(2008)
J. Immunol.
, vol.180
, Issue.9
, pp. 5771-5777
-
-
Couper, K.N.1
Blount, D.G.2
Riley, E.M.3
-
10
-
-
79955102870
-
The role of IL-10 in immune regulation during M. tuberculosis infection
-
Redford, P.S., Murray, P.J., O'Garra, A., The role of IL-10 in immune regulation during M. tuberculosis infection. Mucosal Immunol. 4:3 (2011), 261–270.
-
(2011)
Mucosal Immunol.
, vol.4
, Issue.3
, pp. 261-270
-
-
Redford, P.S.1
Murray, P.J.2
O'Garra, A.3
-
11
-
-
0034897552
-
Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site
-
Josephson, K., Logsdon, N.J., Walter, M.R., Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site. Immunity 15:1 (2001), 35–46.
-
(2001)
Immunity
, vol.15
, Issue.1
, pp. 35-46
-
-
Josephson, K.1
Logsdon, N.J.2
Walter, M.R.3
-
12
-
-
78649744210
-
Structural analysis of cytokines comprising the IL-10 family
-
Zdanov, A., Structural analysis of cytokines comprising the IL-10 family. Cytokine Growth Factor Rev. 21:5 (2010), 325–330.
-
(2010)
Cytokine Growth Factor Rev.
, vol.21
, Issue.5
, pp. 325-330
-
-
Zdanov, A.1
-
13
-
-
0027420575
-
A receptor for interleukin 10 is related to interferon receptors
-
Ho, A.S., et al. A receptor for interleukin 10 is related to interferon receptors. Proc. Natl. Acad. Sci. U. S. A. 90:23 (1993), 11267–11271.
-
(1993)
Proc. Natl. Acad. Sci. U. S. A.
, vol.90
, Issue.23
, pp. 11267-11271
-
-
Ho, A.S.1
-
14
-
-
0030799157
-
Identification and functional characterization of a second chain of the interleukin-10 receptor complex
-
Kotenko, S.V., et al. Identification and functional characterization of a second chain of the interleukin-10 receptor complex. EMBO J. 16:19 (1997), 5894–5903.
-
(1997)
EMBO J.
, vol.16
, Issue.19
, pp. 5894-5903
-
-
Kotenko, S.V.1
-
15
-
-
0027441138
-
Characterization of interleukin-10 receptors on human and mouse cells
-
Tan, J.C., et al. Characterization of interleukin-10 receptors on human and mouse cells. J. Biol. Chem. 268:28 (1993), 21053–21059.
-
(1993)
J. Biol. Chem.
, vol.268
, Issue.28
, pp. 21053-21059
-
-
Tan, J.C.1
-
16
-
-
33845948477
-
Conformational changes mediate interleukin-10 receptor 2 (IL-10R2) binding to IL-10 and assembly of the signaling complex
-
Yoon, S.I., et al. Conformational changes mediate interleukin-10 receptor 2 (IL-10R2) binding to IL-10 and assembly of the signaling complex. J. Biol. Chem. 281:46 (2006), 35088–35096.
-
(2006)
J. Biol. Chem.
, vol.281
, Issue.46
, pp. 35088-35096
-
-
Yoon, S.I.1
-
17
-
-
77952610856
-
Structure and mechanism of receptor sharing by the IL-10R2 common chain
-
Yoon, S.I., et al. Structure and mechanism of receptor sharing by the IL-10R2 common chain. Structure 18:5 (2010), 638–648.
-
(2010)
Structure
, vol.18
, Issue.5
, pp. 638-648
-
-
Yoon, S.I.1
-
18
-
-
0029148046
-
Functional regions of the mouse interleukin-10 receptor cytoplasmic domain
-
Ho, A.S., et al. Functional regions of the mouse interleukin-10 receptor cytoplasmic domain. Mol. Cell. Biol. 15:9 (1995), 5043–5053.
-
(1995)
Mol. Cell. Biol.
, vol.15
, Issue.9
, pp. 5043-5053
-
-
Ho, A.S.1
-
19
-
-
0029118395
-
IL-10 induces the tyrosine phosphorylation of tyk2 and Jak1 and the differential assembly of STAT1 alpha and STAT3 complexes in human T cells and monocytes
-
Finbloom, D.S., Winestock, K.D., IL-10 induces the tyrosine phosphorylation of tyk2 and Jak1 and the differential assembly of STAT1 alpha and STAT3 complexes in human T cells and monocytes. J. Immunol. 155:3 (1995), 1079–1090.
-
(1995)
J. Immunol.
, vol.155
, Issue.3
, pp. 1079-1090
-
-
Finbloom, D.S.1
Winestock, K.D.2
-
20
-
-
13344282731
-
Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway
-
Meraz, M.A., et al. Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell 84:3 (1996), 431–442.
-
(1996)
Cell
, vol.84
, Issue.3
, pp. 431-442
-
-
Meraz, M.A.1
-
21
-
-
0033034365
-
Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils
-
Takeda, K., et al. Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity 10:1 (1999), 39–49.
-
(1999)
Immunity
, vol.10
, Issue.1
, pp. 39-49
-
-
Takeda, K.1
-
22
-
-
33744907022
-
Tyk2 negatively regulates adaptive Th1 immunity by mediating IL-10 signaling and promoting IFN-gamma-dependent IL-10 reactivation
-
Shaw, M.H., et al. Tyk2 negatively regulates adaptive Th1 immunity by mediating IL-10 signaling and promoting IFN-gamma-dependent IL-10 reactivation. J. Immunol. 176:12 (2006), 7263–7271.
-
(2006)
J. Immunol.
, vol.176
, Issue.12
, pp. 7263-7271
-
-
Shaw, M.H.1
-
23
-
-
84922479625
-
The IL-20 subfamily of cytokines--from host defence to tissue homeostasis
-
Rutz, S., Wang, X., Ouyang, W., The IL-20 subfamily of cytokines--from host defence to tissue homeostasis. Nat. Rev. Immunol. 14:12 (2014), 783–795.
-
(2014)
Nat. Rev. Immunol.
, vol.14
, Issue.12
, pp. 783-795
-
-
Rutz, S.1
Wang, X.2
Ouyang, W.3
-
24
-
-
0024408824
-
Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones
-
Fiorentino, D.F., Bond, M.W., Mosmann, T.R., Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J. Exp. Med. 170:6 (1989), 2081–2095.
-
(1989)
J. Exp. Med.
, vol.170
, Issue.6
, pp. 2081-2095
-
-
Fiorentino, D.F.1
Bond, M.W.2
Mosmann, T.R.3
-
25
-
-
0026094306
-
Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes
-
de Waal Malefyt, R., et al. Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J. Exp. Med. 174:5 (1991), 1209–1220.
-
(1991)
J. Exp. Med.
, vol.174
, Issue.5
, pp. 1209-1220
-
-
de Waal Malefyt, R.1
-
26
-
-
0030048535
-
Differential modulation of B7-1 and B7-2 isoform expression on human monocytes by cytokines which influence the development of T helper cell phenotype
-
Creery, W.D., et al. Differential modulation of B7-1 and B7-2 isoform expression on human monocytes by cytokines which influence the development of T helper cell phenotype. Eur. J. Immunol. 26:6 (1996), 1273–1277.
-
(1996)
Eur. J. Immunol.
, vol.26
, Issue.6
, pp. 1273-1277
-
-
Creery, W.D.1
-
27
-
-
0026000892
-
Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression
-
de Waal Malefyt, R., et al. Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression. J. Exp. Med. 174:4 (1991), 915–924.
-
(1991)
J. Exp. Med.
, vol.174
, Issue.4
, pp. 915-924
-
-
de Waal Malefyt, R.1
-
28
-
-
0028299069
-
Interleukin-10 inhibits B7 and intercellular adhesion molecule-1 expression on human monocytes
-
Willems, F., et al. Interleukin-10 inhibits B7 and intercellular adhesion molecule-1 expression on human monocytes. Eur. J. Immunol. 24:4 (1994), 1007–1009.
-
(1994)
Eur. J. Immunol.
, vol.24
, Issue.4
, pp. 1007-1009
-
-
Willems, F.1
-
29
-
-
25444492676
-
IL-12 family members: differential kinetics of their TLR4-mediated induction by Salmonella enteritidis and the impact of IL-10 in bone marrow-derived macrophages
-
Schuetze, N., et al. IL-12 family members: differential kinetics of their TLR4-mediated induction by Salmonella enteritidis and the impact of IL-10 in bone marrow-derived macrophages. Int. Immunol. 17:5 (2005), 649–659.
-
(2005)
Int. Immunol.
, vol.17
, Issue.5
, pp. 649-659
-
-
Schuetze, N.1
-
30
-
-
0028911482
-
Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: priming for IL-12 and tumor necrosis factor alpha production
-
D'Andrea, A., et al. Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: priming for IL-12 and tumor necrosis factor alpha production. J. Exp. Med. 181:2 (1995), 537–546.
-
(1995)
J. Exp. Med.
, vol.181
, Issue.2
, pp. 537-546
-
-
D'Andrea, A.1
-
31
-
-
79954608756
-
Memory/effector (CD45RB(lo)) CD4 T cells are controlled directly by IL-10 and cause IL-22-dependent intestinal pathology
-
Kamanaka, M., et al. Memory/effector (CD45RB(lo)) CD4 T cells are controlled directly by IL-10 and cause IL-22-dependent intestinal pathology. J. Exp. Med. 208:5 (2011), 1027–1040.
-
(2011)
J. Exp. Med.
, vol.208
, Issue.5
, pp. 1027-1040
-
-
Kamanaka, M.1
-
32
-
-
79954620910
-
Th17 cells express interleukin-10 receptor and are controlled by Foxp3(-) and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner
-
Huber, S., et al. Th17 cells express interleukin-10 receptor and are controlled by Foxp3(-) and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner. Immunity 34:4 (2011), 554–565.
-
(2011)
Immunity
, vol.34
, Issue.4
, pp. 554-565
-
-
Huber, S.1
-
33
-
-
85011049504
-
CD4(+) Th2 cells are directly regulated by IL-10 during allergic airway inflammation
-
Coomes, S.M., et al. CD4(+) Th2 cells are directly regulated by IL-10 during allergic airway inflammation. Mucosal Immunol. 10:1 (2017), 150–161.
-
(2017)
Mucosal Immunol.
, vol.10
, Issue.1
, pp. 150-161
-
-
Coomes, S.M.1
-
34
-
-
0025820460
-
IL-10: a novel cytotoxic T cell differentiation factor
-
Chen, W.F., Zlotnik, A., IL-10: a novel cytotoxic T cell differentiation factor. J. Immunol. 147:2 (1991), 528–534.
-
(1991)
J. Immunol.
, vol.147
, Issue.2
, pp. 528-534
-
-
Chen, W.F.1
Zlotnik, A.2
-
35
-
-
0026584291
-
Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes
-
Rousset, F., et al. Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes. Proc. Natl. Acad. Sci. U. S. A. 89:5 (1992), 1890–1893.
-
(1992)
Proc. Natl. Acad. Sci. U. S. A.
, vol.89
, Issue.5
, pp. 1890-1893
-
-
Rousset, F.1
-
36
-
-
79954608612
-
Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation
-
Chaudhry, A., et al. Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation. Immunity 34:4 (2011), 566–578.
-
(2011)
Immunity
, vol.34
, Issue.4
, pp. 566-578
-
-
Chaudhry, A.1
-
37
-
-
70350464351
-
Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis
-
Murai, M., et al. Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis. Nat. Immunol. 10:11 (2009), 1178–1184.
-
(2009)
Nat. Immunol.
, vol.10
, Issue.11
, pp. 1178-1184
-
-
Murai, M.1
-
38
-
-
85058925987
-
Molecular and functional heterogeneity of IL-10-producing CD4(+) T cells
-
Brockmann, L., et al. Molecular and functional heterogeneity of IL-10-producing CD4(+) T cells. Nat. Commun., 9(1), 2018, 5457.
-
(2018)
Nat. Commun.
, vol.9
, Issue.1
, pp. 5457
-
-
Brockmann, L.1
-
39
-
-
84991643976
-
Regulation of Interleukin-10 expression
-
Rutz, S., Ouyang, W., Regulation of Interleukin-10 expression. Adv. Exp. Med. Biol. 941 (2016), 89–116.
-
(2016)
Adv. Exp. Med. Biol.
, vol.941
, pp. 89-116
-
-
Rutz, S.1
Ouyang, W.2
-
40
-
-
0032536530
-
The orphan receptor CRF2-4 is an essential subunit of the interleukin 10 receptor
-
Spencer, S.D., et al. The orphan receptor CRF2-4 is an essential subunit of the interleukin 10 receptor. J. Exp. Med. 187:4 (1998), 571–578.
-
(1998)
J. Exp. Med.
, vol.187
, Issue.4
, pp. 571-578
-
-
Spencer, S.D.1
-
41
-
-
0032412057
-
Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice
-
Sellon, R.K., et al. Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice. Infect. Immun. 66:11 (1998), 5224–5231.
-
(1998)
Infect. Immun.
, vol.66
, Issue.11
, pp. 5224-5231
-
-
Sellon, R.K.1
-
42
-
-
0034116557
-
Antibiotic therapy attenuates colitis in interleukin 10 gene-deficient mice
-
Madsen, K.L., et al. Antibiotic therapy attenuates colitis in interleukin 10 gene-deficient mice. Gastroenterology 118:6 (2000), 1094–1105.
-
(2000)
Gastroenterology
, vol.118
, Issue.6
, pp. 1094-1105
-
-
Madsen, K.L.1
-
43
-
-
55049111426
-
Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility
-
Franke, A., et al. Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility. Nat. Genet. 40:11 (2008), 1319–1323.
-
(2008)
Nat. Genet.
, vol.40
, Issue.11
, pp. 1319-1323
-
-
Franke, A.1
-
44
-
-
70350453460
-
IL-10 and TNF-alpha promoter haplotypes are associated with childhood Crohn's disease location
-
Sanchez, R., et al. IL-10 and TNF-alpha promoter haplotypes are associated with childhood Crohn's disease location. World J. Gastroenterol. 15:30 (2009), 3776–3782.
-
(2009)
World J. Gastroenterol.
, vol.15
, Issue.30
, pp. 3776-3782
-
-
Sanchez, R.1
-
45
-
-
78649489009
-
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
-
Franke, A., et al. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat. Genet. 42:12 (2010), 1118–1125.
-
(2010)
Nat. Genet.
, vol.42
, Issue.12
, pp. 1118-1125
-
-
Franke, A.1
-
46
-
-
84873733916
-
IL-10R polymorphisms are associated with very-early-onset ulcerative colitis
-
Moran, C.J., et al. IL-10R polymorphisms are associated with very-early-onset ulcerative colitis. Inflamm. Bowel Dis. 19:1 (2013), 115–123.
-
(2013)
Inflamm. Bowel Dis.
, vol.19
, Issue.1
, pp. 115-123
-
-
Moran, C.J.1
-
47
-
-
70949087383
-
Inflammatory bowel disease and mutations affecting the interleukin-10 receptor
-
Glocker, E.O., et al. Inflammatory bowel disease and mutations affecting the interleukin-10 receptor. N. Engl. J. Med. 361:21 (2009), 2033–2045.
-
(2009)
N. Engl. J. Med.
, vol.361
, Issue.21
, pp. 2033-2045
-
-
Glocker, E.O.1
-
48
-
-
79961023788
-
Defective IL10 signaling defining a subgroup of patients with inflammatory bowel disease
-
Begue, B., et al. Defective IL10 signaling defining a subgroup of patients with inflammatory bowel disease. Am. J. Gastroenterol. 106:8 (2011), 1544–1555.
-
(2011)
Am. J. Gastroenterol.
, vol.106
, Issue.8
, pp. 1544-1555
-
-
Begue, B.1
-
49
-
-
84864118162
-
Exome sequencing identifies novel compound heterozygous mutations of IL-10 receptor 1 in neonatal-onset Crohn's disease
-
Mao, H., et al. Exome sequencing identifies novel compound heterozygous mutations of IL-10 receptor 1 in neonatal-onset Crohn's disease. Genes Immun. 13:5 (2012), 437–442.
-
(2012)
Genes Immun.
, vol.13
, Issue.5
, pp. 437-442
-
-
Mao, H.1
-
50
-
-
84864206050
-
Loss of interleukin-10 signaling and infantile inflammatory bowel disease: implications for diagnosis and therapy
-
Kotlarz, D., et al. Loss of interleukin-10 signaling and infantile inflammatory bowel disease: implications for diagnosis and therapy. Gastroenterology 143:2 (2012), 347–355.
-
(2012)
Gastroenterology
, vol.143
, Issue.2
, pp. 347-355
-
-
Kotlarz, D.1
-
51
-
-
84883654160
-
Interleukin-10 receptor mutations in children with neonatal-onset Crohn's disease and intractable ulcerating enterocolitis
-
Shim, J.O., et al. Interleukin-10 receptor mutations in children with neonatal-onset Crohn's disease and intractable ulcerating enterocolitis. Eur. J. Gastroenterol. Hepatol. 25:10 (2013), 1235–1240.
-
(2013)
Eur. J. Gastroenterol. Hepatol.
, vol.25
, Issue.10
, pp. 1235-1240
-
-
Shim, J.O.1
-
52
-
-
84890324714
-
Synergistic effect of interleukin-10-receptor variants in a case of early-onset ulcerative colitis
-
Galatola, M., et al. Synergistic effect of interleukin-10-receptor variants in a case of early-onset ulcerative colitis. World J. Gastroenterol. 19:46 (2013), 8659–8670.
-
(2013)
World J. Gastroenterol.
, vol.19
, Issue.46
, pp. 8659-8670
-
-
Galatola, M.1
-
53
-
-
84898056696
-
Very early onset inflammatory bowel disease associated with aberrant trafficking of IL-10R1 and cure by T cell replete haploidentical bone marrow transplantation
-
Murugan, D., et al. Very early onset inflammatory bowel disease associated with aberrant trafficking of IL-10R1 and cure by T cell replete haploidentical bone marrow transplantation. J. Clin. Immunol. 34:3 (2014), 331–339.
-
(2014)
J. Clin. Immunol.
, vol.34
, Issue.3
, pp. 331-339
-
-
Murugan, D.1
-
54
-
-
84958527429
-
Control of intestinal inflammation by interleukin-10
-
Kole, A., Maloy, K.J., Control of intestinal inflammation by interleukin-10. Curr. Top. Microbiol. Immunol. 380 (2014), 19–38.
-
(2014)
Curr. Top. Microbiol. Immunol.
, vol.380
, pp. 19-38
-
-
Kole, A.1
Maloy, K.J.2
-
55
-
-
70149098555
-
Nonredundant roles for B cell-derived IL-10 in immune counter-regulation
-
Madan, R., et al. Nonredundant roles for B cell-derived IL-10 in immune counter-regulation. J. Immunol. 183:4 (2009), 2312–2320.
-
(2009)
J. Immunol.
, vol.183
, Issue.4
, pp. 2312-2320
-
-
Madan, R.1
-
56
-
-
33845574337
-
Interleukin-10 derived from macrophages and/or neutrophils regulates the inflammatory response to LPS but not the response to CpG DNA
-
Siewe, L., et al. Interleukin-10 derived from macrophages and/or neutrophils regulates the inflammatory response to LPS but not the response to CpG DNA. Eur. J. Immunol. 36:12 (2006), 3248–3255.
-
(2006)
Eur. J. Immunol.
, vol.36
, Issue.12
, pp. 3248-3255
-
-
Siewe, L.1
-
57
-
-
84900448316
-
Macrophage-restricted interleukin-10 receptor deficiency, but not IL-10 deficiency, causes severe spontaneous colitis
-
Zigmond, E., et al. Macrophage-restricted interleukin-10 receptor deficiency, but not IL-10 deficiency, causes severe spontaneous colitis. Immunity 40:5 (2014), 720–733.
-
(2014)
Immunity
, vol.40
, Issue.5
, pp. 720-733
-
-
Zigmond, E.1
-
58
-
-
9244237038
-
T cell-specific inactivation of the interleukin 10 gene in mice results in enhanced T cell responses but normal innate responses to lipopolysaccharide or skin irritation
-
Roers, A., et al. T cell-specific inactivation of the interleukin 10 gene in mice results in enhanced T cell responses but normal innate responses to lipopolysaccharide or skin irritation. J. Exp. Med. 200:10 (2004), 1289–1297.
-
(2004)
J. Exp. Med.
, vol.200
, Issue.10
, pp. 1289-1297
-
-
Roers, A.1
-
59
-
-
41549159660
-
Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces
-
Rubtsov, Y.P., et al. Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. Immunity 28:4 (2008), 546–558.
-
(2008)
Immunity
, vol.28
, Issue.4
, pp. 546-558
-
-
Rubtsov, Y.P.1
-
60
-
-
85061712972
-
c-Maf-dependent Treg cell control of intestinal TH17 cells and IgA establishes host-microbiota homeostasis
-
Neumann, C., et al. c-Maf-dependent Treg cell control of intestinal TH17 cells and IgA establishes host-microbiota homeostasis. Nat. Immunol. 20:4 (2019), 471–481.
-
(2019)
Nat. Immunol.
, vol.20
, Issue.4
, pp. 471-481
-
-
Neumann, C.1
-
61
-
-
0027517545
-
Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice
-
Powrie, F., et al. Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice. Int. Immunol. 5:11 (1993), 1461–1471.
-
(1993)
Int. Immunol.
, vol.5
, Issue.11
, pp. 1461-1471
-
-
Powrie, F.1
-
62
-
-
0033523607
-
An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation
-
Asseman, C., et al. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J. Exp. Med. 190:7 (1999), 995–1004.
-
(1999)
J. Exp. Med.
, vol.190
, Issue.7
, pp. 995-1004
-
-
Asseman, C.1
-
63
-
-
50149092873
-
IL-23 and Th17 cytokines in intestinal homeostasis
-
Maloy, K.J., Kullberg, M.C., IL-23 and Th17 cytokines in intestinal homeostasis. Mucosal Immunol. 1:5 (2008), 339–349.
-
(2008)
Mucosal Immunol.
, vol.1
, Issue.5
, pp. 339-349
-
-
Maloy, K.J.1
Kullberg, M.C.2
-
64
-
-
85047955282
-
Essential immunologic orchestrators of intestinal homeostasis
-
Zhou, L., Sonnenberg, G.F., Essential immunologic orchestrators of intestinal homeostasis. Sci. Immunol., 3(20), 2018.
-
(2018)
Sci. Immunol.
, vol.3
, Issue.20
-
-
Zhou, L.1
Sonnenberg, G.F.2
-
65
-
-
79960919901
-
Control of TH17 cells occurs in the small intestine
-
Esplugues, E., et al. Control of TH17 cells occurs in the small intestine. Nature 475:7357 (2011), 514–518.
-
(2011)
Nature
, vol.475
, Issue.7357
, pp. 514-518
-
-
Esplugues, E.1
-
66
-
-
84929955331
-
Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation
-
Gagliani, N., et al. Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation. Nature 523:7559 (2015), 221–225.
-
(2015)
Nature
, vol.523
, Issue.7559
, pp. 221-225
-
-
Gagliani, N.1
-
67
-
-
85014699932
-
IL-10 receptor signaling is essential for TR1 cell function in vivo
-
Brockmann, L., et al. IL-10 receptor signaling is essential for TR1 cell function in vivo. J. Immunol. 198:3 (2017), 1130–1141.
-
(2017)
J. Immunol.
, vol.198
, Issue.3
, pp. 1130-1141
-
-
Brockmann, L.1
-
68
-
-
70049113279
-
CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner
-
Chaudhry, A., et al. CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner. Science 326:5955 (2009), 986–991.
-
(2009)
Science
, vol.326
, Issue.5955
, pp. 986-991
-
-
Chaudhry, A.1
-
69
-
-
84939793511
-
Intestinal monocyte-derived macrophages control commensal-specific Th17 responses
-
Panea, C., et al. Intestinal monocyte-derived macrophages control commensal-specific Th17 responses. Cell Rep. 12:8 (2015), 1314–1324.
-
(2015)
Cell Rep.
, vol.12
, Issue.8
, pp. 1314-1324
-
-
Panea, C.1
-
70
-
-
84902581045
-
Intestinal IgA production and its role in host-microbe interaction
-
Gutzeit, C., Magri, G., Cerutti, A., Intestinal IgA production and its role in host-microbe interaction. Immunol. Rev. 260:1 (2014), 76–85.
-
(2014)
Immunol. Rev.
, vol.260
, Issue.1
, pp. 76-85
-
-
Gutzeit, C.1
Magri, G.2
Cerutti, A.3
-
71
-
-
84904384753
-
Foxp3(+) T cells regulate immunoglobulin a selection and facilitate diversification of bacterial species responsible for immune homeostasis
-
Kawamoto, S., et al. Foxp3(+) T cells regulate immunoglobulin a selection and facilitate diversification of bacterial species responsible for immune homeostasis. Immunity 41:1 (2014), 152–165.
-
(2014)
Immunity
, vol.41
, Issue.1
, pp. 152-165
-
-
Kawamoto, S.1
-
72
-
-
0026563156
-
Interleukin 10 and transforming growth factor beta cooperate to induce anti-CD40-activated naive human B cells to secrete immunoglobulin A
-
Defrance, T., et al. Interleukin 10 and transforming growth factor beta cooperate to induce anti-CD40-activated naive human B cells to secrete immunoglobulin A. J. Exp. Med. 175:3 (1992), 671–682.
-
(1992)
J. Exp. Med.
, vol.175
, Issue.3
, pp. 671-682
-
-
Defrance, T.1
-
73
-
-
84877726564
-
Microbe-dependent CD11b+ IgA+ plasma cells mediate robust early-phase intestinal IgA responses in mice
-
Kunisawa, J., et al. Microbe-dependent CD11b+ IgA+ plasma cells mediate robust early-phase intestinal IgA responses in mice. Nat. Commun., 4, 2013, 1772.
-
(2013)
Nat. Commun.
, vol.4
, pp. 1772
-
-
Kunisawa, J.1
-
74
-
-
79961151137
-
Foxp3+ follicular regulatory T cells control the germinal center response
-
Linterman, M.A., et al. Foxp3+ follicular regulatory T cells control the germinal center response. Nat. Med. 17:8 (2011), 975–982.
-
(2011)
Nat. Med.
, vol.17
, Issue.8
, pp. 975-982
-
-
Linterman, M.A.1
-
75
-
-
79961158055
-
Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions
-
Chung, Y., et al. Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions. Nat. Med. 17:8 (2011), 983–988.
-
(2011)
Nat. Med.
, vol.17
, Issue.8
, pp. 983-988
-
-
Chung, Y.1
-
76
-
-
84896851032
-
Intestinal epithelial cells: regulators of barrier function and immune homeostasis
-
Peterson, L.W., Artis, D., Intestinal epithelial cells: regulators of barrier function and immune homeostasis. Nat. Rev. Immunol. 14:3 (2014), 141–153.
-
(2014)
Nat. Rev. Immunol.
, vol.14
, Issue.3
, pp. 141-153
-
-
Peterson, L.W.1
Artis, D.2
-
77
-
-
85056487225
-
T helper cell cytokines modulate intestinal stem cell renewal and differentiation
-
1307-1320 e22
-
Biton, M., et al. T helper cell cytokines modulate intestinal stem cell renewal and differentiation. Cell, 175(5), 2018 1307-1320 e22.
-
(2018)
Cell
, vol.175
, Issue.5
-
-
Biton, M.1
-
78
-
-
84946224148
-
IL-10-producing CD4(+) T cells negatively regulate fucosylation of epithelial cells in the gut
-
Goto, Y., et al. IL-10-producing CD4(+) T cells negatively regulate fucosylation of epithelial cells in the gut. Sci. Rep., 5, 2015, 15918.
-
(2015)
Sci. Rep.
, vol.5
, pp. 15918
-
-
Goto, Y.1
-
79
-
-
84992347228
-
Epithelial glycosylation in gut homeostasis and inflammation
-
Goto, Y., Uematsu, S., Kiyono, H., Epithelial glycosylation in gut homeostasis and inflammation. Nat. Immunol. 17:11 (2016), 1244–1251.
-
(2016)
Nat. Immunol.
, vol.17
, Issue.11
, pp. 1244-1251
-
-
Goto, Y.1
Uematsu, S.2
Kiyono, H.3
-
80
-
-
33846234333
-
Interleukin-10 blocked endoplasmic reticulum stress in intestinal epithelial cells: impact on chronic inflammation
-
Shkoda, A., et al. Interleukin-10 blocked endoplasmic reticulum stress in intestinal epithelial cells: impact on chronic inflammation. Gastroenterology 132:1 (2007), 190–207.
-
(2007)
Gastroenterology
, vol.132
, Issue.1
, pp. 190-207
-
-
Shkoda, A.1
-
81
-
-
84880653498
-
IL-10 promotes production of intestinal mucus by suppressing protein misfolding and endoplasmic reticulum stress in goblet cells
-
357-368 e9
-
Hasnain, S.Z., et al. IL-10 promotes production of intestinal mucus by suppressing protein misfolding and endoplasmic reticulum stress in goblet cells. Gastroenterology, 144(2), 2013 357-368 e9.
-
(2013)
Gastroenterology
, vol.144
, Issue.2
-
-
Hasnain, S.Z.1
-
82
-
-
33751114964
-
IL-10 protects mouse intestinal epithelial cells from Fas-induced apoptosis via modulating Fas expression and altering caspase-8 and FLIP expression
-
Bharhani, M.S., et al. IL-10 protects mouse intestinal epithelial cells from Fas-induced apoptosis via modulating Fas expression and altering caspase-8 and FLIP expression. Am. J. Physiol. Gastrointest. Liver Physiol. 291:5 (2006), G820–9.
-
(2006)
Am. J. Physiol. Gastrointest. Liver Physiol.
, vol.291
, Issue.5
, pp. G820-9
-
-
Bharhani, M.S.1
-
83
-
-
0033966397
-
Expression of IL-10 receptors on epithelial cells from the murine small and large intestine
-
Denning, T.L., et al. Expression of IL-10 receptors on epithelial cells from the murine small and large intestine. Int. Immunol. 12:2 (2000), 133–139.
-
(2000)
Int. Immunol.
, vol.12
, Issue.2
, pp. 133-139
-
-
Denning, T.L.1
-
84
-
-
0032966445
-
Lack of interleukin 10 regulation of antigen presentation-associated molecules expressed on colonic epithelial cells
-
Bourreille, A., et al. Lack of interleukin 10 regulation of antigen presentation-associated molecules expressed on colonic epithelial cells. Eur. J. Clin. Invest. 29:1 (1999), 48–55.
-
(1999)
Eur. J. Clin. Invest.
, vol.29
, Issue.1
, pp. 48-55
-
-
Bourreille, A.1
-
85
-
-
85018820908
-
Tryptophan metabolite activation of the aryl hydrocarbon receptor regulates IL-10 receptor expression on intestinal epithelia
-
Lanis, J.M., et al. Tryptophan metabolite activation of the aryl hydrocarbon receptor regulates IL-10 receptor expression on intestinal epithelia. Mucosal Immunol. 10:5 (2017), 1133–1144.
-
(2017)
Mucosal Immunol.
, vol.10
, Issue.5
, pp. 1133-1144
-
-
Lanis, J.M.1
-
86
-
-
84893378205
-
IFN-gamma-mediated induction of an apical IL-10 receptor on polarized intestinal epithelia
-
Kominsky, D.J., et al. IFN-gamma-mediated induction of an apical IL-10 receptor on polarized intestinal epithelia. J. Immunol. 192:3 (2014), 1267–1276.
-
(2014)
J. Immunol.
, vol.192
, Issue.3
, pp. 1267-1276
-
-
Kominsky, D.J.1
-
87
-
-
84873688049
-
IL-22, not simply a Th17 cytokine
-
Rutz, S., Eidenschenk, C., Ouyang, W., IL-22, not simply a Th17 cytokine. Immunol. Rev. 252:1 (2013), 116–132.
-
(2013)
Immunol. Rev.
, vol.252
, Issue.1
, pp. 116-132
-
-
Rutz, S.1
Eidenschenk, C.2
Ouyang, W.3
-
88
-
-
85068153449
-
IL-23-producing IL-10Ralpha-deficient gut macrophages elicit an IL-22-driven proinflammatory epithelial cell response
-
Bernshtein, B., et al. IL-23-producing IL-10Ralpha-deficient gut macrophages elicit an IL-22-driven proinflammatory epithelial cell response. Sci. Immunol., 4(36), 2019.
-
(2019)
Sci. Immunol.
, vol.4
, Issue.36
-
-
Bernshtein, B.1
-
89
-
-
34249678457
-
T(H)1 cells control themselves by producing interleukin-10
-
O'Garra, A., Vieira, P., T(H)1 cells control themselves by producing interleukin-10. Nat. Rev. Immunol. 7:6 (2007), 425–428.
-
(2007)
Nat. Rev. Immunol.
, vol.7
, Issue.6
, pp. 425-428
-
-
O'Garra, A.1
Vieira, P.2
-
90
-
-
33750499311
-
Interleukin-10 determines viral clearance or persistence in vivo
-
Brooks, D.G., et al. Interleukin-10 determines viral clearance or persistence in vivo. Nat. Med. 12:11 (2006), 1301–1309.
-
(2006)
Nat. Med.
, vol.12
, Issue.11
, pp. 1301-1309
-
-
Brooks, D.G.1
-
91
-
-
33750530611
-
Resolution of a chronic viral infection after interleukin-10 receptor blockade
-
Ejrnaes, M., et al. Resolution of a chronic viral infection after interleukin-10 receptor blockade. J. Exp. Med. 203:11 (2006), 2461–2472.
-
(2006)
J. Exp. Med.
, vol.203
, Issue.11
, pp. 2461-2472
-
-
Ejrnaes, M.1
-
92
-
-
41149130734
-
IL-10 blockade facilitates DNA vaccine-induced T cell responses and enhances clearance of persistent virus infection
-
Brooks, D.G., et al. IL-10 blockade facilitates DNA vaccine-induced T cell responses and enhances clearance of persistent virus infection. J. Exp. Med. 205:3 (2008), 533–541.
-
(2008)
J. Exp. Med.
, vol.205
, Issue.3
, pp. 533-541
-
-
Brooks, D.G.1
-
93
-
-
0025335354
-
Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI
-
Moore, K.W., et al. Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI. Science 248:4960 (1990), 1230–1234.
-
(1990)
Science
, vol.248
, Issue.4960
, pp. 1230-1234
-
-
Moore, K.W.1
-
94
-
-
33750302586
-
A deletion defining a common Asian lineage of Mycobacterium tuberculosis associates with immune subversion
-
Newton, S.M., et al. A deletion defining a common Asian lineage of Mycobacterium tuberculosis associates with immune subversion. Proc. Natl. Acad. Sci. U. S. A. 103:42 (2006), 15594–15598.
-
(2006)
Proc. Natl. Acad. Sci. U. S. A.
, vol.103
, Issue.42
, pp. 15594-15598
-
-
Newton, S.M.1
-
95
-
-
84865546544
-
Infected CD8alpha- dendritic cells are the predominant source of IL-10 during establishment of persistent viral infection
-
Ng, C.T., Oldstone, M.B., Infected CD8alpha- dendritic cells are the predominant source of IL-10 during establishment of persistent viral infection. Proc. Natl. Acad. Sci. U. S. A. 109:35 (2012), 14116–14121.
-
(2012)
Proc. Natl. Acad. Sci. U. S. A.
, vol.109
, Issue.35
, pp. 14116-14121
-
-
Ng, C.T.1
Oldstone, M.B.2
-
96
-
-
33847163271
-
CD4(+)CD25(-)Foxp3(-) Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis
-
Anderson, C.F., et al. CD4(+)CD25(-)Foxp3(-) Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis. J. Exp. Med. 204:2 (2007), 285–297.
-
(2007)
J. Exp. Med.
, vol.204
, Issue.2
, pp. 285-297
-
-
Anderson, C.F.1
-
97
-
-
2242423605
-
CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity
-
Belkaid, Y., et al. CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity. Nature 420:6915 (2002), 502–507.
-
(2002)
Nature
, vol.420
, Issue.6915
, pp. 502-507
-
-
Belkaid, Y.1
-
98
-
-
40349089873
-
IL-10 from CD4CD25Foxp3CD127 adaptive regulatory T cells modulates parasite clearance and pathology during malaria infection
-
Couper, K.N., et al. IL-10 from CD4CD25Foxp3CD127 adaptive regulatory T cells modulates parasite clearance and pathology during malaria infection. PLoS Pathog., 4(2), 2008, e1000004.
-
(2008)
PLoS Pathog.
, vol.4
, Issue.2
, pp. e1000004
-
-
Couper, K.N.1
-
99
-
-
33847144180
-
Conventional T-bet(+)Foxp3(-) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection
-
Jankovic, D., et al. Conventional T-bet(+)Foxp3(-) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection. J. Exp. Med. 204:2 (2007), 273–283.
-
(2007)
J. Exp. Med.
, vol.204
, Issue.2
, pp. 273-283
-
-
Jankovic, D.1
-
100
-
-
85021654987
-
T cell-derived IL-10 impairs host resistance to Mycobacterium tuberculosis infection
-
Moreira-Teixeira, L., et al. T cell-derived IL-10 impairs host resistance to Mycobacterium tuberculosis infection. J. Immunol. 199:2 (2017), 613–623.
-
(2017)
J. Immunol.
, vol.199
, Issue.2
, pp. 613-623
-
-
Moreira-Teixeira, L.1
-
101
-
-
84958544987
-
Role of IL-22 in microbial host defense
-
Eidenschenk, C., et al. Role of IL-22 in microbial host defense. Curr. Top. Microbiol. Immunol. 380 (2014), 213–236.
-
(2014)
Curr. Top. Microbiol. Immunol.
, vol.380
, pp. 213-236
-
-
Eidenschenk, C.1
-
102
-
-
84856567798
-
IL-27 promotes IL-10 production by effector Th1 CD4+ T cells: a critical mechanism for protection from severe immunopathology during malaria infection
-
Freitas do Rosario, A.P., et al. IL-27 promotes IL-10 production by effector Th1 CD4+ T cells: a critical mechanism for protection from severe immunopathology during malaria infection. J. Immunol. 188:3 (2012), 1178–1190.
-
(2012)
J. Immunol.
, vol.188
, Issue.3
, pp. 1178-1190
-
-
Freitas do Rosario, A.P.1
-
103
-
-
77955385939
-
Enhanced protection to Mycobacterium tuberculosis infection in IL-10-deficient mice is accompanied by early and enhanced Th1 responses in the lung
-
Redford, P.S., et al. Enhanced protection to Mycobacterium tuberculosis infection in IL-10-deficient mice is accompanied by early and enhanced Th1 responses in the lung. Eur. J. Immunol. 40:8 (2010), 2200–2210.
-
(2010)
Eur. J. Immunol.
, vol.40
, Issue.8
, pp. 2200-2210
-
-
Redford, P.S.1
-
104
-
-
85054630864
-
Bhlhe40 is an essential repressor of IL-10 during Mycobacterium tuberculosis infection
-
Huynh, J.P., et al. Bhlhe40 is an essential repressor of IL-10 during Mycobacterium tuberculosis infection. J. Exp. Med. 215:7 (2018), 1823–1838.
-
(2018)
J. Exp. Med.
, vol.215
, Issue.7
, pp. 1823-1838
-
-
Huynh, J.P.1
-
105
-
-
0036883973
-
In vivo IL-10 production reactivates chronic pulmonary tuberculosis in C57BL/6 mice
-
Turner, J., et al. In vivo IL-10 production reactivates chronic pulmonary tuberculosis in C57BL/6 mice. J. Immunol. 169:11 (2002), 6343–6351.
-
(2002)
J. Immunol.
, vol.169
, Issue.11
, pp. 6343-6351
-
-
Turner, J.1
-
106
-
-
85025066643
-
Human genetic factors in tuberculosis: an update
-
van Tong, H., et al. Human genetic factors in tuberculosis: an update. Trop. Med. Int. Health 22:9 (2017), 1063–1071.
-
(2017)
Trop. Med. Int. Health
, vol.22
, Issue.9
, pp. 1063-1071
-
-
van Tong, H.1
-
107
-
-
84920107262
-
Host genetic studies in adult pulmonary tuberculosis
-
Meyer, C.G., Thye, T., Host genetic studies in adult pulmonary tuberculosis. Semin. Immunol. 26:6 (2014), 445–453.
-
(2014)
Semin. Immunol.
, vol.26
, Issue.6
, pp. 445-453
-
-
Meyer, C.G.1
Thye, T.2
-
108
-
-
68649116551
-
Interleukin-10 production by Th1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation by high antigen dose
-
Saraiva, M., et al. Interleukin-10 production by Th1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation by high antigen dose. Immunity 31:2 (2009), 209–219.
-
(2009)
Immunity
, vol.31
, Issue.2
, pp. 209-219
-
-
Saraiva, M.1
-
109
-
-
0030584733
-
IL-12-induced IL-10 production by human T cells as a negative feedback for IL-12-induced immune responses
-
Meyaard, L., et al. IL-12-induced IL-10 production by human T cells as a negative feedback for IL-12-induced immune responses. J. Immunol. 156:8 (1996), 2776–2782.
-
(1996)
J. Immunol.
, vol.156
, Issue.8
, pp. 2776-2782
-
-
Meyaard, L.1
-
110
-
-
0029984051
-
Interleukin-12 primes human CD4 and CD8 T cell clones for high production of both interferon-gamma and interleukin-10
-
Gerosa, F., et al. Interleukin-12 primes human CD4 and CD8 T cell clones for high production of both interferon-gamma and interleukin-10. J. Exp. Med. 183:6 (1996), 2559–2569.
-
(1996)
J. Exp. Med.
, vol.183
, Issue.6
, pp. 2559-2569
-
-
Gerosa, F.1
-
111
-
-
33644843538
-
GATA-3 directly remodels the IL-10 locus independently of IL-4 in CD4+ T cells
-
Shoemaker, J., Saraiva, M., O'Garra, A., GATA-3 directly remodels the IL-10 locus independently of IL-4 in CD4+ T cells. J. Immunol. 176:6 (2006), 3470–3479.
-
(2006)
J. Immunol.
, vol.176
, Issue.6
, pp. 3470-3479
-
-
Shoemaker, J.1
Saraiva, M.2
O'Garra, A.3
-
112
-
-
34147163337
-
Expression of IL-10 in Th memory lymphocytes is conditional on IL-12 or IL-4, unless the IL-10 gene is imprinted by GATA-3
-
Chang, H.D., et al. Expression of IL-10 in Th memory lymphocytes is conditional on IL-12 or IL-4, unless the IL-10 gene is imprinted by GATA-3. Eur. J. Immunol. 37:3 (2007), 807–817.
-
(2007)
Eur. J. Immunol.
, vol.37
, Issue.3
, pp. 807-817
-
-
Chang, H.D.1
-
113
-
-
36248951161
-
Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10
-
Stumhofer, J.S., et al. Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10. Nat. Immunol. 8:12 (2007), 1363–1371.
-
(2007)
Nat. Immunol.
, vol.8
, Issue.12
, pp. 1363-1371
-
-
Stumhofer, J.S.1
-
114
-
-
73249149628
-
c-Maf regulates IL-10 expression during Th17 polarization
-
Xu, J., et al. c-Maf regulates IL-10 expression during Th17 polarization. J. Immunol. 182:10 (2009), 6226–6236.
-
(2009)
J. Immunol.
, vol.182
, Issue.10
, pp. 6226-6236
-
-
Xu, J.1
-
115
-
-
34247523141
-
Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation
-
Kastelein, R.A., Hunter, C.A., Cua, D.J., Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation. Annu. Rev. Immunol. 25 (2007), 221–242.
-
(2007)
Annu. Rev. Immunol.
, vol.25
, pp. 221-242
-
-
Kastelein, R.A.1
Hunter, C.A.2
Cua, D.J.3
-
116
-
-
84870873399
-
Interleukin-27: balancing protective and pathological immunity
-
Hunter, C.A., Kastelein, R., Interleukin-27: balancing protective and pathological immunity. Immunity 37:6 (2012), 960–969.
-
(2012)
Immunity
, vol.37
, Issue.6
, pp. 960-969
-
-
Hunter, C.A.1
Kastelein, R.2
-
117
-
-
0345570521
-
The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infection
-
Villarino, A., et al. The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infection. Immunity 19:5 (2003), 645–655.
-
(2003)
Immunity
, vol.19
, Issue.5
, pp. 645-655
-
-
Villarino, A.1
-
118
-
-
33747593830
-
Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system
-
Stumhofer, J.S., et al. Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system. Nat. Immunol. 7:9 (2006), 937–945.
-
(2006)
Nat. Immunol.
, vol.7
, Issue.9
, pp. 937-945
-
-
Stumhofer, J.S.1
-
119
-
-
42149162217
-
Notch regulates IL-10 production by T helper 1 cells
-
Rutz, S., et al. Notch regulates IL-10 production by T helper 1 cells. Proc. Natl. Acad. Sci. U. S. A. 105:9 (2008), 3497–3502.
-
(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
, Issue.9
, pp. 3497-3502
-
-
Rutz, S.1
-
120
-
-
76249101454
-
Cutting edge: plasmacytoid dendritic cells induce IL-10 production in T cells via the delta-like-4/Notch axis
-
Kassner, N., et al. Cutting edge: plasmacytoid dendritic cells induce IL-10 production in T cells via the delta-like-4/Notch axis. J. Immunol. 184:2 (2010), 550–554.
-
(2010)
J. Immunol.
, vol.184
, Issue.2
, pp. 550-554
-
-
Kassner, N.1
-
121
-
-
84907215689
-
Type I IFN induces IL-10 production in an IL-27-independent manner and blocks responsiveness to IFN-gamma for production of IL-12 and bacterial killing in Mycobacterium tuberculosis-infected macrophages
-
McNab, F.W., et al. Type I IFN induces IL-10 production in an IL-27-independent manner and blocks responsiveness to IFN-gamma for production of IL-12 and bacterial killing in Mycobacterium tuberculosis-infected macrophages. J. Immunol. 193:7 (2014), 3600–3612.
-
(2014)
J. Immunol.
, vol.193
, Issue.7
, pp. 3600-3612
-
-
McNab, F.W.1
-
122
-
-
84937416933
-
A Jekyll and Hyde profile: type 1 Interferon signaling plays a prominent role in the initiation and maintenance of a persistent virus infection
-
Oldstone, M.B., A Jekyll and Hyde profile: type 1 Interferon signaling plays a prominent role in the initiation and maintenance of a persistent virus infection. J. Infect. Dis. 212:Suppl. 1 (2015), S31–6.
-
(2015)
J. Infect. Dis.
, vol.212
, pp. S31-6
-
-
Oldstone, M.B.1
-
123
-
-
84876311772
-
Persistent LCMV infection is controlled by blockade of type I interferon signaling
-
Teijaro, J.R., et al. Persistent LCMV infection is controlled by blockade of type I interferon signaling. Science 340:6129 (2013), 207–211.
-
(2013)
Science
, vol.340
, Issue.6129
, pp. 207-211
-
-
Teijaro, J.R.1
-
124
-
-
84876299371
-
Blockade of chronic type I interferon signaling to control persistent LCMV infection
-
Wilson, E.B., et al. Blockade of chronic type I interferon signaling to control persistent LCMV infection. Science 340:6129 (2013), 202–207.
-
(2013)
Science
, vol.340
, Issue.6129
, pp. 202-207
-
-
Wilson, E.B.1
-
125
-
-
85058183708
-
The biology of t regulatory type 1 cells and their therapeutic application in immune-mediated diseases
-
Roncarolo, M.G., et al. The biology of t regulatory type 1 cells and their therapeutic application in immune-mediated diseases. Immunity 49:6 (2018), 1004–1019.
-
(2018)
Immunity
, vol.49
, Issue.6
, pp. 1004-1019
-
-
Roncarolo, M.G.1
-
126
-
-
84990041994
-
Safety, antitumor activity, and immune activation of pegylated recombinant human Interleukin-10 (AM0010) in patients with advanced solid tumors
-
Naing, A., et al. Safety, antitumor activity, and immune activation of pegylated recombinant human Interleukin-10 (AM0010) in patients with advanced solid tumors. J. Clin. Oncol. 34:29 (2016), 3562–3569.
-
(2016)
J. Clin. Oncol.
, vol.34
, Issue.29
, pp. 3562-3569
-
-
Naing, A.1
-
127
-
-
85055890244
-
PEGylated IL-10 (Pegilodecakin) induces systemic immune activation, CD8(+) T cell invigoration and polyclonal t cell expansion in cancer patients
-
775-791 e3
-
Naing, A., et al. PEGylated IL-10 (Pegilodecakin) induces systemic immune activation, CD8(+) T cell invigoration and polyclonal t cell expansion in cancer patients. Cancer Cell, 34(5), 2018 775-791 e3.
-
(2018)
Cancer Cell
, vol.34
, Issue.5
-
-
Naing, A.1
-
128
-
-
0032055224
-
Inhibitory and stimulatory effects of IL-10 on human CD8+ T cells
-
Groux, H., et al. Inhibitory and stimulatory effects of IL-10 on human CD8+ T cells. J. Immunol. 160:7 (1998), 3188–3193.
-
(1998)
J. Immunol.
, vol.160
, Issue.7
, pp. 3188-3193
-
-
Groux, H.1
-
129
-
-
83455173552
-
IL-10 elicits IFNgamma-dependent tumor immune surveillance
-
Mumm, J.B., et al. IL-10 elicits IFNgamma-dependent tumor immune surveillance. Cancer Cell 20:6 (2011), 781–796.
-
(2011)
Cancer Cell
, vol.20
, Issue.6
, pp. 781-796
-
-
Mumm, J.B.1
-
130
-
-
84863973465
-
IL-10 directly activates and expands tumor-resident CD8(+) T cells without de novo infiltration from secondary lymphoid organs
-
Emmerich, J., et al. IL-10 directly activates and expands tumor-resident CD8(+) T cells without de novo infiltration from secondary lymphoid organs. Cancer Res. 72:14 (2012), 3570–3581.
-
(2012)
Cancer Res.
, vol.72
, Issue.14
, pp. 3570-3581
-
-
Emmerich, J.1
-
131
-
-
85057107627
-
The effect of regulatory T cells on tolerance to airborne allergens and allergen immunotherapy
-
Bacher, P., Scheffold, A., The effect of regulatory T cells on tolerance to airborne allergens and allergen immunotherapy. J. Allergy Clin. Immunol. 142:6 (2018), 1697–1709.
-
(2018)
J. Allergy Clin. Immunol.
, vol.142
, Issue.6
, pp. 1697-1709
-
-
Bacher, P.1
Scheffold, A.2
-
132
-
-
57149128460
-
Primary immune deficiencies with aberrant IgE production
-
quiz 1063-4
-
Ozcan, E., Notarangelo, L.D., Geha, R.S., Primary immune deficiencies with aberrant IgE production. J. Allergy Clin. Immunol. 122:6 (2008), 1054–1062 quiz 1063-4.
-
(2008)
J. Allergy Clin. Immunol.
, vol.122
, Issue.6
, pp. 1054-1062
-
-
Ozcan, E.1
Notarangelo, L.D.2
Geha, R.S.3
-
133
-
-
85072129383
-
Regulatory t cells: the many faces of Foxp3
-
Georgiev, P., Charbonnier, L.M., Chatila, T.A., Regulatory t cells: the many faces of Foxp3. J. Clin. Immunol. 39:7 (2019), 623–640.
-
(2019)
J. Clin. Immunol.
, vol.39
, Issue.7
, pp. 623-640
-
-
Georgiev, P.1
Charbonnier, L.M.2
Chatila, T.A.3
-
134
-
-
84943240073
-
Genetics of inflammatory bowel diseases
-
1163-1176 e2
-
McGovern, D.P., Kugathasan, S., Cho, J.H., Genetics of inflammatory bowel diseases. Gastroenterology, 149(5), 2015 1163-1176 e2.
-
(2015)
Gastroenterology
, vol.149
, Issue.5
-
-
McGovern, D.P.1
Kugathasan, S.2
Cho, J.H.3
-
135
-
-
84880617946
-
Association between variants of PRDM1 and NDP52 and Crohn's disease, based on exome sequencing and functional studies
-
Ellinghaus, D., et al. Association between variants of PRDM1 and NDP52 and Crohn's disease, based on exome sequencing and functional studies. Gastroenterology 145:2 (2013), 339–347.
-
(2013)
Gastroenterology
, vol.145
, Issue.2
, pp. 339-347
-
-
Ellinghaus, D.1
-
136
-
-
85058097343
-
Impact of genetic polymorphisms on human immune cell gene expression
-
1701-1715 e16
-
Schmiedel, B.J., et al. Impact of genetic polymorphisms on human immune cell gene expression. Cell, 175(6), 2018 1701-1715 e16.
-
(2018)
Cell
, vol.175
, Issue.6
-
-
Schmiedel, B.J.1
-
137
-
-
84953409202
-
The crossroads of autoimmunity and immunodeficiency: lessons from polygenic traits and monogenic defects
-
Grimbacher, B., et al. The crossroads of autoimmunity and immunodeficiency: lessons from polygenic traits and monogenic defects. J. Allergy Clin. Immunol. 137:1 (2016), 3–17.
-
(2016)
J. Allergy Clin. Immunol.
, vol.137
, Issue.1
, pp. 3-17
-
-
Grimbacher, B.1
-
138
-
-
84887058596
-
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis
-
International Multiple Sclerosis Genetics, C, et al. Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nat. Genet. 45:11 (2013), 1353–1360.
-
(2013)
Nat. Genet.
, vol.45
, Issue.11
, pp. 1353-1360
-
-
International Multiple Sclerosis Genetics, C,1
-
139
-
-
85013782844
-
Genetic predisposition of IL-10 promoter polymorphisms with risk of multiple sclerosis: a meta-analysis
-
Ramakrishnan, V., Akram Husain, R.S., Ahmed, S.S., Genetic predisposition of IL-10 promoter polymorphisms with risk of multiple sclerosis: a meta-analysis. J. Neuroimmunol. 306 (2017), 11–18.
-
(2017)
J. Neuroimmunol.
, vol.306
, pp. 11-18
-
-
Ramakrishnan, V.1
Akram Husain, R.S.2
Ahmed, S.S.3
-
140
-
-
85058332058
-
Genetics of rheumatoid arthritis: 2018 status
-
Okada, Y., et al. Genetics of rheumatoid arthritis: 2018 status. Ann. Rheum. Dis. 78:4 (2019), 446–453.
-
(2019)
Ann. Rheum. Dis.
, vol.78
, Issue.4
, pp. 446-453
-
-
Okada, Y.1
-
141
-
-
77957113600
-
A large-scale, consortium-based genomewide association study of asthma
-
Moffatt, M.F., et al. A large-scale, consortium-based genomewide association study of asthma. N. Engl. J. Med. 363:13 (2010), 1211–1221.
-
(2010)
N. Engl. J. Med.
, vol.363
, Issue.13
, pp. 1211-1221
-
-
Moffatt, M.F.1
-
142
-
-
85047178605
-
A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases
-
Zhu, Z., et al. A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases. Nat. Genet. 50:6 (2018), 857–864.
-
(2018)
Nat. Genet.
, vol.50
, Issue.6
, pp. 857-864
-
-
Zhu, Z.1
-
143
-
-
67349199566
-
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes
-
Barrett, J.C., et al. Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nat. Genet. 41:6 (2009), 703–707.
-
(2009)
Nat. Genet.
, vol.41
, Issue.6
, pp. 703-707
-
-
Barrett, J.C.1
-
144
-
-
84964772502
-
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci
-
Ellinghaus, D., et al. Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. Nat. Genet. 48:5 (2016), 510–518.
-
(2016)
Nat. Genet.
, vol.48
, Issue.5
, pp. 510-518
-
-
Ellinghaus, D.1
-
145
-
-
84883114740
-
Immunopathogenic mechanisms of systemic autoimmune disease
-
Wahren-Herlenius, M., Dorner, T., Immunopathogenic mechanisms of systemic autoimmune disease. Lancet 382:9894 (2013), 819–831.
-
(2013)
Lancet
, vol.382
, Issue.9894
, pp. 819-831
-
-
Wahren-Herlenius, M.1
Dorner, T.2
-
146
-
-
70350650472
-
A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus
-
Gateva, V., et al. A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus. Nat. Genet. 41:11 (2009), 1228–1233.
-
(2009)
Nat. Genet.
, vol.41
, Issue.11
, pp. 1228-1233
-
-
Gateva, V.1
-
147
-
-
84907202723
-
Intersection of population variation and autoimmunity genetics in human T cell activation
-
Ye, C.J., et al. Intersection of population variation and autoimmunity genetics in human T cell activation. Science, 345(6202), 2014, 1254665.
-
(2014)
Science
, vol.345
, Issue.6202
, pp. 1254665
-
-
Ye, C.J.1
-
148
-
-
84929993521
-
New technologies for monitoring human antigen-specific T cells and regulatory T cells by flow-cytometry
-
Bacher, P., Scheffold, A., New technologies for monitoring human antigen-specific T cells and regulatory T cells by flow-cytometry. Curr. Opin. Pharmacol. 23 (2015), 17–24.
-
(2015)
Curr. Opin. Pharmacol.
, vol.23
, pp. 17-24
-
-
Bacher, P.1
Scheffold, A.2
-
149
-
-
84875432419
-
Type 1 diabetes: translating mechanistic observations into effective clinical outcomes
-
Herold, K.C., et al. Type 1 diabetes: translating mechanistic observations into effective clinical outcomes. Nat. Rev. Immunol. 13:4 (2013), 243–256.
-
(2013)
Nat. Rev. Immunol.
, vol.13
, Issue.4
, pp. 243-256
-
-
Herold, K.C.1
-
150
-
-
84940453103
-
Immunopathology of multiple sclerosis
-
Dendrou, C.A., Fugger, L., Friese, M.A., Immunopathology of multiple sclerosis. Nat. Rev. Immunol. 15:9 (2015), 545–558.
-
(2015)
Nat. Rev. Immunol.
, vol.15
, Issue.9
, pp. 545-558
-
-
Dendrou, C.A.1
Fugger, L.2
Friese, M.A.3
-
151
-
-
85019031108
-
Homeostatic immunity and the microbiota
-
Belkaid, Y., Harrison, O.J., Homeostatic immunity and the microbiota. Immunity 46:4 (2017), 562–576.
-
(2017)
Immunity
, vol.46
, Issue.4
, pp. 562-576
-
-
Belkaid, Y.1
Harrison, O.J.2
-
152
-
-
85047945557
-
Antigen-specific regulatory T-cell responses against aeroantigens and their role in allergy
-
Bacher, P., Scheffold, A., Antigen-specific regulatory T-cell responses against aeroantigens and their role in allergy. Mucosal Immunol. 11:6 (2018), 1537–1550.
-
(2018)
Mucosal Immunol.
, vol.11
, Issue.6
, pp. 1537-1550
-
-
Bacher, P.1
Scheffold, A.2
-
153
-
-
85046171487
-
Molecular aspects of allergens and allergy
-
Valenta, R., et al. Molecular aspects of allergens and allergy. Adv. Immunol. 138 (2018), 195–256.
-
(2018)
Adv. Immunol.
, vol.138
, pp. 195-256
-
-
Valenta, R.1
-
154
-
-
58149306013
-
In vivo switch to IL-10-secreting T regulatory cells in high dose allergen exposure
-
Meiler, F., et al. In vivo switch to IL-10-secreting T regulatory cells in high dose allergen exposure. J. Exp. Med. 205:12 (2008), 2887–2898.
-
(2008)
J. Exp. Med.
, vol.205
, Issue.12
, pp. 2887-2898
-
-
Meiler, F.1
-
155
-
-
2942685507
-
Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells
-
Akdis, M., et al. Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells. J. Exp. Med. 199:11 (2004), 1567–1575.
-
(2004)
J. Exp. Med.
, vol.199
, Issue.11
, pp. 1567-1575
-
-
Akdis, M.1
-
156
-
-
85035134690
-
Mechanisms of allergen immunotherapy for inhaled allergens and predictive biomarkers
-
Shamji, M.H., Durham, S.R., Mechanisms of allergen immunotherapy for inhaled allergens and predictive biomarkers. J. Allergy Clin. Immunol. 140:6 (2017), 1485–1498.
-
(2017)
J. Allergy Clin. Immunol.
, vol.140
, Issue.6
, pp. 1485-1498
-
-
Shamji, M.H.1
Durham, S.R.2
-
157
-
-
84994876193
-
Regulatory T cell specificity directs tolerance versus allergy against aeroantigens in humans
-
1067-1078 e16
-
Bacher, P., et al. Regulatory T cell specificity directs tolerance versus allergy against aeroantigens in humans. Cell, 167(4), 2016 1067-1078 e16.
-
(2016)
Cell
, vol.167
, Issue.4
-
-
Bacher, P.1
-
158
-
-
28244474539
-
Distal enhancer elements transcribe intergenic RNA in the IL-10 family gene cluster
-
Jones, E.A., Flavell, R.A., Distal enhancer elements transcribe intergenic RNA in the IL-10 family gene cluster. J. Immunol. 175:11 (2005), 7437–7446.
-
(2005)
J. Immunol.
, vol.175
, Issue.11
, pp. 7437-7446
-
-
Jones, E.A.1
Flavell, R.A.2
-
159
-
-
13544254619
-
Regulation of IL-10 gene expression in Th2 cells by Jun proteins
-
Wang, Z.Y., et al. Regulation of IL-10 gene expression in Th2 cells by Jun proteins. J. Immunol. 174:4 (2005), 2098–2105.
-
(2005)
J. Immunol.
, vol.174
, Issue.4
, pp. 2098-2105
-
-
Wang, Z.Y.1
-
160
-
-
8744258956
-
Chromatin-level regulation of the IL10 gene in T cells
-
Im, S.H., et al. Chromatin-level regulation of the IL10 gene in T cells. J. Biol. Chem. 279:45 (2004), 46818–46825.
-
(2004)
J. Biol. Chem.
, vol.279
, Issue.45
, pp. 46818-46825
-
-
Im, S.H.1
-
161
-
-
79953222926
-
Highly activated cytotoxic CD8 T cells express protective IL-10 at the peak of coronavirus-induced encephalitis
-
Trandem, K., et al. Highly activated cytotoxic CD8 T cells express protective IL-10 at the peak of coronavirus-induced encephalitis. J. Immunol. 186:6 (2011), 3642–3652.
-
(2011)
J. Immunol.
, vol.186
, Issue.6
, pp. 3642-3652
-
-
Trandem, K.1
-
162
-
-
84867581744
-
A validated regulatory network for Th17 cell specification
-
Ciofani, M., et al. A validated regulatory network for Th17 cell specification. Cell 151:2 (2012), 289–303.
-
(2012)
Cell
, vol.151
, Issue.2
, pp. 289-303
-
-
Ciofani, M.1
-
163
-
-
84867884822
-
Compensatory dendritic cell development mediated by BATF-IRF interactions
-
Tussiwand, R., et al. Compensatory dendritic cell development mediated by BATF-IRF interactions. Nature 490:7421 (2012), 502–507.
-
(2012)
Nature
, vol.490
, Issue.7421
, pp. 502-507
-
-
Tussiwand, R.1
-
164
-
-
84869116884
-
A genomic regulatory element that directs assembly and function of immune-specific AP-1-IRF complexes
-
Glasmacher, E., et al. A genomic regulatory element that directs assembly and function of immune-specific AP-1-IRF complexes. Science 338:6109 (2012), 975–980.
-
(2012)
Science
, vol.338
, Issue.6109
, pp. 975-980
-
-
Glasmacher, E.1
-
165
-
-
84867861268
-
BATF-JUN is critical for IRF4-mediated transcription in T cells
-
Li, P., et al. BATF-JUN is critical for IRF4-mediated transcription in T cells. Nature 490:7421 (2012), 543–546.
-
(2012)
Nature
, vol.490
, Issue.7421
, pp. 543-546
-
-
Li, P.1
-
166
-
-
84879689439
-
Specificity through cooperation: BATF-IRF interactions control immune-regulatory networks
-
Murphy, T.L., Tussiwand, R., Murphy, K.M., Specificity through cooperation: BATF-IRF interactions control immune-regulatory networks. Nat. Rev. Immunol. 13:7 (2013), 499–509.
-
(2013)
Nat. Rev. Immunol.
, vol.13
, Issue.7
, pp. 499-509
-
-
Murphy, T.L.1
Tussiwand, R.2
Murphy, K.M.3
-
167
-
-
68149125188
-
IFN regulatory factor 4 regulates the expression of a subset of Th2 cytokines
-
Ahyi, A.N., et al. IFN regulatory factor 4 regulates the expression of a subset of Th2 cytokines. J. Immunol. 183:3 (2009), 1598–1606.
-
(2009)
J. Immunol.
, vol.183
, Issue.3
, pp. 1598-1606
-
-
Ahyi, A.N.1
-
168
-
-
20644466433
-
NFAT proteins: key regulators of T-cell development and function
-
Macian, F., NFAT proteins: key regulators of T-cell development and function. Nat. Rev. Immunol. 5:6 (2005), 472–484.
-
(2005)
Nat. Rev. Immunol.
, vol.5
, Issue.6
, pp. 472-484
-
-
Macian, F.1
-
169
-
-
58249109466
-
A distal cis-regulatory element, CNS-9, controls NFAT1 and IRF4-mediated IL-10 gene activation in T helper cells
-
Lee, C.G., et al. A distal cis-regulatory element, CNS-9, controls NFAT1 and IRF4-mediated IL-10 gene activation in T helper cells. Mol. Immunol. 46:4 (2009), 613–621.
-
(2009)
Mol. Immunol.
, vol.46
, Issue.4
, pp. 613-621
-
-
Lee, C.G.1
-
170
-
-
0038544646
-
IFN-alpha induces the human IL-10 gene by recruiting both IFN regulatory factor 1 and Stat3
-
Ziegler-Heitbrock, L., et al. IFN-alpha induces the human IL-10 gene by recruiting both IFN regulatory factor 1 and Stat3. J. Immunol. 171:1 (2003), 285–290.
-
(2003)
J. Immunol.
, vol.171
, Issue.1
, pp. 285-290
-
-
Ziegler-Heitbrock, L.1
-
171
-
-
43449100316
-
Role of STAT3 in glucocorticoid-induced expression of the human IL-10 gene
-
Unterberger, C., et al. Role of STAT3 in glucocorticoid-induced expression of the human IL-10 gene. Mol. Immunol. 45:11 (2008), 3230–3237.
-
(2008)
Mol. Immunol.
, vol.45
, Issue.11
, pp. 3230-3237
-
-
Unterberger, C.1
-
172
-
-
84906534462
-
Role of Blimp-1 in programing Th effector cells into IL-10 producers
-
Neumann, C., et al. Role of Blimp-1 in programing Th effector cells into IL-10 producers. J. Exp. Med. 211:9 (2014), 1807–1819.
-
(2014)
J. Exp. Med.
, vol.211
, Issue.9
, pp. 1807-1819
-
-
Neumann, C.1
-
173
-
-
77953917067
-
Discrete roles of STAT4 and STAT6 transcription factors in tuning epigenetic modifications and transcription during T helper cell differentiation
-
Wei, L., et al. Discrete roles of STAT4 and STAT6 transcription factors in tuning epigenetic modifications and transcription during T helper cell differentiation. Immunity 32:6 (2010), 840–851.
-
(2010)
Immunity
, vol.32
, Issue.6
, pp. 840-851
-
-
Wei, L.1
-
174
-
-
36248970702
-
Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells
-
Fitzgerald, D.C., et al. Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells. Nat. Immunol. 8:12 (2007), 1372–1379.
-
(2007)
Nat. Immunol.
, vol.8
, Issue.12
, pp. 1372-1379
-
-
Fitzgerald, D.C.1
-
175
-
-
49149119535
-
Cutting edge: IL-27 is a potent inducer of IL-10 but not FoxP3 in murine T cells
-
Batten, M., et al. Cutting edge: IL-27 is a potent inducer of IL-10 but not FoxP3 in murine T cells. J. Immunol. 180:5 (2008), 2752–2756.
-
(2008)
J. Immunol.
, vol.180
, Issue.5
, pp. 2752-2756
-
-
Batten, M.1
-
176
-
-
36248970701
-
A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells
-
Awasthi, A., et al. A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells. Nat. Immunol. 8:12 (2007), 1380–1389.
-
(2007)
Nat. Immunol.
, vol.8
, Issue.12
, pp. 1380-1389
-
-
Awasthi, A.1
-
177
-
-
69249083836
-
Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells
-
Pot, C., et al. Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells. J. Immunol. 183:2 (2009), 797–801.
-
(2009)
J. Immunol.
, vol.183
, Issue.2
, pp. 797-801
-
-
Pot, C.1
-
178
-
-
64849083153
-
IL-21 mediates suppressive effects via its induction of IL-10
-
Spolski, R., et al. IL-21 mediates suppressive effects via its induction of IL-10. J. Immunol. 182:5 (2009), 2859–2867.
-
(2009)
J. Immunol.
, vol.182
, Issue.5
, pp. 2859-2867
-
-
Spolski, R.1
-
179
-
-
79955000536
-
IL-27 and IL-21 are associated with T cell IL-10 responses in human visceral leishmaniasis
-
Ansari, N.A., et al. IL-27 and IL-21 are associated with T cell IL-10 responses in human visceral leishmaniasis. J. Immunol. 186:7 (2011), 3977–3985.
-
(2011)
J. Immunol.
, vol.186
, Issue.7
, pp. 3977-3985
-
-
Ansari, N.A.1
-
180
-
-
84907210923
-
IL-21 is a central memory T cell-associated cytokine that inhibits the generation of pathogenic Th1/17 effector cells
-
Kastirr, I., et al. IL-21 is a central memory T cell-associated cytokine that inhibits the generation of pathogenic Th1/17 effector cells. J. Immunol. 193:7 (2014), 3322–3331.
-
(2014)
J. Immunol.
, vol.193
, Issue.7
, pp. 3322-3331
-
-
Kastirr, I.1
-
181
-
-
77958584113
-
Generation of pathogenic T(H)17 cells in the absence of TGF-beta signalling
-
Ghoreschi, K., et al. Generation of pathogenic T(H)17 cells in the absence of TGF-beta signalling. Nature 467:7318 (2010), 967–971.
-
(2010)
Nature
, vol.467
, Issue.7318
, pp. 967-971
-
-
Ghoreschi, K.1
-
182
-
-
0142219250
-
Transforming growth factor (TGF)-beta1-producing regulatory T cells induce Smad-mediated interleukin 10 secretion that facilitates coordinated immunoregulatory activity and amelioration of TGF-beta1-mediated fibrosis
-
Kitani, A., et al. Transforming growth factor (TGF)-beta1-producing regulatory T cells induce Smad-mediated interleukin 10 secretion that facilitates coordinated immunoregulatory activity and amelioration of TGF-beta1-mediated fibrosis. J. Exp. Med. 198:8 (2003), 1179–1188.
-
(2003)
J. Exp. Med.
, vol.198
, Issue.8
, pp. 1179-1188
-
-
Kitani, A.1
-
183
-
-
80053140858
-
TGF-beta signaling via Smad4 drives IL-10 production in effector Th1 cells and reduces T-cell trafficking in EAE
-
Huss, D.J., et al. TGF-beta signaling via Smad4 drives IL-10 production in effector Th1 cells and reduces T-cell trafficking in EAE. Eur. J. Immunol. 41:10 (2011), 2987–2996.
-
(2011)
Eur. J. Immunol.
, vol.41
, Issue.10
, pp. 2987-2996
-
-
Huss, D.J.1
-
184
-
-
0037039160
-
Physical and functional interaction between GATA-3 and Smad3 allows TGF-beta regulation of GATA target genes
-
Blokzijl, A., ten Dijke, P., Ibanez, C.F., Physical and functional interaction between GATA-3 and Smad3 allows TGF-beta regulation of GATA target genes. Curr. Biol. 12:1 (2002), 35–45.
-
(2002)
Curr. Biol.
, vol.12
, Issue.1
, pp. 35-45
-
-
Blokzijl, A.1
ten Dijke, P.2
Ibanez, C.F.3
-
185
-
-
56349154943
-
Transforming growth factor-beta’ reprograms’ the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset
-
Veldhoen, M., et al. Transforming growth factor-beta’ reprograms’ the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset. Nat. Immunol. 9:12 (2008), 1341–1346.
-
(2008)
Nat. Immunol.
, vol.9
, Issue.12
, pp. 1341-1346
-
-
Veldhoen, M.1
-
186
-
-
56349093347
-
IL-4 inhibits TGF-beta-induced Foxp3+ t cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector t cells
-
Dardalhon, V., et al. IL-4 inhibits TGF-beta-induced Foxp3+ t cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector t cells. Nat. Immunol. 9:12 (2008), 1347–1355.
-
(2008)
Nat. Immunol.
, vol.9
, Issue.12
, pp. 1347-1355
-
-
Dardalhon, V.1
-
187
-
-
84893850913
-
TNF-alpha blockade induces IL-10 expression in human CD4+ T cells
-
Evans, H.G., et al. TNF-alpha blockade induces IL-10 expression in human CD4+ T cells. Nat. Commun., 5, 2014, 3199.
-
(2014)
Nat. Commun.
, vol.5
, pp. 3199
-
-
Evans, H.G.1
-
188
-
-
85014363690
-
TNF blockade maintains an IL-10(+) phenotype in human effector CD4(+) and CD8(+) t cells
-
Roberts, C.A., et al. TNF blockade maintains an IL-10(+) phenotype in human effector CD4(+) and CD8(+) t cells. Front. Immunol., 8, 2017, 157.
-
(2017)
Front. Immunol.
, vol.8
, pp. 157
-
-
Roberts, C.A.1
-
189
-
-
84870027825
-
STATs shape the active enhancer landscape of T cell populations
-
Vahedi, G., et al. STATs shape the active enhancer landscape of T cell populations. Cell 151:5 (2012), 981–993.
-
(2012)
Cell
, vol.151
, Issue.5
, pp. 981-993
-
-
Vahedi, G.1
-
190
-
-
9244263631
-
Conditional deletion of Gata3 shows its essential function in T(H)1-T(H)2 responses
-
Zhu, J., et al. Conditional deletion of Gata3 shows its essential function in T(H)1-T(H)2 responses. Nat. Immunol. 5:11 (2004), 1157–1165.
-
(2004)
Nat. Immunol.
, vol.5
, Issue.11
, pp. 1157-1165
-
-
Zhu, J.1
-
191
-
-
0033152267
-
The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokines
-
Kim, J.I., et al. The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokines. Immunity 10:6 (1999), 745–751.
-
(1999)
Immunity
, vol.10
, Issue.6
, pp. 745-751
-
-
Kim, J.I.1
-
192
-
-
65549118531
-
Sequential polarization and imprinting of type 1 T helper lymphocytes by interferon-gamma and interleukin-12
-
Schulz, E.G., et al. Sequential polarization and imprinting of type 1 T helper lymphocytes by interferon-gamma and interleukin-12. Immunity 30:5 (2009), 673–683.
-
(2009)
Immunity
, vol.30
, Issue.5
, pp. 673-683
-
-
Schulz, E.G.1
-
193
-
-
85059236194
-
RORgammat represses IL-10 production in Th17 cells to maintain their pathogenicity in inducing intestinal inflammation
-
Sun, M., et al. RORgammat represses IL-10 production in Th17 cells to maintain their pathogenicity in inducing intestinal inflammation. J. Immunol. 202:1 (2019), 79–92.
-
(2019)
J. Immunol.
, vol.202
, Issue.1
, pp. 79-92
-
-
Sun, M.1
-
194
-
-
58449124804
-
The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells
-
Bauquet, A.T., et al. The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells. Nat. Immunol. 10:2 (2009), 167–175.
-
(2009)
Nat. Immunol.
, vol.10
, Issue.2
, pp. 167-175
-
-
Bauquet, A.T.1
-
195
-
-
77955903212
-
The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27
-
Apetoh, L., et al. The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27. Nat. Immunol. 11:9 (2010), 854–861.
-
(2010)
Nat. Immunol.
, vol.11
, Issue.9
, pp. 854-861
-
-
Apetoh, L.1
-
196
-
-
85045444334
-
c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4(+) T cells
-
Gabrysova, L., et al. c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4(+) T cells. Nat. Immunol. 19:5 (2018), 497–507.
-
(2018)
Nat. Immunol.
, vol.19
, Issue.5
, pp. 497-507
-
-
Gabrysova, L.1
-
197
-
-
85042146013
-
c-MAF-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont
-
Xu, M., et al. c-MAF-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont. Nature 554:7692 (2018), 373–377.
-
(2018)
Nature
, vol.554
, Issue.7692
, pp. 373-377
-
-
Xu, M.1
-
198
-
-
81255136238
-
Transcription factor c-Maf mediates the TGF-beta-dependent suppression of IL-22 production in T(H)17 cells
-
Rutz, S., et al. Transcription factor c-Maf mediates the TGF-beta-dependent suppression of IL-22 production in T(H)17 cells. Nat. Immunol. 12:12 (2011), 1238–1245.
-
(2011)
Nat. Immunol.
, vol.12
, Issue.12
, pp. 1238-1245
-
-
Rutz, S.1
-
199
-
-
85053329887
-
An immunoregulatory and tissue-residency program modulated by c-MAF in human TH17 cells
-
Aschenbrenner, D., et al. An immunoregulatory and tissue-residency program modulated by c-MAF in human TH17 cells. Nat. Immunol. 19:10 (2018), 1126–1136.
-
(2018)
Nat. Immunol.
, vol.19
, Issue.10
, pp. 1126-1136
-
-
Aschenbrenner, D.1
-
200
-
-
85060943397
-
The cholesterol biosynthesis pathway regulates IL-10 expression in human Th1 cells
-
Perucha, E., et al. The cholesterol biosynthesis pathway regulates IL-10 expression in human Th1 cells. Nat. Commun., 10(1), 2019, 498.
-
(2019)
Nat. Commun.
, vol.10
, Issue.1
, pp. 498
-
-
Perucha, E.1
-
201
-
-
77955859470
-
Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell-like and Foxp3(+) regulatory T cells
-
Gandhi, R., et al. Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell-like and Foxp3(+) regulatory T cells. Nat. Immunol. 11:9 (2010), 846–853.
-
(2010)
Nat. Immunol.
, vol.11
, Issue.9
, pp. 846-853
-
-
Gandhi, R.1
-
202
-
-
42649095378
-
Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor
-
Quintana, F.J., et al. Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor. Nature 453:7191 (2008), 65–71.
-
(2008)
Nature
, vol.453
, Issue.7191
, pp. 65-71
-
-
Quintana, F.J.1
-
203
-
-
42649106556
-
The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins
-
Veldhoen, M., et al. The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins. Nature 453:7191 (2008), 106–109.
-
(2008)
Nature
, vol.453
, Issue.7191
, pp. 106-109
-
-
Veldhoen, M.1
-
204
-
-
85016945979
-
Activin-A co-opts IRF4 and AhR signaling to induce human regulatory T cells that restrain asthmatic responses
-
Tousa, S., et al. Activin-A co-opts IRF4 and AhR signaling to induce human regulatory T cells that restrain asthmatic responses. Proc. Natl. Acad. Sci. U. S. A. 114:14 (2017), E2891–E2900.
-
(2017)
Proc. Natl. Acad. Sci. U. S. A.
, vol.114
, Issue.14
, pp. E2891-E2900
-
-
Tousa, S.1
-
205
-
-
85052400624
-
The transcription factor Bhlhe40 is a switch of inflammatory versus antiinflammatory Th1 cell fate determination
-
Yu, F., et al. The transcription factor Bhlhe40 is a switch of inflammatory versus antiinflammatory Th1 cell fate determination. J. Exp. Med. 215:7 (2018), 1813–1821.
-
(2018)
J. Exp. Med.
, vol.215
, Issue.7
, pp. 1813-1821
-
-
Yu, F.1
-
206
-
-
84961196714
-
IL-1-induced Bhlhe40 identifies pathogenic T helper cells in a model of autoimmune neuroinflammation
-
Lin, C.C., et al. IL-1-induced Bhlhe40 identifies pathogenic T helper cells in a model of autoimmune neuroinflammation. J. Exp. Med. 213:2 (2016), 251–271.
-
(2016)
J. Exp. Med.
, vol.213
, Issue.2
, pp. 251-271
-
-
Lin, C.C.1
-
207
-
-
85054689768
-
Regulating the regulator: Bhlhe40 directly keeps IL-10 in check
-
Gabrysova, L., O'Garra, A., Regulating the regulator: Bhlhe40 directly keeps IL-10 in check. J. Exp. Med. 215:7 (2018), 1767–1769.
-
(2018)
J. Exp. Med.
, vol.215
, Issue.7
, pp. 1767-1769
-
-
Gabrysova, L.1
O'Garra, A.2
-
208
-
-
33645979374
-
Transcriptional repressor Blimp-1 is essential for T cell homeostasis and self-tolerance
-
Kallies, A., et al. Transcriptional repressor Blimp-1 is essential for T cell homeostasis and self-tolerance. Nat. Immunol. 7:5 (2006), 466–474.
-
(2006)
Nat. Immunol.
, vol.7
, Issue.5
, pp. 466-474
-
-
Kallies, A.1
-
209
-
-
33646010346
-
Transcriptional repressor Blimp-1 regulates T cell homeostasis and function
-
Martins, G.A., et al. Transcriptional repressor Blimp-1 regulates T cell homeostasis and function. Nat. Immunol. 7:5 (2006), 457–465.
-
(2006)
Nat. Immunol.
, vol.7
, Issue.5
, pp. 457-465
-
-
Martins, G.A.1
-
210
-
-
79952994082
-
CD4+ T cell help and innate-derived IL-27 induce Blimp-1-dependent IL-10 production by antiviral CTLs
-
Sun, J., et al. CD4+ T cell help and innate-derived IL-27 induce Blimp-1-dependent IL-10 production by antiviral CTLs. Nat. Immunol. 12:4 (2011), 327–334.
-
(2011)
Nat. Immunol.
, vol.12
, Issue.4
, pp. 327-334
-
-
Sun, J.1
-
211
-
-
84876436991
-
Egr-2 transcription factor is required for Blimp-1-mediated IL-10 production in IL-27-stimulated CD4+ T cells
-
Iwasaki, Y., et al. Egr-2 transcription factor is required for Blimp-1-mediated IL-10 production in IL-27-stimulated CD4+ T cells. Eur. J. Immunol. 43:4 (2013), 1063–1073.
-
(2013)
Eur. J. Immunol.
, vol.43
, Issue.4
, pp. 1063-1073
-
-
Iwasaki, Y.1
-
212
-
-
79952955744
-
The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells
-
Cretney, E., et al. The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells. Nat. Immunol. 12:4 (2011), 304–311.
-
(2011)
Nat. Immunol.
, vol.12
, Issue.4
, pp. 304-311
-
-
Cretney, E.1
-
213
-
-
84905482250
-
Chronic viral infection promotes sustained Th1-derived immunoregulatory IL-10 via BLIMP-1
-
Parish, I.A., et al. Chronic viral infection promotes sustained Th1-derived immunoregulatory IL-10 via BLIMP-1. J. Clin. Invest. 124:8 (2014), 3455–3468.
-
(2014)
J. Clin. Invest.
, vol.124
, Issue.8
, pp. 3455-3468
-
-
Parish, I.A.1
-
214
-
-
42649120075
-
Regulation and functions of Blimp-1 in t and B lymphocytes
-
Martins, G., Calame, K., Regulation and functions of Blimp-1 in t and B lymphocytes. Annu. Rev. Immunol. 26 (2008), 133–169.
-
(2008)
Annu. Rev. Immunol.
, vol.26
, pp. 133-169
-
-
Martins, G.1
Calame, K.2
-
215
-
-
85028924924
-
Eomesodermin promotes the development of type 1 regulatory T (TR1) cells
-
Zhang, P., et al. Eomesodermin promotes the development of type 1 regulatory T (TR1) cells. Sci. Immunol., 2(10), 2017.
-
(2017)
Sci. Immunol.
, vol.2
, Issue.10
-
-
Zhang, P.1
-
216
-
-
85056821108
-
Eomesodermin controls a unique differentiation program in human IL-10 and IFN-gamma coproducing regulatory T cells
-
Gruarin, P., et al. Eomesodermin controls a unique differentiation program in human IL-10 and IFN-gamma coproducing regulatory T cells. Eur. J. Immunol. 49:1 (2019), 96–111.
-
(2019)
Eur. J. Immunol.
, vol.49
, Issue.1
, pp. 96-111
-
-
Gruarin, P.1
-
217
-
-
9344260280
-
Interferon-alpha stimulates production of interleukin-10 in activated CD4+ T cells and monocytes
-
Aman, M.J., et al. Interferon-alpha stimulates production of interleukin-10 in activated CD4+ T cells and monocytes. Blood 87:11 (1996), 4731–4736.
-
(1996)
Blood
, vol.87
, Issue.11
, pp. 4731-4736
-
-
Aman, M.J.1
-
218
-
-
84885783510
-
Type I interferon potentiates T-cell receptor mediated induction of IL-10-producing CD4(+) T cells
-
Corre, B., et al. Type I interferon potentiates T-cell receptor mediated induction of IL-10-producing CD4(+) T cells. Eur. J. Immunol. 43:10 (2013), 2730–2740.
-
(2013)
Eur. J. Immunol.
, vol.43
, Issue.10
, pp. 2730-2740
-
-
Corre, B.1
-
219
-
-
0035339884
-
IFN-alpha and IL-10 induce the differentiation of human type 1 T regulatory cells
-
Levings, M.K., et al. IFN-alpha and IL-10 induce the differentiation of human type 1 T regulatory cells. J. Immunol. 166:9 (2001), 5530–5539.
-
(2001)
J. Immunol.
, vol.166
, Issue.9
, pp. 5530-5539
-
-
Levings, M.K.1
-
220
-
-
84878739093
-
Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis
-
Hinks, A., et al. Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis. Nat. Genet. 45:6 (2013), 664–669.
-
(2013)
Nat. Genet.
, vol.45
, Issue.6
, pp. 664-669
-
-
Hinks, A.1
-
221
-
-
85024906085
-
Transancestral mapping and genetic load in systemic lupus erythematosus
-
Langefeld, C.D., et al. Transancestral mapping and genetic load in systemic lupus erythematosus. Nat. Commun., 8, 2017, 16021.
-
(2017)
Nat. Commun.
, vol.8
, pp. 16021
-
-
Langefeld, C.D.1
-
222
-
-
76049083598
-
Genome-wide association study in a high-risk isolate for multiple sclerosis reveals associated variants in STAT3 gene
-
Jakkula, E., et al. Genome-wide association study in a high-risk isolate for multiple sclerosis reveals associated variants in STAT3 gene. Am. J. Hum. Genet. 86:2 (2010), 285–291.
-
(2010)
Am. J. Hum. Genet.
, vol.86
, Issue.2
, pp. 285-291
-
-
Jakkula, E.1
-
223
-
-
84255194782
-
Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci
-
Patsopoulos, N.A., et al. Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci. Ann. Neurol. 70:6 (2011), 897–912.
-
(2011)
Ann. Neurol.
, vol.70
, Issue.6
, pp. 897-912
-
-
Patsopoulos, N.A.1
-
224
-
-
80051684615
-
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
-
International Multiple Sclerosis Genetics, C, et al. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature 476:7359 (2011), 214–219.
-
(2011)
Nature
, vol.476
, Issue.7359
, pp. 214-219
-
-
International Multiple Sclerosis Genetics, C,1
-
225
-
-
48349136889
-
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
-
Barrett, J.C., et al. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat. Genet. 40:8 (2008), 955–962.
-
(2008)
Nat. Genet.
, vol.40
, Issue.8
, pp. 955-962
-
-
Barrett, J.C.1
-
226
-
-
84890107642
-
Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data
-
Denny, J.C., et al. Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data. Nat. Biotechnol. 31:12 (2013), 1102–1110.
-
(2013)
Nat. Biotechnol.
, vol.31
, Issue.12
, pp. 1102-1110
-
-
Denny, J.C.1
-
227
-
-
84949087646
-
Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis
-
Paternoster, L., et al. Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis. Nat. Genet. 47:12 (2015), 1449–1456.
-
(2015)
Nat. Genet.
, vol.47
, Issue.12
, pp. 1449-1456
-
-
Paternoster, L.1
-
228
-
-
4644369302
-
Interleukin-2 is essential for CD4+CD25+ regulatory T cell function
-
de la Rosa, M., et al. Interleukin-2 is essential for CD4+CD25+ regulatory T cell function. Eur. J. Immunol. 34:9 (2004), 2480–2488.
-
(2004)
Eur. J. Immunol.
, vol.34
, Issue.9
, pp. 2480-2488
-
-
de la Rosa, M.1
-
229
-
-
14944386649
-
CD25+ CD4+ T cells compete with naive CD4+ T cells for IL-2 and exploit it for the induction of IL-10 production
-
Barthlott, T., et al. CD25+ CD4+ T cells compete with naive CD4+ T cells for IL-2 and exploit it for the induction of IL-10 production. Int. Immunol. 17:3 (2005), 279–288.
-
(2005)
Int. Immunol.
, vol.17
, Issue.3
, pp. 279-288
-
-
Barthlott, T.1
-
230
-
-
85035776645
-
Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology
-
Ferreira, M.A., et al. Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology. Nat. Genet. 49:12 (2017), 1752–1757.
-
(2017)
Nat. Genet.
, vol.49
, Issue.12
, pp. 1752-1757
-
-
Ferreira, M.A.1
-
231
-
-
85065824400
-
Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies
-
Pividori, M., et al. Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies. Lancet Respir. Med. 7:6 (2019), 509–522.
-
(2019)
Lancet Respir. Med.
, vol.7
, Issue.6
, pp. 509-522
-
-
Pividori, M.1
-
232
-
-
85063686271
-
Genetic architectures of childhood- and adult-onset asthma are partly distinct
-
Ferreira, M.A.R., et al. Genetic architectures of childhood- and adult-onset asthma are partly distinct. Am. J. Hum. Genet. 104:4 (2019), 665–684.
-
(2019)
Am. J. Hum. Genet.
, vol.104
, Issue.4
, pp. 665-684
-
-
Ferreira, M.A.R.1
-
233
-
-
0032189103
-
The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis
-
Fishman, D., et al. The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J. Clin. Invest. 102:7 (1998), 1369–1376.
-
(1998)
J. Clin. Invest.
, vol.102
, Issue.7
, pp. 1369-1376
-
-
Fishman, D.1
-
234
-
-
84870531924
-
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis
-
Eyre, S., et al. High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. Nat. Genet. 44:12 (2012), 1336–1340.
-
(2012)
Nat. Genet.
, vol.44
, Issue.12
, pp. 1336-1340
-
-
Eyre, S.1
-
235
-
-
0030704726
-
A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
-
Groux, H., et al. A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 389:6652 (1997), 737–742.
-
(1997)
Nature
, vol.389
, Issue.6652
, pp. 737-742
-
-
Groux, H.1
-
236
-
-
84940771118
-
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations
-
Liu, J.Z., et al. Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations. Nat. Genet. 47:9 (2015), 979–986.
-
(2015)
Nat. Genet.
, vol.47
, Issue.9
, pp. 979-986
-
-
Liu, J.Z.1
-
237
-
-
70649103789
-
Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region
-
Consortium, U.I.G., et al. Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region. Nat. Genet. 41:12 (2009), 1330–1334.
-
(2009)
Nat. Genet.
, vol.41
, Issue.12
, pp. 1330-1334
-
-
Consortium, U.I.G.1
-
238
-
-
77950296637
-
Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL)
-
Franke, A., et al. Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL). Nat. Genet. 42:4 (2010), 292–294.
-
(2010)
Nat. Genet.
, vol.42
, Issue.4
, pp. 292-294
-
-
Franke, A.1
-
239
-
-
84949097483
-
Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus
-
Bentham, J., et al. Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus. Nat. Genet. 47:12 (2015), 1457–1464.
-
(2015)
Nat. Genet.
, vol.47
, Issue.12
, pp. 1457-1464
-
-
Bentham, J.1
-
240
-
-
85008712412
-
Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease
-
de Lange, K.M., et al. Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease. Nat. Genet. 49:2 (2017), 256–261.
-
(2017)
Nat. Genet.
, vol.49
, Issue.2
, pp. 256-261
-
-
de Lange, K.M.1
-
241
-
-
84945529572
-
Characterization of genetic loci that affect susceptibility to inflammatory bowel diseases in African Americans
-
Huang, C., et al. Characterization of genetic loci that affect susceptibility to inflammatory bowel diseases in African Americans. Gastroenterology 149:6 (2015), 1575–1586.
-
(2015)
Gastroenterology
, vol.149
, Issue.6
, pp. 1575-1586
-
-
Huang, C.1
-
242
-
-
84941025159
-
Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases
-
Li, Y.R., et al. Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases. Nat. Med. 21:9 (2015), 1018–1027.
-
(2015)
Nat. Med.
, vol.21
, Issue.9
, pp. 1018-1027
-
-
Li, Y.R.1
-
243
-
-
85058877156
-
Genome-wide meta-analysis reveals shared new loci in systemic seropositive rheumatic diseases
-
Acosta-Herrera, M., et al. Genome-wide meta-analysis reveals shared new loci in systemic seropositive rheumatic diseases. Ann. Rheum. Dis. 78:3 (2019), 311–319.
-
(2019)
Ann. Rheum. Dis.
, vol.78
, Issue.3
, pp. 311-319
-
-
Acosta-Herrera, M.1
-
244
-
-
67649876123
-
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci
-
De Jager, P.L., et al. Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. Nat. Genet. 41:7 (2009), 776–782.
-
(2009)
Nat. Genet.
, vol.41
, Issue.7
, pp. 776-782
-
-
De Jager, P.L.1
-
245
-
-
79953743757
-
Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production
-
Chung, S.A., et al. Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production. PLoS Genet., 7(3), 2011, e1001323.
-
(2011)
PLoS Genet.
, vol.7
, Issue.3
, pp. e1001323
-
-
Chung, S.A.1
-
246
-
-
84978153699
-
Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus
-
Morris, D.L., et al. Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus. Nat. Genet. 48:8 (2016), 940–946.
-
(2016)
Nat. Genet.
, vol.48
, Issue.8
, pp. 940-946
-
-
Morris, D.L.1
-
247
-
-
84881026639
-
A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci
-
Hinds, D.A., et al. A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci. Nat. Genet. 45:8 (2013), 907–911.
-
(2013)
Nat. Genet.
, vol.45
, Issue.8
, pp. 907-911
-
-
Hinds, D.A.1
-
248
-
-
70149105112
-
IL-27 is a key regulator of IL-10 and IL-17 production by human CD4+ T cells
-
Murugaiyan, G., et al. IL-27 is a key regulator of IL-10 and IL-17 production by human CD4+ T cells. J. Immunol. 183:4 (2009), 2435–2443.
-
(2009)
J. Immunol.
, vol.183
, Issue.4
, pp. 2435-2443
-
-
Murugaiyan, G.1
-
249
-
-
85068490457
-
A genome-wide association study identifying RAP1A as a novel susceptibility gene for Crohn's disease in Japanese individuals
-
Kakuta, Y., et al. A genome-wide association study identifying RAP1A as a novel susceptibility gene for Crohn's disease in Japanese individuals. J. Crohns Colitis 13:5 (2019), 648–658.
-
(2019)
J. Crohns Colitis
, vol.13
, Issue.5
, pp. 648-658
-
-
Kakuta, Y.1
-
250
-
-
84968649781
-
Detection and interpretation of shared genetic influences on 42 human traits
-
Pickrell, J.K., et al. Detection and interpretation of shared genetic influences on 42 human traits. Nat. Genet. 48:7 (2016), 709–717.
-
(2016)
Nat. Genet.
, vol.48
, Issue.7
, pp. 709-717
-
-
Pickrell, J.K.1
-
251
-
-
85049975477
-
Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis
-
Waage, J., et al. Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis. Nat. Genet. 50:8 (2018), 1072–1080.
-
(2018)
Nat. Genet.
, vol.50
, Issue.8
, pp. 1072-1080
-
-
Waage, J.1
-
252
-
-
77952888454
-
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci
-
Stahl, E.A., et al. Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. Nat. Genet. 42:6 (2010), 508–514.
-
(2010)
Nat. Genet.
, vol.42
, Issue.6
, pp. 508-514
-
-
Stahl, E.A.1
-
253
-
-
0347895101
-
Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype
-
Kemper, C., et al. Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype. Nature 421:6921 (2003), 388–392.
-
(2003)
Nature
, vol.421
, Issue.6921
, pp. 388-392
-
-
Kemper, C.1
-
254
-
-
77955876612
-
Complement regulator CD46 temporally regulates cytokine production by conventional and unconventional T cells
-
Cardone, J., et al. Complement regulator CD46 temporally regulates cytokine production by conventional and unconventional T cells. Nat. Immunol. 11:9 (2010), 862–871.
-
(2010)
Nat. Immunol.
, vol.11
, Issue.9
, pp. 862-871
-
-
Cardone, J.1
-
255
-
-
84868336049
-
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
-
Jostins, L., et al. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature 491:7422 (2012), 119–124.
-
(2012)
Nature
, vol.491
, Issue.7422
, pp. 119-124
-
-
Jostins, L.1
-
256
-
-
79952195585
-
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
-
Anderson, C.A., et al. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nat. Genet. 43:3 (2011), 246–252.
-
(2011)
Nat. Genet.
, vol.43
, Issue.3
, pp. 246-252
-
-
Anderson, C.A.1
-
257
-
-
69549124480
-
CD4+CD25-LAG3+ regulatory T cells controlled by the transcription factor Egr-2
-
Okamura, T., et al. CD4+CD25-LAG3+ regulatory T cells controlled by the transcription factor Egr-2. Proc. Natl. Acad. Sci. U. S. A. 106:33 (2009), 13974–13979.
-
(2009)
Proc. Natl. Acad. Sci. U. S. A.
, vol.106
, Issue.33
, pp. 13974-13979
-
-
Okamura, T.1
-
258
-
-
84939133461
-
Dissecting allele architecture of early onset IBD using high-density genotyping
-
Cutler, D.J., et al. Dissecting allele architecture of early onset IBD using high-density genotyping. PLoS One, 10(6), 2015, e0128074.
-
(2015)
PLoS One
, vol.10
, Issue.6
, pp. e0128074
-
-
Cutler, D.J.1
-
259
-
-
84894288992
-
Genetics of rheumatoid arthritis contributes to biology and drug discovery
-
Okada, Y., et al. Genetics of rheumatoid arthritis contributes to biology and drug discovery. Nature 506:7488 (2014), 376–381.
-
(2014)
Nature
, vol.506
, Issue.7488
, pp. 376-381
-
-
Okada, Y.1
-
260
-
-
85066303169
-
Genetic influences on susceptibility to rheumatoid arthritis in African-Americans
-
Laufer, V.A., et al. Genetic influences on susceptibility to rheumatoid arthritis in African-Americans. Hum. Mol. Genet. 28:5 (2019), 858–874.
-
(2019)
Hum. Mol. Genet.
, vol.28
, Issue.5
, pp. 858-874
-
-
Laufer, V.A.1
-
261
-
-
85014914802
-
Etv5 regulates IL-10 production in Th cells
-
Koh, B., et al. Etv5 regulates IL-10 production in Th cells. J. Immunol. 198:5 (2017), 2165–2171.
-
(2017)
J. Immunol.
, vol.198
, Issue.5
, pp. 2165-2171
-
-
Koh, B.1
-
262
-
-
79954992071
-
The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells
-
Motomura, Y., et al. The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells. Nat. Immunol. 12:5 (2011), 450–459.
-
(2011)
Nat. Immunol.
, vol.12
, Issue.5
, pp. 450-459
-
-
Motomura, Y.1
-
263
-
-
84928106416
-
High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci
-
Kim, K., et al. High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci. Ann. Rheum. Dis., 74(3), 2015, e13.
-
(2015)
Ann. Rheum. Dis.
, vol.74
, Issue.3
, pp. e13
-
-
Kim, K.1
-
264
-
-
79954421203
-
IRF4 regulates IL-10 gene expression in CD4(+) T cells through differential nuclear translocation
-
Lee, C.G., et al. IRF4 regulates IL-10 gene expression in CD4(+) T cells through differential nuclear translocation. Cell. Immunol. 268:2 (2011), 97–104.
-
(2011)
Cell. Immunol.
, vol.268
, Issue.2
, pp. 97-104
-
-
Lee, C.G.1
-
265
-
-
85059493220
-
Leveraging polygenic functional enrichment to improve GWAS power
-
Kichaev, G., et al. Leveraging polygenic functional enrichment to improve GWAS power. Am. J. Hum. Genet. 104:1 (2019), 65–75.
-
(2019)
Am. J. Hum. Genet.
, vol.104
, Issue.1
, pp. 65-75
-
-
Kichaev, G.1
-
266
-
-
14244251950
-
Ets-1, a functional cofactor of T-bet, is essential for Th1 inflammatory responses
-
Grenningloh, R., Kang, B.Y., Ho, I.C., Ets-1, a functional cofactor of T-bet, is essential for Th1 inflammatory responses. J. Exp. Med. 201:4 (2005), 615–626.
-
(2005)
J. Exp. Med.
, vol.201
, Issue.4
, pp. 615-626
-
-
Grenningloh, R.1
Kang, B.Y.2
Ho, I.C.3
-
267
-
-
84863184174
-
Interaction of Ets-1 with HDAC1 represses IL-10 expression in Th1 cells
-
Lee, C.G., et al. Interaction of Ets-1 with HDAC1 represses IL-10 expression in Th1 cells. J. Immunol. 188:5 (2012), 2244–2253.
-
(2012)
J. Immunol.
, vol.188
, Issue.5
, pp. 2244-2253
-
-
Lee, C.G.1
-
268
-
-
84927103576
-
Glycogen synthase kinase-3 controls IL-10 expression in CD4(+) effector T-cell subsets through epigenetic modification of the IL-10 promoter
-
Hill, E.V., et al. Glycogen synthase kinase-3 controls IL-10 expression in CD4(+) effector T-cell subsets through epigenetic modification of the IL-10 promoter. Eur. J. Immunol. 45:4 (2015), 1103–1115.
-
(2015)
Eur. J. Immunol.
, vol.45
, Issue.4
, pp. 1103-1115
-
-
Hill, E.V.1
|