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Volumn 14, Issue 3, 2014, Pages 141-153

Intestinal epithelial cells: Regulators of barrier function and immune homeostasis

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN A; TIGHT JUNCTION PROTEIN;

EID: 84896851032     PISSN: 14741733     EISSN: 14741741     Source Type: Journal    
DOI: 10.1038/nri3608     Document Type: Review
Times cited : (2227)

References (196)
  • 1
    • 34249933089 scopus 로고    scopus 로고
    • Altered permeability in inflammatory bowel disease: Pathophysiology and clinical implications
    • Mankertz, J. & Schulzke, J.-D. Altered permeability in inflammatory bowel disease: pathophysiology and clinical implications. Curr. Opin. Gastroenterol. 23, 379-383 (2007).
    • (2007) Curr. Opin. Gastroenterol , vol.23 , pp. 379-383
    • Mankertz, J.1    Schulzke, J.-D.2
  • 2
    • 33845532053 scopus 로고    scopus 로고
    • Microbial translocation is a cause of systemic immune activation in chronic HIV infection
    • Brenchley, J. M. et al. Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nature Med. 12, 1365-1371 (2006).
    • (2006) Nature Med , vol.12 , pp. 1365-1371
    • Brenchley, J.M.1
  • 3
    • 80053606297 scopus 로고    scopus 로고
    • Host response to translocated microbial products predicts outcomes of patients with HBV or HCV infection
    • Sandler, N. G. et al. Host response to translocated microbial products predicts outcomes of patients with HBV or HCV infection. Gastroenterology 141, 1220-1230 (2011).
    • (2011) Gastroenterology , vol.141 , pp. 1220-1230
    • Sandler, N.G.1
  • 4
    • 34347399563 scopus 로고    scopus 로고
    • Metabolic endotoxemia initiates obesity and insulin resistance
    • Cani, P. D. et al. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes 56, 1761-1772 (2007).
    • (2007) Diabetes , vol.56 , pp. 1761-1772
    • Cani, P.D.1
  • 5
    • 80052278497 scopus 로고    scopus 로고
    • Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: Molecular mechanisms and probiotic treatment
    • Amar, J. et al. Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment. EMBO Mol. Med. 3, 559-572 (2011).
    • (2011) EMBO Mol. Med , vol.3 , pp. 559-572
    • Amar, J.1
  • 6
    • 54549122338 scopus 로고    scopus 로고
    • Innate immunity and intestinal microbiota in the development of type 1 diabetes
    • Wen, L. et al. Innate immunity and intestinal microbiota in the development of type 1 diabetes. Nature 455, 1109-1113 (2008).
    • (2008) Nature , vol.455 , pp. 1109-1113
    • Wen, L.1
  • 7
    • 79952748674 scopus 로고    scopus 로고
    • Colloquium paper: Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis
    • Lee, Y. K., Menezes, J. S., Umesaki, Y. & Mazmanian, S. K. Colloquium paper: Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis. Proc. Natl Acad. Sci. USA 108, 4615-4622 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.108 , pp. 4615-4622
    • Lee, Y.K.1    Menezes, J.S.2    Umesaki, Y.3    Mazmanian, S.K.4
  • 8
    • 81855167104 scopus 로고    scopus 로고
    • Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination
    • Berer, K. et al. Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination. Nature 479, 538-541 (2011).
    • (2011) Nature , vol.479 , pp. 538-541
    • Berer, K.1
  • 9
    • 77953913586 scopus 로고    scopus 로고
    • Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells
    • Wu, H.-J. et al. Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells. Immunity 32, 815-827 (2010).
    • (2010) Immunity , vol.32 , pp. 815-827
    • Wu, H.-J.1
  • 10
    • 84876913132 scopus 로고    scopus 로고
    • Role of the gut microbiota in immunity and inflammatory disease
    • Kamada, N., Seo, S.-U., Chen, G. Y. & Nez, G. Role of the gut microbiota in immunity and inflammatory disease. Nature Rev. Immunol. 13, 321-335 (2013).
    • (2013) Nature Rev. Immunol , vol.13 , pp. 321-335
    • Kamada, N.1    Seo, S.-U.2    Chen, G.Y.3    Nez, G.4
  • 11
    • 84861980130 scopus 로고    scopus 로고
    • Interactions between the microbiota and the immune system
    • Hooper, L. V., Littman, D. R. & Macpherson, A. J. Interactions between the microbiota and the immune system. Science 336, 1268-1273 (2012).
    • (2012) Science , vol.336 , pp. 1268-1273
    • Hooper, L.V.1    Littman, D.R.2    Macpherson, A.J.3
  • 12
    • 84859389254 scopus 로고    scopus 로고
    • The microbiome in infectious disease and inflammation
    • Honda, K. & Littman, D. R. The microbiome in infectious disease and inflammation. Annu. Rev. Immunol. 30, 759-795 (2012).
    • (2012) Annu. Rev. Immunol , vol.30 , pp. 759-795
    • Honda, K.1    Littman, D.R.2
  • 13
    • 84866167497 scopus 로고    scopus 로고
    • Reciprocal interactions of the intestinal microbiota and immune system
    • Maynard, C. L., Elson, C. O., Hatton, R. D. & Weaver, C. T. Reciprocal interactions of the intestinal microbiota and immune system. Nature 489, 231-241 (2012).
    • (2012) Nature , vol.489 , pp. 231-241
    • Maynard, C.L.1    Elson, C.O.2    Hatton, R.D.3    Weaver, C.T.4
  • 14
    • 84865278789 scopus 로고    scopus 로고
    • Viral interactions with the host and microbiota in the intestine
    • Moon, C. & Stappenbeck, T. S. Viral interactions with the host and microbiota in the intestine. Curr. Opin. Immunol. 24, 405-410 (2012).
    • (2012) Curr. Opin. Immunol , vol.24 , pp. 405-410
    • Moon, C.1    Stappenbeck, T.S.2
  • 15
    • 33646182727 scopus 로고    scopus 로고
    • Organizing cell renewal in the intestine: Stem cells, signals and combinatorial control
    • Crosnier, C., Stamataki, D. & Lewis, J. Organizing cell renewal in the intestine: stem cells, signals and combinatorial control. Nature Rev. Genet. 7, 349-359 (2006).
    • (2006) Nature Rev. Genet , vol.7 , pp. 349-359
    • Crosnier, C.1    Stamataki, D.2    Lewis, J.3
  • 16
    • 67651159312 scopus 로고    scopus 로고
    • Stem cells, self-renewal, and differentiation in the intestinal epithelium
    • Van der Flier, L. G. & Clevers, H. Stem cells, self-renewal, and differentiation in the intestinal epithelium. Annu. Rev. Physiol. 71, 241-260 (2009).
    • (2009) Annu. Rev. Physiol , vol.71 , pp. 241-260
    • Van Der Flier, L.G.1    Clevers, H.2
  • 17
    • 77958170401 scopus 로고    scopus 로고
    • Intestinal goblet cells and mucins in health and disease: Recent insights and progress
    • Kim, Y. S. & Ho, S. B. Intestinal goblet cells and mucins in health and disease: recent insights and progress. Curr. Gastroenterol. Rep. 12, 319-330 (2010).
    • (2010) Curr. Gastroenterol. Rep , vol.12 , pp. 319-330
    • Kim, Y.S.1    Ho, S.B.2
  • 18
    • 84862862332 scopus 로고    scopus 로고
    • Epithelial antimicrobial defence of the skin and intestine
    • Gallo, R. L. & Hooper, L. V. Epithelial antimicrobial defence of the skin and intestine. Nature Rev. Immunol. 12, 503-516 (2012).
    • (2012) Nature Rev. Immunol , vol.12 , pp. 503-516
    • Gallo, R.L.1    Hooper, L.V.2
  • 19
    • 54449083567 scopus 로고    scopus 로고
    • The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria
    • Johansson, M. E. V. et al. The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria. Proc. Natl Acad. Sci. USA 105, 15064-15069 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 15064-15069
    • Johansson, M.E.V.1
  • 20
    • 0036500996 scopus 로고    scopus 로고
    • Colorectal cancer in mice genetically deficient in the mucin Muc2
    • Velcich, A. et al. Colorectal cancer in mice genetically deficient in the mucin Muc2. Science 295, 1726-1729 (2002).
    • (2002) Science , vol.295 , pp. 1726-1729
    • Velcich, A.1
  • 21
    • 33745746660 scopus 로고    scopus 로고
    • Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection
    • Van der Sluis, M. et al. Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection. Gastroenterology 131, 117-129 (2006).
    • (2006) Gastroenterology , vol.131 , pp. 117-129
    • Van Der Sluis, M.1
  • 22
    • 0034681162 scopus 로고    scopus 로고
    • Intestinal trefoil factor confers colonic epithelial resistance to apoptosis
    • Taupin, D. R., Kinoshita, K. & Podolsky, D. K. Intestinal trefoil factor confers colonic epithelial resistance to apoptosis. Proc. Natl Acad. Sci. USA 97, 799-804 (2000).
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 799-804
    • Taupin, D.R.1    Kinoshita, K.2    Podolsky, D.K.3
  • 23
    • 0028360991 scopus 로고
    • Trefoil peptides promote epithelial migration through a transforming growth factor ?-independent pathway
    • Dignass, A., Lynch-Devaney, K., Kindon, H., Thim, L. & Podolsky, D. K. Trefoil peptides promote epithelial migration through a transforming growth factor ?-independent pathway. J. Clin. Invest. 94, 376-383 (1994).
    • (1994) J. Clin. Invest , vol.94 , pp. 376-383
    • Dignass, A.1    Lynch-Devaney, K.2    Kindon, H.3    Thim, L.4    Podolsky, D.K.5
  • 24
    • 4544300682 scopus 로고    scopus 로고
    • RELM?/FIZZ2 is a goblet cell-specific immune-effector molecule in the gastrointestinal tract
    • Artis, D. et al. RELM?/FIZZ2 is a goblet cell-specific immune-effector molecule in the gastrointestinal tract. Proc. Natl Acad. Sci. USA 101, 13596-13600 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 13596-13600
    • Artis, D.1
  • 25
    • 58149286587 scopus 로고    scopus 로고
    • Goblet cell-derived resistin-like molecule ? Augments CD4+ T cell production of IFN-? And infection-induced intestinal inflammation
    • Nair, M. G. et al. Goblet cell-derived resistin-like molecule ? augments CD4+ T cell production of IFN-? and infection-induced intestinal inflammation. J. Immunol. 181, 4709-4715 (2008).
    • (2008) J. Immunol , vol.181 , pp. 4709-4715
    • Nair, M.G.1
  • 26
    • 79954915318 scopus 로고    scopus 로고
    • Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis
    • Bevins, C. L. & Salzman, N. H. Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis. Nature Rev. Microbiol. 9, 356-368 (2011).
    • (2011) Nature Rev. Microbiol , vol.9 , pp. 356-368
    • Bevins, C.L.1    Salzman, N.H.2
  • 27
    • 84892373963 scopus 로고    scopus 로고
    • Antibacterial membrane attack by a pore-forming intestinal C-type lectin
    • Mukherjee, S. et al. Antibacterial membrane attack by a pore-forming intestinal C-type lectin. Nature 505, 103-107 (2014).
    • (2014) Nature , vol.505 , pp. 103-107
    • Mukherjee, S.1
  • 28
    • 33745343647 scopus 로고    scopus 로고
    • Positional specificity of defensin gene expression reveals Paneth cell heterogeneity in mouse small intestine
    • Darmoul, D. & Ouellette, A. J. Positional specificity of defensin gene expression reveals Paneth cell heterogeneity in mouse small intestine. Am. J. Physiol. 271, G68-G74 (1996).
    • (1996) Am. J. Physiol , vol.271
    • Darmoul, D.1    Ouellette, A.J.2
  • 29
    • 80054122238 scopus 로고    scopus 로고
    • The antibacterial lectin RegIII? Promotes the spatial segregation of microbiota and host in the intestine
    • Vaishnava, S. et al. The antibacterial lectin RegIII? promotes the spatial segregation of microbiota and host in the intestine. Science 334, 255-258 (2011).
    • (2011) Science , vol.334 , pp. 255-258
    • Vaishnava, S.1
  • 30
    • 44149126798 scopus 로고    scopus 로고
    • Secreted enteric antimicrobial activity localises to the mucus surface layer
    • Meyer-Hoffert, U. et al. Secreted enteric antimicrobial activity localises to the mucus surface layer. Gut 57, 764-771 (2008).
    • (2008) Gut , vol.57 , pp. 764-771
    • Meyer-Hoffert, U.1
  • 31
    • 33846627302 scopus 로고    scopus 로고
    • A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1
    • Hampe, J. et al. A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Nature Genet. 39, 207-211 (2007).
    • (2007) Nature Genet , vol.39 , pp. 207-211
    • Hampe, J.1
  • 32
    • 34247554965 scopus 로고    scopus 로고
    • Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis
    • Rioux, J. D. et al. Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nature Genet. 39, 596-604 (2007).
    • (2007) Nature Genet , vol.39 , pp. 596-604
    • Rioux, J.D.1
  • 33
    • 56249135538 scopus 로고    scopus 로고
    • A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells
    • Cadwell, K. et al. A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature 456, 259-263 (2008).
    • (2008) Nature , vol.456 , pp. 259-263
    • Cadwell, K.1
  • 34
    • 50249086073 scopus 로고    scopus 로고
    • XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease
    • Kaser, A. et al. XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell 134, 743-756 (2008).
    • (2008) Cell , vol.134 , pp. 743-756
    • Kaser, A.1
  • 35
    • 62549129560 scopus 로고    scopus 로고
    • Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response
    • Brandl, K. et al. Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response. Proc. Natl Acad. Sci. USA 106, 3300-3305 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 3300-3305
    • Brandl, K.1
  • 36
    • 77953904042 scopus 로고    scopus 로고
    • Virus-plus-susceptibility gene interaction determines Crohns disease gene Atg16L1 phenotypes in intestine
    • Cadwell, K. et al. Virus-plus-susceptibility gene interaction determines Crohns disease gene Atg16L1 phenotypes in intestine. Cell 141, 1135-1145 (2010).
    • (2010) Cell , vol.141 , pp. 1135-1145
    • Cadwell, K.1
  • 37
    • 79959216005 scopus 로고    scopus 로고
    • Genetics and pathogenesis of inflammatory bowel disease
    • Khor, B., Gardet, A. & Xavier, R. J. Genetics and pathogenesis of inflammatory bowel disease. Nature 474, 307-317 (2011).
    • (2011) Nature , vol.474 , pp. 307-317
    • Khor, B.1    Gardet, A.2    Xavier, R.J.3
  • 38
    • 84879107779 scopus 로고    scopus 로고
    • Intestinal epithelial autophagy is essential for host defense against invasive bacteria
    • Benjamin, J. L., Sumpter, R. Jr, Levine, B. & Hooper, L. V. Intestinal epithelial autophagy is essential for host defense against invasive bacteria. Cell Host Microbe 13, 723-734 (2013).
    • (2013) Cell Host Microbe , vol.13 , pp. 723-734
    • Benjamin, J.L.1    Sumpter Jr., R.2    Levine, B.3    Hooper, L.V.4
  • 39
    • 84887621906 scopus 로고    scopus 로고
    • Paneth cells as a site of origin for intestinal inflammation
    • Adolph, T. E. et al. Paneth cells as a site of origin for intestinal inflammation. Nature 503, 272-276 (2013).
    • (2013) Nature , vol.503 , pp. 272-276
    • Adolph, T.E.1
  • 40
    • 80054963764 scopus 로고    scopus 로고
    • Regulation of the polymeric immunoglobulin receptor and IgA transport: New advances in environmental factors that stimulate pIgR expression and its role in mucosal immunity
    • Johansen, F.-E. & Kaetzel, C. S. Regulation of the polymeric immunoglobulin receptor and IgA transport: new advances in environmental factors that stimulate pIgR expression and its role in mucosal immunity. Mucosal Immunol. 4, 598-602 (2011).
    • (2011) Mucosal Immunol , vol.4 , pp. 598-602
    • Johansen, F.-E.1    Kaetzel, C.S.2
  • 41
    • 0033523608 scopus 로고    scopus 로고
    • Absence of epithelial immunoglobulin a transport, with increased mucosal leakiness, in polymeric immunoglobulin receptor/ secretory component-deficient mice
    • Johansen, F.-E. et al. Absence of epithelial immunoglobulin a transport, with increased mucosal leakiness, in polymeric immunoglobulin receptor/ secretory component-deficient mice. J. Exp. Med. 190, 915-922 (1999).
    • (1999) J. Exp. Med , vol.190 , pp. 915-922
    • Johansen, F.-E.1
  • 42
    • 84856083002 scopus 로고    scopus 로고
    • Crosstalk between B lymphocytes, microbiota and the intestinal epithelium governs immunity versus metabolism in the gut
    • Shulzhenko, N. et al. Crosstalk between B lymphocytes, microbiota and the intestinal epithelium governs immunity versus metabolism in the gut. Nature Med. 17, 1585-1593 (2011).
    • (2011) Nature Med , vol.17 , pp. 1585-1593
    • Shulzhenko, N.1
  • 43
    • 1242296822 scopus 로고    scopus 로고
    • Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut
    • Suzuki, K. et al. Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut. Proc. Natl Acad. Sci. USA 101, 1981-1986 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 1981-1986
    • Suzuki, K.1
  • 44
    • 84879336857 scopus 로고    scopus 로고
    • Microfold (M) cells: Important immunosurveillance posts in the intestinal epithelium
    • Mabbott, N. A., Donaldson, D. S., Ohno, H., Williams, I. R. & Mahajan, A. Microfold (M) cells: important immunosurveillance posts in the intestinal epithelium. Mucosal Immunol. 6, 666-677 (2013).
    • (2013) Mucosal Immunol , vol.6 , pp. 666-677
    • Mabbott, N.A.1    Donaldson, D.S.2    Ohno, H.3    Williams, I.R.4    Mahajan, A.5
  • 45
    • 0038316325 scopus 로고    scopus 로고
    • Anatomical basis of tolerance and immunity to intestinal antigens
    • Mowat, A. M. Anatomical basis of tolerance and immunity to intestinal antigens. Nature Rev. Immunol. 3, 331-341 (2003).
    • (2003) Nature Rev. Immunol , vol.3 , pp. 331-341
    • Mowat, A.M.1
  • 46
    • 70449653428 scopus 로고    scopus 로고
    • Uptake through glycoprotein 2 of FimH+ bacteria by M cells initiates mucosal immune response
    • Hase, K. et al. Uptake through glycoprotein 2 of FimH+ bacteria by M cells initiates mucosal immune response. Nature 462, 226-230 (2009).
    • (2009) Nature , vol.462 , pp. 226-230
    • Hase, K.1
  • 47
    • 84863230541 scopus 로고    scopus 로고
    • Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine
    • McDole, J. R. et al. Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine. Nature 483, 345-349 (2012).
    • (2012) Nature , vol.483 , pp. 345-349
    • McDole, J.R.1
  • 48
    • 0035321325 scopus 로고    scopus 로고
    • Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria
    • Rescigno, M. et al. Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria. Nature Immunol. 2, 361-367 (2001).
    • (2001) Nature Immunol , vol.2 , pp. 361-367
    • Rescigno, M.1
  • 49
    • 33845910419 scopus 로고    scopus 로고
    • Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TLR engagement
    • Chieppa, M., Rescigno, M., Huang, A. Y. C. & Germain, R. N. Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TLR engagement. J. Exp. Med. 203, 2841-2852 (2006).
    • (2006) J. Exp. Med , vol.203 , pp. 2841-2852
    • Chieppa, M.1    Rescigno, M.2    Huang, A.Y.C.3    Germain, R.N.4
  • 50
    • 84886280379 scopus 로고    scopus 로고
    • Mucus enhances gut homeostasis and oral tolerance by delivering immunoregulatory signals
    • Shan, M. et al. Mucus enhances gut homeostasis and oral tolerance by delivering immunoregulatory signals. Science 342, 447-453 (2013).
    • (2013) Science , vol.342 , pp. 447-453
    • Shan, M.1
  • 51
    • 75649093343 scopus 로고    scopus 로고
    • Toll-like receptor signalling in the intestinal epithelium: How bacterial recognition shapes intestinal function
    • Abreu, M. T. Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function. Nature Rev. Immunol. 10, 131-144 (2010).
    • (2010) Nature Rev. Immunol , vol.10 , pp. 131-144
    • Abreu, M.T.1
  • 52
    • 81855228056 scopus 로고    scopus 로고
    • Inflammasomes in intestinal inflammation and cancer
    • Chen, G. Y. & Nez, G. Inflammasomes in intestinal inflammation and cancer. Gastroenterology 141, 1986-1999 (2011).
    • (2011) Gastroenterology , vol.141 , pp. 1986-1999
    • Chen, G.Y.1    Nez, G.2
  • 53
    • 84874028928 scopus 로고    scopus 로고
    • Integrative inflammasome activity in the regulation of intestinal mucosal immune responses
    • Elinav, E., Henao-Mejia, J. & Flavell, R. A. Integrative inflammasome activity in the regulation of intestinal mucosal immune responses. Mucosal Immunol. 6, 4-13 (2013).
    • (2013) Mucosal Immunol , vol.6 , pp. 4-13
    • Elinav, E.1    Henao-Mejia, J.2    Flavell, R.A.3
  • 54
    • 80054810643 scopus 로고    scopus 로고
    • Mitochondrial antiviral signaling protein (MAVS) monitors commensal bacteria and induces an immune response that prevents experimental colitis
    • Li, X.-D. et al. Mitochondrial antiviral signaling protein (MAVS) monitors commensal bacteria and induces an immune response that prevents experimental colitis. Proc. Natl Acad. Sci. USA 108, 17390-17395 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 17390-17395
    • Li, X.-D.1
  • 55
    • 79251564770 scopus 로고    scopus 로고
    • RIG-I/MDA5/MAVS are required to signal a protective IFN response in rotavirus-infected intestinal epithelium
    • Broquet, A. H., Hirata, Y., McAllister, C. S. & Kagnoff, M. F. RIG-I/MDA5/MAVS are required to signal a protective IFN response in rotavirus-infected intestinal epithelium. J. Immunol. 186, 1618-1626 (2011).
    • (2011) J. Immunol , vol.186 , pp. 1618-1626
    • Broquet, A.H.1    Hirata, Y.2    McAllister, C.S.3    Kagnoff, M.F.4
  • 56
    • 3242664636 scopus 로고    scopus 로고
    • Recognition of commensal microflora by Toll-like receptors is required for intestinal homeostasis
    • Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S. & Medzhitov, R. Recognition of commensal microflora by Toll-like receptors is required for intestinal homeostasis. Cell 118, 229-241 (2004).
    • (2004) Cell , vol.118 , pp. 229-241
    • Rakoff-Nahoum, S.1    Paglino, J.2    Eslami-Varzaneh, F.3    Edberg, S.4    Medzhitov, R.5
  • 57
    • 78650548872 scopus 로고    scopus 로고
    • MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands
    • Brandl, K. et al. MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands. Proc. Natl Acad. Sci. USA 107, 19967-19972 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 19967-19972
    • Brandl, K.1
  • 58
    • 67649231565 scopus 로고    scopus 로고
    • Colitis-associated variant of TLR2 causes impaired mucosal repair because of TFF3 deficiency
    • Podolsky, D. K., Gerken, G., Eyking, A. & Cario, E. Colitis-associated variant of TLR2 causes impaired mucosal repair because of TFF3 deficiency. Gastroenterology 137, 209-220 (2009).
    • (2009) Gastroenterology , vol.137 , pp. 209-220
    • Podolsky, D.K.1    Gerken, G.2    Eyking, A.3    Cario, E.4
  • 59
    • 3242692641 scopus 로고    scopus 로고
    • Toll-like receptor 2 enhances ZO-1-associated intestinal epithelial barrier integrity via protein kinase C
    • Cario, E., Gerken, G. & Podolsky, D. K. Toll-like receptor 2 enhances ZO-1-associated intestinal epithelial barrier integrity via protein kinase C. Gastroenterology 127, 224-238 (2004).
    • (2004) Gastroenterology , vol.127 , pp. 224-238
    • Cario, E.1    Gerken, G.2    Podolsky, D.K.3
  • 60
    • 4043088499 scopus 로고    scopus 로고
    • IKK? Links inflammation and tumorigenesis in a mouse model of colitis-associated cancer
    • Greten, F. R. et al. IKK? links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell 118, 285-296 (2004).
    • (2004) Cell , vol.118 , pp. 285-296
    • Greten, F.R.1
  • 61
    • 34047173496 scopus 로고    scopus 로고
    • Epithelial NEMO links innate immunity to chronic intestinal inflammation
    • Nenci, A. et al. Epithelial NEMO links innate immunity to chronic intestinal inflammation. Nature 446, 557-561 (2007).
    • (2007) Nature , vol.446 , pp. 557-561
    • Nenci, A.1
  • 62
    • 0035978651 scopus 로고    scopus 로고
    • Association of NOD2 leucine-rich repeat variants with susceptibility to Crohns disease
    • Hugot, J.-P. et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohns disease. Nature 411, 599-603 (2001).
    • (2001) Nature , vol.411 , pp. 599-603
    • Hugot, J.-P.1
  • 63
    • 0035978533 scopus 로고    scopus 로고
    • A frameshift mutation in NOD2 associated with susceptibility to Crohns disease
    • Ogura, Y. et al. A frameshift mutation in NOD2 associated with susceptibility to Crohns disease. Nature 411, 603-606 (2001).
    • (2001) Nature , vol.411 , pp. 603-606
    • Ogura, Y.1
  • 64
    • 79953084107 scopus 로고    scopus 로고
    • The Nlrp3 inflammasome: Contributions to intestinal homeostasis
    • Zaki, M. H., Lamkanfi, M. & Kanneganti, T.-D. The Nlrp3 inflammasome: contributions to intestinal homeostasis. Trends Immunol. 32, 171-179 (2011).
    • (2011) Trends Immunol , vol.32 , pp. 171-179
    • Zaki, M.H.1    Lamkanfi, M.2    Kanneganti, T.-D.3
  • 65
    • 79957670765 scopus 로고    scopus 로고
    • Enteric commensal bacteria potentiate epithelial restitution via reactive oxygen species-mediated inactivation of focal adhesion kinase phosphatases
    • Swanson, P. A. et al. Enteric commensal bacteria potentiate epithelial restitution via reactive oxygen species-mediated inactivation of focal adhesion kinase phosphatases. Proc. Natl Acad. Sci. USA 108, 8803-8808 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 8803-8808
    • Swanson, P.A.1
  • 66
    • 84873816901 scopus 로고    scopus 로고
    • Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair
    • Leoni, G. et al. Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair. J. Clin. Invest. 123, 443-454 (2012).
    • (2012) J. Clin. Invest , vol.123 , pp. 443-454
    • Leoni, G.1
  • 67
    • 70349617474 scopus 로고    scopus 로고
    • Bacterial-modulated host immunity and stem cell activation for gut homeostasis
    • Lee, W.-J. Bacterial-modulated host immunity and stem cell activation for gut homeostasis. Genes Dev. 23, 2260-2265 (2009).
    • (2009) Genes Dev , vol.23 , pp. 2260-2265
    • Lee, W.-J.1
  • 68
    • 79551610653 scopus 로고    scopus 로고
    • Redox regulation by Keap1 and Nrf2 controls intestinal stem cell proliferation in
    • Hochmuth, C. E., Biteau, B., Bohmann, D. & Jasper, H. Redox regulation by Keap1 and Nrf2 controls intestinal stem cell proliferation in Drosophila. Cell Stem Cell 8, 188-199 (2011).
    • (2011) Drosophila. Cell Stem Cell , vol.8 , pp. 188-199
    • Hochmuth, C.E.1    Biteau, B.2    Bohmann, D.3    Jasper, H.4
  • 69
    • 84888864785 scopus 로고    scopus 로고
    • Symbiotic lactobacilli stimulate gut epithelial proliferation via Nox-mediated generation of reactive oxygen species
    • Jones, R. M. et al. Symbiotic lactobacilli stimulate gut epithelial proliferation via Nox-mediated generation of reactive oxygen species. EMBO J. 32, 3017-3028 (2013).
    • (2013) EMBO J , vol.32 , pp. 3017-3028
    • Jones, R.M.1
  • 70
    • 34447296425 scopus 로고    scopus 로고
    • Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88
    • Rakoff-Nahoum, S. & Medzhitov, R. Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88. Science 317, 124-127 (2007).
    • (2007) Science , vol.317 , pp. 124-127
    • Rakoff-Nahoum, S.1    Medzhitov, R.2
  • 71
    • 77953196709 scopus 로고    scopus 로고
    • ERK activation drives intestinal tumorigenesis in Apcmin/+ mice
    • Lee, S. H. et al. ERK activation drives intestinal tumorigenesis in Apcmin/+ mice. Nature Med. 16, 665-670 (2010).
    • (2010) Nature Med , vol.16 , pp. 665-670
    • Lee, S.H.1
  • 72
    • 79959944892 scopus 로고    scopus 로고
    • Constitutive IKK2 activation in intestinal epithelial cells induces intestinal tumors in mice
    • Vlantis, K. et al. Constitutive IKK2 activation in intestinal epithelial cells induces intestinal tumors in mice. J. Clin. Invest. 121, 2781-2793 (2011).
    • (2011) J. Clin. Invest , vol.121 , pp. 2781-2793
    • Vlantis, K.1
  • 73
    • 84872600554 scopus 로고    scopus 로고
    • Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties
    • Schwitalla, S. et al. Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties. Cell 152, 25-38 (2013).
    • (2013) Cell , vol.152 , pp. 25-38
    • Schwitalla, S.1
  • 74
    • 36549082403 scopus 로고    scopus 로고
    • Toll-Like receptor-4 promotes the development of colitis-associated colorectal tumors
    • Fukata, M. et al. Toll-Like receptor-4 promotes the development of colitis-associated colorectal tumors. Gastroenterology 133, 1869-1869 (2007).
    • (2007) Gastroenterology , vol.133 , pp. 1869-1869
    • Fukata, M.1
  • 75
    • 34247175428 scopus 로고    scopus 로고
    • The Toll-interleukin-1 receptor member SIGIRR regulates colonic epithelial homeostasis, inflammation, and tumorigenesis
    • Xiao, H. et al. The Toll-interleukin-1 receptor member SIGIRR regulates colonic epithelial homeostasis, inflammation, and tumorigenesis. Immunity 26, 461-475 (2007).
    • (2007) Immunity , vol.26 , pp. 461-475
    • Xiao, H.1
  • 76
    • 77949965210 scopus 로고    scopus 로고
    • Control of intestinal homeostasis, colitis, and colitis-associated colorectal cancer by the inflammatory caspases
    • Dupaul-Chicoine, J. et al. Control of intestinal homeostasis, colitis, and colitis-associated colorectal cancer by the inflammatory caspases. Immunity 32, 367-378 (2010).
    • (2010) Immunity , vol.32 , pp. 367-378
    • Dupaul-Chicoine, J.1
  • 77
    • 78650735879 scopus 로고    scopus 로고
    • Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4
    • Hu, B. et al. Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4. PNAS 107, 21635-21640 (2010).
    • (2010) PNAS , vol.107 , pp. 21635-21640
    • Hu, B.1
  • 78
    • 81255189478 scopus 로고    scopus 로고
    • The NOD-like receptor NLRP12 attenuates colon inflammation and tumorigenesis
    • Zaki, M. H. et al. The NOD-like receptor NLRP12 attenuates colon inflammation and tumorigenesis. Cancer Cell 20, 649-660 (2011).
    • (2011) Cancer Cell , vol.20 , pp. 649-660
    • Zaki, M.H.1
  • 79
    • 79959369355 scopus 로고    scopus 로고
    • Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injury
    • Normand, S. et al. Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injury. Proc. Natl Acad. Sci. USA 108, 9601-9606 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 9601-9606
    • Normand, S.1
  • 80
    • 84861460062 scopus 로고    scopus 로고
    • NLRP12 suppresses colon inflammation and tumorigenesis through the negative regulation of noncanonical NF-?B signaling
    • Allen, I. C. et al. NLRP12 suppresses colon inflammation and tumorigenesis through the negative regulation of noncanonical NF-?B signaling. Immunity 36, 742-754 (2012).
    • (2012) Immunity , vol.36 , pp. 742-754
    • Allen, I.C.1
  • 81
    • 77955350419 scopus 로고    scopus 로고
    • MyD88-mediated signaling prevents development of adenocarcinomas of the colon: Role of interleukin 18
    • Salcedo, R. et al. MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18. J. Exp. Med. 207, 1625-1636 (2010).
    • (2010) J. Exp. Med , vol.207 , pp. 1625-1636
    • Salcedo, R.1
  • 82
    • 84868615556 scopus 로고    scopus 로고
    • IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine
    • Huber, S. et al. IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine. Nature 491, 259-263 (2012).
    • (2012) Nature , vol.491 , pp. 259-263
    • Huber, S.1
  • 83
    • 1842583729 scopus 로고    scopus 로고
    • Mechanisms of cross hyporesponsiveness to Toll-like receptor bacterial ligands in intestinal epithelial cells
    • Otte, J.-M., Cario, E. & Podolsky, D. K. Mechanisms of cross hyporesponsiveness to Toll-like receptor bacterial ligands in intestinal epithelial cells. Gastroenterology 126, 1054-1070 (2004).
    • (2004) Gastroenterology , vol.126 , pp. 1054-1070
    • Otte, J.-M.1    Cario, E.2    Podolsky, D.K.3
  • 84
    • 33645843063 scopus 로고    scopus 로고
    • Postnatal acquisition of endotoxin tolerance in intestinal epithelial cells
    • Lotz, M. et al. Postnatal acquisition of endotoxin tolerance in intestinal epithelial cells. J. Exp. Med. 203, 973-984 (2006).
    • (2006) J. Exp. Med , vol.203 , pp. 973-984
    • Lotz, M.1
  • 85
    • 77954391573 scopus 로고    scopus 로고
    • Enterocyte-specific A20 deficiency sensitizes to tumor necrosis factor-induced toxicity and experimental colitis
    • Vereecke, L. et al. Enterocyte-specific A20 deficiency sensitizes to tumor necrosis factor-induced toxicity and experimental colitis. J. Exp. Med. 207, 1513-1523 (2010).
    • (2010) J. Exp. Med , vol.207 , pp. 1513-1523
    • Vereecke, L.1
  • 86
    • 77958105934 scopus 로고    scopus 로고
    • MiR-146a mediates protective innate immune tolerance in the neonate intestine
    • Chassin, C. et al. miR-146a mediates protective innate immune tolerance in the neonate intestine. Cell Host Microbe 8, 358-368 (2010).
    • (2010) Cell Host Microbe , vol.8 , pp. 358-368
    • Chassin, C.1
  • 87
    • 80054842204 scopus 로고    scopus 로고
    • Constitutive intestinal NF-?B does not trigger destructive inflammation unless accompanied by MAPK activation
    • Guma, M. et al. Constitutive intestinal NF-?B does not trigger destructive inflammation unless accompanied by MAPK activation. J. Exp. Med. 208, 1889-1900 (2011).
    • (2011) J. Exp. Med , vol.208 , pp. 1889-1900
    • Guma, M.1
  • 88
    • 0034284803 scopus 로고    scopus 로고
    • Prokaryotic regulation of epithelial responses by inhibition of I?B-? Ubiquitination
    • Neish, A. S. et al. Prokaryotic regulation of epithelial responses by inhibition of I?B-? ubiquitination. Science 289, 1560-1563 (2000).
    • (2000) Science , vol.289 , pp. 1560-1563
    • Neish, A.S.1
  • 89
    • 59849113820 scopus 로고    scopus 로고
    • The bacterial fermentation product butyrate influences epithelial signaling via reactive oxygen species-mediated changes in cullin-1 neddylation
    • Kumar, A. et al. The bacterial fermentation product butyrate influences epithelial signaling via reactive oxygen species-mediated changes in cullin-1 neddylation. J. Immunol. 182, 538-546 (2009).
    • (2009) J. Immunol , vol.182 , pp. 538-546
    • Kumar, A.1
  • 90
    • 84865298775 scopus 로고    scopus 로고
    • Dissecting negative regulation of Toll-like receptor signaling
    • Kondo, T., Kawai, T. & Akira, S. Dissecting negative regulation of Toll-like receptor signaling. Trends Immunol. 33, 449-458 (2012).
    • (2012) Trends Immunol , vol.33 , pp. 449-458
    • Kondo, T.1    Kawai, T.2    Akira, S.3
  • 91
    • 84857546470 scopus 로고    scopus 로고
    • Beyond pattern recognition: Five immune checkpoints for scaling the microbial threat
    • Blander, J. M. & Sander, L. E. Beyond pattern recognition: five immune checkpoints for scaling the microbial threat. Nature Rev. Immunol. 12, 215-225 (2012).
    • (2012) Nature Rev. Immunol , vol.12 , pp. 215-225
    • Blander, J.M.1    Sander, L.E.2
  • 92
    • 0035881675 scopus 로고    scopus 로고
    • Cutting edge: Bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression
    • Gewirtz, A. T., Navas, T. A., Lyons, S., Godowski, P. J. & Madara, J. L. Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression. J. Immunol. 167, 1882-1885 (2001).
    • (2001) J. Immunol , vol.167 , pp. 1882-1885
    • Gewirtz, A.T.1    Navas, T.A.2    Lyons, S.3    Godowski, P.J.4    Madara, J.L.5
  • 93
    • 26444440067 scopus 로고    scopus 로고
    • Pathophysiological role of Toll-like receptor 5 engagement by bacterial flagellin in colonic inflammation
    • Rhee, S. H. et al. Pathophysiological role of Toll-like receptor 5 engagement by bacterial flagellin in colonic inflammation. Proc. Natl Acad. Sci. USA 102, 13610-13615 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 13610-13615
    • Rhee, S.H.1
  • 94
    • 33751551466 scopus 로고    scopus 로고
    • Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells
    • Lee, J. et al. Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells. Nature Cell Biol. 8, 1327-1336 (2006).
    • (2006) Nature Cell Biol , vol.8 , pp. 1327-1336
    • Lee, J.1
  • 95
    • 22244465576 scopus 로고    scopus 로고
    • Membrane recruitment of NOD2 in intestinal epithelial cells is essential for nuclear factor-?B activation in muramyl dipeptide recognition
    • Barnich, N., Aguirre, J. E., Reinecker, H.-C., Xavier, R. & Podolsky, D. K. Membrane recruitment of NOD2 in intestinal epithelial cells is essential for nuclear factor-?B activation in muramyl dipeptide recognition. J. Cell Biol. 170, 21-26 (2005).
    • (2005) J. Cell Biol , vol.170 , pp. 21-26
    • Barnich, N.1    Aguirre, J.E.2    Reinecker, H.-C.3    Xavier, R.4    Podolsky, D.K.5
  • 96
    • 84871837817 scopus 로고    scopus 로고
    • RNAi screening identifies mediators of NOD2 signaling: Implications for spatial specificity of MDP recognition
    • Lipinski, S. et al. RNAi screening identifies mediators of NOD2 signaling: Implications for spatial specificity of MDP recognition. Proc. Natl Acad. Sci. USA 109, 21426-21431 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 21426-21431
    • Lipinski, S.1
  • 97
    • 0037066427 scopus 로고    scopus 로고
    • The danger model: A renewed sense of self
    • Matzinger, P. The danger model: A renewed sense of self. Science 296, 301-305 (2002).
    • (2002) Science , vol.296 , pp. 301-305
    • Matzinger, P.1
  • 98
    • 79959242498 scopus 로고    scopus 로고
    • Detection of prokaryotic mRNA signifies microbial viability and promotes immunity
    • Sander, L. E. et al. Detection of prokaryotic mRNA signifies microbial viability and promotes immunity. Nature 474, 385-389 (2011).
    • (2011) Nature , vol.474 , pp. 385-389
    • Sander, L.E.1
  • 99
    • 0037340434 scopus 로고    scopus 로고
    • Angiogenins: A new class of microbicidal proteins involved in innate immunity
    • Hooper, L. V., Stappenbeck, T. S., Hong, C. V. & Gordon, J. I. Angiogenins: a new class of microbicidal proteins involved in innate immunity. Nature Immunol. 4, 269-273 (2003).
    • (2003) Nature Immunol , vol.4 , pp. 269-273
    • Hooper, L.V.1    Stappenbeck, T.S.2    Hong, C.V.3    Gordon, J.I.4
  • 100
    • 13244292161 scopus 로고    scopus 로고
    • Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract
    • Kobayashi, K. S. et al. Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science 307, 731-734 (2005).
    • (2005) Science , vol.307 , pp. 731-734
    • Kobayashi, K.S.1
  • 101
    • 58549111588 scopus 로고    scopus 로고
    • Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface
    • Vaishnava, S., Behrendt, C. L., Ismail, A. S., Eckmann, L. & Hooper, L. V. Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface. Proc. Natl Acad. Sci. USA 105, 20858-20863 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 20858-20863
    • Vaishnava, S.1    Behrendt, C.L.2    Ismail, A.S.3    Eckmann, L.4    Hooper, L.V.5
  • 102
    • 79959459365 scopus 로고    scopus 로고
    • Regulation of the polymeric immunoglobulin receptor by the classical and alternative NF-?B pathways in intestinal epithelial cells
    • Bruno, M. E. C., Frantz, A. L., Rogier, E. W., Johansen, F.-E. & Kaetzel, C. S. Regulation of the polymeric immunoglobulin receptor by the classical and alternative NF-?B pathways in intestinal epithelial cells. Mucosal Immunol. 4, 468-478 (2011).
    • (2011) Mucosal Immunol , vol.4 , pp. 468-478
    • Bruno, M.E.C.1    Frantz, A.L.2    Rogier, E.W.3    Johansen, F.-E.4    Kaetzel, C.S.5
  • 103
    • 18244387204 scopus 로고    scopus 로고
    • Intestinal immune homeostasis is regulated by the crosstalk between epithelial cells and dendritic cells
    • Rimoldi, M. et al. Intestinal immune homeostasis is regulated by the crosstalk between epithelial cells and dendritic cells. Nature Immunol. 6, 507-514 (2005).
    • (2005) Nature Immunol , vol.6 , pp. 507-514
    • Rimoldi, M.1
  • 104
    • 37849032964 scopus 로고    scopus 로고
    • Epithelial cells prime the immune response to an array of gut-derived commensals towards a tolerogenic phenotype through distinct actions of thymic stromal lymphopoietin and transforming growth factor-?
    • Zeuthen, L. H., Fink, L. N. & Frokiaer, H. Epithelial cells prime the immune response to an array of gut-derived commensals towards a tolerogenic phenotype through distinct actions of thymic stromal lymphopoietin and transforming growth factor-?. Immunology 123, 197-208 (2008).
    • (2008) Immunology , vol.123 , pp. 197-208
    • Zeuthen, L.H.1    Fink, L.N.2    Frokiaer, H.3
  • 105
    • 33947573767 scopus 로고    scopus 로고
    • Epithelial-cell-intrinsic IKK? Expression regulates intestinal immune homeostasis
    • Zaph, C. et al. Epithelial-cell-intrinsic IKK? expression regulates intestinal immune homeostasis. Nature 446, 552-556 (2007).
    • (2007) Nature , vol.446 , pp. 552-556
    • Zaph, C.1
  • 106
    • 85027947787 scopus 로고    scopus 로고
    • Induction of colonic regulatory T cells by indigenous Clostridium species
    • Atarashi, K. et al. Induction of colonic regulatory T cells by indigenous Clostridium species. Science 331, 337-341 (2011).
    • (2011) Science , vol.331 , pp. 337-341
    • Atarashi, K.1
  • 107
    • 53349120339 scopus 로고    scopus 로고
    • Commensal-dependent expression of IL-25 regulates the IL-23-IL-17 axis in the intestine
    • Zaph, C. et al. Commensal-dependent expression of IL-25 regulates the IL-23-IL-17 axis in the intestine. J. Exp. Med. 205, 2191-2198 (2008).
    • (2008) J. Exp. Med , vol.205 , pp. 2191-2198
    • Zaph, C.1
  • 108
    • 34250205694 scopus 로고    scopus 로고
    • Intestinal bacteria trigger T cell-independent immunoglobulin A2 class switching by inducing epithelial-cell secretion of the cytokine APRIL
    • He, B. et al. Intestinal bacteria trigger T cell-independent immunoglobulin A2 class switching by inducing epithelial-cell secretion of the cytokine APRIL. Immunity 26, 812-826 (2007).
    • (2007) Immunity , vol.26 , pp. 812-826
    • He, B.1
  • 109
    • 34247181001 scopus 로고    scopus 로고
    • Epithelial cells trigger frontline immunoglobulin class switching through a pathway regulated by the inhibitor SLPI
    • Xu, W. et al. Epithelial cells trigger frontline immunoglobulin class switching through a pathway regulated by the inhibitor SLPI. Nature Immunol. 8, 294-303 (2007).
    • (2007) Nature Immunol , vol.8 , pp. 294-303
    • Xu, W.1
  • 110
    • 63449112387 scopus 로고    scopus 로고
    • TSLP regulates intestinal immunity and inflammation in mouse models of helminth infection and colitis
    • Taylor, B. C. et al. TSLP regulates intestinal immunity and inflammation in mouse models of helminth infection and colitis. J. Exp. Med. 206, 655-667 (2009).
    • (2009) J. Exp. Med , vol.206 , pp. 655-667
    • Taylor, B.C.1
  • 111
    • 77956112107 scopus 로고    scopus 로고
    • The puzzle of intestinal lamina propria dendritic cells and macrophages
    • Pabst, O. & Bernhardt, G. The puzzle of intestinal lamina propria dendritic cells and macrophages. Eur. J. Immunol. 40, 2107-2111 (2010).
    • (2010) Eur. J. Immunol , vol.40 , pp. 2107-2111
    • Pabst, O.1    Bernhardt, G.2
  • 112
    • 70049098070 scopus 로고    scopus 로고
    • Origin of the lamina propria dendritic cell network
    • Bogunovic, M. et al. Origin of the lamina propria dendritic cell network. Immunity 31, 513-525 (2009).
    • (2009) Immunity , vol.31 , pp. 513-525
    • Bogunovic, M.1
  • 113
    • 70049099836 scopus 로고    scopus 로고
    • Intestinal lamina propria dendritic cell subsets have different origin and functions
    • Varol, C. et al. Intestinal lamina propria dendritic cell subsets have different origin and functions. Immunity 31, 502-512 (2009).
    • (2009) Immunity , vol.31 , pp. 502-512
    • Varol, C.1
  • 114
    • 84856815290 scopus 로고    scopus 로고
    • Inflammation switches the differentiation program of Ly6Chi monocytes from antiinflammatory macrophages to inflammatory dendritic cells in the colon
    • Rivollier, A., He, J., Kole, A., Valatas, V. & Kelsall, B. L. Inflammation switches the differentiation program of Ly6Chi monocytes from antiinflammatory macrophages to inflammatory dendritic cells in the colon. J. Exp. Med. 209, 139-155 (2012).
    • (2012) J. Exp. Med , vol.209 , pp. 139-155
    • Rivollier, A.1    He, J.2    Kole, A.3    Valatas, V.4    Kelsall, B.L.5
  • 115
    • 84875830139 scopus 로고    scopus 로고
    • Intestinal macrophages: Well educated exceptions from the rule
    • Zigmond, E. & Jung, S. Intestinal macrophages: well educated exceptions from the rule. Trends Immunol. 34, 162-168 (2013).
    • (2013) Trends Immunol , vol.34 , pp. 162-168
    • Zigmond, E.1    Jung, S.2
  • 116
    • 73949107838 scopus 로고    scopus 로고
    • Intestinal CD103+, but not CX3CR1+, antigen sampling cells migrate in lymph and serve classical dendritic cell functions
    • Schulz, O. et al. Intestinal CD103+, but not CX3CR1+, antigen sampling cells migrate in lymph and serve classical dendritic cell functions. J. Exp. Med. 206, 3101-3114 (2009).
    • (2009) J. Exp. Med , vol.206 , pp. 3101-3114
    • Schulz, O.1
  • 117
    • 1542618118 scopus 로고    scopus 로고
    • Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria
    • Macpherson, A. J. & Uhr, T. Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria. Science 303, 1662-1665 (2004).
    • (2004) Science , vol.303 , pp. 1662-1665
    • Macpherson, A.J.1    Uhr, T.2
  • 118
    • 34547788180 scopus 로고    scopus 로고
    • A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-?- and retinoic acid- dependent mechanism
    • Coombes, J. L. et al. A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-?- and retinoic acid- dependent mechanism. J. Exp. Med. 204, 1757-1764 (2007).
    • (2007) J. Exp. Med , vol.204 , pp. 1757-1764
    • Coombes, J.L.1
  • 119
    • 34547757390 scopus 로고    scopus 로고
    • Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid
    • Sun, C.-M. et al. Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid. J. Exp. Med. 204, 1775-1785 (2007).
    • (2007) J. Exp. Med , vol.204 , pp. 1775-1785
    • Sun, C.-M.1
  • 120
    • 0038264036 scopus 로고    scopus 로고
    • Selective imprinting of gut-homing T cells by Peyers patch dendritic cells
    • Mora, J. R. et al. Selective imprinting of gut-homing T cells by Peyers patch dendritic cells. Nature 424, 88-93 (2003).
    • (2003) Nature , vol.424 , pp. 88-93
    • Mora, J.R.1
  • 121
    • 26844538936 scopus 로고    scopus 로고
    • Functional specialization of gut CD103+ dendritic cells in the regulation of tissue-selective T cell homing
    • Johansson-Lindbom, B. et al. Functional specialization of gut CD103+ dendritic cells in the regulation of tissue-selective T cell homing. J. Exp. Med. 202, 1063-1073 (2005).
    • (2005) J. Exp. Med , vol.202 , pp. 1063-1073
    • Johansson-Lindbom, B.1
  • 122
    • 5644300399 scopus 로고    scopus 로고
    • Retinoic acid imprints gut-homing specificity on T cells
    • Iwata, M. et al. Retinoic acid imprints gut-homing specificity on T cells. Immunity 21, 527-538 (2004).
    • (2004) Immunity , vol.21 , pp. 527-538
    • Iwata, M.1
  • 123
    • 51049092467 scopus 로고    scopus 로고
    • Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans
    • Jaensson, E. et al. Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans. J. Exp. Med. 205, 2139-2149 (2008).
    • (2008) J. Exp. Med , vol.205 , pp. 2139-2149
    • Jaensson, E.1
  • 124
    • 48849115839 scopus 로고    scopus 로고
    • Differentiation and homing of IgA-secreting cells
    • Mora, J. R. & von Andrian, U. H. Differentiation and homing of IgA-secreting cells. Mucosal Immunol. 1, 96-109 (2008).
    • (2008) Mucosal Immunol , vol.1 , pp. 96-109
    • Mora, J.R.1    Von Andrian, U.H.2
  • 125
    • 12244297799 scopus 로고    scopus 로고
    • CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance
    • Niess, J. H. et al. CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science 307, 254-258 (2005).
    • (2005) Science , vol.307 , pp. 254-258
    • Niess, J.H.1
  • 126
    • 79951772860 scopus 로고    scopus 로고
    • Intestinal tolerance requires gut homing and expansion of FoxP3+ regulatory T cells in the lamina propria
    • Hadis, U. et al. Intestinal tolerance requires gut homing and expansion of FoxP3+ regulatory T cells in the lamina propria. Immunity 34, 237-246 (2011).
    • (2011) Immunity , vol.34 , pp. 237-246
    • Hadis, U.1
  • 127
    • 70350464351 scopus 로고    scopus 로고
    • Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis
    • Murai, M. et al. Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis. Nature Immunol. 10, 1178-1184 (2009).
    • (2009) Nature Immunol , vol.10 , pp. 1178-1184
    • Murai, M.1
  • 128
    • 84859452120 scopus 로고    scopus 로고
    • Intestinal CX3C chemokine receptor 1high (CX3CR1high) myeloid cells prevent T-cell-dependent colitis
    • Kayama, H. et al. Intestinal CX3C chemokine receptor 1high (CX3CR1high) myeloid cells prevent T-cell-dependent colitis. Proc. Natl Acad. Sci. USA 109, 5010-5015 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 5010-5015
    • Kayama, H.1
  • 129
    • 84856584612 scopus 로고    scopus 로고
    • Intestinal epithelial cell-derived semaphorin 7A negatively regulates development of colitis via ?v?1 integrin
    • Kang, S. et al. Intestinal epithelial cell-derived semaphorin 7A negatively regulates development of colitis via ?v?1 integrin. J. Immunol. 188, 1108-1116 (2012).
    • (2012) J. Immunol , vol.188 , pp. 1108-1116
    • Kang, S.1
  • 130
    • 77951817294 scopus 로고    scopus 로고
    • IL25 elicits a multipotent progenitor cell population that promotes TH2 cytokine responses
    • Saenz, S. A. et al. IL25 elicits a multipotent progenitor cell population that promotes TH2 cytokine responses. Nature 464, 1362-1366 (2010).
    • (2010) Nature , vol.464 , pp. 1362-1366
    • Saenz, S.A.1
  • 131
    • 80052582016 scopus 로고    scopus 로고
    • TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation
    • Siracusa, M. C. et al. TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation. Nature 477, 229-233 (2011).
    • (2011) Nature , vol.477 , pp. 229-233
    • Siracusa, M.C.1
  • 132
    • 84886630206 scopus 로고    scopus 로고
    • IL-25 simultaneously elicits distinct populations of innate lymphoid cells and multipotent progenitor type 2 (MPPtype2) cells
    • Saenz, S. A. et al. IL-25 simultaneously elicits distinct populations of innate lymphoid cells and multipotent progenitor type 2 (MPPtype2) cells. J. Exp. Med. 210, 1823-1837 (2013).
    • (2013) J. Exp. Med , vol.210 , pp. 1823-1837
    • Saenz, S.A.1
  • 133
    • 84890150269 scopus 로고    scopus 로고
    • Thymic stromal lymphopoietin-mediated extramedullary hematopoiesis promotes allergic inflammation
    • Siracusa, M. C. et al. Thymic stromal lymphopoietin-mediated extramedullary hematopoiesis promotes allergic inflammation. Immunity 39, 1158-1170 (2013).
    • (2013) Immunity , vol.39 , pp. 1158-1170
    • Siracusa, M.C.1
  • 134
    • 84859384082 scopus 로고    scopus 로고
    • Innate lymphoid cells: Emerging insights in development, lineage relationships, and function
    • Spits, H. & Cupedo, T. Innate lymphoid cells: emerging insights in development, lineage relationships, and function. Annu. Rev. Immunol. 30, 647-675 (2012).
    • (2012) Annu. Rev. Immunol , vol.30 , pp. 647-675
    • Spits, H.1    Cupedo, T.2
  • 135
    • 84862688241 scopus 로고    scopus 로고
    • Innate lymphoid cells: Critical regulators of allergic inflammation and tissue repair in the lung
    • Monticelli, L. A., Sonnenberg, G. F. & Artis, D. Innate lymphoid cells: critical regulators of allergic inflammation and tissue repair in the lung. Curr. Opin. Immunol. 24, 284-289 (2012).
    • (2012) Curr. Opin. Immunol , vol.24 , pp. 284-289
    • Monticelli, L.A.1    Sonnenberg, G.F.2    Artis, D.3
  • 136
    • 84874055169 scopus 로고    scopus 로고
    • TSLP elicits IL-33-independent innate lymphoid cell responses to promote skin inflammation
    • Kim, B. S. et al. TSLP elicits IL-33-independent innate lymphoid cell responses to promote skin inflammation. Sci. Transl. Med. 5, 170ra16 (2013).
    • (2013) Sci. Transl. Med , vol.5
    • Kim, B.S.1
  • 137
    • 84867636023 scopus 로고    scopus 로고
    • Innate lymphoid cells: Balancing immunity, inflammation, and tissue repair in the intestine
    • Tait Wojno, E. D. & Artis, D. Innate lymphoid cells: balancing immunity, inflammation, and tissue repair in the intestine. Cell Host Microbe 12, 445-457 (2012).
    • (2012) Cell Host Microbe , vol.12 , pp. 445-457
    • Tait Wojno, E.D.1    Artis, D.2
  • 139
    • 84862690161 scopus 로고    scopus 로고
    • Development and function of intestinal innate lymphoid cells
    • Cherrier, M., Ohnmacht, C., Cording, S. & Eberl, G. Development and function of intestinal innate lymphoid cells. Curr. Opin. Immunol. 24, 277-283 (2012).
    • (2012) Curr. Opin. Immunol , vol.24 , pp. 277-283
    • Cherrier, M.1    Ohnmacht, C.2    Cording, S.3    Eberl, G.4
  • 140
    • 84872977452 scopus 로고    scopus 로고
    • Innate lymphoid cells - A proposal for uniform nomenclature
    • Spits, H. et al. Innate lymphoid cells - a proposal for uniform nomenclature. Nature Rev. Immunol. 13, 145-149 (2013).
    • (2013) Nature Rev. Immunol , vol.13 , pp. 145-149
    • Spits, H.1
  • 141
    • 85027945857 scopus 로고    scopus 로고
    • Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues
    • Bernink, J. H. et al. Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues. Nature Immunol. 14, 221-229 (2013).
    • (2013) Nature Immunol , vol.14 , pp. 221-229
    • Bernink, J.H.1
  • 142
    • 84876780238 scopus 로고    scopus 로고
    • Intraepithelial type 1 innate lymphoid cells are a unique subset of IL-12- and IL-15-responsive IFN-?-producing cells
    • Fuchs, A. et al. Intraepithelial type 1 innate lymphoid cells are a unique subset of IL-12- and IL-15-responsive IFN-?-producing cells. Immunity 38, 769-781 (2013).
    • (2013) Immunity , vol.38 , pp. 769-781
    • Fuchs, A.1
  • 143
    • 75749122181 scopus 로고    scopus 로고
    • Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells
    • Moro, K. et al. Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells. Nature 463, 540-544 (2009).
    • (2009) Nature , vol.463 , pp. 540-544
    • Moro, K.1
  • 144
    • 77951817855 scopus 로고    scopus 로고
    • Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity
    • Neill, D. R. et al. Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity. Nature 464, 1367-1370 (2010).
    • (2010) Nature , vol.464 , pp. 1367-1370
    • Neill, D.R.1
  • 145
    • 77954926597 scopus 로고    scopus 로고
    • Systemically dispersed innate IL-13-expressing cells in type 2 immunity
    • Price, A. E. et al. Systemically dispersed innate IL-13-expressing cells in type 2 immunity. Proc. Natl Acad. Sci. USA 107, 11489-11494 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 11489-11494
    • Price, A.E.1
  • 146
    • 85027948313 scopus 로고    scopus 로고
    • Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus
    • Monticelli, L. A. et al. Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus. Nature Immunol. 12, 1045-1054 (2011).
    • (2011) Nature Immunol , vol.12 , pp. 1045-1054
    • Monticelli, L.A.1
  • 147
    • 79959380307 scopus 로고    scopus 로고
    • Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity
    • Chang, Y.-J. et al. Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity. Nature Immunol. 12, 631-638 (2011).
    • (2011) Nature Immunol , vol.12 , pp. 631-638
    • Chang, Y.-J.1
  • 148
    • 80054927155 scopus 로고    scopus 로고
    • An IL-9 fate reporter demonstrates the induction of an innate IL-9 response in lung inflammation
    • Wilhelm, C. et al. An IL-9 fate reporter demonstrates the induction of an innate IL-9 response in lung inflammation. Nature Immunol. 12, 1071-1077 (2011).
    • (2011) Nature Immunol , vol.12 , pp. 1071-1077
    • Wilhelm, C.1
  • 149
    • 84858775590 scopus 로고    scopus 로고
    • Lung natural helper cells are a critical source of Th2 cell-type cytokines in protease allergen-induced airway inflammation
    • Halim, T. Y. F., Krau?, R. H., Sun, A. C. & Takei, F. Lung natural helper cells are a critical source of Th2 cell-type cytokines in protease allergen-induced airway inflammation. Immunity 36, 451-463 (2012).
    • (2012) Immunity , vol.36 , pp. 451-463
    • Halim, T.Y.F.1    Krau, R.H.2    Sun, A.C.3    Takei, F.4
  • 150
    • 84867773093 scopus 로고    scopus 로고
    • The transcription factor GATA3 Is essential for the function of human type 2 innate lymphoid cells
    • Mj?sberg, J. et al. The transcription factor GATA3 Is essential for the function of human type 2 innate lymphoid cells. Immunity 37, 649-659 (2012).
    • (2012) Immunity , vol.37 , pp. 649-659
    • Mjsberg, J.1
  • 151
    • 0030710079 scopus 로고    scopus 로고
    • Developing lymph nodes collect, CD4+CD3? LT?+ cells that can differentiate to APC, NK cells, and follicular cells but not T or B cells
    • Mebius, R. E., Rennert, P. & Weissman, I. L. Developing lymph nodes collect, CD4+CD3? LT?+ cells that can differentiate to APC, NK cells, and follicular cells but not T or B cells. Immunity 7, 493-504 (1997).
    • (1997) Immunity , vol.7 , pp. 493-504
    • Mebius, R.E.1    Rennert, P.2    Weissman, I.L.3
  • 152
    • 57449090428 scopus 로고    scopus 로고
    • Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease
    • Zenewicz, L. A. et al. Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease. Immunity 29, 947-957 (2008).
    • (2008) Immunity , vol.29 , pp. 947-957
    • Zenewicz, L.A.1
  • 153
    • 78751706261 scopus 로고    scopus 로고
    • CD4+ lymphoid tissue-inducer cells promote innate immunity in the gut
    • Sonnenberg, G. F., Monticelli, L. A., Elloso, M. M., Fouser, L. A. & Artis, D. CD4+ lymphoid tissue-inducer cells promote innate immunity in the gut. Immunity 34, 122-134 (2011).
    • (2011) Immunity , vol.34 , pp. 122-134
    • Sonnenberg, G.F.1    Monticelli, L.A.2    Elloso, M.M.3    Fouser, L.A.4    Artis, D.5
  • 154
    • 84861989207 scopus 로고    scopus 로고
    • Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria
    • Sonnenberg, G. F. et al. Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria. Science 336, 1321-1325 (2012).
    • (2012) Science , vol.336 , pp. 1321-1325
    • Sonnenberg, G.F.1
  • 155
    • 84865401664 scopus 로고    scopus 로고
    • Interleukin-22 protects intestinal stem cells from immune-mediated tissue damage and regulates sensitivity to graft versus host disease
    • Hanash, A. M. et al. Interleukin-22 protects intestinal stem cells from immune-mediated tissue damage and regulates sensitivity to graft versus host disease. Immunity 37, 339-350 (2012).
    • (2012) Immunity , vol.37 , pp. 339-350
    • Hanash, A.M.1
  • 156
    • 84879571464 scopus 로고    scopus 로고
    • Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model
    • Kirchberger, S. et al. Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model. J. Exp. Med. 210, 917-931 (2013).
    • (2013) J. Exp. Med , vol.210 , pp. 917-931
    • Kirchberger, S.1
  • 157
    • 73949103213 scopus 로고    scopus 로고
    • Interleukin (IL)-23 mediates Toxoplasma gondii-induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17
    • Muoz, M. et al. Interleukin (IL)-23 mediates Toxoplasma gondii-induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17. J. Exp. Med. 206, 3047-3059 (2009).
    • (2009) J. Exp. Med , vol.206 , pp. 3047-3059
    • Muoz, M.1
  • 158
    • 77951878587 scopus 로고    scopus 로고
    • Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology
    • Buonocore, S. et al. Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology. Nature 464, 1371-1375 (2010).
    • (2010) Nature , vol.464 , pp. 1371-1375
    • Buonocore, S.1
  • 159
    • 79958277385 scopus 로고    scopus 로고
    • IL-23-responsive innate lymphoid cells are increased in inflammatory bowel disease
    • Geremia, A. et al. IL-23-responsive innate lymphoid cells are increased in inflammatory bowel disease. J. Exp. Med. 208, 1127-1133 (2011).
    • (2011) J. Exp. Med , vol.208 , pp. 1127-1133
    • Geremia, A.1
  • 160
    • 84866362664 scopus 로고    scopus 로고
    • IL-1? Mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4+ Th17 cells
    • Coccia, M. et al. IL-1? mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4+ Th17 cells. J. Exp. Med. 209, 1595-1609 (2012).
    • (2012) J. Exp. Med , vol.209 , pp. 1595-1609
    • Coccia, M.1
  • 161
    • 79952986650 scopus 로고    scopus 로고
    • ROR?t+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota
    • Sawa, S. et al. ROR?t+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota. Nature Immunol. 12, 320-326 (2011).
    • (2011) Nature Immunol , vol.12 , pp. 320-326
    • Sawa, S.1
  • 162
    • 78649360369 scopus 로고    scopus 로고
    • Regulated expression of nuclear receptor ROR?t confers distinct functional fates to NK cell receptor-expressing ROR?t+ innate lymphocytes
    • Vonarbourg, C. et al. Regulated expression of nuclear receptor ROR?t confers distinct functional fates to NK cell receptor-expressing ROR?t+ innate lymphocytes. Immunity 33, 736-751 (2010).
    • (2010) Immunity , vol.33 , pp. 736-751
    • Vonarbourg, C.1
  • 163
    • 57449118239 scopus 로고    scopus 로고
    • Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense
    • Satoh-Takayama, N. et al. Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense. Immunity 29, 958-970 (2008).
    • (2008) Immunity , vol.29 , pp. 958-970
    • Satoh-Takayama, N.1
  • 164
    • 33646466776 scopus 로고    scopus 로고
    • MyD88-dependent signaling for IL-15 production plays an important role in maintenance of CD8 TCR and TCR intestinal intraepithelial lymphocytes
    • Yu, Q. et al. MyD88-dependent signaling for IL-15 production plays an important role in maintenance of CD8 TCR and TCR intestinal intraepithelial lymphocytes. J. Immunol. 176, 6180-6185 (2006).
    • (2006) J. Immunol , vol.176 , pp. 6180-6185
    • Yu, Q.1
  • 165
    • 79959664629 scopus 로고    scopus 로고
    • The light and dark sides of intestinal intraepithelial lymphocytes
    • Cheroutre, H., Lambolez, F. & Mucida, D. The light and dark sides of intestinal intraepithelial lymphocytes. Nature Rev. Immunol. 11, 445-456 (2011).
    • (2011) Nature Rev. Immunol , vol.11 , pp. 445-456
    • Cheroutre, H.1    Lambolez, F.2    Mucida, D.3
  • 166
    • 84860807200 scopus 로고    scopus 로고
    • Dynamic migration of intraepithelial lymphocytes requires occludin
    • Edelblum, K. L. et al. Dynamic migration of intraepithelial lymphocytes requires occludin. Proc. Natl Acad. Sci. USA 109, 7097-7102 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 7097-7102
    • Edelblum, K.L.1
  • 167
    • 79957701773 scopus 로고    scopus 로고
    • Intraepithelial lymphocytes are essential mediators of host-microbial homeostasis at the intestinal mucosal surface
    • Ismail, A. S. et al. intraepithelial lymphocytes are essential mediators of host-microbial homeostasis at the intestinal mucosal surface. Proc. Natl Acad. Sci. USA 108, 8743-8748 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 8743-8748
    • Ismail, A.S.1
  • 168
    • 85027952412 scopus 로고    scopus 로고
    • Transcriptional reprogramming of mature CD4+ helper T cells generates distinct MHC class II-restricted cytotoxic T lymphocytes
    • Mucida, D. et al. Transcriptional reprogramming of mature CD4+ helper T cells generates distinct MHC class II-restricted cytotoxic T lymphocytes. Nature Immunol. 14, 281-289 (2013).
    • (2013) Nature Immunol , vol.14 , pp. 281-289
    • Mucida, D.1
  • 169
    • 84871713120 scopus 로고    scopus 로고
    • Peripheral tissue surveillance and residency by memory T cells
    • Gebhardt, T., Mueller, S. N., Heath, W. R. & Carbone, F. R. Peripheral tissue surveillance and residency by memory T cells. Trends Immunol. 34, 27-32 (2013).
    • (2013) Trends Immunol , vol.34 , pp. 27-32
    • Gebhardt, T.1    Mueller, S.N.2    Heath, W.R.3    Carbone, F.R.4
  • 170
    • 84872772721 scopus 로고    scopus 로고
    • Distribution and compartmentalization of human circulating and tissue-resident memory T cell subsets
    • Sathaliyawala, T. et al. Distribution and compartmentalization of human circulating and tissue-resident memory T cell subsets. Immunity 38, 187-197 (2013).
    • (2013) Immunity , vol.38 , pp. 187-197
    • Sathaliyawala, T.1
  • 171
    • 0033151953 scopus 로고    scopus 로고
    • Mucosal T lymphocyte numbers are selectively reduced in integrin ?E (CD103)-deficient mice
    • Sch?n, M. P. et al. Mucosal T lymphocyte numbers are selectively reduced in integrin ?E (CD103)-deficient mice. J. Immunol. 162, 6641-6649 (1999).
    • (1999) J. Immunol , vol.162 , pp. 6641-6649
    • Schn, M.P.1
  • 172
    • 19344361971 scopus 로고    scopus 로고
    • TGF-?-dependent CD103 expression by CD8+ T cells promotes selective destruction of the host intestinal epithelium during graft-versus-host disease
    • El-Asady, R. et al. TGF-?-dependent CD103 expression by CD8+ T cells promotes selective destruction of the host intestinal epithelium during graft-versus-host disease. J. Exp. Med. 201, 1647-1657 (2005).
    • (2005) J. Exp. Med , vol.201 , pp. 1647-1657
    • El-Asady, R.1
  • 173
    • 80054897931 scopus 로고    scopus 로고
    • Mucosal memory CD8+ T cells are selected in the periphery by an MHC class i molecule
    • Huang, Y. et al. Mucosal memory CD8+ T cells are selected in the periphery by an MHC class I molecule. Nature Immunol. 12, 1086-1095 (2011).
    • (2011) Nature Immunol , vol.12 , pp. 1086-1095
    • Huang, Y.1
  • 174
    • 84860788997 scopus 로고    scopus 로고
    • Long-lived epithelial immunity by tissue-resident memory T (TRM) cells in the absence of persisting local antigen presentation
    • Mackay, L. K. et al. Long-lived epithelial immunity by tissue-resident memory T (TRM) cells in the absence of persisting local antigen presentation. Proc. Natl Acad. Sci. USA 109, 7037-7042 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 7037-7042
    • Mackay, L.K.1
  • 175
    • 84869082967 scopus 로고    scopus 로고
    • A vaccine strategy that protects against genital herpes by establishing local memory T cells
    • Shin, H. & Iwasaki, A. A vaccine strategy that protects against genital herpes by establishing local memory T cells. Nature 491, 463-467 (2012).
    • (2012) Nature , vol.491 , pp. 463-467
    • Shin, H.1    Iwasaki, A.2
  • 176
    • 79957618772 scopus 로고    scopus 로고
    • Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine
    • Hansen, S. G. et al. Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine. Nature 473, 523-527 (2011).
    • (2011) Nature , vol.473 , pp. 523-527
    • Hansen, S.G.1
  • 177
    • 44349195660 scopus 로고    scopus 로고
    • The regulation of IgA class switching
    • Cerutti, A. The regulation of IgA class switching. Nature Rev. Immunol. 8, 421-434 (2008).
    • (2008) Nature Rev. Immunol , vol.8 , pp. 421-434
    • Cerutti, A.1
  • 178
    • 33751223544 scopus 로고    scopus 로고
    • Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells
    • Mora, J. R. et al. Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells. Science 314, 1157-1160 (2006).
    • (2006) Science , vol.314 , pp. 1157-1160
    • Mora, J.R.1
  • 179
    • 0036732753 scopus 로고    scopus 로고
    • DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL
    • Litinskiy, M. B. et al. DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL. Nature Immunol. 3, 822-829 (2002).
    • (2002) Nature Immunol , vol.3 , pp. 822-829
    • Litinskiy, M.B.1
  • 180
    • 12344297875 scopus 로고    scopus 로고
    • TACI and BAFF-R mediate isotype switching in B cells
    • Castigli, E. et al. TACI and BAFF-R mediate isotype switching in B cells. J. Exp. Med. 201, 35-39 (2005).
    • (2005) J. Exp. Med , vol.201 , pp. 35-39
    • Castigli, E.1
  • 181
    • 23044443492 scopus 로고    scopus 로고
    • Mutations in TNFRSF13B encoding TACI are associated with common variable immunodeficiency in humans
    • Salzer, U. et al. Mutations in TNFRSF13B encoding TACI are associated with common variable immunodeficiency in humans. Nature Genet. 37, 820-828 (2005).
    • (2005) Nature Genet , vol.37 , pp. 820-828
    • Salzer, U.1
  • 182
    • 23044463627 scopus 로고    scopus 로고
    • TACI is mutant in common variable immunodeficiency and IgA deficiency
    • Castigli, E. et al. TACI is mutant in common variable immunodeficiency and IgA deficiency. Nature Genet. 37, 829-834 (2005).
    • (2005) Nature Genet , vol.37 , pp. 829-834
    • Castigli, E.1
  • 183
    • 35548974423 scopus 로고    scopus 로고
    • Identification of stem cells in small intestine and colon by marker gene Lgr5
    • Barker, N. et al. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 449, 1003-1007 (2007).
    • (2007) Nature , vol.449 , pp. 1003-1007
    • Barker, N.1
  • 184
    • 83255193921 scopus 로고    scopus 로고
    • Interconversion between intestinal stem cell populations in distinct niches
    • Takeda, N. et al. Interconversion between intestinal stem cell populations in distinct niches. Science 334, 1420-1424 (2011).
    • (2011) Science , vol.334 , pp. 1420-1424
    • Takeda, N.1
  • 185
    • 84862946094 scopus 로고    scopus 로고
    • The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations
    • Yan, K. S. et al. The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations. Proc. Natl Acad. Sci. USA 109, 466-471 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 466-471
    • Yan, K.S.1
  • 186
    • 84867660831 scopus 로고    scopus 로고
    • IFN-? and TNF-?-induced GBP-1 inhibits epithelial cell proliferation through suppression of ?-catenin/TCF signaling
    • Capaldo, C. T. et al. IFN-? and TNF-?-induced GBP-1 inhibits epithelial cell proliferation through suppression of ?-catenin/TCF signaling. Mucosal Immunol. 5, 681-690 (2012).
    • (2012) Mucosal Immunol , vol.5 , pp. 681-690
    • Capaldo, C.T.1
  • 187
    • 77949937466 scopus 로고    scopus 로고
    • Interferon-? Regulates intestinal epithelial homeostasis through converging ?-Catenin signaling pathways
    • Nava, P. et al. Interferon-? regulates intestinal epithelial homeostasis through converging ?-catenin signaling pathways. Immunity 32, 392-402 (2010).
    • (2010) Immunity , vol.32 , pp. 392-402
    • Nava, P.1
  • 188
    • 84889565117 scopus 로고    scopus 로고
    • Histone deacetylase 3 coordinates commensal-bacteria-dependent intestinal homeostasis
    • Alenghat, T. et al. Histone deacetylase 3 coordinates commensal-bacteria-dependent intestinal homeostasis. Nature 504, 153-157 (2013).
    • (2013) Nature , vol.504 , pp. 153-157
    • Alenghat, T.1
  • 189
    • 30944443377 scopus 로고    scopus 로고
    • Epithelial myosin light chain kinase expression and activity are upregulated in inflammatory bowel disease
    • Blair, S. A., Kane, S. V., Clayburgh, D. R. & Turner, J. R. Epithelial myosin light chain kinase expression and activity are upregulated in inflammatory bowel disease. Lab. Invest. 86, 191-201 (2006).
    • (2006) Lab. Invest , vol.86 , pp. 191-201
    • Blair, S.A.1    Kane, S.V.2    Clayburgh, D.R.3    Turner, J.R.4
  • 190
    • 77950585581 scopus 로고    scopus 로고
    • Caveolin-1-dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo
    • Marchiando, A. M. et al. Caveolin-1-dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo. J. Cell Biol. 189, 111-126 (2010).
    • (2010) J. Cell Biol , vol.189 , pp. 111-126
    • Marchiando, A.M.1
  • 191
    • 79952089399 scopus 로고    scopus 로고
    • Active deformation of apoptotic intestinal epithelial cells with adhesion-restricted polarity contributes to apoptotic clearance
    • Wang, F. et al. Active deformation of apoptotic intestinal epithelial cells with adhesion-restricted polarity contributes to apoptotic clearance. Lab. Invest. 91, 462-471 (2011).
    • (2011) Lab. Invest , vol.91 , pp. 462-471
    • Wang, F.1
  • 192
    • 84860109015 scopus 로고    scopus 로고
    • Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia
    • Eisenhoffer, G. T. et al. Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia. Nature 484, 546-549 (2012).
    • (2012) Nature , vol.484 , pp. 546-549
    • Eisenhoffer, G.T.1
  • 193
    • 0032871326 scopus 로고    scopus 로고
    • Intestinal permeability test as a predictor of clinical course in Crohns disease
    • DInc, R. et al. Intestinal permeability test as a predictor of clinical course in Crohns disease. Am. J. Gastroenterol. 94, 2956-2960 (1999).
    • (1999) Am. J. Gastroenterol , vol.94 , pp. 2956-2960
    • Dinc, R.1
  • 194
    • 0027217379 scopus 로고
    • Intestinal permeability and the prediction of relapse in Crohns disease
    • Wyatt, J. & Vogelsang, H. Intestinal permeability and the prediction of relapse in Crohns disease. Lancet 341, 1437 (1993).
    • (1993) Lancet , vol.341 , pp. 1437
    • Wyatt, J.1    Vogelsang, H.2
  • 195
    • 84866523733 scopus 로고    scopus 로고
    • Compromised intestinal epithelial barrier induces adaptive immune compensation that protects from colitis
    • Khounlotham, M. et al. Compromised intestinal epithelial barrier induces adaptive immune compensation that protects from colitis. Immunity 37, 563-573 (2012).
    • (2012) Immunity , vol.37 , pp. 563-573
    • Khounlotham, M.1
  • 196
    • 58649090901 scopus 로고    scopus 로고
    • Targeted epithelial tight junction dysfunction causes immune activation and contributes to development of experimental colitis
    • Su, L. et al. Targeted epithelial tight junction dysfunction causes immune activation and contributes to development of experimental colitis. Gastroenterology 136, 551-563 (2009).
    • (2009) Gastroenterology , vol.136 , pp. 551-563
    • Su, L.1


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