메뉴 건너뛰기




Volumn 9, Issue 1, 2018, Pages

Molecular and functional heterogeneity of IL-10-producing CD4 + T cells

(28)  Brockmann, Leonie a   Soukou, Shiwa a   Steglich, Babett a   Czarnewski, Paulo b   Zhao, Lilan a   Wende, Sandra a   Bedke, Tanja a   Ergen, Can a   Manthey, Carolin a   Agalioti, Theodora a   Geffken, Maria a   Seiz, Oliver a   Parigi, Sara M b   Sorini, Chiara b   Geginat, Jens c   Fujio, Keishi d   Jacobs, Thomas e   Roesch, Thomas a   Izbicki, Jacob R a   Lohse, Ansgar W a   more..


Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 2 RECEPTOR ALPHA; TRANSCRIPTION FACTOR FOXP3; TRANSCRIPTOME; IL10 PROTEIN, HUMAN; IL10 PROTEIN, MOUSE;

EID: 85058925987     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/s41467-018-07581-4     Document Type: Article
Times cited : (91)

References (80)
  • 1
    • 70949087383 scopus 로고    scopus 로고
    • Inflammatory bowel disease and mutations affecting the interleukin-10 receptor
    • COI: 1:CAS:528:DC%2BD1MXhsVequ7bM
    • Glocker, E. O. et al. Inflammatory bowel disease and mutations affecting the interleukin-10 receptor. N. Engl. J. Med. 361, 2033–2045 (2009).
    • (2009) N. Engl. J. Med. , vol.361 , pp. 2033-2045
    • Glocker, E.O.1
  • 2
    • 84864206050 scopus 로고    scopus 로고
    • Loss of interleukin-10 signaling and infantile inflammatory bowel disease: implications for diagnosis and therapy
    • COI: 1:CAS:528:DC%2BC38XhtV2ntbvN
    • Kotlarz, D. et al. Loss of interleukin-10 signaling and infantile inflammatory bowel disease: implications for diagnosis and therapy. Gastroenterology 143, 347–355 (2012).
    • (2012) Gastroenterology , vol.143 , pp. 347-355
    • Kotlarz, D.1
  • 3
    • 0029028515 scopus 로고
    • Circulating antiinflammatory cytokine IL-10 in patients with inflammatory bowel disease (IBD)
    • COI: 1:STN:280:DyaK2M3pt1eqsQ%3D%3D
    • Kucharzik, T., Stoll, R., Lugering, N. & Domschke, W. Circulating antiinflammatory cytokine IL-10 in patients with inflammatory bowel disease (IBD). Clin. Exp. Immunol. 100, 452–456 (1995).
    • (1995) Clin. Exp. Immunol. , vol.100 , pp. 452-456
    • Kucharzik, T.1    Stoll, R.2    Lugering, N.3    Domschke, W.4
  • 4
    • 0033782650 scopus 로고    scopus 로고
    • IL-10 secretion and sensitivity in normal human intestine and inflammatory bowel disease
    • COI: 1:CAS:528:DC%2BD3cXnvV2ktbg%3D
    • Gasche, C. et al. IL-10 secretion and sensitivity in normal human intestine and inflammatory bowel disease. J. Clin. Immunol. 20, 362–370 (2000).
    • (2000) J. Clin. Immunol. , vol.20 , pp. 362-370
    • Gasche, C.1
  • 5
    • 0141650591 scopus 로고    scopus 로고
    • Over-expression of interleukin 10 in mucosal T cells of patients with active ulcerative colitis
    • COI: 1:CAS:528:DC%2BD3sXos1Cks7c%3D
    • Melgar, S. et al. Over-expression of interleukin 10 in mucosal T cells of patients with active ulcerative colitis. Clin. Exp. Immunol. 134, 127–137 (2003).
    • (2003) Clin. Exp. Immunol. , vol.134 , pp. 127-137
    • Melgar, S.1
  • 6
    • 84964311408 scopus 로고    scopus 로고
    • Two FOXP3(+)CD4(+) T cell subpopulations distinctly control the prognosis of colorectal cancers
    • COI: 1:CAS:528:DC%2BC28Xms1OnsbY%3D
    • Saito, T. et al. Two FOXP3(+)CD4(+) T cell subpopulations distinctly control the prognosis of colorectal cancers. Nat. Med. 22, 679–684 (2016).
    • (2016) Nat. Med. , vol.22 , pp. 679-684
    • Saito, T.1
  • 7
    • 33750375612 scopus 로고    scopus 로고
    • Characterization of Foxp3+CD4+CD25+and IL-10-secreting CD4+CD25+T cells during cure of colitis
    • COI: 1:CAS:528:DC%2BD28XhtFSns77E
    • Uhlig, H. H. et al. Characterization of Foxp3+CD4+CD25+and IL-10-secreting CD4+CD25+T cells during cure of colitis. J. Immunol. 177, 5852–5860 (2006).
    • (2006) J. Immunol. , vol.177 , pp. 5852-5860
    • Uhlig, H.H.1
  • 8
    • 34249309861 scopus 로고    scopus 로고
    • Expression and functional characterization of FOXP3+CD4+regulatory T cells in ulcerative colitis
    • Yu, Q. T. et al. Expression and functional characterization of FOXP3+CD4+regulatory T cells in ulcerative colitis. Inflamm. Bowel Dis. 13, 191–199 (2007).
    • (2007) Inflamm. Bowel Dis. , vol.13 , pp. 191-199
    • Yu, Q.T.1
  • 9
    • 20444434616 scopus 로고    scopus 로고
    • Peripheral and intestinal regulatory CD4+CD25(high) T cells in inflammatory bowel disease
    • COI: 1:CAS:528:DC%2BD2MXlvFKlsLo%3D
    • Maul, J. et al. Peripheral and intestinal regulatory CD4+CD25(high) T cells in inflammatory bowel disease. Gastroenterology 128, 1868–1878 (2005).
    • (2005) Gastroenterology , vol.128 , pp. 1868-1878
    • Maul, J.1
  • 10
    • 33746338535 scopus 로고    scopus 로고
    • Interleukin-10-secreting type 1 regulatory T cells in rodents and humans
    • COI: 1:CAS:528:DC%2BD28XpvFegtr4%3D
    • Roncarolo, M. G. et al. Interleukin-10-secreting type 1 regulatory T cells in rodents and humans. Immunol. Rev. 212, 28–50 (2006).
    • (2006) Immunol. Rev. , vol.212 , pp. 28-50
    • Roncarolo, M.G.1
  • 11
    • 84880275285 scopus 로고    scopus 로고
    • Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells
    • COI: 1:CAS:528:DC%2BC3sXms1Wmu7c%3D
    • Gagliani, N. et al. Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells. Nat. Med. 19, 739–746 (2013).
    • (2013) Nat. Med. , vol.19 , pp. 739-746
    • Gagliani, N.1
  • 12
    • 84953639850 scopus 로고    scopus 로고
    • IL-10-producing forkhead box protein 3-negative regulatory T cells inhibit B-cell responses and are involved in systemic lupus erythematosus
    • COI: 1:CAS:528:DC%2BC28XjvFOrug%3D%3D, e315
    • Facciotti, F. et al. IL-10-producing forkhead box protein 3-negative regulatory T cells inhibit B-cell responses and are involved in systemic lupus erythematosus. J. Allergy Clin. Immunol. 137, 318–321 (2016). e315.
    • (2016) J. Allergy Clin. Immunol. , vol.137 , pp. 318-321
    • Facciotti, F.1
  • 13
    • 84895561909 scopus 로고    scopus 로고
    • Immunological outcome in haploidentical-HSC transplanted patients treated with IL-10-anergized donor T cells
    • Bacchetta, R. et al. Immunological outcome in haploidentical-HSC transplanted patients treated with IL-10-anergized donor T cells. Front. Immunol. 5, 16 (2014).
    • (2014) Front. Immunol. , vol.5 , pp. 16
    • Bacchetta, R.1
  • 14
    • 84994796857 scopus 로고    scopus 로고
    • Identification of tonsillar CD4+CD25-LAG3+T cells as naturally occurring IL-10-producing regulatory T cells in human lymphoid tissue
    • COI: 1:CAS:528:DC%2BC28XhsFCmtr7I
    • Sumitomo, S. et al. Identification of tonsillar CD4+CD25-LAG3+T cells as naturally occurring IL-10-producing regulatory T cells in human lymphoid tissue. J. Autoimmun. 76, 75–84 (2017).
    • (2017) J. Autoimmun. , vol.76 , pp. 75-84
    • Sumitomo, S.1
  • 15
    • 84964027075 scopus 로고    scopus 로고
    • Mixed chimerism evolution is associated with T regulatory type 1 (Tr1) cells in a beta-thalassemic patient after haploidentical haematopoietic stem cell transplantation
    • Andreani, M. et al. Mixed chimerism evolution is associated with T regulatory type 1 (Tr1) cells in a beta-thalassemic patient after haploidentical haematopoietic stem cell transplantation. Chimerism 5, 75–79 (2014).
    • (2014) Chimerism , vol.5 , pp. 75-79
    • Andreani, M.1
  • 16
    • 84926302707 scopus 로고    scopus 로고
    • HLA-G expression levels influence the tolerogenic activity of human DC-10
    • Amodio, G. et al. HLA-G expression levels influence the tolerogenic activity of human DC-10. Haematologica 100, 548–557 (2015).
    • (2015) Haematologica , vol.100 , pp. 548-557
    • Amodio, G.1
  • 17
    • 84941209805 scopus 로고    scopus 로고
    • Generation of donor-specific T regulatory type 1 cells from patients on dialysis for cell therapy after kidney transplantation
    • COI: 1:CAS:528:DC%2BC2MXht12lu7rL
    • Petrelli, A. et al. Generation of donor-specific T regulatory type 1 cells from patients on dialysis for cell therapy after kidney transplantation. Transplantation 99, 1582–1589 (2015).
    • (2015) Transplantation , vol.99 , pp. 1582-1589
    • Petrelli, A.1
  • 18
    • 84936768445 scopus 로고    scopus 로고
    • Tr1 cells, but not Foxp3+regulatory T cells, suppress NLRP3 inflammasome activation via an IL-10-dependent mechanism
    • COI: 1:CAS:528:DC%2BC2MXhtFSms7jL
    • Yao, Y. et al. Tr1 cells, but not Foxp3+regulatory T cells, suppress NLRP3 inflammasome activation via an IL-10-dependent mechanism. J. Immunol. 195, 488–497 (2015).
    • (2015) J. Immunol. , vol.195 , pp. 488-497
    • Yao, Y.1
  • 19
    • 84930576092 scopus 로고    scopus 로고
    • Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-alpha
    • COI: 1:CAS:528:DC%2BC2MXhtFemtr7P
    • Mascanfroni, I. D. et al. Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-alpha. Nat. Med. 21, 638–646 (2015).
    • (2015) Nat. Med. , vol.21 , pp. 638-646
    • Mascanfroni, I.D.1
  • 20
    • 84907371316 scopus 로고    scopus 로고
    • Sequential transcriptional changes dictate safe and effective antigen-specific immunotherapy
    • COI: 1:CAS:528:DC%2BC2MXksVCis74%3D
    • Burton, B. R. et al. Sequential transcriptional changes dictate safe and effective antigen-specific immunotherapy. Nat. Commun. 5, 4741 (2014).
    • (2014) Nat. Commun. , vol.5
    • Burton, B.R.1
  • 21
    • 69249083836 scopus 로고    scopus 로고
    • Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells
    • COI: 1:CAS:528:DC%2BD1MXotFWgt70%3D
    • Pot, C. et al. Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells. J. Immunol. 183, 797–801 (2009).
    • (2009) J. Immunol. , vol.183 , pp. 797-801
    • Pot, C.1
  • 22
    • 84876436991 scopus 로고    scopus 로고
    • Egr-2 transcription factor is required for Blimp-1-mediated IL-10 production in IL-27-stimulated CD4+T cells
    • COI: 1:CAS:528:DC%2BC3sXivFyjtL4%3D
    • Iwasaki, Y. et al. Egr-2 transcription factor is required for Blimp-1-mediated IL-10 production in IL-27-stimulated CD4+T cells. Eur. J. Immunol. 43, 1063–1073 (2013).
    • (2013) Eur. J. Immunol. , vol.43 , pp. 1063-1073
    • Iwasaki, Y.1
  • 23
    • 69549124480 scopus 로고    scopus 로고
    • CD4+CD25-LAG3+regulatory T cells controlled by the transcription factor Egr-2
    • COI: 1:CAS:528:DC%2BD1MXhtFWgt7nE
    • Okamura, T. et al. CD4+CD25-LAG3+regulatory T cells controlled by the transcription factor Egr-2. Proc. Natl Acad. Sci. USA 106, 13974–13979 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 13974-13979
    • Okamura, T.1
  • 24
    • 85011685238 scopus 로고    scopus 로고
    • Critical role of IRF1 and BATF in forming chromatin landscape during type 1 regulatory cell differentiation
    • COI: 1:CAS:528:DC%2BC2sXitlyitrw%3D
    • Karwacz, K. et al. Critical role of IRF1 and BATF in forming chromatin landscape during type 1 regulatory cell differentiation. Nat. Immunol. 18, 412–421 (2017).
    • (2017) Nat. Immunol. , vol.18 , pp. 412-421
    • Karwacz, K.1
  • 25
    • 85028924924 scopus 로고    scopus 로고
    • Eomesodermin promotes the development of type 1 regulatory T (TR1) cells
    • Zhang, P. et al. Eomesodermin promotes the development of type 1 regulatory T (TR1) cells. Sci. Immunol. 2, eaah7152 (2017).
    • (2017) Sci. Immunol. , vol.2 , pp. eaah7152
    • Zhang, P.1
  • 26
    • 85021092072 scopus 로고    scopus 로고
    • ITK signalling via the Ras/IRF4 pathway regulates the development and function of Tr1 cells
    • COI: 1:CAS:528:DC%2BC2sXhtVeqtbvF
    • Huang, W., Solouki, S., Koylass, N., Zheng, S. G. & August, A. ITK signalling via the Ras/IRF4 pathway regulates the development and function of Tr1 cells. Nat. Commun. 8, 15871 (2017).
    • (2017) Nat. Commun. , vol.8
    • Huang, W.1    Solouki, S.2    Koylass, N.3    Zheng, S.G.4    August, A.5
  • 27
    • 85014699932 scopus 로고    scopus 로고
    • IL-10 receptor signaling is essential for TR1 cell function in vivo
    • COI: 1:CAS:528:DC%2BC2sXhtlaitbk%3D
    • Brockmann, L. et al. IL-10 receptor signaling is essential for TR1 cell function in vivo. J. Immunol. 198, 1130–1141 (2017).
    • (2017) J. Immunol. , vol.198 , pp. 1130-1141
    • Brockmann, L.1
  • 28
    • 84929955331 scopus 로고    scopus 로고
    • Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation
    • COI: 1:CAS:528:DC%2BC2MXnsVWruro%3D
    • Gagliani, N. et al. Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation. Nature 523, 221–225 (2015).
    • (2015) Nature , vol.523 , pp. 221-225
    • Gagliani, N.1
  • 29
    • 79954608756 scopus 로고    scopus 로고
    • Memory/effector (CD45RB(lo)) CD4 T cells are controlled directly by IL-10 and cause IL-22-dependent intestinal pathology
    • COI: 1:CAS:528:DC%2BC3MXmt1Wrsb8%3D
    • Kamanaka, M. et al. Memory/effector (CD45RB(lo)) CD4 T cells are controlled directly by IL-10 and cause IL-22-dependent intestinal pathology. J. Exp. Med. 208, 1027–1040 (2011).
    • (2011) J. Exp. Med. , vol.208 , pp. 1027-1040
    • Kamanaka, M.1
  • 30
    • 79960919901 scopus 로고    scopus 로고
    • Control of TH17 cells occurs in the small intestine
    • COI: 1:CAS:528:DC%2BC3MXovFygsrc%3D
    • Esplugues, E. et al. Control of TH17 cells occurs in the small intestine. Nature 475, 514–518 (2011).
    • (2011) Nature , vol.475 , pp. 514-518
    • Esplugues, E.1
  • 31
    • 85020052926 scopus 로고    scopus 로고
    • Intratumoral FoxP3+Helios+regulatory T cells upregulating immunosuppressive molecules are expanded in human colorectal cancer
    • Syed Khaja, A. S., Toor, S. M., El Salhat, H., Ali, B. R. & Elkord, E. Intratumoral FoxP3+Helios+regulatory T cells upregulating immunosuppressive molecules are expanded in human colorectal cancer. Front. Immunol. 8, 619 (2017).
    • (2017) Front. Immunol. , vol.8 , pp. 619
    • Syed Khaja, A.S.1    Toor, S.M.2    El Salhat, H.3    Ali, B.R.4    Elkord, E.5
  • 32
    • 77951638740 scopus 로고    scopus 로고
    • Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+T regulatory cells
    • COI: 1:CAS:528:DC%2BC3cXjs1Wrt78%3D
    • Thornton, A. M. et al. Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+T regulatory cells. J. Immunol. 184, 3433–3441 (2010).
    • (2010) J. Immunol. , vol.184 , pp. 3433-3441
    • Thornton, A.M.1
  • 33
    • 84991678476 scopus 로고    scopus 로고
    • An essential role for the IL-2 receptor in Treg cell function
    • COI: 1:CAS:528:DC%2BC28XhsVGjs7%2FE
    • Chinen, T. et al. An essential role for the IL-2 receptor in Treg cell function. Nat. Immunol. 17, 1322–1333 (2016).
    • (2016) Nat. Immunol. , vol.17 , pp. 1322-1333
    • Chinen, T.1
  • 34
    • 85021239333 scopus 로고    scopus 로고
    • CTLA-4 expressed by FOXP3+regulatory T cells prevents inflammatory tissue attack and not T-cell priming in arthritis
    • COI: 1:CAS:528:DC%2BC2sXht1OjtrrI
    • Klocke, K., Holmdahl, R. & Wing, K. CTLA-4 expressed by FOXP3+regulatory T cells prevents inflammatory tissue attack and not T-cell priming in arthritis. Immunology 152, 125–137 (2017).
    • (2017) Immunology , vol.152 , pp. 125-137
    • Klocke, K.1    Holmdahl, R.2    Wing, K.3
  • 35
    • 84874100871 scopus 로고    scopus 로고
    • CTLA-4 promotes Foxp3 induction and regulatory T cell accumulation in the intestinal lamina propria
    • COI: 1:CAS:528:DC%2BC38Xht1ems7bM
    • Barnes, M. J. et al. CTLA-4 promotes Foxp3 induction and regulatory T cell accumulation in the intestinal lamina propria. Mucosal Immunol. 6, 324–334 (2013).
    • (2013) Mucosal Immunol. , vol.6 , pp. 324-334
    • Barnes, M.J.1
  • 36
    • 77955903212 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27
    • COI: 1:CAS:528:DC%2BC3cXpsFWltbo%3D
    • Apetoh, L. et al. The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27. Nat. Immunol. 11, 854–861 (2010).
    • (2010) Nat. Immunol. , vol.11 , pp. 854-861
    • Apetoh, L.1
  • 37
    • 84904727902 scopus 로고    scopus 로고
    • Id2 and Id3 maintain the regulatory T cell pool to suppress inflammatory disease
    • COI: 1:CAS:528:DC%2BC2cXhtVKlsrnL
    • Miyazaki, M. et al. Id2 and Id3 maintain the regulatory T cell pool to suppress inflammatory disease. Nat. Immunol. 15, 767–776 (2014).
    • (2014) Nat. Immunol. , vol.15 , pp. 767-776
    • Miyazaki, M.1
  • 38
    • 84969795465 scopus 로고    scopus 로고
    • Id2 reinforces TH1 differentiation and inhibits E2A to repress TFH differentiation
    • COI: 1:CAS:528:DC%2BC28XosFWhtrk%3D
    • Shaw, L. A. et al. Id2 reinforces TH1 differentiation and inhibits E2A to repress TFH differentiation. Nat. Immunol. 17, 834–843 (2016).
    • (2016) Nat. Immunol. , vol.17 , pp. 834-843
    • Shaw, L.A.1
  • 39
    • 77955859470 scopus 로고    scopus 로고
    • Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell-like and Foxp3(+) regulatory T cells
    • COI: 1:CAS:528:DC%2BC3cXpsFWks70%3D
    • Gandhi, R. et al. Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell-like and Foxp3(+) regulatory T cells. Nat. Immunol. 11, 846–853 (2010).
    • (2010) Nat. Immunol. , vol.11 , pp. 846-853
    • Gandhi, R.1
  • 40
    • 5644238762 scopus 로고    scopus 로고
    • Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells
    • COI: 1:CAS:528:DC%2BD2cXpslKjtb4%3D
    • Grossman, W. J. et al. Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells. Blood 104, 2840–2848 (2004).
    • (2004) Blood , vol.104 , pp. 2840-2848
    • Grossman, W.J.1
  • 41
    • 84877822326 scopus 로고    scopus 로고
    • An emerging role for Serine Protease Inhibitors in T lymphocyte immunity and beyond
    • COI: 1:CAS:528:DC%2BC3sXos12ltLw%3D
    • Ashton-Rickardt, P. G. An emerging role for Serine Protease Inhibitors in T lymphocyte immunity and beyond. Immunol. Lett. 152, 65–76 (2013).
    • (2013) Immunol. Lett. , vol.152 , pp. 65-76
    • Ashton-Rickardt, P.G.1
  • 42
    • 84883386689 scopus 로고    scopus 로고
    • Serine protease inhibitor 6 plays a critical role in protecting murine granzyme B-producing regulatory T cells
    • COI: 1:CAS:528:DC%2BC3sXhtlSgtbzP
    • Azzi, J. et al. Serine protease inhibitor 6 plays a critical role in protecting murine granzyme B-producing regulatory T cells. J. Immunol. 191, 2319–2327 (2013).
    • (2013) J. Immunol. , vol.191 , pp. 2319-2327
    • Azzi, J.1
  • 43
    • 82955248134 scopus 로고    scopus 로고
    • Induction of CD4+CD25+Foxp3+T regulatory cells by dendritic cells derived from ILT3 lentivirus-transduced human CD34+cells
    • Ge, G. et al. Induction of CD4+CD25+Foxp3+T regulatory cells by dendritic cells derived from ILT3 lentivirus-transduced human CD34+cells. Transpl. Immunol. 26, 19–26 (2012).
    • (2012) Transpl. Immunol. , vol.26 , pp. 19-26
    • Ge, G.1
  • 44
    • 70549104804 scopus 로고    scopus 로고
    • The inhibitory receptor LILRB4 (ILT3) modulates antigen presenting cell phenotype and, along with LILRB2 (ILT4), is upregulated in response to Salmonella infection
    • Brown, D. P. et al. The inhibitory receptor LILRB4 (ILT3) modulates antigen presenting cell phenotype and, along with LILRB2 (ILT4), is upregulated in response to Salmonella infection. BMC Immunol. 10, 56 (2009).
    • (2009) BMC Immunol. , vol.10 , pp. 56
    • Brown, D.P.1
  • 45
    • 84923490401 scopus 로고    scopus 로고
    • Protein kinase CK2 enables regulatory T cells to suppress excessive TH2 responses in vivo
    • COI: 1:CAS:528:DC%2BC2MXpvFWhsQ%3D%3D
    • Ulges, A. et al. Protein kinase CK2 enables regulatory T cells to suppress excessive TH2 responses in vivo. Nat. Immunol. 16, 267–275 (2015).
    • (2015) Nat. Immunol. , vol.16 , pp. 267-275
    • Ulges, A.1
  • 46
    • 56149105366 scopus 로고    scopus 로고
    • IL-12R beta 2 promotes the development of CD4+CD25+regulatory T cells
    • COI: 1:CAS:528:DC%2BD1cXhtVKntLvL
    • Zhao, Z. et al. IL-12R beta 2 promotes the development of CD4+CD25+regulatory T cells. J. Immunol. 181, 3870–3876 (2008).
    • (2008) J. Immunol. , vol.181 , pp. 3870-3876
    • Zhao, Z.1
  • 47
    • 0036885067 scopus 로고    scopus 로고
    • The lineage decisions of helper T cells
    • COI: 1:CAS:528:DC%2BD38XptFKnu7g%3D
    • Murphy, K. M. & Reiner, S. L. The lineage decisions of helper T cells. Nat. Rev. Immunol. 2, 933–944 (2002).
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 933-944
    • Murphy, K.M.1    Reiner, S.L.2
  • 48
    • 84899475568 scopus 로고    scopus 로고
    • Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells
    • COI: 1:CAS:528:DC%2BC2cXktlCktrk%3D
    • Mahmud, S. A. et al. Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells. Nat. Immunol. 15, 473–481 (2014).
    • (2014) Nat. Immunol. , vol.15 , pp. 473-481
    • Mahmud, S.A.1
  • 49
    • 0036170938 scopus 로고    scopus 로고
    • Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance
    • COI: 1:CAS:528:DC%2BD38XhtVygur8%3D
    • Shimizu, J., Yamazaki, S., Takahashi, T., Ishida, Y. & Sakaguchi, S. Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance. Nat. Immunol. 3, 135–142 (2002).
    • (2002) Nat. Immunol. , vol.3 , pp. 135-142
    • Shimizu, J.1    Yamazaki, S.2    Takahashi, T.3    Ishida, Y.4    Sakaguchi, S.5
  • 50
    • 58149337013 scopus 로고    scopus 로고
    • Tr1 and naturally occurring regulatory T cells induce IgG4 in B cells through GITR/GITR-L interaction, IL-10 and TGF-beta
    • COI: 1:CAS:528:DC%2BD1cXhsVymsLnM
    • Satoguina, J. S. et al. Tr1 and naturally occurring regulatory T cells induce IgG4 in B cells through GITR/GITR-L interaction, IL-10 and TGF-beta. Eur. J. Immunol. 38, 3101–3113 (2008).
    • (2008) Eur. J. Immunol. , vol.38 , pp. 3101-3113
    • Satoguina, J.S.1
  • 51
    • 84880280631 scopus 로고    scopus 로고
    • viSNE enables visualization of high dimensional single-cell data and reveals phenotypic heterogeneity of leukemia
    • Amir el, A. D. et al. viSNE enables visualization of high dimensional single-cell data and reveals phenotypic heterogeneity of leukemia. Nat. Biotechnol. 31, 545–552 (2013).
    • (2013) Nat. Biotechnol. , vol.31 , pp. 545-552
    • Amir el, A.D.1
  • 52
    • 85002252379 scopus 로고    scopus 로고
    • Acute malaria induces PD1+CTLA4+effector T cells with cell-extrinsic suppressor function
    • Mackroth, M. S., Abel, A., Steeg, C., Schulze Zur Wiesch, J. & Jacobs, T. Acute malaria induces PD1+CTLA4+effector T cells with cell-extrinsic suppressor function. PLoS Pathog. 12, e1005909 (2016).
    • (2016) PLoS Pathog. , vol.12
    • Mackroth, M.S.1    Abel, A.2    Steeg, C.3    Schulze Zur Wiesch, J.4    Jacobs, T.5
  • 53
    • 84881131933 scopus 로고    scopus 로고
    • The DREAM complex: master coordinator of cell cycle-dependent gene expression
    • COI: 1:CAS:528:DC%2BC3sXhtVykur%2FI
    • Sadasivam, S. & DeCaprio, J. A. The DREAM complex: master coordinator of cell cycle-dependent gene expression. Nat. Rev. Cancer 13, 585–595 (2013).
    • (2013) Nat. Rev. Cancer , vol.13 , pp. 585-595
    • Sadasivam, S.1    DeCaprio, J.A.2
  • 54
    • 18344393150 scopus 로고    scopus 로고
    • The E2F transcriptional network: old acquaintances with new faces
    • COI: 1:CAS:528:DC%2BD2MXjtlehs7g%3D
    • Dimova, D. K. & Dyson, N. J. The E2F transcriptional network: old acquaintances with new faces. Oncogene 24, 2810–2826 (2005).
    • (2005) Oncogene , vol.24 , pp. 2810-2826
    • Dimova, D.K.1    Dyson, N.J.2
  • 55
    • 84983619668 scopus 로고    scopus 로고
    • PLZF mutation alters mouse hematopoietic stem cell function and cell cycle progression
    • COI: 1:CAS:528:DC%2BC28XhsVaqtrzF
    • Vincent-Fabert, C. et al. PLZF mutation alters mouse hematopoietic stem cell function and cell cycle progression. Blood 127, 1881–1885 (2016).
    • (2016) Blood , vol.127 , pp. 1881-1885
    • Vincent-Fabert, C.1
  • 56
    • 84978388845 scopus 로고    scopus 로고
    • Liver X receptor and STAT1 cooperate downstream of Gas6/Mer to induce anti-inflammatory arginase 2 expression in macrophages
    • COI: 1:CAS:528:DC%2BC2sXksVeku7c%3D
    • Kim, S. Y. et al. Liver X receptor and STAT1 cooperate downstream of Gas6/Mer to induce anti-inflammatory arginase 2 expression in macrophages. Sci. Rep. 6, 29673 (2016).
    • (2016) Sci. Rep. , vol.6
    • Kim, S.Y.1
  • 57
    • 33644651160 scopus 로고    scopus 로고
    • Liver X receptors as integrators of metabolic and inflammatory signaling
    • COI: 1:CAS:528:DC%2BD28XitlGkt7o%3D
    • Zelcer, N. & Tontonoz, P. Liver X receptors as integrators of metabolic and inflammatory signaling. J. Clin. Invest. 116, 607–614 (2006).
    • (2006) J. Clin. Invest. , vol.116 , pp. 607-614
    • Zelcer, N.1    Tontonoz, P.2
  • 58
    • 84938335974 scopus 로고    scopus 로고
    • LXRs link metabolism to inflammation through Abca1-dependent regulation of membrane composition and TLR signaling
    • Ito, A. et al. LXRs link metabolism to inflammation through Abca1-dependent regulation of membrane composition and TLR signaling. eLife 4, e08009 (2015).
    • (2015) eLife , vol.4
    • Ito, A.1
  • 59
    • 85029792296 scopus 로고    scopus 로고
    • Liver X receptor activation promotes differentiation of regulatory T cells
    • Herold, M. et al. Liver X receptor activation promotes differentiation of regulatory T cells. PLoS ONE 12, e0184985 (2017).
    • (2017) PLoS ONE , vol.12
    • Herold, M.1
  • 60
    • 84959450362 scopus 로고    scopus 로고
    • Expanding antigen-specific regulatory networks to treat autoimmunity
    • COI: 1:CAS:528:DC%2BC28XislOqu7c%3D
    • Clemente-Casares, X. et al. Expanding antigen-specific regulatory networks to treat autoimmunity. Nature 530, 434–440 (2016).
    • (2016) Nature , vol.530 , pp. 434-440
    • Clemente-Casares, X.1
  • 61
    • 85013448421 scopus 로고    scopus 로고
    • Generation of donor-specific Tr1 cells to be used after kidney transplantation and definition of the timing of their in vivo infusion in the presence of immunosuppression
    • Mfarrej, B. et al. Generation of donor-specific Tr1 cells to be used after kidney transplantation and definition of the timing of their in vivo infusion in the presence of immunosuppression. J. Transl. Med. 15, 40 (2017).
    • (2017) J. Transl. Med. , vol.15
    • Mfarrej, B.1
  • 62
    • 85016945979 scopus 로고    scopus 로고
    • Activin-A co-opts IRF4 and AhR signaling to induce human regulatory T cells that restrain asthmatic responses
    • COI: 1:CAS:528:DC%2BC2sXksV2rsLs%3D
    • Tousa, S. et al. Activin-A co-opts IRF4 and AhR signaling to induce human regulatory T cells that restrain asthmatic responses. Proc. Natl Acad. Sci. USA 114, E2891–E2900 (2017).
    • (2017) Proc. Natl Acad. Sci. USA , vol.114 , pp. E2891-E2900
    • Tousa, S.1
  • 63
    • 84948401411 scopus 로고    scopus 로고
    • Increased frequency of CD49b/LAG-3(+) type 1 regulatory T cells in HIV-infected individuals
    • COI: 1:CAS:528:DC%2BC2MXhvFertL7J
    • Koch, K. et al. Increased frequency of CD49b/LAG-3(+) type 1 regulatory T cells in HIV-infected individuals. AIDS Res. Hum. Retroviruses 31, 1238–1246 (2015).
    • (2015) AIDS Res. Hum. Retroviruses , vol.31 , pp. 1238-1246
    • Koch, K.1
  • 64
    • 85018298907 scopus 로고    scopus 로고
    • Peptide-MHC-based nanomedicines for autoimmunity function as T-cell receptor microclustering devices
    • COI: 1:CAS:528:DC%2BC2sXmvVCmtrs%3D
    • Singha, S. et al. Peptide-MHC-based nanomedicines for autoimmunity function as T-cell receptor microclustering devices. Nat. Nanotechnol. 12, 701–710 (2017).
    • (2017) Nat. Nanotechnol. , vol.12 , pp. 701-710
    • Singha, S.1
  • 65
    • 84908153894 scopus 로고    scopus 로고
    • The oxysterol receptor LXRbeta protects against DSS- and TNBS-induced colitis in mice
    • COI: 1:CAS:528:DC%2BC2cXns1ajtLs%3D
    • Jakobsson, T. et al. The oxysterol receptor LXRbeta protects against DSS- and TNBS-induced colitis in mice. Mucosal Immunol. 7, 1416–1428 (2014).
    • (2014) Mucosal Immunol. , vol.7 , pp. 1416-1428
    • Jakobsson, T.1
  • 66
    • 0037188553 scopus 로고    scopus 로고
    • Synthetic LXR ligand inhibits the development of atherosclerosis in mice
    • COI: 1:CAS:528:DC%2BD38XktlCrsr8%3D
    • Joseph, S. B. et al. Synthetic LXR ligand inhibits the development of atherosclerosis in mice. Proc. Natl Acad. Sci. USA 99, 7604–7609 (2002).
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 7604-7609
    • Joseph, S.B.1
  • 67
    • 0034669171 scopus 로고    scopus 로고
    • Role of LXRs in control of lipogenesis
    • COI: 1:CAS:528:DC%2BD3cXos1ehsLg%3D
    • Schultz, J. R. et al. Role of LXRs in control of lipogenesis. Genes Dev. 14, 2831–2838 (2000).
    • (2000) Genes Dev. , vol.14 , pp. 2831-2838
    • Schultz, J.R.1
  • 68
    • 85029801818 scopus 로고    scopus 로고
    • IL-27-induced type 1 regulatory T-cells produce oxysterols that constrain IL-10 production
    • Vigne, S. et al. IL-27-induced type 1 regulatory T-cells produce oxysterols that constrain IL-10 production. Front. Immunol. 8, 1184 (2017).
    • (2017) Front. Immunol. , vol.8 , pp. 1184
    • Vigne, S.1
  • 69
    • 85054630864 scopus 로고    scopus 로고
    • Bhlhe40 is an essential repressor of IL-10 during Mycobacterium tuberculosis infection
    • COI: 1:CAS:528:DC%2BC1cXhvFaqsLzJ, PID: 29773644
    • Huynh, J. P. et al. Bhlhe40 is an essential repressor of IL-10 during Mycobacterium tuberculosis infection. J. Exp. Med. 215, 1823–1838 (2018).
    • (2018) J. Exp. Med. , vol.215 , pp. 1823-1838
    • Huynh, J.P.1
  • 70
    • 84868109200 scopus 로고    scopus 로고
    • Safety and efficacy of antigen-specific regulatory T-cell therapy for patients with refractory Crohn’s disease
    • COI: 1:CAS:528:DC%2BC38XhsVSlur%2FM, e1201-1202
    • Desreumaux, P. et al. Safety and efficacy of antigen-specific regulatory T-cell therapy for patients with refractory Crohn’s disease. Gastroenterology 143, 1207–1217 (2012). e1201-1202.
    • (2012) Gastroenterology , vol.143 , pp. 1207-1217
    • Desreumaux, P.1
  • 71
    • 84880076939 scopus 로고    scopus 로고
    • Why interleukin-10 supplementation does not work in Crohn’s disease patients
    • Marlow, G. J., van Gent, D. & Ferguson, L. R. Why interleukin-10 supplementation does not work in Crohn’s disease patients. World J. Gastroenterol. 19, 3931–3941 (2013).
    • (2013) World J. Gastroenterol. , vol.19 , pp. 3931-3941
    • Marlow, G.J.1    van Gent, D.2    Ferguson, L.R.3
  • 72
    • 0035101931 scopus 로고    scopus 로고
    • Hepatic cholesterol metabolism and resistance to dietary cholesterol in LXRbeta-deficient mice
    • COI: 1:CAS:528:DC%2BD3MXhs12ns7s%3D
    • Alberti, S. et al. Hepatic cholesterol metabolism and resistance to dietary cholesterol in LXRbeta-deficient mice. J. Clin. Invest. 107, 565–573 (2001).
    • (2001) J. Clin. Invest. , vol.107 , pp. 565-573
    • Alberti, S.1
  • 73
    • 84871809302 scopus 로고    scopus 로고
    • STAR: ultrafast universal RNA-seq aligner
    • COI: 1:CAS:528:DC%2BC38XhvV2gsbnF
    • Dobin, A. et al. STAR: ultrafast universal RNA-seq aligner. Bioinformatics 29, 15–21 (2013).
    • (2013) Bioinformatics , vol.29 , pp. 15-21
    • Dobin, A.1
  • 74
    • 74549125753 scopus 로고    scopus 로고
    • An abundance of ubiquitously expressed genes revealed by tissue transcriptome sequence data
    • Ramskold, D., Wang, E. T., Burge, C. B. & Sandberg, R. An abundance of ubiquitously expressed genes revealed by tissue transcriptome sequence data. PLoS Comput. Biol. 5, e1000598 (2009).
    • (2009) PLoS Comput. Biol. , vol.5
    • Ramskold, D.1    Wang, E.T.2    Burge, C.B.3    Sandberg, R.4
  • 75
    • 84872534134 scopus 로고    scopus 로고
    • Efficient and comprehensive representation of uniqueness for next-generation sequencing by minimum unique length analyses
    • COI: 1:CAS:528:DC%2BC3sXhvFCis7k%3D
    • Storvall, H., Ramskold, D. & Sandberg, R. Efficient and comprehensive representation of uniqueness for next-generation sequencing by minimum unique length analyses. PLoS One 8, e53822 (2013).
    • (2013) PLoS One , vol.8
    • Storvall, H.1    Ramskold, D.2    Sandberg, R.3
  • 76
    • 85091232873 scopus 로고    scopus 로고
    • RNA-Seq workflow: gene-level exploratory analysis and differential expression
    • Love, M. I., Anders, S., Kim, V. & Huber, W. RNA-Seq workflow: gene-level exploratory analysis and differential expression. F1000Research 4, 1070 (2015).
    • (2015) F1000Research , vol.4 , pp. 1070
    • Love, M.I.1    Anders, S.2    Kim, V.3    Huber, W.4
  • 77
    • 84924629414 scopus 로고    scopus 로고
    • Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
    • Love, M. I., Huber, W. & Anders, S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 15, 550 (2014).
    • (2014) Genome Biol. , vol.15
    • Love, M.I.1    Huber, W.2    Anders, S.3
  • 78
    • 85010931059 scopus 로고    scopus 로고
    • A step-by-step workflow for low-level analysis of single-cell RNA-seq data with Bioconductor
    • PID: 27909575
    • Lun, A. T., McCarthy, D. J. & Marioni, J. C. A step-by-step workflow for low-level analysis of single-cell RNA-seq data with Bioconductor. F1000Res. 5, 2122 (2016).
    • (2016) F1000Res. , vol.5 , pp. 2122
    • Lun, A.T.1    McCarthy, D.J.2    Marioni, J.C.3
  • 79
    • 84939772971 scopus 로고    scopus 로고
    • Computational assignment of cell-cycle stage from single-cell transcriptome data
    • COI: 1:CAS:528:DC%2BC2MXhtF2kurjF
    • Scialdone, A. et al. Computational assignment of cell-cycle stage from single-cell transcriptome data. Methods 85, 54–61 (2015).
    • (2015) Methods , vol.85 , pp. 54-61
    • Scialdone, A.1
  • 80
    • 84964556059 scopus 로고    scopus 로고
    • Pooling across cells to normalize single-cell RNA sequencing data with many zero counts
    • Lun, A. T., Bach, K. & Marioni, J. C. Pooling across cells to normalize single-cell RNA sequencing data with many zero counts. Genome Biol. 17, 75 (2016).
    • (2016) Genome Biol. , vol.17
    • Lun, A.T.1    Bach, K.2    Marioni, J.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.