IL-10 promotes production of intestinal mucus by suppressing protein misfolding and endoplasmic reticulum stress in goblet cells

Gastroenterology

Volumn 144, Issue 2, 2013, Pages

  Hasnain, Sumaira Z ^a   Tauro, Sharyn ^a   Das, Indrajit ^a   Tong, Hui ^a   Chen, Alicec H ^a   Jeffery, Penny L ^a   McDonald, Victoria ^a   Florin, Timothy H ^a   McGuckin, Michael A ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Immune regulation; Immunosuppression; Mucosal barrier; Unfolded Protein response

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; ANTERIOR GRADIENT HOMOLOG 2; GAMMA INTERFERON; GLUCOSE REGULATED PROTEIN 78; INTERLEUKIN 10; INTERLEUKIN 10 ANTIBODY; INTERLEUKIN 10 RECEPTOR; INTERLEUKIN 10 RECEPTOR 1; INTERLEUKIN 13; INTERLEUKIN 17; MUCIN 2; NEUTRALIZING ANTIBODY; PROTEIN; REACTIVE OXYGEN METABOLITE; RECOMBINANT INTERLEUKIN 10; SPDEF PROTEIN; STAT1 PROTEIN; STAT3 PROTEIN; TUMOR NECROSIS FACTOR ALPHA; TUNICAMYCIN; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1;

ANIMAL EXPERIMENT; ARTICLE; ASCENDING COLON; COLITIS; CONTROLLED STUDY; DESCENDING COLON; ENDOPLASMIC RETICULUM STRESS; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; GLYCOSYLATION; GOBLET CELL; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE MICROSCOPY; INTESTINAL MUCUS; MISSENSE MUTATION; MOUSE; MUCUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN MISFOLDING; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION; WEIGHT REDUCTION; WESTERN BLOTTING; WILD TYPE; ANIMAL; C57BL MOUSE; CELL CULTURE; COMPARATIVE STUDY; DISEASE MODEL; DRUG EFFECT; ENDOPLASMIC RETICULUM; INTESTINE MUCOSA; METABOLISM; PATHOLOGY; PROTEOSTASIS DEFICIENCY; SECRETION (PROCESS);

ANIMALS; CELLS, CULTURED; DISEASE MODELS, ANIMAL; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; GOBLET CELLS; HUMANS; INTERLEUKIN-10; INTESTINAL MUCOSA; MICE; MICE, INBRED C57BL; MUCUS; PROTEOSTASIS DEFICIENCIES;

EID: 84880653498     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2012.10.043     Document Type: Article

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